Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Clinical Associate- Cornea Fellowship, Ophthalmology, Duke University 2006 - 2008
  • Ophthalmology, University of Pittsburgh 2005 - 2006
  • Ophthalmology, University of Pittsburgh 2003 - 2005
  • Internal Medicine, University of Pittsburgh 2002 - 2003
  • M.D., Vanderbilt University 2002
• 

  Duke Appointment History

  • Assistant Professor of Ophthalmology, Ophthalmology, Corneal Diseases, Ophthalmology 2008 - 2017
  • Clinical Associate in the Department of Ophthalmology, Ophthalmology, Corneal Diseases, Ophthalmology 2007 - 2008
  • Clinical Associate in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2006 - 2007
• Research
• 

  Selected Grants

  • Targeting Scleral Stiffness as a Novel Therapeutic Approach in Glaucoma awarded by Georgia Institute of Technology 2015 - 2020
  • Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye Care awarded by National Institutes of Health 2014 - 2019
  • OCT Technology Development to Assess Ocular Integrity and Characterize Intraocular Scatterers awarded by United States Army Medical Research Acquisition Activity 2016 - 2019
  • Temporal dynamics of retinal ganglion cell neurodegeneration in glaucoma awarded by National Institutes of Health 2015 - 2018
  • Variability of Landmark Based Keratometry (VERION) Compared to Standard Automated Keratometry awarded by Alcon Research, Inc. 2016 - 2017
  • Intraoperative OCT Guidance of Intraocular Surgery awarded by National Institutes of Health 2013 - 2017
  • Field Deployable Optical Coherence Tomography for Triage of Ocular Trauma awarded by United States Army Medical Research and Materiel Command 2012 - 2016
  • Imaging to predict refractive outcomes after corneal endothelial keratoplasty awarded by National Institutes of Health 2011 - 2015
  • Motion Artifact Reduced SDOCT of the Anterior Segment awarded by National Institutes of Health 2010 - 2012
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Migacz, J, Carrasco-Zevallos, O, Hahn, P, Kuo, A, Toth, C, and Izatt, JA. "Intraoperative retinal optical coherence tomography." In Optical Coherence Tomography: Technology and Applications, Second Edition, 1771-1796. January 1, 2015.  Full Text

  • Conference Papers

    • Draelos, M, Keller, B, Toth, C, Kuo, A, Hauser, K, and Izatt, J. "Teleoperating robots from arbitrary viewpoints in surgical contexts." December 13, 2017.  Full Text
    • McNabb, RP, Viehland, C, Keller, B, Vann, RR, Izatt, JA, and Kuo, AN. "Truly simultaneous SS-OCT of the anterior and posterior human eye with full anterior chamber and 50 degrees retinal field of views." 2017.  Full Text  Link to Item
    • Bhullar, PK, Pasricha, ND, Zevallos-Carrasco, OM, Viehland, C, Keller, B, Daluvoy, MB, Challa, P, Freedman, SF, Izatt, JA, Toth, CA, and Kuo, AN. "4D Microscope-Integrated OCT to Visualize Depth-Related Steps During Anterior Segment and External Eye Procedures." September 2016.  Link to Item
    • McNabb, RP, Keller, B, Izatt, JA, and Kuo, AN. "Truly simultaneous OCT of the anterior and posterior eye with full anterior chamber depth and 30 degrees retinal field of view." September 2016.  Link to Item
    • Nariani, A, Kumar, DA, Agarwal, A, Perry, I, Tramber, M, Kuo, AN, Daluvoy, MB, Carlson, AN, and Kim, T. "Eye Bank Graft Preparation for Pre-Descemet's Endothelial Keratoplasty." September 2016.  Link to Item
    • Polans, J, LaRocca, F, Carrasco-Zevallos, O, Keller, B, Lad, EM, Whitson, H, Kuo, AN, Farsiu, S, and Izatt, JA. "Wide-Field Sensorless Adaptive Optics Optical Coherence Tomography for Enhanced Visualization of the Retinal Periphery." September 2016.  Link to Item
    • Shen, L, Keller, B, Carrasco-Zevallos, O, Viehland, C, Bhullar, PK, Waterman, G, Kuo, AN, Toth, CA, and Izatt, JA. "Oculus Rift (R) as a Head Tracking, Stereoscopic Head Mounted Display for Intra-Operative OCT in Ophthalmic Surgery." September 2016.  Link to Item
    • Carrasco-Zevallos, O, Keller, B, Viehland, C, Shen, L, Todorich, B, Shieh, C, Kuo, A, Toth, C, and Izatt, JA. "4D microscope-integrated OCT improves accuracy of ophthalmic surgical maneuvers." January 1, 2016.  Full Text
    • Bozho-Todorich, , Shieh, C, DeSouza, P, Carrasco-Zevallos, O, Cunefare, D, Izatt, JA, Farsiu, S, Mruthyunjaya, P, Kuo, AN, and Toth, CA. "Impact of Microscope Integrated OCT on ophthalmology resident performance of anterior segment maneuvers in model eyes." June 2015.  Link to Item
    • Carrasco-Zevallos, O, Keller, B, Viehland, C, Shen, L, Waterman, G, Chukwurah, C, Hahn, P, Kuo, AN, Toth, CA, and Izatt, JA. "Real-time 4D Stereoscopic Visualization of Human Ophthalmic Surgery with Swept-Source Microscope Integrated Optical Coherence Tomography." June 2015.  Link to Item
    • McNabb, RP, Grewal, DS, Schuman, S, Mruthyunjaya, P, Izatt, JA, and Kuo, AN. "Ultra wide-field swept-source optical coherence tomography for peripheral eye disease." June 2015.  Link to Item
    • Nankivil, D, Waterman, G, Keller, B, Kuo, AN, and Izatt, JA. "Handheld Convertible Anterior/Posterior Segment Swept Source Optical Coherence Tomography System." June 2015.  Link to Item
    • Pasricha, ND, Shieh, C, Carrasco-Zevallos, O, Keller, B, Daluvoy, M, Izatt, JA, Toth, CA, and Kuo, AN. "4D Intrasurgical Monitoring and Guidance of Anterior Segment Surgeries with Swept-Source Microscope Integrated Optical Coherence Tomography." June 2015.  Link to Item
    • Shen, L, Carrasco-Zevallos, O, Keller, B, Viehland, C, Waterman, G, Hahn, P, Kuo, AN, Toth, CA, and Izatt, JA. "Novel Microscope-Integrated Stereoscopic Heads-up Display for Intrasurgical OCT in Ophthalmic Surgery." June 2015.  Link to Item
    • Toth, CA, Carrasco-Zevallos, O, Keller, B, Shen, L, Viehland, C, Nam, DH, Hahn, P, Kuo, AN, and Izatt, JA. "Surgically integrated swept source optical coherence tomography (SSOCT) to guide vitreoretinal (VR) surgery." June 2015.  Link to Item
    • McNabb, RP, LaRocca, F, Farsiu, S, Kuo, AN, and Izatt, JA. "Distributed scan SDOCT improves post refractive surgery corneal biometry." December 1, 2012.
    • Dhalla, A-H, Bustamante, T, Nankivil, D, Hendargo, H, McNabb, R, Kuo, A, and Izatt, JA. "Dual-depth SSOCT for simultaneous complex resolved anterior segment and conventional retinal imaging." 2012.  Full Text  Link to Item

  • Journal Articles

    • Deng, SX, Lee, WB, Hammersmith, KM, Kuo, AN, Li, JY, Shen, JF, Weikert, MP, and Shtein, RM. "Descemet Membrane Endothelial Keratoplasty: Safety and Outcomes: A Report by the American Academy of Ophthalmology." Ophthalmology 125, no. 2 (February 2018): 295-310.  Full Text
    • Bhullar, PK, Carrasco-Zevallos, OM, Dandridge, A, Pasricha, ND, Keller, B, Shen, L, Izatt, JA, Toth, CA, and Kuo, AN. "Intraocular Pressure and Big Bubble Diameter in Deep Anterior Lamellar Keratoplasty: An Ex-Vivo Microscope-Integrated OCT With Heads-Up Display Study." Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 6, no. 5 (September 2017): 412-417.  Full Text
    • McNabb, RP, Tian, J, Farsiu, S, Izatt, JA, Lad, EM, and Kuo, AN. "Retinal imaging in human autopsy eyes using a custom optical coherence tomography periscope." Biomedical optics express 8, no. 9 (September 2017): 4152-4159.  Full Text
    • Grewal, DS, Bhullar, PK, Pasricha, ND, Carrasco-Zevallos, OM, Viehland, C, Keller, B, Shen, L, Izatt, JA, Kuo, AN, Toth, CA, and Mruthyunjaya, P. "Intraoperative 4-Dimensional Microscope-Integrated Optical Coherence Tomography-Guided 27-Gauge Transvitreal Choroidal Biopsy for Choroidal Melanoma." Retina (Philadelphia, Pa.) 37, no. 4 (April 2017): 796-799.  Full Text
    • Carrasco-Zevallos, OM, Viehland, C, Keller, B, Draelos, M, Kuo, AN, Toth, CA, and Izatt, JA. "Review of intraoperative optical coherence tomography: technology and applications [Invited]." Biomedical optics express 8, no. 3 (March 2017): 1607-1637.  Full Text
    • Pasricha, ND, Bhullar, PK, Shieh, C, Carrasco-Zevallos, OM, Keller, B, Izatt, JA, Toth, CA, Freedman, SF, and Kuo, AN. "Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery." Journal of pediatric ophthalmology and strabismus 54 (February 14, 2017): e1-e5.  Full Text
    • Margeta, MA, Kuo, AN, Proia, AD, and Freedman, SF. "Staying away from the optic nerve: a formula for modifying glaucoma drainage device surgery in pediatric and other small eyes." Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 21, no. 1 (February 2017): 39-43.e1.  Full Text
    • Mehta, R, Nankivil, D, Zielinski, DJ, Waterman, G, Keller, B, Limkakeng, AT, Kopper, R, Izatt, JA, and Kuo, AN. "Wireless, Web-Based Interactive Control of Optical Coherence Tomography with Mobile Devices." Translational vision science & technology 6, no. 1 (January 20, 2017): 5-.  Full Text  Open Access Copy
    • Mukherjee, N, McBurney-Lin, S, Kuo, A, Bedlack, R, and Tseng, H. "Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease." PloS one 12, no. 9 (January 2017): e0185242-.  Full Text
    • Pasricha, ND, Bhullar, PK, Shieh, C, Viehland, C, Carrasco-Zevallos, OM, Keller, B, Izatt, JA, Toth, CA, Challa, P, and Kuo, AN. "Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries." Indian journal of ophthalmology 65, no. 1 (January 2017): 57-59.  Full Text
    • Lezama, J, Mukherjee, D, McNabb, RP, Sapiro, G, Kuo, AN, and Farsiu, S. "Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes." Biomedical optics express 7, no. 12 (December 2016): 4827-4846.  Full Text
    • Pasricha, ND, Shieh, C, Carrasco-Zevallos, OM, Keller, B, Cunefare, D, Mehta, JS, Farsiu, S, Izatt, JA, Toth, CA, and Kuo, AN. "Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study." Cornea 35, no. 11 (November 2016): 1471-1477.  Full Text
    • McNabb, RP, Blanco, T, Bomze, HM, Tseng, HC, Saban, DR, Izatt, JA, and Kuo, AN. "Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice." Experimental eye research 151 (October 2016): 68-74.  Full Text
    • McNabb, RP, Grewal, DS, Mehta, R, Schuman, SG, Izatt, JA, Mahmoud, TH, Jaffe, GJ, Mruthyunjaya, P, and Kuo, AN. "Wide field of view swept-source optical coherence tomography for peripheral retinal disease." The British journal of ophthalmology 100, no. 10 (October 2016): 1377-1382.  Full Text
    • Mehta, R, Nankivil, D, Zielinski, DJ, Waterman, G, Keller, B, Adari, P, Kopper, R, Izatt, JA, and Kuo, AN. "Remote, web-based interface control of handheld swept source OCT system for acute care settings." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 57, no. 12 (September 2016).  Link to Item
    • Carrasco-Zevallos, OM, Keller, B, Viehland, C, Shen, L, Waterman, G, Todorich, B, Shieh, C, Hahn, P, Farsiu, S, Kuo, AN, Toth, CA, and Izatt, JA. "Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography." Scientific reports 6 (August 19, 2016): 31689-.  Full Text  Open Access Copy
    • Kuo, AN, Verkicharla, PK, McNabb, RP, Cheung, CY, Hilal, S, Farsiu, S, Chen, C, Wong, TY, Ikram, MK, Cheng, CY, Young, TL, Saw, SM, and Izatt, JA. "Posterior Eye Shape Measurement With Retinal OCT Compared to MRI." Investigative ophthalmology & visual science 57, no. 9 (July 2016): OCT196-OCT203.  Full Text
    • Todorich, B, Shieh, C, DeSouza, PJ, Carrasco-Zevallos, OM, Cunefare, DL, Stinnett, SS, Izatt, JA, Farsiu, S, Mruthyunjaya, P, Kuo, AN, and Toth, CA. "Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes." Investigative ophthalmology & visual science 57, no. 9 (July 2016): OCT146-OCT153.  Full Text
    • Shen, L, Carrasco-Zevallos, O, Keller, B, Viehland, C, Waterman, G, Hahn, PS, Kuo, AN, Toth, CA, and Izatt, JA. "Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography." Biomedical optics express 7, no. 5 (May 2016): 1711-1726.  Full Text
    • Viehland, C, Keller, B, Carrasco-Zevallos, OM, Nankivil, D, Shen, L, Mangalesh, S, Viet, DT, Kuo, AN, Toth, CA, and Izatt, JA. "Enhanced volumetric visualization for real time 4D intraoperative ophthalmic swept-source OCT." Biomedical optics express 7, no. 5 (May 2016): 1815-1829.  Full Text
    • Nankivil, D, Waterman, G, LaRocca, F, Keller, B, Kuo, AN, and Izatt, JA. "Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe." Biomedical optics express 6, no. 11 (November 2015): 4516-4528.  Full Text
    • McNabb, RP, Challa, P, Kuo, AN, and Izatt, JA. "Complete 360° circumferential gonioscopic optical coherence tomography imaging of the iridocorneal angle." Biomedical optics express 6, no. 4 (April 2015): 1376-1391.  Full Text
    • Kim, K, Alder, B, Vora, GK, Carlson, AN, Afshari, NA, Kuo, AN, and Kim, T. "Textural interface opacity after Descemet-stripping automated endothelial keratoplasty." Journal of cataract and refractive surgery 40, no. 9 (September 2014): 1514-1520.  Full Text
    • McNabb, RP, Kuo, AN, and Izatt, JA. "Complete 360° circumferential SSOCT gonioscopy of the iridocorneal angle." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8930 (January 1, 2014).  Full Text
    • Muir, KW, Lim, A, Stinnett, S, Kuo, A, Tseng, H, and Walsh, MM. "Risk factors for exposure of glaucoma drainage devices: a retrospective observational study." BMJ open 4, no. 5 (January 2014): e004560-.  Full Text
    • Fang, L, Li, S, McNabb, RP, Nie, Q, Kuo, AN, Toth, CA, Izatt, JA, and Farsiu, S. "Fast acquisition and reconstruction of optical coherence tomography images via sparse representation." IEEE Trans Med Imaging 32, no. 11 (November 2013): 2034-2049.  Full Text  Link to Item
    • Kuo, AN, McNabb, RP, Chiu, SJ, El-Dairi, MA, Farsiu, S, Toth, CA, and Izatt, JA. "Correction of ocular shape in retinal optical coherence tomography and effect on current clinical measures." Am J Ophthalmol 156, no. 2 (August 2013): 304-311.  Full Text  Link to Item
    • Hahn, P, Migacz, J, O'Donnell, R, Day, S, Lee, A, Lin, P, Vann, R, Kuo, A, Fekrat, S, Mruthyunjaya, P, Postel, EA, Izatt, JA, and Toth, CA. "Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device." Retina 33, no. 7 (July 2013): 1328-1337.  Full Text  Link to Item
    • McNabb, RP, Kuo, AN, and Izatt, JA. "Quantitative single and multi-surface clinical corneal topography utilizing optical coherence tomography." Opt Lett 38, no. 8 (April 15, 2013): 1212-1214.  Link to Item
    • McNabb, RP, Larocca, F, Farsiu, S, Kuo, AN, and Izatt, JA. "Distributed scanning volumetric SDOCT for motion corrected corneal biometry." Biomed Opt Express 3, no. 9 (September 1, 2012): 2050-2065.  Full Text  Link to Item
    • Dhalla, A-H, Nankivil, D, Bustamante, T, Kuo, A, and Izatt, JA. "Simultaneous swept source optical coherence tomography of the anterior segment and retina using coherence revival." Opt Lett 37, no. 11 (June 1, 2012): 1883-1885.  Link to Item
    • Kuo, AN, McNabb, RP, Zhao, M, Larocca, F, Stinnett, SS, Farsiu, S, and Izatt, JA. "Corneal biometry from volumetric SDOCT and comparison with existing clinical modalities." Biomed Opt Express 3, no. 6 (June 1, 2012): 1279-1290.  Full Text  Link to Item
    • Dhalla, A, Bustamante, T, Nankivil, D, Hendargo, H, McNabb, R, Kuo, AN, and Izatt, JA. "Dual-depth SSOCT for simultaneous complex resolved anterior segment and conventional retinal imaging." Edited by JA Izatt, JG Fujimoto, and VV Tuchin. Proceedings of SPIE (2012).  Full Text
    • Larocca, F, Chiu, SJ, McNabb, RP, Kuo, AN, Izatt, JA, and Farsiu, S. "Robust automatic segmentation of corneal layer boundaries in SDOCT images using graph theory and dynamic programming." Biomed Opt Express 2, no. 6 (June 1, 2011): 1524-1538.  Full Text  Link to Item
    • Zhao, M, Kuo, AN, and Izatt, JA. "3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea." Opt Express 18, no. 9 (April 26, 2010): 8923-8936.  Open Access Copy  Link to Item
    • Jun, B, Berdahl, JP, Kuo, AN, Cummings, TJ, and Kim, T. "Corneal wound architecture and integrity after torsional and mixed phacoemulsification: evaluation of standard and microincisional coaxial techniques." Ophthalmic Surg Lasers Imaging 41, no. 1 (January 2010): 128-134.  Full Text  Link to Item
    • Hong, A, Caldwell, MC, Kuo, AN, and Afshari, NA. "Air bubble-associated endothelial trauma in descemet stripping automated endothelial keratoplasty." Am J Ophthalmol 148, no. 2 (August 2009): 256-259.  Full Text  Link to Item
    • Jun, B, Kuo, AN, Afshari, NA, Carlson, AN, and Kim, T. "Refractive change after descemet stripping automated endothelial keratoplasty surgery and its correlation with graft thickness and diameter." Cornea 28, no. 1 (January 2009): 19-23.  Full Text  Link to Item
    • Kuo, AN, Harvey, TM, and Afshari, NA. "Novel delivery method to reduce endothelial injury in descemet stripping automated endothelial keratoplasty." Am J Ophthalmol 145, no. 1 (January 2008): 91-96.  Full Text  Link to Item
    • Summar, M, Hall, L, Eeds, A, Hutcheson, H, Kuo, A, Willis, A, Rubio, V, Arvin, M, Schofield, J, and Dawson, E. "Characterization of genomic structure and polymorphisms in the human carbamyl phosphate synthetase I gene." Gene 311 (June 2003): 51-57.  Full Text
    • Kuo, A, Sinatra, RB, and Donahue, SP. "Distribution of refractive error in healthy infants." Journal of AAPOS 7, no. 3 (2003): 174-177.  Full Text

  • Other Articles

    • McNabb, RP, Farsiu, S, Stinnett, SS, Izatt, JA, and Kuo, AN. "Reply." Ophthalmology 123, no. 1 (January 2016): e6-e7. (Letter)  Full Text
    • Kuo, AN, Carrasco-Zevallos, O, Toth, CA, and Izatt, JA. "Caveats to obtaining retinal topography with optical coherence tomography." Investigative ophthalmology & visual science 55, no. 9 (September 11, 2014): 5730-5731. (Letter)  Full Text
    • McNabb, RP, Kuo, AN, and Izatt, JA. "Quantifying the cornea's optical performance." Optics and Photonics News 25, no. 4 (January 1, 2014): 34-41.  Full Text
    • Kuo, AN, and Kim, T. "Persistent anterior chamber gas bubbles during IntraLASIK." J Cataract Refract Surg 33, no. 6 (June 2007): 1134-1135. (Letter)  Full Text  Link to Item
• Teaching & Mentoring
• 

  Recent Courses

  • BME 494: Projects in Biomedical Engineering (GE) 2018
  • PHYSICS 495: Thesis Independent Study 2018
  • BME 394: Projects in Biomedical Engineering (GE) 2017
  • BME 493: Projects in Biomedical Engineering (GE) 2017

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