Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Residency in Psychiatry, Psychiatry And Behavioral Sciences, Duke University School of Medicine 2009 - 2013
  • M.Sc., National and Capodistrian University of Athens (Greece) 2010
  • M.D., National and Capodistrian University of Athens (Greece) 2004
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Zannas, AS, Arloth, J, Carrillo-Roa, T, Iurato, S, Röh, S, Ressler, KJ, Nemeroff, CB, Smith, AK, Bradley, B, Heim, C, Menke, A, Lange, JF, Brückl, T, Ising, M, Wray, NR, Erhardt, A, Binder, EB, and Mehta, D. "Correction to: Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling." Genome Biology 19, no. 1 (December 2018).  Full Text
    • Pape, JC, Carrillo-Roa, T, Rothbaum, BO, Nemeroff, CB, Czamara, D, Zannas, AS, Iosifescu, D, Mathew, SJ, Neylan, TC, Mayberg, HS, Dunlop, BW, and Binder, EB. "DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder." Clinical Epigenetics 10, no. 1 (November 3, 2018): 136-null.  Full Text
    • Zannas, AS. "Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging." Current Neuropharmacology 16, no. 3 (March 2018): 327-333. (Review)  Full Text
    • Emeny, RT, Baumert, J, Zannas, AS, Kunze, S, Wahl, S, Iurato, S, Arloth, J, Erhardt, A, Balsevich, G, Schmidt, MV, Weber, P, Kretschmer, A, Pfeiffer, L, Kruse, J, Strauch, K, Roden, M, Herder, C, Koenig, W, Gieger, C, Waldenberger, M, Peters, A, Binder, EB, and Ladwig, K-H. "Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 43, no. 2 (January 2018): 342-353.  Full Text
    • Rakesh, G, Szabo, ST, Alexopoulos, GS, and Zannas, AS. "Strategies for dementia prevention: latest evidence and implications." Therapeutic Advances in Chronic Disease 8, no. 8-9 (August 1, 2017): 121-136. (Review)  Full Text
    • Koudoumas, D, Terrovitis, J, Glentis, P, Ntalianis, A, Tsolakis, E, Zannas, AS, Tseliou, E, Papalois, A, Drakos, S, and Nanas, JN. "Comparison of two biventricular infarct patterns with respect to the infarct burden required to induce cardiogenic shock: An experimental study." Hellenic Journal of Cardiology : Hjc = Hellenike Kardiologike Epitheorese 58, no. 4 (July 2017): 306-309. (Letter)  Full Text
    • Zannas, AS, and Chrousos, GP. "Epigenetic programming by stress and glucocorticoids along the human lifespan." Molecular Psychiatry 22, no. 5 (May 2017): 640-646.  Full Text
    • Gassen, NC, Chrousos, GP, Binder, EB, and Zannas, AS. "Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases." Neuroscience and Biobehavioral Reviews 74, no. Pt B (March 2017): 356-365. (Review)  Full Text
    • Zannas, AS, Kim, JH, and West, AE. "Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice." Psychopharmacology 234, no. 6 (March 2017): 913-923.  Full Text
    • Volk, N, Pape, JC, Engel, M, Zannas, AS, Cattane, N, Cattaneo, A, Binder, EB, and Chen, A. "Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress." Cell Reports 17, no. 7 (November 2016): 1882-1891.  Full Text
    • Zannas, AS, Balsevich, G, and Gassen, NC. "The emerging role of FKBP5 in the regulation of metabolism and body weight." Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery 12, no. 8 (September 2016): 1560-1561.  Full Text
    • Zannas, AS. "Freud and the human connectome." Acta psychiatrica Scandinavica 134, no. 3 (September 2016): 275-. (Letter)  Full Text
    • Zannas, AS. "Editorial Perspective: Psychological stress and epigenetic aging - what can we learn and how can we prevent?." Journal of child psychology and psychiatry, and allied disciplines 57, no. 6 (June 2016): 674-675.  Full Text
    • Kao, C-Y, He, Z, Zannas, AS, Hahn, O, Kühne, C, Reichel, JM, Binder, EB, Wotjak, CT, Khaitovich, P, and Turck, CW. "Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder." Journal of psychiatric research 76 (May 2016): 74-83.  Full Text
    • Whelan, CD, Hibar, DP, van Velzen, LS, Zannas, AS, Carrillo-Roa, T, McMahon, K, Prasad, G, Kelly, S, Faskowitz, J, deZubiracay, G, Iglesias, JE, van Erp, TGM, Frodl, T, Martin, NG, Wright, MJ, Jahanshad, N, Schmaal, L, Sämann, PG, Thompson, PM, and Alzheimer's Disease Neuroimaging Initiative, . "Heritability and reliability of automatically segmented human hippocampal formation subregions." Neuroimage 128 (March 2016): 125-137.  Full Text
    • Gassen, NC, Hartmann, J, Zannas, AS, Kretzschmar, A, Zschocke, J, Maccarrone, G, Hafner, K, Zellner, A, Kollmannsberger, LK, Wagner, KV, Mehta, D, Kloiber, S, Turck, CW, Lucae, S, Chrousos, GP, Holsboer, F, Binder, EB, Ising, M, Schmidt, MV, and Rein, T. "FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications." Molecular psychiatry 21, no. 2 (February 2016): 277-289.  Full Text
    • Zannas, AS, Wiechmann, T, Gassen, NC, and Binder, EB. "Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 41, no. 1 (January 2016): 261-274. (Review)  Full Text
    • Zannas, AS, Arloth, J, Carrillo-Roa, T, Iurato, S, Röh, S, Ressler, KJ, Nemeroff, CB, Smith, AK, Bradley, B, Heim, C, Menke, A, Lange, JF, Brückl, T, Ising, M, Wray, NR, Erhardt, A, Binder, EB, and Mehta, D. "Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling." Genome Biology 16 (December 17, 2015): 266-null.  Full Text
    • Gassen, NC, Fries, GR, Zannas, AS, Hartmann, J, Zschocke, J, Hafner, K, Carrillo-Roa, T, Steinbacher, J, Preißinger, SN, Hoeijmakers, L, Knop, M, Weber, F, Kloiber, S, Lucae, S, Chrousos, GP, Carell, T, Ising, M, Binder, EB, Schmidt, MV, Rüegg, J, and Rein, T. "Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine." Science Signaling 8, no. 404 (November 24, 2015): ra119-null.  Full Text
    • Zannas, AS, and Chrousos, GP. "Glucocorticoid signaling drives epigenetic and transcription factors to induce key regulators of human parturition." Science Signaling 8, no. 400 (October 27, 2015): fs19-null. (Review)  Full Text
    • Zannas, AS, Provençal, N, and Binder, EB. "Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions." Biological Psychiatry 78, no. 5 (September 2015): 327-335. (Review)  Full Text
    • Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Sippel, C, Zannas, AS, Draenert, R, Binder, EB, Almeida, OFX, Rühter, G, Uhr, M, Schmidt, MV, Touma, C, Bracher, A, and Hausch, F. "Selective inhibitors of the FK506-binding protein 51 by induced fit." Nature Chemical Biology 11, no. 1 (January 2015): 33-37.  Full Text
    • Taylor, WD, McQuoid, DR, Payne, ME, Zannas, AS, MacFall, JR, and Steffens, DC. "Hippocampus atrophy and the longitudinal course of late-life depression." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry 22, no. 12 (December 2014): 1504-1512.  Full Text
    • Zannas, AS, McQuoid, DR, Payne, ME, MacFall, JR, Ashley-Koch, A, Steffens, DC, Potter, GG, and Taylor, WD. "Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age." The American journal of psychiatry 171, no. 11 (November 2014): 1214-1221.  Full Text
    • Zannas, AS, Doraiswamy, PM, Shpanskaya, KS, Murphy, KR, Petrella, JR, Burke, JR, and Wong, TZ. "Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making." Neurocase 20, no. 4 (August 2014): 466-473.  Full Text  Link to Item
    • Wijayatunge, R, Chen, L-F, Cha, YM, Zannas, AS, Frank, CL, and West, AE. "The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival." Molecular and Cellular Neurosciences 61 (July 2014): 187-200.  Full Text
    • Zannas, AS, and West, AE. "Epigenetics and the regulation of stress vulnerability and resilience." Neuroscience 264 (April 4, 2014): 157-170. (Review)  Full Text
    • Zannas, AS, and West, AE. "Epigenetics and the regulation of stress vulnerability and resilience." Neuroscience 264 (April 2014): 157-170. (Review)  Full Text
    • Pelton, GH, Andrews, H, Roose, SP, Marcus, SM, D'Antonio, K, Husn, H, Petrella, JR, Zannas, AS, Doraiswamy, PM, and Devanand, DP. "Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design." Contemporary Clinical Trials 37, no. 2 (March 2014): 200-208.  Full Text
    • Zannas, AS, Okuno, Y, and Doraiswamy, PM. "Cholinesterase inhibitors and Pisa syndrome: a pharmacovigilance study." Pharmacotherapy 34, no. 3 (March 2014): 272-278.  Full Text  Link to Item
    • Zannas, AS, Doraiswamy, PM, Shpanskaya, KS, Murphy, KR, Petrella, JR, Burke, JR, and Wong, TZ. "Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making." Neurocase 20, no. 4 (January 1, 2014): 466-473.  Full Text
    • Zannas, AS, and Binder, EB. "Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism." Genes, Brain, and Behavior 13, no. 1 (January 2014): 25-37. (Review)  Full Text
    • Zannas, AS, McQuoid, DR, Payne, ME, Steffens, DC, MacFall, JR, Ashley-Koch, A, and Taylor, WD. "Negative life stress and longitudinal hippocampal volume changes in older adults with and without depression." Journal of Psychiatric Research 47, no. 6 (June 2013): 829-834.  Full Text
    • Zannas, AS, McQuoid, DR, Steffens, DC, Chrousos, GP, and Taylor, WD. "Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms." Stress (Amsterdam, Netherlands) 15, no. 4 (July 2012): 425-434.  Full Text
    • Zannas, AS, Wong, TZ, and Doraiswamy, PM. "How much is a picture worth? Putting amyloid imaging to the test." Dement Geriatr Cogn Dis Extra 2, no. 1 (January 2012): 649-651.  Full Text  Link to Item

  • Book Sections

    • Zannas, AS, Binder, E, and Mehta, D. "Genomics of PTSD." In Posttraumatic Stress Disorder: From Neurobiology to Treatment, 233-264. January 1, 2016.  Full Text
    • Diakos, NA, Wever-Pinzon, O, and Drakos, SG. "Mechanical unloading and heart remodeling features." In Inflammatory Response in Cardiovascular Surgery, 413-418. January 1, 2013.  Full Text
    • Kaltsas, G, Zannas, AS, and Chrousos, GP. "Hypothalamic-pituitary-adrenal axis and cardiovascular disease." In Stress and Cardiovascular Disease, 71-87. November 1, 2012.  Full Text

  • Conference Papers

    • Pape, J, Carrillo-Roa, T, Wiechmann, T, Roeh, S, Rothbaum, B, Nemeroff, C, Czamara, D, Zannas, A, Iosifescu, D, Mathew, S, Neylan, T, Mayberg, H, Dunlop, B, and Binder, E. "F179. Epigenetic Biomarkers in Women With Posttraumatic Stress Disorder After CRF1 Receptor Antagonist Treatment." May 2018.  Full Text
    • Zannas, A, Jia, M, Baumert, J, Hafner, K, Koedel, M, Haehle, A, Iurato, S, Carrillo-Roa, T, Emeny, R, Lathi, J, Raikkonen, K, Eriksson, J, Drake, A, Waldenberger, M, Wahl, S, Kunze, S, Lucae, S, Bradley, B, Gieger, C, Hausch, F, Smith, A, Ressler, K, Mueller-Myhsok, B, Ladwig, K-H, Rein, T, Gassen, N, and Binder, E. "Aging- and Stress-Related Epigenetic Disinhibition of FKBP5 Contributes to NF-KB-Driven Inflammation and Cardiovascular Risk." 56th Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP) and Cognitive-Neuroscience-Society. Palm Springs, CA. December 3, 2017 - December 7, 2017.: NATURE PUBLISHING GROUP, November 1, 2017.  Link to Item
    • Zannas, A, Carrillo-Roa, T, Iurato, S, Arloth, J, Röh, S, Ressler, K, Nemeroff, C, Smith, A, Bradley, B, Heim, C, Lange, J, Brückl, T, Ising, M, Wray, N, Erhardt, A, Binder, E, and Mehta, D. "P.1.a.031 Lifetime stress accelerates epigenetic aging." September 2015.  Full Text
    • Zannas, AS, Klengel, T, Nemeroff, CB, Carrillo-Roa, T, Heim, CM, Bradley, B, Ressler, KJ, and Binder, EB. "P.1.a.003 Epigenetic regulation at the FKBP5 genetic locus by age and depressive phenotypes: implications for age-related disease." : Elsevier BV, October 2014.  Full Text
    • Zannas, AS, Klengel, T, and Binder, EB. "P.1.027 The role of FKBP5 in mechanisms linking stress and aging." : Elsevier BV, March 2014.  Full Text
    • Taylor, WD, McQuoid, DR, Payne, ME, Zannas, AS, MacFall, JR, and Steffens, DC. "Change in Hippocampus Volume and Longitudinal Course of Late-Life Depression." May 1, 2013.  Link to Item
    • Zannas, AS, Deng, JV, Hutchinson, AN, Wetsel, WC, and West, AE. "Phosphorylation of MeCP2 in Reward-Related Circuits is Required for Amphetamine-Induced Conditioned Place Preference in Mice." May 1, 2013.  Link to Item
    • Zannas, AS, McQuoid, DR, Payne, ME, Steffens, DC, Macfall, JR, and Taylor, WD. "Stressful Life Events and Two-Year Change in Hippocampal Volume in Patients with Late-Life Depression and Elderly Controls." March 2012.  Link to Item

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