Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Residency in Psychiatry, Psychiatry And Behavioral Sciences, Duke University School of Medicine 2009 - 2013
  • M.Sc., National and Capodistrian University of Athens (Greece) 2010
  • M.D., National and Capodistrian University of Athens (Greece) 2004
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Rakesh, Gopalkumar, Rajendra A. Morey, Anthony S. Zannas, Zainab Malik, Christine E. Marx, Ashley N. Clausen, Michael D. Kritzer, and Steven T. Szabo. “Resilience as a translational endpoint in the treatment of PTSD.” Mol Psychiatry 24, no. 9 (September 2019): 1268–83. https://doi.org/10.1038/s41380-019-0383-7.
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    • Zannas, Anthony S., Meiwen Jia, Kathrin Hafner, Jens Baumert, Tobias Wiechmann, Julius C. Pape, Janine Arloth, et al. “Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk.” Proc Natl Acad Sci U S A 116, no. 23 (June 4, 2019): 11370–79. https://doi.org/10.1073/pnas.1816847116.
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    • Palma-Gudiel, Helena, Elisenda Eixarch, Fátima Crispi, Sebastián Morán, Anthony S. Zannas, and Lourdes Fañanás. “Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene.” Clin Epigenetics 11, no. 1 (May 9, 2019): 73. https://doi.org/10.1186/s13148-019-0674-5.
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    • Pape, Julius C., Tania Carrillo-Roa, Barbara O. Rothbaum, Charles B. Nemeroff, Darina Czamara, Anthony S. Zannas, Dan Iosifescu, et al. “DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder.” Clin Epigenetics 10, no. 1 (November 3, 2018): 136. https://doi.org/10.1186/s13148-018-0569-x.
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    • Zannas, Anthony S. “Lithium treatment and mechanisms of aging.” Mol Psychiatry 23, no. 11 (November 2018): 2112–13. https://doi.org/10.1038/s41380-018-0024-6.
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    • Zannas, Anthony S., Janine Arloth, Tania Carrillo-Roa, Stella Iurato, Simone Röh, Kerry J. Ressler, Charles B. Nemeroff, et al. “Correction to: Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.” Genome Biol 19, no. 1 (May 23, 2018): 61. https://doi.org/10.1186/s13059-018-1441-1.
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    • Zannas, Anthony S. “Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging.” Curr Neuropharmacol 16, no. 3 (March 5, 2018): 327–33. https://doi.org/10.2174/1570159X15666171109121452.
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    • Emeny, Rebecca T., Jens Baumert, Anthony S. Zannas, Sonja Kunze, Simone Wahl, Stella Iurato, Janine Arloth, et al. “Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model.” Neuropsychopharmacology 43, no. 2 (January 2018): 342–53. https://doi.org/10.1038/npp.2017.102.
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    • Rakesh, G., S. T. Szabo, G. S. Alexopoulos, and A. S. Zannas. “Strategies for dementia prevention: latest evidence and implications.” Therapeutic Advances in Chronic Disease 8, no. 8–9 (August 1, 2017): 121–36. https://doi.org/10.1177/2040622317712442.
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    • Koudoumas, Dimitrios, John Terrovitis, Panagiotis Glentis, Argyrios Ntalianis, Elias Tsolakis, Anthony S. Zannas, Eleni Tseliou, Apostolos Papalois, Stavros Drakos, and John N. Nanas. “Comparison of two biventricular infarct patterns with respect to the infarct burden required to induce cardiogenic shock: An experimental study.” Hellenic J Cardiol 58, no. 4 (July 2017): 306–9. https://doi.org/10.1016/j.hjc.2016.11.035.
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    • Zannas, A. S., and G. P. Chrousos. “Epigenetic programming by stress and glucocorticoids along the human lifespan.” Molecular Psychiatry 22, no. 5 (May 2017): 640–46. https://doi.org/10.1038/mp.2017.35.
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    • Gassen, Nils C., George P. Chrousos, Elisabeth B. Binder, and Anthony S. Zannas. “Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases.” Neurosci Biobehav Rev 74, no. Pt B (March 2017): 356–65. https://doi.org/10.1016/j.neubiorev.2016.06.003.
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    • Zannas, Anthony S., Jun H. Kim, and Anne E. West. “Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice.” Psychopharmacology (Berl) 234, no. 6 (March 2017): 913–23. https://doi.org/10.1007/s00213-017-4527-7.
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    • Volk, Naama, Julius C. Pape, Mareen Engel, Anthony S. Zannas, Nadia Cattane, Annamaria Cattaneo, Elisabeth B. Binder, and Alon Chen. “Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress.” Cell Rep 17, no. 7 (November 8, 2016): 1882–91. https://doi.org/10.1016/j.celrep.2016.10.038.
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    • Zannas, A. S. “Freud and the human connectome.” Acta Psychiatr Scand 134, no. 3 (September 2016): 275. https://doi.org/10.1111/acps.12598.
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    • Zannas, Anthony S., Georgia Balsevich, and Nils C. Gassen. “The emerging role of FKBP5 in the regulation of metabolism and body weight.” Surg Obes Relat Dis 12, no. 8 (September 2016): 1560–61. https://doi.org/10.1016/j.soard.2016.05.016.
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    • Zannas, Anthony S. “Editorial Perspective: Psychological stress and epigenetic aging - what can we learn and how can we prevent?” Journal of Child Psychology and Psychiatry, and Allied Disciplines 57, no. 6 (June 2016): 674–75. https://doi.org/10.1111/jcpp.12535.
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    • Kao, Chi-Ya, Zhisong He, Anthony S. Zannas, Oliver Hahn, Claudia Kühne, Judith M. Reichel, Elisabeth B. Binder, Carsten T. Wotjak, Philipp Khaitovich, and Christoph W. Turck. “Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder.” J Psychiatr Res 76 (May 2016): 74–83. https://doi.org/10.1016/j.jpsychires.2016.02.003.
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    • Whelan, Christopher D., Derrek P. Hibar, Laura S. van Velzen, Anthony S. Zannas, Tania Carrillo-Roa, Katie McMahon, Gautam Prasad, et al. “Heritability and reliability of automatically segmented human hippocampal formation subregions.” Neuroimage 128 (March 2016): 125–37. https://doi.org/10.1016/j.neuroimage.2015.12.039.
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    • Gassen, N. C., J. Hartmann, A. S. Zannas, A. Kretzschmar, J. Zschocke, G. Maccarrone, K. Hafner, et al. “FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications.” Mol Psychiatry 21, no. 2 (February 2016): 277–89. https://doi.org/10.1038/mp.2015.38.
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    • Zannas, Anthony S., Tobias Wiechmann, Nils C. Gassen, and Elisabeth B. Binder. “Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications.” Neuropsychopharmacology 41, no. 1 (January 2016): 261–74. https://doi.org/10.1038/npp.2015.235.
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    • Zannas, Anthony S., Janine Arloth, Tania Carrillo-Roa, Stella Iurato, Simone Röh, Kerry J. Ressler, Charles B. Nemeroff, et al. “Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.” Genome Biology 16 (December 17, 2015): 266. https://doi.org/10.1186/s13059-015-0828-5.
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    • Gassen, Nils C., Gabriel R. Fries, Anthony S. Zannas, Jakob Hartmann, Jürgen Zschocke, Kathrin Hafner, Tania Carrillo-Roa, et al. “Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.” Science Signaling 8, no. 404 (November 24, 2015): ra119. https://doi.org/10.1126/scisignal.aac7695.
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    • Zannas, Anthony S., and George P. Chrousos. “Glucocorticoid signaling drives epigenetic and transcription factors to induce key regulators of human parturition.” Sci Signal 8, no. 400 (October 27, 2015): fs19. https://doi.org/10.1126/scisignal.aad3022.
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    • Zannas, Anthony S., Nadine Provençal, and Elisabeth B. Binder. “Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions.” Biological Psychiatry 78, no. 5 (September 2015): 327–35. https://doi.org/10.1016/j.biopsych.2015.04.003.
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    • Gaali, Steffen, Alexander Kirschner, Serena Cuboni, Jakob Hartmann, Christian Kozany, Georgia Balsevich, Christian Namendorf, et al. “Selective inhibitors of the FK506-binding protein 51 by induced fit.” Nature Chemical Biology 11, no. 1 (January 2015): 33–37. https://doi.org/10.1038/nchembio.1699.
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    • Taylor, Warren D., Douglas R. McQuoid, Martha E. Payne, Anthony S. Zannas, James R. MacFall, and David C. Steffens. “Hippocampus atrophy and the longitudinal course of late-life depression.” Am J Geriatr Psychiatry 22, no. 12 (December 2014): 1504–12. https://doi.org/10.1016/j.jagp.2013.11.004.
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    • Zannas, Anthony S., Douglas R. McQuoid, Martha E. Payne, James R. MacFall, Allison Ashley-Koch, David C. Steffens, Guy G. Potter, and Warren D. Taylor. “Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age.” Am J Psychiatry 171, no. 11 (November 1, 2014): 1214–21. https://doi.org/10.1176/appi.ajp.2014.13111543.
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    • Zannas, Anthony S., P Murali Doraiswamy, Katie S. Shpanskaya, Kelly R. Murphy, Jeffrey R. Petrella, James R. Burke, and Terence Z. Wong. “Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making.” Neurocase 20, no. 4 (August 2014): 466–73. https://doi.org/10.1080/13554794.2013.791867.
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    • Wijayatunge, Ranjula, Liang-Fu Chen, Young May Cha, Anthony S. Zannas, Christopher L. Frank, and Anne E. West. “The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.” Mol Cell Neurosci 61 (July 2014): 187–200. https://doi.org/10.1016/j.mcn.2014.06.008.
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    • Zannas, A. S., and A. E. West. “Epigenetics and the regulation of stress vulnerability and resilience.” Neuroscience 264 (April 4, 2014): 157–70. https://doi.org/10.1016/j.neuroscience.2013.12.003.
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    • Pelton, Gregory H., Howard Andrews, Steven P. Roose, Sue M. Marcus, Kristina D’Antonio, Hala Husn, Jeffrey R. Petrella, Anthony S. Zannas, P Murali Doraiswamy, and D. P. Devanand. “Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design.” Contemp Clin Trials 37, no. 2 (March 2014): 200–208. https://doi.org/10.1016/j.cct.2013.11.015.
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    • Zannas, Anthony S., Yasushi Okuno, and P Murali Doraiswamy. “Cholinesterase inhibitors and Pisa syndrome: a pharmacovigilance study.” Pharmacotherapy 34, no. 3 (March 2014): 272–78. https://doi.org/10.1002/phar.1359.
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    • Zannas, A. S., and E. B. Binder. “Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism.” Genes, Brain, and Behavior 13, no. 1 (January 2014): 25–37. https://doi.org/10.1111/gbb.12104.
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    • Zannas, Anthony S., Douglas R. McQuoid, Martha E. Payne, David C. Steffens, James R. MacFall, Allison Ashley-Koch, and Warren D. Taylor. “Negative life stress and longitudinal hippocampal volume changes in older adults with and without depression.” J Psychiatr Res 47, no. 6 (June 2013): 829–34. https://doi.org/10.1016/j.jpsychires.2013.02.008.
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    • Zannas, Anthony S., Douglas R. McQuoid, David C. Steffens, George P. Chrousos, and Warren D. Taylor. “Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms.” Stress 15, no. 4 (July 2012): 425–34. https://doi.org/10.3109/10253890.2011.634263.
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    • Zannas, Anthony S., Terence Z. Wong, and P Murali Doraiswamy. “How much is a picture worth? Putting amyloid imaging to the test.” Dement Geriatr Cogn Dis Extra 2, no. 1 (January 2012): 649–51. https://doi.org/10.1159/000345982.
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  • Book Sections

    • Zannas, A. S., E. Binder, and D. Mehta. “Genomics of PTSD.” In Posttraumatic Stress Disorder: From Neurobiology to Treatment, 233–64, 2016. https://doi.org/10.1002/9781118356142.ch10.
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    • Diakos, N. A., O. Wever-Pinzon, and S. G. Drakos. “Mechanical unloading and heart remodeling features.” In Inflammatory Response in Cardiovascular Surgery, 413–18, 2013. https://doi.org/10.1007/9781447144298_49.
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    • Kaltsas, G., A. S. Zannas, and G. P. Chrousos. “Hypothalamic-pituitary-adrenal axis and cardiovascular disease.” In Stress and Cardiovascular Disease, 9781848824195:71–87, 2012. https://doi.org/10.1007/978-1-84882-419-5_5.
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  • Conference Papers

    • Pape, Julius, Tania Carrillo-Roa, Tobias Wiechmann, Simone Roeh, Barbara Rothbaum, Charles Nemeroff, Darina Czamara, et al. “F179. Epigenetic Biomarkers in Women With Posttraumatic Stress Disorder After CRF1 Receptor Antagonist Treatment.” In Biological Psychiatry, 83:S308–S308. Elsevier BV, 2018. https://doi.org/10.1016/j.biopsych.2018.02.793.
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    • Zannas, Antonios, Meiwen Jia, Jens Baumert, Kathrin Hafner, Maik Koedel, Andreas Haehle, Stella Iurato, et al. “Aging- and Stress-Related Epigenetic Disinhibition of FKBP5 Contributes to NF-KB-Driven Inflammation and Cardiovascular Risk.” In Neuropsychopharmacology, 42:S310–11. NATURE PUBLISHING GROUP, 2017.
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    • Zannas, A., T. Carrillo-Roa, S. Iurato, J. Arloth, S. Röh, K. Ressler, C. Nemeroff, et al. “P.1.a.031 Lifetime stress accelerates epigenetic aging.” In European Neuropsychopharmacology, 25:S174–75. Elsevier BV, 2015. https://doi.org/10.1016/s0924-977x(15)30161-9.
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    • Zannas, A. S., T. Klengel, C. B. Nemeroff, T. Carrillo-Roa, C. M. Heim, B. Bradley, K. J. Ressler, and E. B. Binder. “P.1.a.003 Epigenetic regulation at the FKBP5 genetic locus by age and depressive phenotypes: implications for age-related disease.” In European Neuropsychopharmacology, 24:S154–S154. Elsevier BV, 2014. https://doi.org/10.1016/s0924-977x(14)70234-2.
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    • Zannas, A. S., T. Klengel, and E. B. Binder. “P.1.027 The role of FKBP5 in mechanisms linking stress and aging.” In European Neuropsychopharmacology, 24:S25–26. Elsevier BV, 2014. https://doi.org/10.1016/s0924-977x(14)70029-x.
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    • Taylor, Warren D., Douglas R. McQuoid, Martha E. Payne, Anthony S. Zannas, James R. MacFall, and David C. Steffens. “Change in Hippocampus Volume and Longitudinal Course of Late-Life Depression.” In Biological Psychiatry, 73:195S-195S. ELSEVIER SCIENCE INC, 2013.
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    • Zannas, Anthony S., Jay V. Deng, Ashley N. Hutchinson, William C. Wetsel, and Anne E. West. “Phosphorylation of MeCP2 in Reward-Related Circuits is Required for Amphetamine-Induced Conditioned Place Preference in Mice.” In Biological Psychiatry, 73:285S-285S. ELSEVIER SCIENCE INC, 2013.
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    • Zannas, Anthony S., Douglas R. McQuoid, Martha E. Payne, David C. Steffens, James R. Macfall, and Warren D. Taylor. “Stressful Life Events and Two-Year Change in Hippocampal Volume in Patients with Late-Life Depression and Elderly Controls.” In American Journal of Geriatric Psychiatry, 20:S108–S108. ELSEVIER SCIENCE INC, 2012.
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