Gowthami Morey Arepally

Conference Res Pract Thromb Haemost · March 2024 The University of North Carolina Symposia on Hemostasis began in 2002, with The First Symposium on Hemostasis with a Special Focus on FVIIa and Tissue Factor. They have occurred biannually since and have maintained the primary goal of establishing a forum ... Full text Link to item Cite

Mechanism of Complement Activation By PF4/ Heparin Complexes

Conference Blood · December 2, 2016 AbstractThe mechanisms underlying the PF4/heparin immune response are poorly understood. In recent studies, we showed that PF4/heparin complexes, but not PF4 alone or heparin alone, activate complement (C') ... Full text Cite

Novel ELISA-Based Assay for Detection of Complement Activation By PF4/Heparin Complexes

Conference Blood · December 2, 2016 AbstractThe immune response to platelet factor 4 (PF4)/heparin complexes is a frequent iatrogenic complication of heparin therapy associated with development of heparin-induced thrombocytopenia (HIT). Our re ... Full text Cite

RNA Aptamer Against FXa Synergizes with FXa Catalytic Site Inhibitors to Effectively and Reversibly Anticoagulate Blood in an Ex Vivo Oxygenator Circuit

Conference Blood · December 2, 2016 AbstractDespite notable disadvantages, unfractionated heparin (UFH) remains the standard anticoagulant for clinical procedures requiring potent and reversible anticoagulation such as cardiopulmonary bypass ( ... Full text Cite

The Thrombotic Microangiopathy Registry of North America

Conference Blood · December 3, 2015 AbstractThe thrombotic microangiopathies (TMAs) are rare, life-threatening thrombotic disorders of diverse etiologies. Systematic studies of TMA have been difficult to perform due to their rare occurrence, d ... Full text Cite

Thrombocytopenia in Hospitalized Non-ICU Patients

Conference BLOOD · December 3, 2015 Link to item Cite

Characterization of Human and Murine Anti-Protamine/Heparin Antibodies

Conference Blood · December 3, 2015 AbstractProtamine/heparin (PRT/H) antibodies (Abs) are a newly described class of heparin-dependent antibodies found in ~25% of patients exposed to protamine and heparin during cardiopulmonary bypass surgery ... Full text Cite

Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells

Conference BLOOD · December 6, 2014 Link to item Cite

Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT)

Conference BLOOD · December 6, 2014 Link to item Cite

Predicting the Temporal Course of Laboratory Abnormality Resolution in Patients with Thrombotic Microangiopathy

Conference Blood · December 6, 2014 AbstractBackground:Screening for deficiency of ADAMTS- 13, a von Willebrand factor-cleaving protease, is commonly performed when there exists a clinical suspicion for thrombo ... Full text Cite

Biologic Activities of Protamine/Heparin Antibodies

Conference Blood · December 6, 2014 AbstractProtamine/heparin (PRT/H) antibodies (Ab) are a newly described class of heparin-dependent Abs found in ~25% of patients exposed to protamine and heparin during cardiopulmonary bypass surgery (CPB). ... Full text Cite

Characterization of Receptors Involved in Heparin Antibody Complex Mediated Induction of Tissue Factor Expression in Monocytes

Conference BLOOD · November 20, 2009 Link to item Cite

Heparin Forms Macromolecular Complexes with Protamine and Lysozyme.

Conference BLOOD · November 20, 2009 Link to item Cite

Determinants of PF4/heparin immunogenicity in a murine model of HIT.

Conference BLOOD · November 16, 2006 Link to item Cite

Pathogenic role of surface platelet factor 4 complexes in heparin-induced thrombocytopenia: Diagnostic and therapeutic implications.

Conference BLOOD · November 16, 2005 Link to item Cite

Characterization of autoantibodies to PF4/heparin in a rat model of cardiopulmonary bypass.

Conference BLOOD · November 16, 2004 Link to item Cite

Heparin-induced thrombocytopenia is a thymus (T cell) dependent disorder.

Conference BLOOD · November 16, 2004 Link to item Cite

The interaction of platelets and endothelial cells modulates the procoagulant/anticoagulant balance in heparin-induced thrombocytopenia.

Conference BLOOD · November 16, 2003 Link to item Cite

Gowthami Morey Arepally

Scholarly Works - Conferences

Coagulation and platelet biology at the intersection of health and disease: illustrated capsules of the 11th Symposium on Hemostasis at the University of North Carolina.