https://orcid.org/0000-0001-6654-5773
Current Duke Appointments & Affiliations
Research Scholar
Pharmacology & Cancer Biology,
Basic Science Departments
Recent Scholarly Works
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases.
Journal article Sci Adv · November 2024 The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can fibrillize in vitro, whether these fibrils commonly used in research to induc ... Full text Link to item CiteMouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
Preprint · 2024 Full text CiteGut mucosal cells transfer α-synuclein to the vagus nerve.
Journal article JCI Insight · December 8, 2023 Epidemiological and histopathological findings have raised the possibility that misfolded α-synuclein protein might spread from the gut to the brain and increase the risk of Parkinson's disease. Although past experimental studies in mouse models have relie ... Full text Link to item CiteRecent Grants
Efficacies and Pharmacodynamic Assays for LRRk2 Small-Molecule Inhibitors
ResearchResearch Technician II · Awarded by National Institutes of Health · 2018 - 2020View All Grants