Scholars@Duke
Arpine Leblanc

Scholarly Works - Preprints

Structural and functional landscape of α-synuclein fibril conformations amplified from cerebrospinal fluid

Preprint · 2022 Lewy body dementias are pathologically defined by the deposition of α-synuclein fibrils into inclusions throughout the brain. Cerebrospinal fluid(CSF) in disease harbors circulating α-synuclein-fibril seeds, and parental α-synuclein fibrils can template co ... Full text Cite