Current Appointments & Affiliations
Medical Instructor in the Department of Pediatrics
·
2023 - Present
Pediatrics, Hematology-Oncology,
Pediatrics
Medical Instructor in the Department of Neurosurgery
·
2024 - Present
Neurosurgery,
Neurosurgery
Member of of the Duke Cancer Institute
·
2024 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Disruption of ataxia telangiectasia-mutated kinase enhances radiation therapy efficacy in spatially directed diffuse midline glioma models.
Journal Article J Clin Invest · June 16, 2025 Diffuse midline gliomas (DMGs) are lethal brain tumors characterized by p53-inactivating mutations and oncohistone H3.3K27M mutations that rewire the cellular response to genotoxic stress. We used RCAS/tv-a retroviruses and Cre recombinase to inactivate p5 ... Full text Link to item CiteAbstract A020: Liposomal topotecan with low-intensity focused ultrasound utilization to improve drug penetration with brain parenchyma in pediatric brain tumors
Conference Molecular Cancer Therapeutics · December 9, 2024 AbstractThe blood-brain barrier (BBB) remains a significant obstacle in delivering effective chemotherapeutics to treat pediatric brain tumors, limiting drug penetration and reducing therapeutic outcomes. To ... Full text CiteInterplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.
Journal Article Nat Commun · January 25, 2024 Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been implicated in dysfunctional immune signaling. ... Full text Link to item CiteRecent Grants
Targeting DNA replication stress to activate innate inflammation in diffuse midline gliomas with H3K27M mutations
ResearchSignificant Contributor · Awarded by Chadtough Defeat DIPG Foundation · 2024 - 2027View All Grants
Education, Training & Certifications
Kansas City University of Medicine and Biosciences ·
2016
D.O.