Amir H. Rezvani

Journal article Psychopharmacology (Berl) · March 2013 Featured Publication RATIONALE: Nicotine and nicotinic agonists have been shown to improve attentional function. Nicotinic receptors are easily desensitized, and all nicotinic agonists are also desensitizing agents. Although both receptor activation and desensitization are com ... Full text Link to item Cite

Improvement of attentional function with antagonism of nicotinic receptors in female rats.

Journal article Eur J Pharmacol · February 28, 2013 Featured Publication Nicotinic agonists have been shown in a variety of studies to improve cognitive function. Since nicotinic receptors are easily desensitized by agonists, it is not completely clear to what degree receptor desensitization or receptor activation are responsib ... Full text Link to item Cite

Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.

Journal article J Pharmacol Exp Ther · November 2012 Featured Publication Chronic nicotine administration increases α4β2 neuronal nicotinic acetylcholine receptor (nAChR) density in brain. This up-regulation probably contributes to the development and/or maintenance of nicotine dependence. nAChR up-regulation is believed to be t ... Full text Link to item Cite

Effects of ethanol, Δ(9)-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult male rats.

Journal article Neurosci Lett · October 3, 2012 Featured Publication Recent advances have been made in our understanding of the deleterious effects of both ethanol and THC on adolescent behavior and brain development. However, very little is known about the combined effects of EtOH+THC during adolescence, a time in which th ... Full text Link to item Cite

Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.

Journal article Psychopharmacology (Berl) · October 2012 Featured Publication BACKGROUND AND RATIONALE: Nicotinic acetylcholine systems play major roles in cognitive function. Nicotine and a variety of nicotinic agonists improve attention, and nicotinic antagonist exposure impairs it. This study was conducted to investigate the effe ... Full text Link to item Cite

Novel medication targets for the treatment of alcoholism: preclinical studies.

Journal article Recent Pat CNS Drug Discov · August 2012 Featured Publication Alcoholism is a complex heterogeneous disease and a number of neurotransmitter and neuromodulator systems have been implicated in its manifestation. Consequently, it is unlikely that existing medications such as disulfiram (Antabuse®), naltrexone (ReVia®), ... Full text Link to item Cite

Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats.

Journal article Psychopharmacology (Berl) · July 2012 Featured Publication RATIONALE: Sazetidine-A is a selective α4β2 nicotinic receptor desensitizing agent and partial agonist. It has been shown in previous studies to significantly reduce nicotine self-administration in rats after acute or repeated injections. However, the effe ... Full text Link to item Cite

Alcohol and cognition - consideration of age of initiation, usage patterns and gender: a brief review.

Journal article Curr Drug Abuse Rev · June 2012 Featured Publication Heavy alcohol use has numerous negative impacts on cognition. In many cases, it appears that excess drinking influences working memory, problem solving, attention, patterns of regional brain activation, and even gray and white matter volume. Due to these e ... Full text Link to item Cite

Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.

Journal article Eur J Pharmacol · May 5, 2012 Featured Publication Nicotine-induced hypothermia is well established, but the nicotinic receptor actions underlying this effect are not clear. Nicotine causes activation and desensitization at a variety of nicotinic receptor subtypes. Sazetidine-A [6-(5(((S)-azetidine-2-yl)me ... Full text Link to item Cite

Threshold of adulthood for the onset of nicotine self-administration in male and female rats.

Journal article Behav Brain Res · December 1, 2011 Featured Publication The great majority of tobacco addiction begins during adolescence. More heavily addicted smokers begin smoking earlier, but differentiating the neurobehavioral impact of nicotine self-administration during adolescence from self-selection bias (whereby peop ... Full text Link to item Cite

The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.

Journal article Alcohol · September 2011 Featured Publication Neuropeptide Y (NPY) signaling has been shown to modulate stress responses and to be involved in regulation of alcohol intake and dependence. The present study explores the possibility that blockade of NPY Y2 autoreceptors using a novel, blood-brain barrie ... Full text Link to item Cite

Attention-modulating effects of cognitive enhancers.

Journal article Pharmacol Biochem Behav · August 2011 Featured Publication Attention can be readily measured in experimental animal models. Animal models of attention have been used to better understand the neural systems involved in attention, how attention is impaired, and how therapeutic treatments can ameliorate attentional d ... Full text Link to item Cite

Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats.

Journal article Psychopharmacology (Berl) · June 2011 Featured Publication BACKGROUND: Neuronal nicotinic receptor systems have been shown to play key roles in cognition. Nicotine and nicotinic analogs improve attention and nicotinic antagonists impair it. This study was conducted to investigate the role of α4β2 nicotinic recepto ... Full text Link to item Cite

JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.

Journal article Psychopharmacology (Berl) · April 2011 Featured Publication RATIONALE: A few recent studies suggest that brain histamine levels and signaling via H(3) receptors play an important role in modulation of alcohol stimulation and reward in rodents. OBJECTIVE: The present study characterized the effects of a novel, selec ... Full text Link to item Cite

Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.

Journal article Psychopharmacology (Berl) · August 2010 Featured Publication RATIONALE: Manipulations of nicotinic cholinergic receptors have been shown to influence both alcohol and nicotine intake. Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a novel compound that potently and selectively desensi ... Full text Link to item Cite

Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats.

Journal article J Pharmacol Exp Ther · March 2010 Featured Publication Adequate treatment of tobacco addiction remains problematic. Part of the problem with treatment is a poor understanding of the pharmacologic aspects of nicotine contributing to addiction. In addition to activating nicotinic acetylcholine receptors, nicotin ... Full text Link to item Cite

Persistent high alcohol consumption in alcohol-preferring (P) rats results from a lack of normal aversion to alcohol.

Journal article Alcohol Alcohol · 2010 Featured Publication AIMS: In this study, we tested the impact of pretreatment with alcohol on subsequent alcohol drinking in outbred Sprague-Dawley and selectively bred alcohol-preferring (P) rats. METHODS: As a pretreatment, male Sprague-Dawley and P rats were given a passiv ... Full text Link to item Cite

Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol-preferring rats.

Journal article Alcohol Clin Exp Res · August 2009 Featured Publication BACKGROUND: Since 1994, when naltrexone (Revia) was approved by the FDA for the treatment of alcoholism, only 2 other drugs (Campral and Topamax have been approved for alcoholism treatment. However, various experimental drugs, including antiepileptic medic ... Full text Link to item Cite

Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism.

Journal article Prog Neuropsychopharmacol Biol Psychiatry · April 30, 2009 Featured Publication A strong positive association between depression and alcoholism is evident in epidemiological studies. Curiously, the incidence of smoking (nicotine intake) is also very high among depressed individuals. Because neuronal nicotinic receptors have been impli ... Full text Link to item Cite

Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats.

Journal article Prog Neuropsychopharmacol Biol Psychiatry · March 17, 2009 Featured Publication It is well established that nicotinic systems in the brain are critically involved in attentional processes in both animals and humans. The current study assessed the effects of a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist, R3487/ ... Full text Link to item Cite

Attenuation of pharmacologically-induced attentional impairment by methylphenidate in rats.

Journal article Pharmacol Biochem Behav · March 2009 Featured Publication Methylphenidate is widely used as a treatment option for attention deficit hyperactivity disorder. In animal models of attentional impairment, it is an important validation to determine whether this clinically effective treatment attenuates deficits. The p ... Full text Link to item Cite

Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice.

Journal article Behav Brain Res · January 23, 2009 Featured Publication Classically, it has been thought that high-affinity nicotinic receptors-containing beta2 subunits are the most important receptor subtypes for nicotinic involvement in cognitive function and nicotine self-administration, while low affinity alpha7-containin ... Full text Link to item Cite

Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats.

Journal article Eur J Pharmacol · December 14, 2008 Featured Publication Nicotine intake constitutes a principal mechanism for tobacco addiction. In addition to primary effects on nicotinic acetylcholine receptors, nicotine has cascading effects, which may also underlie its neurobehavioral actions. Nicotine induces serotonin (5 ... Full text Link to item Cite

Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration.

Journal article Neuroscience · June 26, 2008 Featured Publication Dopaminergic innervation of the frontal cortex in adults is important for a variety of cognitive functions and behavioral control. However, the role of frontal cortical dopaminergic innervation for neurobehavioral development has received little attention. ... Full text Link to item Cite

Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats.

Journal article Prog Neuropsychopharmacol Biol Psychiatry · May 15, 2008 Featured Publication Blockade of NMDA glutamate receptors with dizocilpine (MK-801) has been shown to cause substantial cognitive deficits and has been used to model symptoms of schizophrenia. Nicotine or nicotinic agonists, in contrast, may enhance cognitive or attentional fu ... Full text Link to item Cite

Early ethanol consumption predicts relapse-like behavior in adolescent male rats.

Journal article Alcohol Clin Exp Res · May 2008 Featured Publication BACKGROUND: Alcohol abuse disorders emerge over time with repeated consumption of ethanol, but not all ethanol drinkers develop these disorders. There are pre-existing characteristics that indicate which drinkers are most likely to abuse alcohol. Adolescen ... Full text Link to item Cite

Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats.

Journal article Int J Neuropsychopharmacol · February 2008 Featured Publication Cognitive impairment is very prevalent in schizophrenia and is currently undertreated in most patients. Attentional deficit is one of the hallmark symptoms of schizophrenia. Antipsychotic drugs, which can be quite effective in combating hallucinations are ... Full text Link to item Cite

Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function.

Journal article Biochem Pharmacol · October 15, 2007 Featured Publication People with schizophrenia often have substantial cognitive impairments, which may be related to nicotinic receptor deficits, (alpha7 and alpha4beta2), documented in the brains of people with schizophrenia. The large majority of people with schizophrenia sm ... Full text Link to item Cite

Further genetic characterization of the fawn-hooded (FH/Wjd) rat, an animal model of comorbid depression and alcoholism.

Journal article Psychiatr Genet · April 2007 Featured Publication OBJECTIVE: The main objective of this study was a more detailed genetic characterization of the alcohol preferring fawn-hooded rat and its intercrosses. Fawn-hooded rats drink substantially more alcohol voluntarily than the ACI rats. The fawn-hooded rats w ... Full text Link to item Cite

Analysis of alcohol-related phenotypes in F2 progeny derived from FH/Wjd and ACI/N rat strains reveals independent measures and sex differences.

Journal article Behav Brain Res · February 12, 2007 Featured Publication Ethanol associated addictive behaviors are governed by a combination of multiple gene action (polygenic or quantitative trait) and environmental factors. We produced F2 progeny from F1 crosses derived from the alcohol-preferring Fawn-Hooded (FH/Wjd) rat st ... Full text Link to item Cite

Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates.

Journal article Neurotoxicol Teratol · 2007 Featured Publication Adolescence is the life stage when tobacco addiction typically begins. Adolescent neurobehavioral development may be altered by nicotine self-administration in a way that persistently potentiates addiction. Previously, we showed that female adolescent rats ... Full text Link to item Cite

Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats.

Journal article Alcohol Clin Exp Res · January 2007 Featured Publication BACKGROUND: N-Phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) is a structurally novel atypical anxiolytic with an overall in vivo profile in animals suggestive of the potential to show anxiolytic efficacy in humans at doses ... Full text Link to item Cite

Depressive-like behavior and high alcohol drinking co-occur in the FH/WJD rat but appear to be under independent genetic control.

Journal article Neurosci Biobehav Rev · 2007 Featured Publication This review will consider the evidence supporting the view that a specific substrain of Fawn-Hooded rat (FH/Wjd) exhibits co-occurring depressive-like behavior and high alcohol intake independently. First, the FH/Wjd rat is compared with other Fawn-Hooded ... Full text Link to item Cite

Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment.

Journal article Addict Biol · September 2006 Featured Publication The Fawn-Hooded rat (FH/Wjd) is an inbred alcohol-preferring rat strain, unlike most of the other strains that were selectively bred for high alcohol intake and preference. It was chosen for study some 16 years ago because of a reported mutation that disru ... Full text Link to item Cite

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization.

Journal article Psychopharmacology (Berl) · March 2006 Featured Publication RATIONALE: Nicotine has been shown in a variety of studies in humans and experimental animals to improve cognitive function. Nicotinic treatments are being developed as therapeutic treatments for cognitive dysfunction. OBJECTIVES: Critical for the developm ... Full text Link to item Cite

Chronic nicotine interactions with clozapine and risperidone and attentional function in rats.

Journal article Prog Neuropsychopharmacol Biol Psychiatry · March 2006 Featured Publication Although antipsychotic drugs are therapeutically effective in attenuating the hallmark symptoms of schizophrenia, these improvements do not return most patients to normative standards of cognitive function. Thus, complementary drug treatment may be needed ... Full text Link to item Cite

Nicotinic-antipsychotic drug interactions and cognitive function.

Journal article EXS · 2006 Featured Publication In summary, neuronal nicotinic systems are important for a variety of aspects of cognitive function impacted by antipsychotic drugs. It has been demonstrated that antipsychotic drugs have memory and attentional impairing effects when given to unimpaired su ... Full text Link to item Cite

Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models.

Journal article Alcohol Clin Exp Res · September 2005 Featured Publication This article presents an overview of the proceedings from a symposium entitled "Is adolescence special? Possible age-related vulnerabilities to chronic alcohol or nicotine exposure," organized by Susan Barron and Linda Spear and held at the 2004 Research S ... Full text Link to item Cite

Nicotinic-serotonergic drug interactions and attentional performance in rats.

Journal article Psychopharmacology (Berl) · May 2005 Featured Publication RATIONALE: Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of ... Full text Link to item Cite

Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding.

Journal article Brain Res · April 18, 2005 Featured Publication Chronic nicotine administration has long been known to increase the number of high-affinity alpha4beta2 nicotinic receptors with lesser effects on low-affinity alpha7 nicotinic receptors. Nicotine has been shown to promote the release of a variety of neuro ... Full text Link to item Cite

Nicotine-antipsychotic drug interactions and attentional performance in female rats.

Journal article Eur J Pharmacol · February 20, 2004 Featured Publication Schizophrenia is marked by pronounced cognitive impairments in addition to the hallmark psychotic symptoms like hallucinations. Antipsychotic drugs can effectively reduce these hallucinations; however, the drugs have not resolved the cognitive impairment. ... Full text Link to item Cite

Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature.

Journal article Int J Dev Neurosci · 2004 Featured Publication Alcohol and nicotine are the most widely abused drugs in the world. The use of these addictive drugs often begins in adolescence, however, little is known about the different impacts of nicotine and alcohol on adolescents versus adults. This study examined ... Full text Link to item Cite

Adolescent-onset nicotine self-administration modeled in female rats.

Journal article Psychopharmacology (Berl) · September 2003 Featured Publication RATIONALE: Although the great majority of tobacco addiction begins during adolescence, little is known about differential nicotine effects in adolescents versus adults. OBJECTIVES: A rat model was used to determine the impact of the age of onset on nicotin ... Full text Link to item Cite

Nicotine-alcohol interactions and attentional performance on an operant visual signal detection task in female rats.

Journal article Pharmacol Biochem Behav · August 2003 Featured Publication Nicotine and alcohol are very often co-used and co-abused. Thus, it is important to understand their interactions. In many ways, nicotine and alcohol have opposing effects. This can be clearly seen in terms of their effects on cognitive function. Nicotine ... Full text Link to item Cite

Plant derivatives in the treatment of alcohol dependency.

Journal article Pharmacol Biochem Behav · June 2003 Featured Publication The present review summarizes the findings of the effects of extracts of purified compounds from several plants on alcohol intake in alcohol-preferring rats. These include St. John's wort (Hypericum perforatum, HPE), kudzu (Pueraria lobata) and ibogaine (T ... Full text Link to item Cite

Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats.

Journal article Eur J Pharmacol · March 28, 2003 Featured Publication Nicotinic systems have been shown to be critically involved in cognitive function including attention. Nicotine has been shown to improve performance on attentional tasks in humans with Alzheimer's disease, schizophrenia and attention deficit hyperactivity ... Full text Link to item Cite

Herbal remedies for alcoholism: promises and possible pitfalls.

Journal article Alcohol Clin Exp Res · February 2003 Featured Publication This review summarizes the findings of the effects on alcohol intake in alcohol-preferring rats of extracts or purified compounds from two of the most promising herbs: kudzu (Pueraria lobata) and St. John's Wort (Hypericum perforatum). It is a summary of a ... Full text Link to item Cite

Autoradiographic quantification of neurochemical markers of serotonin, dopamine and opioid systems in rat brain mesolimbic regions following chronic St John's wort treatment.

Journal article Naunyn Schmiedebergs Arch Pharmacol · February 2003 Featured Publication Effects of chronic treatment with St John's wort (SJW, Hypericum perforatum) on neurochemical markers of serotonin, dopamine and opioid systems in mesolimbic regions of the fawn-hooded rat were investigated by quantitative autoradiography. After 10 days' t ... Full text Link to item Cite

Effects of nicotine and mecamylamine on choice accuracy in an operant visual signal detection task in female rats.

Journal article Psychopharmacology (Berl) · December 2002 Featured Publication RATIONALE: During the past decade, central nicotinic systems have been shown in both experimental animals and humans to play an important role in cognitive function. However, the way in which specific aspects of cognitive function are affected by nicotinic ... Full text Link to item Cite

Nicotinic treatment for cognitive dysfunction.

Journal article Curr Drug Targets CNS Neurol Disord · August 2002 Featured Publication Nicotinic medications may provide beneficial therapeutic treatment for cognitive dysfunction such as Alzheimer's disease, schizophrenia and attention deficit hyperactivity disorder (ADHD). For development of nicotinic treatments we are fortunate to have a ... Full text Link to item Cite

Nicotine-alcohol interactions and cognitive function in rats.

Journal article Pharmacol Biochem Behav · July 2002 Featured Publication Nicotine and ethanol are the most widely abused drugs in the world. They are very often used and abused together. However, little is known about the functional interaction of nicotine and ethanol. The current project studied the interactive effects of nico ... Full text Link to item Cite

The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism.

Journal article Psychiatr Genet · March 2002 Featured Publication The Fawn-Hooded (FH/Wjd) rat is an inbred strain of rat that has been reported to exhibit both high immobility in the forced swim test and high voluntary ethanol intake, measures that have been periodically linked with depression and alcoholism in humans. ... Full text Link to item Cite

Genetic selection of rats with high and low body temperatures.

Journal article J Therm Biol · June 2001 Featured Publication Body (core) temperature (T(c)) directly affects all biological processes, including sensitivity to toxic chemicals, development, aging, and drug metabolism. To understand how T(c) affects these processes it is necessary to alter T(c) independently of other ... Full text Link to item Cite

Cognitive effects of nicotine.

Journal article Biol Psychiatry · February 1, 2001 Featured Publication Nicotine and other nicotinic agonists have been found to improve performance on attention and memory tasks. Clinical studies using nicotine skin patches have demonstrated the efficacy of nicotine in treating cognitive impairments associated with Alzheimer' ... Full text Link to item Cite

Specificity of cognitive impairment from Pfiesteria piscicida exposure in rats: attention and visual function versus behavioral plasticity.

Journal article Neurotoxicol Teratol · 2001 Featured Publication Pfiesteria piscicida is a toxic dinoflagellate that has caused massive fish kills in estuaries along the East Coast of the United States, and exposure of humans to toxic Pfiesteria has been associated with cognitive impairment. A visual signal detection ta ... Full text Link to item Cite

The nicotinic antagonist mecamylamine preferentially inhibits cocaine vs. food self-administration in rats.

Journal article Physiol Behav · December 2000 Featured Publication Nicotinic acetylcholine systems play important roles in addiction, and nicotinic receptor stimulation stimulates dopamine release while the nicotinic antagonist mecamylamine reduces it. Reid et al. [Neuropsychopharmacology 20 (1999) 297.] recently found in ... Full text Link to item Cite

Development of nicotinic drug therapy for cognitive disorders.

Journal article Eur J Pharmacol · March 30, 2000 Featured Publication Nicotine, as well as other nicotinic drugs, may provide useful therapeutic treatment for a variety of cognitive impairments including those found in Alzheimer's disease, schizophrenia and attention deficit hyperactivity disorder (ADHD). We have found that ... Full text Link to item Cite

Combination pharmacotherapy in alcoholism: a novel treatment approach.

Journal article CNS Spectr · February 2000 Featured Publication Combination pharmacotherapy has proven effective in a number of psychiatric disorders, including depression and schizophrenia. However, compared with other affective disorders, few studies have explored the use of combination therapy in alcoholism, and the ... Full text Link to item Cite

Rapid neurobehavioral analysis of Pfiesteria piscicida effects in juvenile and adult rats.

Journal article Neurotoxicol Teratol · 2000 Featured Publication The estuarine dinoflagellate Pfiesteria piscicida is known to kill fish and has been associated with neurocognitive deficits in humans. We have developed a rat model to demonstrate that exposure to Pfiesteria causes significant learning impairments. This h ... Full text Link to item Cite

Combination pharmacotherapy: a mixture of small doses of naltrexone, fluoxetine, and a thyrotropin-releasing hormone analogue reduces alcohol intake in three strains of alcohol-preferring rats.

Journal article Alcohol Alcohol · January 2000 Featured Publication It is common to treat some diseases with more than one medication simultaneously. Since more than one neurotransmitter system is involved in alcohol-seeking behaviour, then a therapeutic approach that targets more than one system should be more effective i ... Full text Link to item Cite

Suppression of alcohol intake by chronic naloxone treatment in P rats: tolerance development and elevation of opiate receptor binding.

Journal article Alcohol Clin Exp Res · November 1999 Featured Publication BACKGROUND: This study was planned to determine the feasibility of using a slow release naloxone preparation to treat alcoholism, because compliance with medication is a significant problem in alcoholics. METHODS: Experiments were performed in alcohol-pref ... Link to item Cite

Ethanol consumption by Fawn-Hooded rats following abstinence: effect of naltrexone and changes in mu-opioid receptor density.

Journal article Alcohol Clin Exp Res · June 1999 Featured Publication BACKGROUND: Relapse after abstinence can be modelled in rats using an alcohol deprivation effect (ADE) of enhanced ethanol consumption after a period of enforced abstinence from ethanol; however, not all rat strains display such an effect. We wanted to exa ... Link to item Cite

Antidepressant effects of nicotine in an animal model of depression.

Journal article Psychopharmacology (Berl) · February 1999 Featured Publication Epidemiological studies indicate a high incidence of cigarette smoking among depressed individuals. Moreover, individuals with a history of depression have a much harder time giving up smoking. It has been postulated that smoking may reflect an attempt at ... Full text Link to item Cite

Behavioural features of alcohol-preferring rats: focus on inbred strains.

Journal article Alcohol Alcohol · 1999 Featured Publication A recent study conducted a factor analysis on 18 behavioural measures obtained from four alcohol-preferring and five alcohol-non-preferring rat lines/strains. It was concluded that variables such as saccharin intake, ultrasonic vocalizations following an a ... Full text Link to item Cite

Attenuation of alcohol intake by extract of Hypericum perforatum (St. John's Wort) in two different strains of alcohol-preferring rats.

Journal article Alcohol Alcohol · 1999 Featured Publication Extract of the common plant Hypericum perforatum L. (St John's Wort, SJW) has been used successfully for the treatment of mild to moderate depression since ancient times and has recently been studied clinically. Depression and alcoholism have some neuroche ... Full text Link to item Cite