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Barbara R. Shaw

William T. Miller Distinguished Professor Emeritus of Chemistry
Chemistry
Box 90346, Durham, NC 27708-0346
1105 French Family Science Ctr, Box 90346, Chemistry Department, Durham, NC 27708-0346

Overview


Our laboratory studies the chemical reactivity of DNA and synthesizes modified nucleic acids as potential antitumor and antisense agents. We use biophysical, biochemical, and genetic techniques together with synthetic chemistry to understand pathways of mutation in DNA and to design novel nucleic acid analogues that might find use in the control of gene expression and signal transduction, in the treatment of tumors and cancer, and in antisense and gene therapy.

Current Appointments & Affiliations


William T. Miller Distinguished Professor Emeritus of Chemistry · 2012 - Present Chemistry, Trinity College of Arts & Sciences
Professor Emeritus of Chemistry · 2012 - Present Chemistry, Trinity College of Arts & Sciences

Recent Publications


Synthesis, Hydrolysis, and Protonation-Promoted Intramolecular Reductive Breakdown of Potential NRTIs: Stavudine α-P-Borano-γ-P-N-l-tryptophanyltriphosphates.

Journal Article Molecules (Basel, Switzerland) · January 2015 Phosphorus-modified prodrugs of dideoxynucleoside triphosphates (ddNTPs) have shown promise as pronucleotide strategies for improving antiviral activity compared to their parent dideoxynucleosides. Borane modified NTPs offer a promising choice as nucleosid ... Full text Cite

Versatility of borane nucleic acids mimics for coding, decoding and modulating genetic information.

Journal Article Nucleic acids symposium series (2004) · January 2007 This presentation will focus on the targeted regulation of gene expression, effective siRNA silencing with boranophosphates, and suppression of drugresistant reverse transcriptase by boranophosphate nucleotide analogues. ... Full text Cite

Synthesis of nucleoside boranophosphoramidate prodrugs conjugated with amino acids.

Journal Article The Journal of organic chemistry · March 2005 [structure: see text] Nucleoside boranophosphates and nucleoside amino acid phosphoramidates have been shown to be potent antiviral and anticancer agents with the potential to act as nucleoside prodrugs. A combination of these two types of compounds result ... Full text Cite
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Recent Grants


RNA Therapeutics for Pancreatic Cancer

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2015

Boronated L-nucleosides targeted against HIV

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2007

Boranophosphate DNA:RNA Hybrids as Probes of RNase H

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2007

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Education, Training & Certifications


University of Washington · 1973 Ph.D.
University of Washington · 1967 M.S.
Bryn Mawr College · 1965 B.A.