Overview
Our laboratory studies the chemical reactivity
of DNA and synthesizes modified nucleic
acids as potential antitumor and antisense
agents. We use biophysical, biochemical, and
genetic techniques together with synthetic
chemistry to understand pathways of mutation
in DNA and to design novel nucleic acid
analogues that might find use in the control of
gene expression and signal transduction, in
the treatment of tumors and cancer, and in
antisense and gene therapy.
Current Appointments & Affiliations
William T. Miller Distinguished Professor Emeritus of Chemistry
·
2012 - Present
Chemistry,
Trinity College of Arts & Sciences
Professor Emeritus of Chemistry
·
2012 - Present
Chemistry,
Trinity College of Arts & Sciences
Recent Publications
Synthesis, Hydrolysis, and Protonation-Promoted Intramolecular Reductive Breakdown of Potential NRTIs: Stavudine α-P-Borano-γ-P-N-l-tryptophanyltriphosphates.
Journal Article Molecules (Basel, Switzerland) · January 2015 Phosphorus-modified prodrugs of dideoxynucleoside triphosphates (ddNTPs) have shown promise as pronucleotide strategies for improving antiviral activity compared to their parent dideoxynucleosides. Borane modified NTPs offer a promising choice as nucleosid ... Full text CiteVersatility of borane nucleic acids mimics for coding, decoding and modulating genetic information.
Journal Article Nucleic acids symposium series (2004) · January 2007 This presentation will focus on the targeted regulation of gene expression, effective siRNA silencing with boranophosphates, and suppression of drugresistant reverse transcriptase by boranophosphate nucleotide analogues. ... Full text CiteSynthesis of nucleoside boranophosphoramidate prodrugs conjugated with amino acids.
Journal Article The Journal of organic chemistry · March 2005 [structure: see text] Nucleoside boranophosphates and nucleoside amino acid phosphoramidates have been shown to be potent antiviral and anticancer agents with the potential to act as nucleoside prodrugs. A combination of these two types of compounds result ... Full text CiteRecent Grants
RNA Therapeutics for Pancreatic Cancer
ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2015Boronated L-nucleosides targeted against HIV
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2007Boranophosphate DNA:RNA Hybrids as Probes of RNase H
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2007View All Grants
Education, Training & Certifications
University of Washington ·
1973
Ph.D.
University of Washington ·
1967
M.S.
Bryn Mawr College ·
1965
B.A.