Overview
Our laboratory studies the chemical reactivity
of DNA and synthesizes modified nucleic
acids as potential antitumor and antisense
agents. We use biophysical, biochemical, and
genetic techniques together with synthetic
chemistry to understand pathways of mutation
in DNA and to design novel nucleic acid
analogues that might find use in the control of
gene expression and signal transduction, in
the treatment of tumors and cancer, and in
antisense and gene therapy.
Current Appointments & Affiliations
William T. Miller Distinguished Professor Emeritus of Chemistry
·
2012 - Present
Chemistry,
Trinity College of Arts & Sciences
Professor Emeritus of Chemistry
·
2012 - Present
Chemistry,
Trinity College of Arts & Sciences
Education, Training & Certifications
University of Washington ·
1973
Ph.D.
University of Washington ·
1967
M.S.
Bryn Mawr College ·
1965
B.A.