Ellen Ruth Bennett

Journal article Ultrasound Med Biol · January 2014 Featured Work With stroke currently the second-leading cause of death globally, and 87% of all strokes classified as ischemic, the development of a fast, accessible, cost-effective approach for imaging occlusive stroke could have a significant impact on health care outc ... Full text Link to item Cite

Simultaneous bilateral real-time 3-d transcranial ultrasound imaging at 1 MHz through poor acoustic windows.

Journal article Ultrasound Med Biol · April 2013 Featured Work Ultrasound imaging has been proposed as a rapid, portable alternative imaging modality to examine stroke patients in pre-hospital or emergency room settings. However, in performing transcranial ultrasound examinations, 8%-29% of patients in a general popul ... Full text Link to item Cite

ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Journal article Exp Neurol · March 2013 Featured Work Growing clinical evidence implicates isoform-specific effects of apolipoprotein E (apoE) in reducing neuroinflammation and mediating adaptive responses following ischemic and traumatic brain injury. However, the intact apoE holoprotein does not cross the b ... Full text Link to item Cite

The ultrasound brain helmet: new transducers and volume registration for in vivo simultaneous multi-transducer 3-D transcranial imaging.

Journal article IEEE Trans Ultrason Ferroelectr Freq Control · June 2011 Featured Work Because stroke remains an important and time-sensitive health concern in developed nations, we present a system capable of fusing 3-D transcranial ultrasound volumes acquired from two sides of the head. This system uses custom sparse array transducers buil ... Full text Link to item Cite

S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage.

Journal article Biomarkers · September 2009 Featured Work OBJECTIVE: To determine the predictive value of S100b and brain natriuretic peptide (BNP) in order to determine accurately and quickly a discharge prognosis after primary supratentorial intracerebral haemorrhage (ICH). METHODS: After IRB approval and infor ... Full text Link to item Cite

Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans.

Journal article J Stroke Cerebrovasc Dis · 2009 Featured Work INTRODUCTION: To address the mechanisms by which apoE polymorphism affects functional outcome after intracerebral hemorrhage in humans, we tested the hypothesis that the presence of the APOE4 allele results in amplified inflammatory responses and increased ... Full text Link to item Cite

The ultrasound brain helmet for 3D transcranial Doppler imaging

Journal article Proceedings - IEEE Ultrasonics Symposium · 2009 Featured Work Transcranial Doppler imaging with contrast enhancement is a promising approach for visualizing a variety of cerebrovascular diseases requiring rapid treatment to minimize long-term effects. To address the time-sensitive nature of these diseases, we present ... Full text Cite

Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction.

Journal article Ultrasound Med Biol · September 2008 Featured Work Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3-D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real ... Full text Link to item Cite

Real-time 3D contrast-enhanced transcranial ultrasound

Journal article Proceedings - IEEE Ultrasonics Symposium · 2007 Featured Work Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real- ... Full text Cite

APOE polymorphism is associated with risk of severe sepsis in surgical patients.

Journal article Crit Care Med · November 2005 Featured Work OBJECTIVE: To test for an association between apolipoprotein E (APOE) genotypes and the occurrence of severe sepsis in an elective surgical cohort. DESIGN: Prospective, observational, single cohort study. SETTING: Sixteen-bed surgical intensive care unit ( ... Full text Link to item Cite

A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.

Journal article Exp Neurol · March 2005 Featured Work Although apolipoprotein E4 (APOE4) was initially identified as a susceptibility gene for the development of Alzheimer's disease, the presence of the APOE4 allele is also associated with poor outcome after acute brain injury. One mechanism by which apoE may ... Full text Link to item Cite

APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.

Journal article J Biol Chem · December 5, 2003 Featured Work Human apolipoprotein E is the major apolipoprotein expressed in the brain and exists as three isoforms, designated E2, E3, and E4. Although evidence suggests that apolipoprotein E plays an important role in modifying systemic and brain inflammatory respons ... Full text Link to item Cite

Burkitt lymphoma arising in organ transplant recipients: a clinicopathologic study of five cases.

Journal article Am J Surg Pathol · June 2003 Featured Work We report five cases of Burkitt lymphoma arising in organ transplant recipients. There were four men and one woman with a mean age of 35 years. All were solid organ recipients with three renal, one liver, and one double lung transplantation. The time inter ... Full text Link to item Cite

Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.

Journal article Neuroscience · 2003 Featured Work Apolipoprotein E (apoE) is a 34-kD protein with multiple biological properties. Recent clinical and preclinical observations implicate a role for apoE in modifying the response of the brain to focal and global ischemia. One mechanism by which apoE might ex ... Full text Link to item Cite

Apolipoprotein E protects against NMDA excitotoxicity.

Journal article Neurobiol Dis · October 2002 Featured Work Preclinical and clinical evidence implicates a role for endogenous apolipoprotein E in modifying the response of the brain to focal and global ischemia. To investigate whether apoE modulates the neuronal response to glutamate excitotoxicity, we exposed pri ... Full text Link to item Cite

Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?

Journal article Anesth Analg · June 2002 Featured Work UNLABELLED: Cardiopulmonary bypass (CPB) is associated with a spectrum of cerebral injuries. The molecular changes in the brain that might contribute to these injuries are not clearly known. We sought to determine whether the expression of apoptotic genes ... Full text Link to item Cite

Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.

Journal article Exp Neurol · January 2001 Featured Work Apolipoprotein E plays an important role in recovery from acute brain injury and risk of developing Alzheimer's disease. We demonstrate that biologically relevant concentrations of apoE suppress microglial activation and release of TNFalpha and NO in a dos ... Full text Link to item Cite

Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.

Journal article Neuroreport · March 9, 1998 Featured Work The human apolipoprotein (apo) E4 isoform is associated with an increased risk for Alzheimer's disease (AD) and poor prognosis after acute CNS injury. Addition of human apoE inhibits murine microglial activation in culture, suggesting that microglia might ... Full text Link to item Cite

Apolipoprotein E suppresses glial cell secretion of TNF alpha.

Journal article J Neuroimmunol · June 1997 Featured Work Apolipoprotein E (apoE) is a 299 amino acid protein with multiple biological functions. Initially described in the context of cholesterol metabolism, apoE also has immunomodulatory properties and recent evidence has implicated a role for apoE in neurologic ... Full text Link to item Cite