Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Research Fellow in Biology, Biology, Massachusetts Institute of Technology 1983 - 1987
  • Ph.D., Rockefeller University 1983
• 

  Previous Appointments & Affiliations

  • Research Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2008 - 2021
  • Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2008 - 2021
  • Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2008 - 2020
• Expertise
• 

  Subject Headings

  • Muser Mentor
• Research
• 

  Selected Grants

  • Temporal E2F Dynamics and Cell-Fate Decisions in Single Mammalian Cells awarded by National Institutes of Health 2014 - 2019
• 

  External Relationships

  • American Academy of Arts and Sciences
  • AstraZeneca
  • Charles River Laboratories
  • Dyne Therapeutics
  • Massachusetts Institute of Technology
  • Maze Therapeutics
  • National Academy of Sciences
  • Novartis
  • RallyBio
  • The Boston Children's Hospital
  • Venable (law firm)
  • Vida
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Chen, Po-Han, Jianli Wu, Chien-Kuang Cornelia Ding, Chao-Chieh Lin, Samuel Pan, Nathan Bossa, Yitong Xu, Wen-Hsuan Yang, Bernard Mathey-Prevot, and Jen-Tsan Chi. “Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism.” Cell Death Differ 27, no. 3 (March 2020): 1008–22. https://doi.org/10.1038/s41418-019-0393-7.
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    • Mathey-Prevot, Bernard, Bao-Tran Parker, Carolyn Im, Cierra Hong, Peng Dong, Guang Yao, and Lingchong You. “Quantifying E2F1 protein dynamics in single cells.” Quant Biol 8, no. 1 (March 2020): 20–30. https://doi.org/10.1007/s40484-019-0193-6.
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    • Dong, Peng, Manoj V. Maddali, Jaydeep K. Srimani, François Thélot, Joseph R. Nevins, Bernard Mathey-Prevot, and Lingchong You. “Author Correction: Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.” Nat Commun 9, no. 1 (November 13, 2018): 4766. https://doi.org/10.1038/s41467-018-07169-y.
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    • Dong, Peng, Carolyn Zhang, Bao-Tran Parker, Lingchong You, and Bernard Mathey-Prevot. “Cyclin D/CDK4/6 activity controls G1 length in mammalian cells.” Plos One 13, no. 1 (2018): e0185637. https://doi.org/10.1371/journal.pone.0185637.
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    • Dong, Peng, Manoj V. Maddali, Jaydeep K. Srimani, François Thélot, Joseph R. Nevins, Bernard Mathey-Prevot, and Lingchong You. “Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.” Nat Commun 5 (September 1, 2014): 4750. https://doi.org/10.1038/ncomms5750.
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    • Lin, Shu-Hong, Lauren Beane, Dawn Chasse, Kevin W. Zhu, Bernard Mathey-Prevot, and Jeffrey T. Chang. “Cross-platform prediction of gene expression signatures.” Plos One 8, no. 11 (2013): e79228. https://doi.org/10.1371/journal.pone.0079228.
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    • Flockhart, Ian T., Matthew Booker, Yanhui Hu, Benjamin McElvany, Quentin Gilly, Bernard Mathey-Prevot, Norbert Perrimon, and Stephanie E. Mohr. “FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update.” Nucleic Acids Res 40, no. Database issue (January 2012): D715–19. https://doi.org/10.1093/nar/gkr953.
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    • Wong, Jeffrey V., Peng Dong, Joseph R. Nevins, Bernard Mathey-Prevot, and Lingchong You. “Network calisthenics: control of E2F dynamics in cell cycle entry.” Cell Cycle 10, no. 18 (September 15, 2011): 3086–94. https://doi.org/10.4161/cc.10.18.17350.
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    • Gatza, Michael L., Joseph E. Lucas, William T. Barry, Jong Wook Kim, Quanli Wang, Matthew D. Crawford, Michael B. Datto, et al. “A pathway-based classification of human breast cancer.” Proc Natl Acad Sci U S A 107, no. 15 (April 13, 2010): 6994–99. https://doi.org/10.1073/pnas.0912708107.
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    • Mathey-Prevot, Bernard, and Norbert Perrimon. “Do-it-yourself RNAi made easy?” Nat Methods 4, no. 4 (April 2007): 308–9. https://doi.org/10.1038/nmeth0407-308.
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    • DasGupta, Ramanuj, Kent Nybakken, Matthew Booker, Bernard Mathey-Prevot, Foster Gonsalves, Binita Changkakoty, and Norbert Perrimon. “A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila.” Genome Biol 8, no. 9 (2007): R203. https://doi.org/10.1186/gb-2007-8-9-r203.
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    • Perrimon, Norbert, Adam Friedman, Bernard Mathey-Prevot, and Ulrike S. Eggert. “Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.” Drug Discov Today 12, no. 1–2 (January 2007): 28–33. https://doi.org/10.1016/j.drudis.2006.10.006.
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    • Perrimon, Norbert, and Bernard Mathey-Prevot. “Applications of high-throughput RNA interference screens to problems in cell and developmental biology.” Genetics 175, no. 1 (January 2007): 7–16. https://doi.org/10.1534/genetics.106.069963.
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    • Ramadan, Nadire, Ian Flockhart, Matthew Booker, Norbert Perrimon, and Bernard Mathey-Prevot. “Design and implementation of high-throughput RNAi screens in cultured Drosophila cells.” Nat Protoc 2, no. 9 (2007): 2245–64. https://doi.org/10.1038/nprot.2007.250.
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    • Perrimon, Norbert, and Bernard Mathey-Prevot. “Matter arising: off-targets and genome-scale RNAi screens in Drosophila.” Fly (Austin) 1, no. 1 (2007): 1–5. https://doi.org/10.4161/fly.3601.
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    • Echeverri, Christophe J., Philip A. Beachy, Buzz Baum, Michael Boutros, Frank Buchholz, Sumit K. Chanda, Julian Downward, et al. “Minimizing the risk of reporting false positives in large-scale RNAi screens.” Nat Methods 3, no. 10 (October 2006): 777–79. https://doi.org/10.1038/nmeth1006-777.
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    • Kulkarni, Meghana M., Matthew Booker, Serena J. Silver, Adam Friedman, Pengyu Hong, Norbert Perrimon, and Bernard Mathey-Prevot. “Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays.” Nat Methods 3, no. 10 (October 2006): 833–38. https://doi.org/10.1038/nmeth935.
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    • Flockhart, Ian, Matthew Booker, Amy Kiger, Michael Boutros, Susan Armknecht, Nadire Ramadan, Kris Richardson, Andrew Xu, Norbert Perrimon, and Bernard Mathey-Prevot. “FlyRNAi: the Drosophila RNAi screening center database.” Nucleic Acids Res 34, no. Database issue (January 1, 2006): D489–94. https://doi.org/10.1093/nar/gkj114.
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    • Mathey-Prevot, B., and N. Perrimon. “Drosophila genome-wide RNAi screens: are they delivering the promise?” Cold Spring Harb Symp Quant Biol 71 (2006): 141–48. https://doi.org/10.1101/sqb.2006.71.027.
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    • Armknecht, Susan, Michael Boutros, Amy Kiger, Kent Nybakken, Bernard Mathey-Prevot, and Norbert Perrimon. “High-throughput RNA interference screens in Drosophila tissue culture cells.” Methods Enzymol 392 (2005): 55–73. https://doi.org/10.1016/S0076-6879(04)92004-6.
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    • Sinenko, Sergey A., and Bernard Mathey-Prevot. “Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes.” Oncogene 23, no. 56 (December 2, 2004): 9120–28. https://doi.org/10.1038/sj.onc.1208156.
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    • Sinenko, Sergey A., Eun Kyung Kim, Rhoda Wynn, Pascal Manfruelli, Istvan Ando, Kristi A. Wharton, Norbert Perrimon, and Bernard Mathey-Prevot. “Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development.” Dev Biol 273, no. 1 (September 1, 2004): 48–62. https://doi.org/10.1016/j.ydbio.2004.05.022.
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    • Agaisse, Hervé, Ulla Maja Petersen, Michael Boutros, Bernard Mathey-Prevot, and Norbert Perrimon. “Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.” Dev Cell 5, no. 3 (September 2003): 441–50. https://doi.org/10.1016/s1534-5807(03)00244-2.
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    • Li, Willis X., Herve Agaisse, Bernard Mathey-Prevot, and Norbert Perrimon. “Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila.” Development 129, no. 18 (September 2002): 4241–48. https://doi.org/10.1242/dev.129.18.4241.
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    • Callus, Bernard A., and Bernard Mathey-Prevot. “SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc.” Oncogene 21, no. 31 (July 18, 2002): 4812–21. https://doi.org/10.1038/sj.onc.1205618.
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    • Rämet, Mika, Pascal Manfruelli, Alan Pearson, Bernard Mathey-Prevot, and R Alan B. Ezekowitz. “Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.” Nature 416, no. 6881 (April 11, 2002): 644–48. https://doi.org/10.1038/nature735.
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    • Callus, B. A., and B. Mathey-Prevot. “Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity.” J Biol Chem 275, no. 22 (June 2, 2000): 16954–62. https://doi.org/10.1074/jbc.M909976199.
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    • Callus, B. A., and B. Mathey-Prevot. “Rapid selection of tetracycline-controlled inducible cell lines using a green fluorescent-transactivator fusion protein.” Biochem Biophys Res Commun 257, no. 3 (April 21, 1999): 874–78. https://doi.org/10.1006/bbrc.1999.0558.
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    • Callus, B. A., and B. Mathey-Prevot. “Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors.” Blood 91, no. 9 (May 1, 1998): 3182–92.
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    • Mathey-Prevot, B., and N. Perrimon. “Mammalian and Drosophila blood: JAK of all trades?” Cell 92, no. 6 (March 20, 1998): 697–700. https://doi.org/10.1016/s0092-8674(00)81396-3.
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    • Jaster, R., Y. Zhu, M. Pless, S. Bhattacharya, B. Mathey-Prevot, and A. D. D’Andrea. “JAK2 is required for induction of the murine DUB-1 gene.” Mol Cell Biol 17, no. 6 (June 1997): 3364–72. https://doi.org/10.1128/MCB.17.6.3364.
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    • Pless, M., K. Norga, M. Carroll, M. H. Heim, A. D. D’Andrea, and B. Mathey-Prevot. “Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding.” Blood 89, no. 9 (May 1, 1997): 3175–85.
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    • Zhu, Y., M. Pless, R. Inhorn, B. Mathey-Prevot, and A. D. D’Andrea. “The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.” Mol Cell Biol 16, no. 9 (September 1996): 4808–17. https://doi.org/10.1128/MCB.16.9.4808.
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    • Taylor, D. S., J. P. Laubach, D. G. Nathan, and B. Mathey-Prevot. “Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3.” J Biol Chem 271, no. 24 (June 14, 1996): 14020–27. https://doi.org/10.1074/jbc.271.24.14020.
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    • Engeland, K., N. C. Andrews, and B. Mathey-Prevot. “Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter.” J Biol Chem 270, no. 41 (October 13, 1995): 24572–79. https://doi.org/10.1074/jbc.270.41.24572.
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    • Norga, K., M. Pless, M. Stanulla, E. C. TePas, and B. Mathey-Prevot. “Multiple transcription start sites and 5' alternate splicing of murine IL-3 receptor beta-chain transcripts.” Biochem Biophys Res Commun 205, no. 1 (November 30, 1994): 886–92. https://doi.org/10.1006/bbrc.1994.2747.
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    • Carroll, M., B. Mathey-Prevot, and A. D’Andrea. “Differentiation domains of the erythropoietin receptor.” Proc Soc Exp Biol Med 206, no. 3 (July 1994): 289–94. https://doi.org/10.3181/00379727-206-43761.
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    • Cameron, S., D. S. Taylor, E. C. TePas, N. A. Speck, and B. Mathey-Prevot. “Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting.” Blood 83, no. 10 (May 15, 1994): 2851–59.
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    • DeMartino, J., M. Carroll, B. Mathey-Prevot, and A. D. D’Andrea. “Erythropoietin receptor contains both growth-promoting activity and differentiation-promoting activity.” Ann N Y Acad Sci 718 (April 15, 1994): 213–21. https://doi.org/10.1111/j.1749-6632.1994.tb55720.x.
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    • Liboi, E., M. Carroll, A. D. D’Andrea, and B. Mathey-Prevot. “Erythropoietin receptor signals both proliferation and erythroid-specific differentiation.” Proc Natl Acad Sci U S A 90, no. 23 (December 1, 1993): 11351–55. https://doi.org/10.1073/pnas.90.23.11351.
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    • Davies, K., E. C. TePas, D. G. Nathan, and B. Mathey-Prevot. “Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.” Blood 81, no. 4 (February 15, 1993): 928–34.
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    • Liboi, E., P. Jubinsky, N. C. Andrews, D. G. Nathan, and B. Mathey-Prevot. “Enhanced expression of interleukin-3 and granulocyte-macrophage colony-stimulating factor receptor subunits in murine hematopoietic cells stimulated with hematopoietic growth factors.” Blood 80, no. 5 (September 1, 1992): 1183–89.
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    • Zon, L. I., J. F. Moreau, J. W. Koo, B. Mathey-Prevot, and A. D. D’Andrea. “The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein.” Mol Cell Biol 12, no. 7 (July 1992): 2949–57. https://doi.org/10.1128/mcb.12.7.2949-2957.1992.
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    • Crosier, K. E., G. G. Wong, B. Mathey-Prevot, D. G. Nathan, and C. A. Sieff. “A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain.” Proc Natl Acad Sci U S A 88, no. 17 (September 1, 1991): 7744–48. https://doi.org/10.1073/pnas.88.17.7744.
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    • D’Emilia, J. C., B. Mathey-Prevot, K. Jaros, B. Wolf, G. Steele, and I. C. Summerhayes. “Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon.” Oncogene 6, no. 2 (February 1991): 303–9.
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    • Mathey-Prevot, B., N. C. Andrews, H. S. Murphy, S. G. Kreissman, and D. G. Nathan. “Positive and negative elements regulate human interleukin 3 expression.” Proc Natl Acad Sci U S A 87, no. 13 (July 1990): 5046–50. https://doi.org/10.1073/pnas.87.13.5046.
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    • Wimperis, J. Z., C. M. Niemeyer, C. A. Sieff, B. Mathey-Prevot, D. G. Nathan, and R. J. Arceci. “Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells.” Blood 74, no. 5 (October 1989): 1525–30.
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    • Niemeyer, C. M., C. A. Sieff, B. Mathey-Prevot, J. Z. Wimperis, B. E. Bierer, S. C. Clark, and D. G. Nathan. “Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines.” Blood 73, no. 4 (March 1989): 945–51.
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    • Andrews, N. C., B. Mathey-Prevot, H. Murphy, and D. G. Nathan. “Regulation of the human interleukin-3 gene.” Trans Assoc Am Physicians 102 (1989): 240–51.
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    • Nussenzweig, M. C., E. V. Schmidt, A. C. Shaw, E. Sinn, J. Campos-Torres, B. Mathey-Prevot, P. K. Pattengale, and P. Leder. “A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice.” Nature 336, no. 6198 (December 1, 1988): 446–50. https://doi.org/10.1038/336446a0.
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    • Mathey-Prevot, B., and D. Baltimore. “Recombinants within the tyrosine kinase region of v-abl and v-src identify a v-abl segment that confers lymphoid specificity.” Mol Cell Biol 8, no. 1 (January 1988): 234–40. https://doi.org/10.1128/mcb.8.1.234-240.1988.
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    • Martinez, R., B. Mathey-Prevot, A. Bernards, and D. Baltimore. “Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart.” Science 237, no. 4813 (July 24, 1987): 411–15. https://doi.org/10.1126/science.2440106.
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    • Mathey-Prevot, B., G. Nabel, R. Palacios, and D. Baltimore. “Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line.” Mol Cell Biol 6, no. 11 (November 1986): 4133–35. https://doi.org/10.1128/mcb.6.11.4133-4135.1986.
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    • Mathey-Prevot, B., and D. Baltimore. “Specific transforming potential of oncogenes encoding protein-tyrosine kinases.” Embo J 4, no. 7 (July 1985): 1769–74. https://doi.org/10.1002/j.1460-2075.1985.tb03849.x.
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    • Samarut, J., B. Mathey-Prevot, and H. Hanafusa. “Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells.” Mol Cell Biol 5, no. 5 (May 1985): 1067–72. https://doi.org/10.1128/mcb.5.5.1067-1072.1985.
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    • Mathey-Prevot, B., M. Shibuya, J. Samarut, and H. Hanafusa. “Revertants and partial transformants of rat fibroblasts infected with Fujinami sarcoma virus.” J Virol 50, no. 2 (May 1984): 325–34. https://doi.org/10.1128/JVI.50.2.325-334.1984.
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    • Neel, B. G., L. H. Wang, B. Mathey-Prevot, T. Hanafusa, H. Hanafusa, and W. S. Hayward. “Isolation of 16L virus: a rapidly transforming sarcoma virus from an avian leukosis virus-induced sarcoma.” Proc Natl Acad Sci U S A 79, no. 16 (August 1982): 5088–92. https://doi.org/10.1073/pnas.79.16.5088.
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    • Mathey-Prevot, B., H. Hanafusa, and S. Kawai. “A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein.” Cell 28, no. 4 (April 1982): 897–906. https://doi.org/10.1016/0092-8674(82)90069-1.
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    • Hanafusa, T., B. Mathey-Prevot, R. A. Feldman, and H. Hanafusa. “Mutants of Fujinami sarcoma virus which are temperature sensitive for cellular transformation and protein kinase activity.” J Virol 38, no. 1 (April 1981): 347–55. https://doi.org/10.1128/JVI.38.1.347-355.1981.
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    • Maulet, Y., B. Mathey-Prevot, G. Kaiser, U. T. Rüegg, and B. W. Fulpius. “Purification and chemical characterization of melittin and acetylated derivatives.” Biochim Biophys Acta 625, no. 2 (October 21, 1980): 274–80. https://doi.org/10.1016/0005-2795(80)90291-3.
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  • Conference Papers

    • Lin, Chao-Chieh, Mayumi Kitagawa, Xiaohu Tang, Ming-Hsin Hou, Jianli Wu, Dan Chen Qu, Vinayaka Srinivas, et al. “CoA synthase regulates mitotic fidelity via CBP-mediated acetylation.” In Nat Commun, 9:1039, 2018. https://doi.org/10.1038/s41467-018-03422-6.
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    • Mathey-Prevot, B., and N. Perrimon. “Drosophila Genome-wide RNAi Screens: Are They Delivering the Promise?” In Regulatory Rnas, 71:141–48, 2006.
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• Teaching & Mentoring
• 

  Recent Courses

  • MOLCAN 819: Cancer as a Disease 2022
  • MOLCAN 819: Cancer as a Disease 2021
  • PHARM 394: Research Independent Study 2021

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