Scholars@Duke
Darell Doty Bigner

Darell Doty Bigner

E. L. and Lucille F. Jones Cancer Distinguished Research Professor, in the School of Medicine
Neurosurgery
bigne001@mc.duke.edu
Duke Box 3156, Durham, NC 27710
177 Med Sci Res Bldg, Durham, NC 27710

Scholarly Works - Conferences

TIP-25. Randomized phase 2 clinical trial of repeated intratumoral and cervical perilymphatic injections (CPLIs) of lerapolturev vs. lomustine in recurrent glioblastoma (rGBM): safety lead-in results

Conference Neuro-Oncology · November 11, 2025 AbstractBACKGROUNDLerapolturev is a modified, non-pathogenic version of the Sabin™ type 1 poliovirus vaccine that infects myelo ... Full text Cite

D2C7 CAR specifically targets tumor-associated EGFR and is effective against peripheral and intracranial cancers 3321

Conference The Journal of Immunology · November 1, 2025 Abstract Description Tumor heterogeneity is a major impedance for the success of chimeric antigen receptor (CAR) T cells. Tumor ... Full text Cite

Abstract B013: Subcutaneous αCD40 injections near tumor-draining lymph nodes augment intratumoral antibody-toxin conjugate antitumor efficacy in glioblastoma model

Conference Cancer Immunology Research · February 23, 2025 AbstractGlioblastoma (GBM), the most aggressive primary brain tumor in adults, has a poor prognosis and is notoriously resistant to conventional treatments, including surgery, radiation, and chemotherapy. Gi ... Full text Cite

P18.37.B REPEATED CONVECTION-ENHANCED DELIVERY (CED) INFUSION OF A POLIO/RHINOVIRUS RECOMBINANT (LERAPOLTUREV; LERA) IN RECURRENT GLIOBLASTOMA (RGBM) PATIENTS, FOLLOWED BY CERVICAL PERILYMPHATIC INJECTIONS OF LERA (LERA-CPLI)

Conference Neuro-Oncology · October 17, 2024 AbstractBACKGROUNDPhase 1 and 2 clinical trials of a single intratumoral injection of LERA (previously PVSRIPO) via CED into enhancing ... Full text Cite

Abstract 4924: Alternative lengthening of telomeres is associated with hypersensitivity to topoisomerase 1 inhibition in glioblastoma xenograft models

Conference Cancer Research · April 4, 2023 AbstractGlioblastoma (GBM), the most common primary malignant brain tumor in adults, is an incurable disease that has an inevitable tendency to recur following standard of care surgery, radiotherapy, and tem ... Full text Cite

D2C7 CAR: A novel CAR T cell that simultaneously targets wildtype EGFR and its mutant isoform EGFRvIII for treatment of glioma

Conference The Journal of Immunology · May 1, 2022 AbstractBrain tumors are the leading cause of cancer death in children and a significant cause of morbidity and mortality in adults. Conventional treatments are suboptimal, thus signifying the need for novel ... Full text Cite

A phase 1 trial of D2C7-it in combination with an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convectionenhanced delivery for adult patients with recurrent malignant glioma (MG).

Conference JOURNAL OF CLINICAL ONCOLOGY · 2022 Background: D2C7 immunotoxin (D2C7-IT) is a dual-specific recombinant immunotoxin comprising an EGFR wild-type and mutant-specific (EGFRvIII) monoclonal antibody (Ab) fragment and a genetically engineered form of the Pseudomonas exotoxin. When injected dir ... Full text Link to item Cite

CTIM-10. REPRODUCIBILITY OF CLINICAL TRIALS USING CMV-TARGETED DENDRITIC CELL VACCINES IN PATIENTS WITH GLIOBLASTOMA

Conference Neuro-Oncology · November 12, 2021 AbstractINTRODUCTIONVaccination with dendritic cells (DCs) fares poorly in primary and recurrent glioblastoma (GBM). Moreover, GBM vac ... Full text Open Access Link to item Cite

BIOM-20. TUMOR-INTRINSIC AND PERIPHERAL FEATURES ASSOCIATE WITH SURVIVAL AFTER POLIO VIROTHERAPY IN RECURRENT GBM

Conference Neuro-Oncology · November 12, 2021 AbstractBACKGROUNDPVSRIPO is a live-attenuated recombinant rhino:poliovirus that mediates antitumor efficacy by engaging antitumor imm ... Full text Cite

739 Intratumor childhood vaccine-specific CD4+ T cell recall helps antitumor CD8 T cells

Conference Regular and Young Investigator Award Abstracts · November 2021 Full text Cite

BIOL-10. DISTRIBUTION AND VULNERABILITY OF TRANSCRIPTIONAL OUTPUTS ACROSS THE GENOME IN MYC-AMPLIFIED MEDULLOBLASTOMA CELLS

Conference Neuro-Oncology · June 1, 2021 AbstractMyc plays a central role in tumorigenesis by orchestrating the expression of genes essential to numerous cellular processes. While it is well established that Myc functions by binding to its target g ... Full text Cite

Oncolytic polio/rhinovirus recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG): Experience with retreatment of survivors from the phase I trial.

Conference Journal of Clinical Oncology · May 20, 2019 2060 Background: We completed a study evaluating a single intratumoral delivery of PVSRIPO in recurrent WHO grade IV MG patients (N Engl J Med. 2018 Jul 12;379(2):150-161). Some patients who originally benefitted from the infusion of PVSRIPO demonstrated ... Full text Link to item Cite

THE GENOMIC LANDSCAPE OF TRIPLE-NEGATIVE GLIOBLASTOMA

Conference NEURO-ONCOLOGY · November 1, 2018 Link to item Cite

THE GENOMIC LANDSCAPE OF TRIPLE-NEGATIVE GLIOBLASTOMA

Conference NEURO-ONCOLOGY · November 1, 2018 Link to item Cite

Abstract A47: Inhibition of histone methyltransferase with novel epipolythiodioxopiperazines (ETP) alkaloids in pediatric high-grade glioma

Conference Cancer Research · October 1, 2018 AbstractPediatric high-grade glioma (HGG), which ranks among the most lethal of cancers among children, contain two recurrent mutations within the histone H3 gene H3F3A (K27M and G34R/V). It is not known whe ... Full text Cite

Abstract A79: Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of antigen-presenting cells and tumor antigen-specific CTLs

Conference Cancer Immunology Research · September 1, 2018 AbstractThe tumor microenvironment favors tumor immune escape by suppressing production, activation and/or function of antitumor T cells. Our group has developed a recombinant Rhino-Poliovirus chimera, PVSRI ... Full text Cite

Abstract LB-302: Oncolytic poliovirus-mediated inflammation and immunity in breast cancer

Conference Cancer Research · July 1, 2018 AbstractBreast cancer is the most common malignancy among women in the United States and the second leading cause of cancer deaths in women. Disease prognosis, local recurrence rates and response to therapy ... Full text Cite

Failure mode analysis of GaN-HEMT under high temperature operation

Conference IEEE International Reliability Physics Symposium Proceedings · May 25, 2018 The purpose of this study is to investigate the physical mechanism of the threshold voltage shift of GaN-HEMT in high temperature storage tests. Using microscopic Raman spectrometry, we analyzed crystal distortion under the gate metal of devices which show ... Full text Cite

Investigation of the pulsed-IV degradation mechanism of GaN-HEMT under high temperature storage tests

Conference IEEE International Reliability Physics Symposium Proceedings · May 25, 2018 The purpose of this study is to investigate the physical mechanism of pulsed-IV degradation under high temperature storage tests. Using the measurements of the pulsed S-parameters immediately after the voltage stress was applied to the GaN-HEMT, we carried ... Full text Cite

Dose finding study of the intratumoral administration of the oncolytic polio/rhinovirus recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG).

Conference Journal of Clinical Oncology · May 20, 2017 e13533 Background: The live attenuated oral poliovirus vaccine was modified to contain a heterologous internal ribosomal entry site stemming from human rhinovirus type 2, creating PVSRIPO. PVSRIPO recognizes CD155, an oncofetal c ... Full text Link to item Cite

Phase 1 single-center, dose escalation study of D2C7-IT administered intratumorally via convection-enhanced delivery for adult patients with recurrent malignant glioma.

Conference Journal of Clinical Oncology · May 20, 2017 e13532 Background: D2C7 immunotoxin (D2C7-IT) is a dual-specific recombinant immunotoxin consisting of EGFR-wt and EGFRvIII monoclonal antibodies with a genetically engineered Pseudomonas exotoxin, PE-38KDEL. The primary objectiv ... Full text Link to item Cite

A combinatorial immunotherapy for malignant brain tumors: D2C7 immunotoxin and immune checkpoint inhibitors.

Conference Journal of Clinical Oncology · March 1, 2017 102 Background: Immunotoxins can induce direct and rapid cytotoxicity by targeting specific tumor antigens. D2C7 is a unique recombinant immunotoxin targeting EGFRwt/EGFRvIII, two frequently overexpressed proteins on gliomas, and ... Full text Cite

Immunotoxin and bcl-2 inhibitor combination therapy targeting chondroitin sulfate proteoglycan 4.

Conference Journal of Clinical Oncology · March 1, 2017 74 Background: Immunotoxins (ITs) are a class of bifunctional chimeric proteins composed of an antibody fragment linked to a toxin. When ITs internalize into target cells, they induce protein synthesis inhibition and apoptosis. W ... Full text Cite

Anti-Podoplanin Immunotoxin Therapy For Lung Cancer Treatment

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma.

Conference Sci Rep · June 3, 2016 Risk or presence of metastasis in medulloblastoma causes substantial treatment-related morbidity and overall mortality. Through the comparison of cytokines and growth factors in the cerebrospinal fluid (CSF) of metastatic medulloblastoma patients with fact ... Full text Link to item Cite

Patient survival on the dose escalation phase of the Oncolytic Polio/Rhinovirus Recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG) clinical trial compared to historical controls.

Conference Journal of Clinical Oncology · May 20, 2016 Background: The live attenuated oral (SABIN) serotype 1 poliovirus vaccine was modified to contain a heterologous internal ribosomal entry site stemming from human rhinovirus type 2, creating PVSRIPO. PVSRIPO recognizes CD155, an oncofetal cell adhesion mo ... Full text Link to item Cite

Phase I trial of combination of antitumor immunotherapy targeted against cytomegalovirus (CMV) plus regulatory T-cell inhibition in patients with newly-diagnosed glioblastoma multiforme (GBM).

Conference Journal of Clinical Oncology · May 20, 2016 ackground: The inherent biologic specificity of immunotherapy offers the prospect of targeting neoplastic cells more precisely. Dendritic cells (DCs) are endowed with an extraordinary ability to activate CD4+ and CD8+ T-cells, and DCs loaded with antigens ... Full text Link to item Cite

Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma

Conference Cancer Research · October 1, 2014 AbstractDespite decades worth of research, glioblastoma remains one of the most lethal cancers. The identification of IDH1 as a major cancer gene in glioblastoma provides a great opportunity for improving ou ... Full text Cite

Frequent ATRX, CIC, FUBP1 and IDH1 Mutations Refine the Classification of Malignant Gliomas

Conference JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY · June 1, 2013 Link to item Cite

Abstract 2079: Antitumoral activity of INC280 against adult glioblastoma brain tumors xenografts.

Conference Cancer Research · April 15, 2013 AbstractINTRODUCTION: INC280 is an oral, highly selective c-Met receptor tyrosine kinase inhibitor. The hepatocyte growth factor (HGF)-c-Met pathway is one of the most frequently dysregulated pathways in hum ... Full text Cite

Lipophilic Mn Porphyrins in the Treatment of Brain Tumors

Conference Free Radical Biology and Medicine · November 2011 Full text Cite

THE GENETIC LANDSCAPE OF MEDULLOBLASTOMA

Conference NEURO-ONCOLOGY · May 1, 2011 Link to item Cite

Abstract 233: OTX2 copy number gain is a driver event in Shh-independent medulloblastomas

Conference Cancer Research · April 15, 2010 AbstractMedulloblastoma is the most common malignant brain tumor in children. With the exception of the Sonic Hedgehog (Shh) and Wnt pathways, the molecular events contributing to medulloblastoma tumorigenes ... Full text Cite

Environmental Exposures and Adult Brain Cancers

Conference Epidemiology · November 2009 Full text Cite

Environmental Exposures and Adult Brain Cancers

Conference EPIDEMIOLOGY · November 1, 2008 Link to item Cite

IDENTIFICATION OF MICROBIAL DNAS IN BRAIN TUMORS

Conference NEURO-ONCOLOGY · October 1, 2008 Link to item Cite

GENOMIC LANDSCAPE OF GLIOBLASTOMA

Conference NEURO-ONCOLOGY · October 1, 2008 Link to item Cite

Temozolomide as a vaccine adjuvant in GBM

Conference JOURNAL OF CLINICAL ONCOLOGY · June 20, 2007 Link to item Cite

Tumor-specific peptide vaccination in newly-diagnosed patients with GBM.

Conference JOURNAL OF CLINICAL ONCOLOGY · June 20, 2006 Link to item Cite

Prognostic significance of OTX2 in medulloblastoma

Conference CANCER RESEARCH · April 1, 2006 Link to item Cite

Molecular genomics of medulloblastoma

Conference NEURO-ONCOLOGY · October 1, 2004 Link to item Cite

Phase I trial study of [131]I-labeled chimeric 81C6 mAb for the treatment of patients with non-Hodgkin's lymphoma

Conference EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING · August 1, 2004 Link to item Cite

Sub-classification of glioblastoma defined by comparative genomic hybridization alterations.

Conference JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY · May 1, 2003 Link to item Cite

NEUROPATHOLOGY OF MULTIPLE VERSUS SINGLE DOSE INTRATHECAL MELPHALAN IN RATS

Conference Journal of Neuropathology and Experimental Neurology · May 1993 Full text Cite

A NUDE RAT MODEL OF LEPTOMENINGEAL TUMOR DISSEMINATION (LTD) OF HUMAN MEDULLOBLASTOMA

Conference Journal of Neuropathology and Experimental Neurology · May 1989 Full text Cite

EXPERIMENTAL CHEMOTHERAPY OF VIRAL-INDUCED BRAIN TUMORS

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · 1974 Link to item Cite

ANALYSIS OF I-125 LABELED ANTIGLIOMA ANTIBODIES ADSORBED BY INTACT MONOLAYERS OF CULTURED GLIOMA CELLS

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · 1973 Link to item Cite

HAMSTER BRAIN TUMORS INDUCED BY 4 STRAINS OF AVIAN SARCOMA-VIRUS (ASV)

Conference JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY · 1973 Link to item Cite

AVIAN SARCOMA-VIRUS INDUCED BRAIN TUMORS IN CDF RATS

Conference JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY · 1973 Link to item Cite