Scholars@Duke
Darell Doty Bigner

Darell Doty Bigner

E. L. and Lucille F. Jones Cancer Distinguished Research Professor, in the School of Medicine
Neurosurgery
bigne001@mc.duke.edu
Duke Box 3156, Durham, NC 27710
177 Med Sci Res Bldg, Durham, NC 27710

Scholarly Works - Other

Supplementary Figure S5 from Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration

Other · February 3, 2026 <p>Supplementary Figure S5. PVSRIPO is shed in phosphatidyl-serine enriched vesicles from A375 melanoma cells (extended data relating to Figure 4G).</p> ... Full text Cite

Supplementary Figure S4 from Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration

Other · February 3, 2026 <p>Supplementary Figure S4. a,b, Extended data relating to Figure 4C-G. MECA-79+ HEV, which harbor (-)strand vRNA in CT2A glioma-bearing mice after dual site (IT+CPLI) PVSRIPO, stain positive for the poliovirus receptor CD155.</p> Full text Cite

Supplementary Figure S2 from Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration

Other · February 3, 2026 <p>Supplementary Figure S2. Differences in gene expression and hallmark pathways between single-site (IT or CPLI) and dual-site (IT plus CPLI) treatment cohorts compared to mock treatment as shown.</p> ... Full text Cite

Supplementary Figure S3 from Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration

Other · February 3, 2026 <p>Supplementary Figure S3. Dual-site (IT+CPLI) PVSRIPO in CT2A-bearing mice changes immune cell composition in cLN (extended data relating to Figure 3).</p> ... Full text Cite

Supplementary Table S3 from Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration

Other · February 3, 2026 <p>Supplementary Table S3. Top-20 differentially expressed genes in tumor-infiltrating T cell subsets (extended data relating to Figure 5D).</p> ... Full text Cite

Supplementary Figure S6 from Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration

Other · February 3, 2026 <p>Supplementary Figure S6. a-c, Extended data relating to Figure 5. Umap of snRNAseq of combined samples from three intervals (see Figure 5D); individual cell types are labeled (a). Umap of cells identified as T cells in a; individual subset ... Full text Cite

Data from Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration

Other · February 3, 2026 <div>Abstract<p>Tumor-draining lymph nodes are a pivotal site for antitumor T-cell priming. However, their mechanistic roles in cancer immune surveillance and immunotherapy response remain poorly defined. Intratumor (IT) virotherapy gen ... Full text Cite

Supplementary Figure S1 from Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration

Other · February 3, 2026 <p>Supplementary Figure S1. Extended data on cLN phenotypes after IT PVSRIPO infusion in CT2A mouse glioma.</p> ... Full text Cite

Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.

Other Oncogene · June 1, 1995 The high incidence of loss of chromosome 10 alleles in glioblastoma multiforme suggests the presence on this chromosome of a tumor suppressor gene that is important in glioma tumorigenesis and progression. Our initial deletion mapping studies using restric ... Link to item Cite

BRAIN TUMOR SYMPOSIUM - PANEL DISCUSSION - MONDAY, OCTOBER 5, 1970

Other PROGRESS IN EXPERIMENTAL TUMOR RESEARCH · 1972 Link to item Cite