Blanche Capel
James B. Duke Distinguished Professor of Cell Biology
In mammals, the primary step in male sex determination is the initiation of testis development in the bipotential gonad primordium. This step depends on the Y-linked male sex-determining gene, Sry
. Expression of Sry
in the XY gonad, or as a transgene in an XX gonad, leads to the differentiation of Sertoli cells. Failures in Sertoli cell differentiation in the XY gonad result in sex reversal and ovary formation. In addition to Sertoli cell differentiation, we are studying the signaling pathways between Sry
expression and early steps in testis organogenesis using mouse as a model system. Using genetic and cell biology approaches, we determined the origin of several key cell types of the testis. We also identified two pathways, proliferation and cell migration, that are controlled by Sry
and lead to the architectural patterning of the testis. Currently we are investigating the novel hypothesis that reciprocal signals between the vasculature and Sertoli cells are involved in patterning testis cords. Testis organogenesis is an ideal model system to study the integration of vasculature during development of organ structure. In addition, we are investigating critical signals between Sertoli cells and germ cells during testis cord formation. Defects in these signals result in teratomas and gonadal blastomas, common neoplasias in young boys. Experimental approaches include the use of molecular and biochemical techniques, mutant mice, transgenics, organ culture assays, differential screens, immunocytochemistry imaging techniques, and classic mouse genetics.
Current Appointments & Affiliations
- James B. Duke Distinguished Professor of Cell Biology, Cell Biology, Basic Science Departments 2010
- Professor of Cell Biology, Cell Biology, Basic Science Departments 2005
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1993
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- 307 Research Drive, Nanaline Bldg Room 452, Durham, NC 27710
- Duke Box 3709 Med Ctr, Durham, NC 27710
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blanche.capel@duke.edu
(919) 684-6390
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Capel Lab
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Department of Cell Biology
- Background
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Education, Training, & Certifications
- Ph.D., University of Pennsylvania 1989
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Previous Appointments & Affiliations
- Associate Professor of Cell Biology with Tenure, Cell Biology, Basic Science Departments 2000 - 2005
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 1993 - 2000
- Recognition
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In the News
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Awards & Honors
- Research
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Selected Grants
- Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- DND1 Mediates Epigenetic Reprogramming During Cell Cycle Arrest In Male Germ Cells awarded by National Institutes of Health 2021 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Opposing Pathways in Mammalian Sex Determination awarded by National Institutes of Health 1998 - 2026
- Duke Women's Reproductive Health Research Scholars awarded by National Institutes of Health 2020 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Identification of a Genetic Pathway Linking Temperature with Epigenetic Control of Gonad Determination in T. scripta awarded by National Science Foundation 2019 - 2024
- Functions of the rete ovarii in ovary development, adult homeostasis, and female reproductive longevity awarded by National Institutes of Health 2021 - 2023
- Investigating the role of the ECM in sex determination awarded by Lalor Foundation, Inc. 2022 - 2023
- IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation 2019 - 2023
- Zeiss Lightsheet Upgrade to Expand Imaging Capabilities awarded by National Institutes of Health 2021 - 2022
- Defining Mechanisms of Ovarian Rescue awarded by National Institutes of Health 2017 - 2022
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7 awarded by National Institutes of Health 2020 - 2021
- DND1 Mediated Posttranscriptional Regulation in Murine Prospermatogonia During G1/G0 Arrest awarded by National Institutes of Health 2018 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Mechanisms of ovarian rescue in chemotherapy-treated female mice awarded by American Cancer Society, Inc. 2017 - 2020
- Center for Molecular & Cellular Studies of Ped Disease awarded by National Institutes of Health 2003 - 2018
- Temporal profiling and functional analysis of temperature-dependent sex determination awarded by National Science Foundation 2013 - 2017
- Role of Lamin B Receptor in Male Germ Cell Differentiation and Epigenetic Regulation awarded by Lalor Foundation, Inc. 2016 - 2017
- The Seventh International Symposium on the Biology of Vertebrate Sex Determination awarded by March of Dimes 2015
- Multidisciplinary Neonatal Training Grant awarded by National Institutes of Health 2010 - 2015
- Regulation of Germ Cell Pluripotency Through The RNA-Binding Protein, DND1 awarded by National Institutes of Health 2010 - 2014
- A new cell population regulating cell fate and morphogenesis in the mouse testis awarded by National Institutes of Health 2009 - 2012
- A Functional Assay to Test Conserved Mechanisms of Sex Determination in the Turtle, T. scripta awarded by National Science Foundation 2009 - 2011
- WNT4- Mediated Signaling During Mammalian Sex Determination awarded by National Institutes of Health 2007 - 2010
- Organ Specific Mechanisms of Vascular Development awarded by National Institutes of Health 1999 - 2008
- Mechanisms of Gonad Organogenesis in the red-eared slider tutle (Trachemys scripta) awarded by National Science Foundation 2003 - 2008
- Fourth Annual Symposium on the Biology of Vertebrate Sex Determination awarded by National Institutes of Health 2006
- Zeiss LSM510 META confocal-fluorescence spectroscopy awarded by National Institutes of Health 2003 - 2004
- Analysis of Sonic Hedgehog Function During Gonadogenesis awarded by National Institutes of Health 2001 - 2004
- Same awarded by National Science Foundation 1999 - 2002
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External Relationships
- Cornell University
- HUGODECA
- Society for Developmental Biology
- Society for the Study of Reproduction Annual Meeting
- University of Pennsylvania
- University of Wisconsin
- Publications & Artistic Works
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Selected Publications
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Books
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Capel, Blanche. Preface. Vol. 134, 2019. https://doi.org/10.1016/S0070-2153(19)30050-X.Full Text Link to Item
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Academic Articles
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Bunce, Corey, Lindsey Barske, Gloria Zhang, and Blanche Capel. “Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse.” Development 150, no. 5 (March 1, 2023). https://doi.org/10.1242/dev.201060.Full Text Link to Item
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Ruthig, Victor A., Talia Hatkevich, Josiah Hardy, Matthew B. Friedersdorf, Chloé Mayère, Serge Nef, Jack D. Keene, and Blanche Capel. “The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation.” Plos Genet 19, no. 3 (March 2023): e1010656. https://doi.org/10.1371/journal.pgen.1010656.Full Text Link to Item
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Bustamante-Marin, Ximena M., and Blanche Capel. “Oxygen availability influences the incidence of testicular teratoma in Dnd1Ter/+ mice.” Front Genet 14 (2023): 1179256. https://doi.org/10.3389/fgene.2023.1179256.Full Text Link to Item
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McKey, Jennifer, Dilara N. Anbarci, Corey Bunce, Alejandra E. Ontiveros, Richard R. Behringer, and Blanche Capel. “Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii.” Elife 11 (September 27, 2022). https://doi.org/10.7554/eLife.81088.Full Text Link to Item
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Mayère, Chloé, Violaine Regard, Aitana Perea-Gomez, Corey Bunce, Yasmine Neirijnck, Cyril Djari, Natividad Bellido-Carreras, et al. “Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.” Sci Adv 8, no. 21 (May 27, 2022): eabm0972. https://doi.org/10.1126/sciadv.abm0972.Full Text Link to Item
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Capel, B. “Beatrice Mintz (1921-2022): an innovator in embryo research and cancer biology.” Development (Cambridge, England) 149, no. 5 (March 1, 2022). https://doi.org/10.1242/dev.200607.Full Text
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Li, Shu-Yun, Xiaowei Gu, Anna Heinrich, Emily G. Hurley, Blanche Capel, and Tony DeFalco. “Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†.” Biol Reprod 105, no. 4 (October 11, 2021): 958–75. https://doi.org/10.1093/biolre/ioab098.Full Text Link to Item
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Bunce, Corey, Jennifer McKey, and Blanche Capel. “Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging.” Development 148, no. 18 (September 15, 2021). https://doi.org/10.1242/dev.199208.Full Text Link to Item
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Bunce, Corey, Jennifer McKey, and Blanche Capel. “Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging.” Development 148, no. 18 (September 15, 2021). https://doi.org/10.1242/dev.199208.Full Text Link to Item
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Stöck, Matthias, Lukáš Kratochvíl, Heiner Kuhl, Michail Rovatsos, Ben J. Evans, Alexander Suh, Nicole Valenzuela, et al. “A brief review of vertebrate sex evolution with a pledge for integrative research: towards 'sexomics'.” Philos Trans R Soc Lond B Biol Sci 376, no. 1832 (August 30, 2021): 20200426. https://doi.org/10.1098/rstb.2020.0426.Full Text Link to Item
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Weber, Ceri, and Blanche Capel. “Sex determination without sex chromosomes.” Philos Trans R Soc Lond B Biol Sci 376, no. 1832 (August 30, 2021): 20200109. https://doi.org/10.1098/rstb.2020.0109.Full Text Link to Item
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Yokonishi, Tetsuhiro, and Blanche Capel. “Differentiation of fetal sertoli cells in the adult testis.” Reproduction 162, no. 2 (July 8, 2021): 141–47. https://doi.org/10.1530/REP-21-0106.Full Text Link to Item
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Garrett, Aliesha, Nikolai Rakhilin, Nian Wang, Jennifer McKey, Gary Cofer, Robert Bj Anderson, Blanche Capel, G Allan Johnson, and Xiling Shen. “Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography.” J Neural Eng 18, no. 4 (June 8, 2021). https://doi.org/10.1088/1741-2552/ac0089.Full Text Link to Item
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Ruthig, Victor A., Tetsuhiro Yokonishi, Matthew B. Friedersdorf, Sofia Batchvarova, Josiah Hardy, Jason A. Garness, Jack D. Keene, and Blanche Capel. “A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†.” Biol Reprod 104, no. 4 (April 1, 2021): 861–74. https://doi.org/10.1093/biolre/ioaa233.Full Text Link to Item
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Dupont, Shannon, and Blanche Capel. “The Chromatin State during Gonadal Sex Determination.” Sex Dev 15, no. 5–6 (2021): 308–16. https://doi.org/10.1159/000520007.Full Text Link to Item
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McKey, Jennifer, Lisa A. Cameron, Devon Lewis, Iordan S. Batchvarov, and Blanche Capel. “Combined iDISCO and CUBIC tissue clearing and lightsheet microscopy for in toto analysis of the adult mouse ovary†.” Biol Reprod 102, no. 5 (April 24, 2020): 1080–89. https://doi.org/10.1093/biolre/ioaa012.Full Text Link to Item
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Weber, Ceri, Yingjie Zhou, Jong Gwan Lee, Loren L. Looger, Guoying Qian, Chutian Ge, and Blanche Capel. “Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b.” Science 368, no. 6488 (April 17, 2020): 303–6. https://doi.org/10.1126/science.aaz4165.Full Text Link to Item
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Huang, Qiang, Malkiel A. Cohen, Fernando C. Alsina, Garth Devlin, Aliesha Garrett, Jennifer McKey, Patrick Havlik, et al. “Intravital imaging of mouse embryos.” Science 368, no. 6487 (April 10, 2020): 181–86. https://doi.org/10.1126/science.aba0210.Full Text Open Access Copy Link to Item
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Yokonishi, Tetsuhiro, Jennifer McKey, Shintaro Ide, and Blanche Capel. “Sertoli cell ablation and replacement of the spermatogonial niche in mouse.” Nat Commun 11, no. 1 (January 2, 2020): 40. https://doi.org/10.1038/s41467-019-13879-8.Full Text Link to Item
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Capel, Blanche. “WOMEN IN REPRODUCTIVE SCIENCE: To be or not to be a testis.” Reproduction 158, no. 6 (December 2019): F101–11. https://doi.org/10.1530/REP-19-0151.Full Text Open Access Copy Link to Item
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Nicol, Barbara, Sara A. Grimm, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, and Humphrey H-C Yao. “RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.” Nat Commun 10, no. 1 (November 11, 2019): 5116. https://doi.org/10.1038/s41467-019-13060-1.Full Text Link to Item
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Ruthig, Victor A., Matthew B. Friedersdorf, Jason A. Garness, Steve C. Munger, Corey Bunce, Jack D. Keene, and Blanche Capel. “The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.” Development 146, no. 19 (July 25, 2019). https://doi.org/10.1242/dev.175950.Full Text Open Access Copy Link to Item
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Capel, Blanche. “Commentary on "Direct visualization, by β-galactosidase histochemistry, of differentiated normal cells derived from malignant teratocarcinoma in allophenic mice" by Dewey and Mintz 1978.” Dev Biol 450, no. 2 (June 15, 2019): 65–75. https://doi.org/10.1016/j.ydbio.2019.04.009.Full Text Link to Item
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Garcia-Moreno, S Alexandra, Yi-Tzu Lin, Christopher R. Futtner, Isabella M. Salamone, Blanche Capel, and Danielle M. Maatouk. “CBX2 is required to stabilize the testis pathway by repressing Wnt signaling.” Plos Genet 15, no. 5 (May 2019): e1007895. https://doi.org/10.1371/journal.pgen.1007895.Full Text Link to Item
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Kumar, T Rajendra. “An interview with Dr Blanche Capel.” Biol Reprod 100, no. 4 (April 1, 2019): 865–68. https://doi.org/10.1093/biolre/ioz033.Full Text Link to Item
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McKey, Jennifer, Corey Bunce, Iordan S. Batchvarov, David M. Ornitz, and Blanche Capel. “Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.” Proc Natl Acad Sci U S A 116, no. 12 (March 19, 2019): 5570–75. https://doi.org/10.1073/pnas.1814930116.Full Text Link to Item
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Weber, Ceri, and Blanche Capel. “Sex reversal.” Curr Biol 28, no. 21 (November 5, 2018): R1234–36. https://doi.org/10.1016/j.cub.2018.09.043.Full Text Link to Item
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Garcia-Moreno, S Alexandra, Michael P. Plebanek, and Blanche Capel. “Epigenetic regulation of male fate commitment from an initially bipotential system.” Mol Cell Endocrinol 468 (June 15, 2018): 19–30. https://doi.org/10.1016/j.mce.2018.01.009.Full Text Link to Item
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Ge, Chutian, Jian Ye, Ceri Weber, Wei Sun, Haiyan Zhang, Yingjie Zhou, Cheng Cai, Guoying Qian, and Blanche Capel. “The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species.” Science 360, no. 6389 (May 11, 2018): 645–48. https://doi.org/10.1126/science.aap8328.Full Text Link to Item
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Pierpont, Timothy M., Amy M. Lyndaker, Claire M. Anderson, Qiming Jin, Elizabeth S. Moore, Jamie L. Roden, Alicia Braxton, et al. “Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer.” Cell Rep 21, no. 7 (November 14, 2017): 1896–1909. https://doi.org/10.1016/j.celrep.2017.10.078.Full Text Link to Item
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Capel, Blanche. “Vertebrate sex determination: evolutionary plasticity of a fundamental switch.” Nat Rev Genet 18, no. 11 (November 2017): 675–89. https://doi.org/10.1038/nrg.2017.60.Full Text Link to Item
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Ge, Chutian, Jian Ye, Haiyan Zhang, Yi Zhang, Wei Sun, Yapeng Sang, Blanche Capel, and Guoying Qian. “Dmrt1 induces the male pathway in a turtle species with temperature-dependent sex determination.” Development 144, no. 12 (June 15, 2017): 2222–33. https://doi.org/10.1242/dev.152033.Full Text Link to Item
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Maatouk, Danielle M., Anirudh Natarajan, Yoichiro Shibata, Lingyun Song, Gregory E. Crawford, Uwe Ohler, and Blanche Capel. “Genome-wide identification of regulatory elements in Sertoli cells.” Development 144, no. 4 (February 15, 2017): 720–30. https://doi.org/10.1242/dev.142554.Full Text Link to Item
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Czerwinski, Michael, Anirudh Natarajan, Lindsey Barske, Loren L. Looger, and Blanche Capel. “A timecourse analysis of systemic and gonadal effects of temperature on sexual development of the red-eared slider turtle Trachemys scripta elegans.” Dev Biol 420, no. 1 (December 1, 2016): 166–77. https://doi.org/10.1016/j.ydbio.2016.09.018.Full Text Link to Item
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Batchvarov, Iordan Stefanov, Rachel Williamson Taylor, Ximena Bustamante-Marín, Michael Czerwinski, Erika Segear Johnson, Sally Kornbluth, and Blanche Capel. “A grafted ovarian fragment rescues host fertility after chemotherapy.” Mol Hum Reprod 22, no. 12 (December 2016): 842–51. https://doi.org/10.1093/molehr/gaw064.Full Text Link to Item
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Bunce, Corey, and Blanche Capel. “Cycling in the Cell Fate Landscape.” Curr Top Dev Biol 116 (2016): 153–65. https://doi.org/10.1016/bs.ctdb.2015.10.001.Full Text Link to Item
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Bustamante-Marin, Ximena M., Matthew S. Cook, Jessica Gooding, Christopher Newgard, and Blanche Capel. “Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites.” Biol Reprod 93, no. 3 (September 2015): 78. https://doi.org/10.1095/biolreprod.115.128850.Full Text Link to Item
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DeFalco, Tony, Sarah J. Potter, Alyna V. Williams, Brittain Waller, Matthew J. Kan, and Blanche Capel. “Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.” Cell Rep 12, no. 7 (August 18, 2015): 1107–19. https://doi.org/10.1016/j.celrep.2015.07.015.Full Text Link to Item
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Lin, Yi-Tzu, and Blanche Capel. “Cell fate commitment during mammalian sex determination.” Curr Opin Genet Dev 32 (June 2015): 144–52. https://doi.org/10.1016/j.gde.2015.03.003.Full Text Link to Item
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Capel, Blanche. “Ovarian epithelium regeneration by Lgr5(+) cells.” Nat Cell Biol 16, no. 8 (August 2014): 743–44. https://doi.org/10.1038/ncb3020.Full Text Link to Item
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DeFalco, Tony, Indrashis Bhattacharya, Alyna V. Williams, Dustin M. Sams, and Blanche Capel. “Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis.” Proc Natl Acad Sci U S A 111, no. 23 (June 10, 2014): E2384–93. https://doi.org/10.1073/pnas.1400057111.Full Text Link to Item
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Mork, Lindsey, Michael Czerwinski, and Blanche Capel. “Predetermination of sexual fate in a turtle with temperature-dependent sex determination.” Dev Biol 386, no. 1 (February 1, 2014): 264–71. https://doi.org/10.1016/j.ydbio.2013.11.026.Full Text Link to Item
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Capel, Blanche. “Development. The minimalist Y.” Science 343, no. 6166 (January 3, 2014): 32–33. https://doi.org/10.1126/science.1248486.Full Text Link to Item
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Maatouk, Danielle M., Lindsey Mork, Anne-Amandine Chassot, Marie-Christine Chaboissier, and Blanche Capel. “Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.” Dev Biol 383, no. 2 (November 15, 2013): 295–306. https://doi.org/10.1016/j.ydbio.2013.08.026.Full Text Link to Item
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Garcia, Thomas Xavier, Tony DeFalco, Blanche Capel, and Marie-Claude Hofmann. “Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence.” Dev Biol 377, no. 1 (May 1, 2013): 188–201. https://doi.org/10.1016/j.ydbio.2013.01.031.Full Text Link to Item
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Defalco, Tony, Anirudh Saraswathula, Anaïs Briot, M Luisa Iruela-Arispe, and Blanche Capel. “Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.” Biol Reprod 88, no. 4 (April 2013): 91. https://doi.org/10.1095/biolreprod.112.106138.Full Text Link to Item
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Capel, Blanche, and Minoru Tanaka. “Forward to the special issue on sex determination.” Dev Dyn 242, no. 4 (April 2013): 303–6. https://doi.org/10.1002/dvdy.23937.Full Text Link to Item
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Shaffer, H Bradley, Patrick Minx, Daniel E. Warren, Andrew M. Shedlock, Robert C. Thomson, Nicole Valenzuela, John Abramyan, et al. “The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.” Genome Biol 14, no. 3 (March 28, 2013): R28. https://doi.org/10.1186/gb-2013-14-3-r28.Full Text Link to Item
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Bustamante-Marín, Ximena, Jason A. Garness, and Blanche Capel. “Testicular teratomas: an intersection of pluripotency, differentiation and cancer biology.” Int J Dev Biol 57, no. 2–4 (2013): 201–10. https://doi.org/10.1387/ijdb.130136bc.Full Text Link to Item
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Munger, Steven C., Anirudh Natarajan, Loren L. Looger, Uwe Ohler, and Blanche Capel. “Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination.” Plos Genet 9, no. 7 (2013): e1003630. https://doi.org/10.1371/journal.pgen.1003630.Full Text Link to Item
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Shaffer, H. B., P. Minx, D. E. Warren, A. M. Shedlock, R. C. Thomson, N. Valenzuela, J. Abramyan, et al. “The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.” Genome Biology 14, no. 3 (2013). https://doi.org/10.1186/gb-2013-14-3-r28.Full Text
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Mork, Lindsey, and Blanche Capel. “Conserved action of β-catenin during female fate determination in the red-eared slider turtle.” Evol Dev 15, no. 2 (2013): 96–106. https://doi.org/10.1111/ede.12020.Full Text Link to Item
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Jameson, Samantha A., Yi-Tzu Lin, and Blanche Capel. “Testis development requires the repression of Wnt4 by Fgf signaling.” Dev Biol 370, no. 1 (October 1, 2012): 24–32. https://doi.org/10.1016/j.ydbio.2012.06.009.Full Text Link to Item
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Mork, Lindsey, Danielle M. Maatouk, Jill A. McMahon, Jin Jin Guo, Pumin Zhang, Andrew P. McMahon, and Blanche Capel. “Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice.” Biol Reprod 86, no. 2 (February 2012): 37. https://doi.org/10.1095/biolreprod.111.095208.Full Text Link to Item
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Maatouk, Danielle M., Lindsey Mork, Ashley Hinson, Akio Kobayashi, Andrew P. McMahon, and Blanche Capel. “Germ cells are not required to establish the female pathway in mouse fetal gonads.” Plos One 7, no. 10 (2012): e47238. https://doi.org/10.1371/journal.pone.0047238.Full Text Link to Item
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Cool, Jonah, Tony DeFalco, and Blanche Capel. “Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis.” Wiley Interdiscip Rev Dev Biol 1, no. 6 (2012): 847–59. https://doi.org/10.1002/wdev.62.Full Text Link to Item
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Jameson, Samantha A., Anirudh Natarajan, Jonah Cool, Tony DeFalco, Danielle M. Maatouk, Lindsey Mork, Steven C. Munger, and Blanche Capel. “Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad.” Plos Genet 8, no. 3 (2012): e1002575. https://doi.org/10.1371/journal.pgen.1002575.Full Text Link to Item
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Mork, Lindsey, Hao Tang, Iordan Batchvarov, and Blanche Capel. “Mouse germ cell clusters form by aggregation as well as clonal divisions.” Mech Dev 128, no. 11–12 (2012): 591–96. https://doi.org/10.1016/j.mod.2011.12.005.Full Text Link to Item
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Munger, Steven C., and Blanche Capel. “Sex and the circuitry: progress toward a systems-level understanding of vertebrate sex determination.” Wiley Interdiscip Rev Syst Biol Med 4, no. 4 (2012): 401–12. https://doi.org/10.1002/wsbm.1172.Full Text Link to Item
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DeFalco, Tony, Satoru Takahashi, and Blanche Capel. “Two distinct origins for Leydig cell progenitors in the fetal testis.” Dev Biol 352, no. 1 (April 1, 2011): 14–26. https://doi.org/10.1016/j.ydbio.2011.01.011.Full Text Link to Item
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Cool, Jonah, Tony J. DeFalco, and Blanche Capel. “Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning.” Proc Natl Acad Sci U S A 108, no. 1 (January 4, 2011): 167–72. https://doi.org/10.1073/pnas.1010299108.Full Text Link to Item
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Cook, Matthew S., Steven C. Munger, Joseph H. Nadeau, and Blanche Capel. “Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background.” Development 138, no. 1 (January 2011): 23–32. https://doi.org/10.1242/dev.057000.Full Text Open Access Copy Link to Item
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Mork, Lindsey, and Blanche Capel. “Oestrogen shuts the door on SOX9.” Bmc Biol 8 (August 31, 2010): 110. https://doi.org/10.1186/1741-7007-8-110.Full Text Open Access Copy Link to Item
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Barske, Lindsey A., and Blanche Capel. “Estrogen represses SOX9 during sex determination in the red-eared slider turtle Trachemys scripta.” Dev Biol 341, no. 1 (May 1, 2010): 305–14. https://doi.org/10.1016/j.ydbio.2010.02.010.Full Text Link to Item
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Barske, Lindsey A., and Blanche Capel. “Sex determination: An avian sexual revolution.” Nature 464, no. 7286 (March 11, 2010): 171–72. https://doi.org/10.1038/464171a.Full Text Link to Item
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Cook, Matthew S., and Blanche Capel. “Shifting gears and putting on the brakes: Female germ cells transition into meiosis.” Cell Cycle 9, no. 3 (February 1, 2010): 447–48.Link to Item
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Maatouk, Danielle M., and Blanche Capel. “Unmasking a role for sex chromosomes in gene silencing.” Genome Biol 11, no. 9 (2010): 134. https://doi.org/10.1186/gb-2010-11-9-134.Full Text Open Access Copy Link to Item
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Krentz, Anthony D., Mark W. Murphy, Shinseog Kim, Matthew S. Cook, Blanche Capel, Rui Zhu, Angabin Matin, et al. “The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.” Proc Natl Acad Sci U S A 106, no. 52 (December 29, 2009): 22323–28. https://doi.org/10.1073/pnas.0905431106.Full Text Link to Item
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Munger, Steven C., David L. Aylor, Haider Ali Syed, Paul M. Magwene, David W. Threadgill, and Blanche Capel. “Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.” Genes Dev 23, no. 21 (November 1, 2009): 2521–36. https://doi.org/10.1101/gad.1835809.Full Text Link to Item
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Capel, B. “Choosing Sex.” Scientist 23, no. 10 (October 1, 2009).
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Cool, Jonah, and Blanche Capel. “VEGF mediated endothelial migration is required for testis morphogenesis.” Developmental Biology 331, no. 2 (July 2009): 497–497. https://doi.org/10.1016/j.ydbio.2009.05.418.Full Text
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Moniot, Brigitte, Faustine Declosmenil, Francisco Barrionuevo, Gerd Scherer, Kosuke Aritake, Safia Malki, Laetitia Marzi, et al. “The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation.” Development 136, no. 11 (June 2009): 1813–21. https://doi.org/10.1242/dev.032631.Full Text Link to Item
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Cook, Matthew S., Douglas Coveney, Iordan Batchvarov, Joseph H. Nadeau, and Blanche Capel. “BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice.” Dev Biol 328, no. 2 (April 15, 2009): 377–83. https://doi.org/10.1016/j.ydbio.2009.01.041.Full Text Link to Item
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Capel, B. “Gonad Morphogenesis in Vertebrates: Somatic-Germ Cell Interactions.” Annu Rev Cell Dev Biol, January 12, 2009. https://doi.org/10.1146/annurev.cellbio.042308.113350.Full Text Link to Item
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Cool, Jonah, and Blanche Capel. “Mixed signals: development of the testis.” Semin Reprod Med 27, no. 1 (January 2009): 5–13. https://doi.org/10.1055/s-0028-1108005.Full Text Link to Item
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DeFalco, Tony, and Blanche Capel. “Gonad morphogenesis in vertebrates: divergent means to a convergent end.” Annu Rev Cell Dev Biol 25 (2009): 457–82. https://doi.org/10.1146/annurev.cellbio.042308.13350.Full Text Link to Item
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Barske, Lindsey A., and Blanche Capel. “Blurring the edges in vertebrate sex determination.” Curr Opin Genet Dev 18, no. 6 (December 2008): 499–505. https://doi.org/10.1016/j.gde.2008.11.004.Full Text Link to Item
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Capel, Blanche, and Jordan Batchvarov. “Sex chromatin staining in amnion cells.” Csh Protoc 2008 (November 1, 2008): pdb.prot5079. https://doi.org/10.1101/pdb.prot5079.Full Text Link to Item
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Capel, Blanche, and Jordan Batchvarov. “Preparing recombinant gonad organ cultures.” Csh Protoc 2008 (November 1, 2008): pdb.prot5078. https://doi.org/10.1101/pdb.prot5078.Full Text Link to Item
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Tang, Hao, Jennifer Brennan, Jeannie Karl, Yoshio Hamada, Lori Raetzman, and Blanche Capel. “Notch signaling maintains Leydig progenitor cells in the mouse testis.” Development 135, no. 22 (November 2008): 3745–53. https://doi.org/10.1242/dev.024786.Full Text Link to Item
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Maatouk, Danielle M., Leo DiNapoli, Ashley Alvers, Keith L. Parker, Makoto M. Taketo, and Blanche Capel. “Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal.” Hum Mol Genet 17, no. 19 (October 1, 2008): 2949–55. https://doi.org/10.1093/hmg/ddn193.Full Text Link to Item
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Coveney, D., A. J. Ross, J. D. Slone, and B. Capel. “Erratum to "A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation" [Gene Expression Patterns 7 (2007) 82-92].” Gene Expression Patterns 8, no. 7–8 (September 1, 2008): 528. https://doi.org/10.1016/j.gep.2008.05.005.Full Text
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Coveney, Douglas, Andrea J. Ross, Jesse D. Slone, and Blanche Capel. “A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.” Gene Expr Patterns 8, no. 7–8 (September 2008): 529–37. https://doi.org/10.1016/j.gep.2008.05.006.Full Text Link to Item
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Tang, Hao, Andrea Ross, and Blanche Capel. “Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam.” Dev Biol 318, no. 1 (June 1, 2008): 73–81. https://doi.org/10.1016/j.ydbio.2008.03.001.Full Text Link to Item
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Coveney, Douglas, Jonah Cool, Tim Oliver, and Blanche Capel. “Four-dimensional analysis of vascularization during primary development of an organ, the gonad.” Proc Natl Acad Sci U S A 105, no. 20 (May 20, 2008): 7212–17. https://doi.org/10.1073/pnas.0707674105.Full Text Link to Item
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Cool, J., F. D. Carmona, J. C. Szucsik, and B. Capel. “Peritubular myoid cells are not the migrating population required for testis cord formation in the XY gonad.” Sex Dev 2, no. 3 (2008): 128–33. https://doi.org/10.1159/000143430.Full Text Link to Item
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DiNapoli, Leo, and Blanche Capel. “SRY and the standoff in sex determination.” Mol Endocrinol 22, no. 1 (January 2008): 1–9. https://doi.org/10.1210/me.2007-0250.Full Text Link to Item
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Durcova-Hills, Gabriela, and Blanche Capel. “Development of germ cells in the mouse.” Curr Top Dev Biol 83 (2008): 185–212. https://doi.org/10.1016/S0070-2153(08)00406-7.Full Text Link to Item
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Maatouk, Danielle M., and Blanche Capel. “Sexual development of the soma in the mouse.” Curr Top Dev Biol 83 (2008): 151–83. https://doi.org/10.1016/S0070-2153(08)00405-5.Full Text Link to Item
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Little, M. H., J. Brennan, K. Georgas, J. A. Davies, D. R. Davidson, R. A. Baldock, A. Beverdam, et al. “Corrigendum to "A high-resolution anatomical ontology of the developing murine genitourinary tract" [Gene Expression Patterns 7 (2007) 680-699] (DOI:10.1016/j.modgep.2007.03.002).” Gene Expression Patterns 8, no. 1 (December 1, 2007): 47–50. https://doi.org/10.1016/j.modgep.2007.07.003.Full Text
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Kim, Yuna, Nathan Bingham, Ryohei Sekido, Keith L. Parker, Robin Lovell-Badge, and Blanche Capel. “Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination.” Proc Natl Acad Sci U S A 104, no. 42 (October 16, 2007): 16558–63. https://doi.org/10.1073/pnas.0702581104.Full Text Link to Item
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DiNapoli, Leo, Paula Dietrich, and Blanche Capel. “Optimized regimen for expression of heat-inducible Cre in mice.” Biotechniques 42, no. 6 (June 2007): 710–14. https://doi.org/10.2144/000112495.Full Text Link to Item
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Little, Melissa H., Jane Brennan, Kylie Georgas, Jamie A. Davies, Duncan R. Davidson, Richard A. Baldock, Annemiek Beverdam, et al. “A high-resolution anatomical ontology of the developing murine genitourinary tract.” Gene Expr Patterns 7, no. 6 (June 2007): 680–99. https://doi.org/10.1016/j.modgep.2007.03.002.Full Text Link to Item
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DiNapoli, Leo, and Blanche Capel. “Germ cell depletion does not alter the morphogenesis of the fetal testis or ovary in the red-eared slider turtle (Trachemys scripta).” J Exp Zool B Mol Dev Evol 308, no. 3 (May 15, 2007): 236–41. https://doi.org/10.1002/jez.b.21136.Full Text Link to Item
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Coveney, Douglas, Andrea J. Ross, Jesse D. Slone, and Blanche Capel. “A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.” Gene Expr Patterns 7, no. 1–2 (January 2007): 82–92. https://doi.org/10.1016/j.modgep.2006.05.012.Full Text Link to Item
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Ross, A., S. Munger, and B. Capel. “Bmp7 regulates germ cell proliferation in mouse fetal gonads.” Sex Dev 1, no. 2 (2007): 127–37. https://doi.org/10.1159/000100034.Full Text Link to Item
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Capel, Blanche. “R-spondin1 tips the balance in sex determination.” Nat Genet 38, no. 11 (November 2006): 1233–34. https://doi.org/10.1038/ng1106-1233.Full Text Link to Item
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Chiu, Ernest S., Brian C. Capell, Robert Press, Sherell J. Aston, Elizabeth B. Jelks, and Glenn W. Jelks. “Successful management of orbital cellulitis and temporary visual loss after blepharoplasty.” Plast Reconstr Surg 118, no. 3 (September 2006): 67e-72e. https://doi.org/10.1097/01.prs.0000233031.17109.c6.Full Text Link to Item
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Kim, Yuna, and Blanche Capel. “Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem.” Dev Dyn 235, no. 9 (September 2006): 2292–2300. https://doi.org/10.1002/dvdy.20894.Full Text Link to Item
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Kim, Y., A. Kobayashi, R. Sekido, L. DiNapoli, J. Brennan, M. C. Chaboissier, F. Poulat, R. R. Behringer, R. Lovell-Badge, and B. Capel. “Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.” Plos Biology 4, no. 6 (June 26, 2006): 1000–1009. https://doi.org/10.1007/11558958_121.Full Text
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Kim, Yuna, Akio Kobayashi, Ryohei Sekido, Leo DiNapoli, Jennifer Brennan, Marie-Christine Chaboissier, Francis Poulat, Richard R. Behringer, Robin Lovell-Badge, and Blanche Capel. “Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.” Plos Biol 4, no. 6 (June 2006): e187. https://doi.org/10.1371/journal.pbio.0040187.Full Text Link to Item
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DiNapoli, Leo, Jordan Batchvarov, and Blanche Capel. “FGF9 promotes survival of germ cells in the fetal testis.” Development 133, no. 8 (April 2006): 1519–27. https://doi.org/10.1242/dev.02303.Full Text Link to Item
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Koubova, Jana, Douglas B. Menke, Qing Zhou, Blanche Capel, Michael D. Griswold, and David C. Page. “Retinoic acid regulates sex-specific timing of meiotic initiation in mice.” Proc Natl Acad Sci U S A 103, no. 8 (February 21, 2006): 2474–79. https://doi.org/10.1073/pnas.0510813103.Full Text Link to Item
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Yao, Humphrey H-C, and Blanche Capel. “Temperature, genes, and sex: a comparative view of sex determination in Trachemys scripta and Mus musculus.” J Biochem 138, no. 1 (July 2005): 5–12. https://doi.org/10.1093/jb/mvi097.Full Text Link to Item
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Peng, X., C. Bhattacharya, M. D. Jian, R. Behringer, K. Youngren, B. Lamb, D. Coveney, et al. “New clues to the genetic basis of testicular cancer suggest dead end mutations.” Cancer Biology and Therapy 4, no. 6 (June 1, 2005).
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Youngren, Kirsten K., Douglas Coveney, Xiaoning Peng, Chitralekha Bhattacharya, Laura S. Schmidt, Michael L. Nickerson, Bruce T. Lamb, et al. “The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.” Nature 435, no. 7040 (May 19, 2005): 360–64. https://doi.org/10.1038/nature03595.Full Text Link to Item
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Ross, Andrea J., and Blanche Capel. “Signaling at the crossroads of gonad development.” Trends Endocrinol Metab 16, no. 1 (2005): 19–25. https://doi.org/10.1016/j.tem.2004.11.004.Full Text Link to Item
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Yao, Humphrey H-C, Leo DiNapoli, and Blanche Capel. “Cellular mechanisms of sex determination in the red-eared slider turtle, Trachemys scripta.” Mech Dev 121, no. 11 (November 2004): 1393–1401. https://doi.org/10.1016/j.mod.2004.06.001.Full Text Link to Item
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Capel, Blanche, and Doug Coveney. “Frank Lillie's freemartin: illuminating the pathway to 21st century reproductive endocrinology.” J Exp Zool a Comp Exp Biol 301, no. 11 (November 1, 2004): 853–56. https://doi.org/10.1002/jez.a.107.Full Text Link to Item
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Takada, Shuji, Leo DiNapoli, Blanche Capel, and Peter Koopman. “Sox8 is expressed at similar levels in gonads of both sexes during the sex determining period in turtles.” Dev Dyn 231, no. 2 (October 2004): 387–95. https://doi.org/10.1002/dvdy.20132.Full Text Link to Item
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Cui, Shiying, Andrea Ross, Nancy Stallings, Keith L. Parker, Blanche Capel, and Susan E. Quaggin. “Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice.” Development 131, no. 16 (August 2004): 4095–4105. https://doi.org/10.1242/dev.01266.Full Text Link to Item
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Schmahl, Jennifer, Yuna Kim, Jennifer S. Colvin, David M. Ornitz, and Blanche Capel. “Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.” Development 131, no. 15 (August 2004): 3627–36. https://doi.org/10.1242/dev.01239.Full Text Link to Item
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Brennan, Jennifer, and Blanche Capel. “One tissue, two fates: molecular genetic events that underlie testis versus ovary development.” Nat Rev Genet 5, no. 7 (July 2004): 509–21. https://doi.org/10.1038/nrg1381.Full Text Link to Item
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Yao, Humphrey H. C., Martin M. Matzuk, Carolina J. Jorgez, Douglas B. Menke, David C. Page, Amanda Swain, and Blanche Capel. “Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.” Dev Dyn 230, no. 2 (June 2004): 210–15. https://doi.org/10.1002/dvdy.20042.Full Text Link to Item
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Ross, Andrea J., Christopher Tilman, Humphrey Yao, David MacLaughlin, and Blanche Capel. “AMH induces mesonephric cell migration in XX gonads.” Mol Cell Endocrinol 211, no. 1–2 (December 15, 2003): 1–7. https://doi.org/10.1016/j.mce.2003.09.021.Full Text Link to Item
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Yao, Humphrey H-C, Leo DiNapoli, and Blanche Capel. “Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads.” Development 130, no. 24 (December 2003): 5895–5902. https://doi.org/10.1242/dev.00836.Full Text Link to Item
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Atchison, Fawn W., Blanche Capel, and Anthony R. Means. “Pin1 regulates the timing of mammalian primordial germ cell proliferation.” Development 130, no. 15 (August 2003): 3579–86. https://doi.org/10.1242/dev.00584.Full Text Link to Item
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Jeays-Ward, Katherine, Christine Hoyle, Jennifer Brennan, Mathieu Dandonneau, Graham Alldus, Blanche Capel, and Amanda Swain. “Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad.” Development 130, no. 16 (August 2003): 3663–70. https://doi.org/10.1242/dev.00591.Full Text Link to Item
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Schmahl, Jennifer, and Blanche Capel. “Cell proliferation is necessary for the determination of male fate in the gonad.” Dev Biol 258, no. 2 (June 15, 2003): 264–76. https://doi.org/10.1016/s0012-1606(03)00122-2.Full Text Link to Item
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Schmahl, Jennifer, Humphrey H. Yao, Fernando Pierucci-Alves, and Blanche Capel. “Colocalization of WT1 and cell proliferation reveals conserved mechanisms in temperature-dependent sex determination.” Genesis 35, no. 4 (April 2003): 193–201. https://doi.org/10.1002/gene.10176.Full Text Link to Item
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Brennan, Jennifer, Christopher Tilmann, and Blanche Capel. “Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad.” Genes Dev 17, no. 6 (March 15, 2003): 800–810. https://doi.org/10.1101/gad.1052503.Full Text Link to Item
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Yao, Humphrey Hung-Chang, and Blanche Capel. “Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis.” Dev Biol 246, no. 2 (June 15, 2002): 356–65. https://doi.org/10.1006/dbio.2002.0663.Full Text Link to Item
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Yao, Humphrey Hung-Chang, Wendy Whoriskey, and Blanche Capel. “Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis.” Genes Dev 16, no. 11 (June 1, 2002): 1433–40. https://doi.org/10.1101/gad.981202.Full Text Link to Item
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Brennan, Jennifer, Jeannie Karl, and Blanche Capel. “Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad.” Dev Biol 244, no. 2 (April 15, 2002): 418–28. https://doi.org/10.1006/dbio.2002.0578.Full Text Link to Item
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Tilmann, Christopher, and Blanche Capel. “Cellular and molecular pathways regulating mammalian sex determination.” Recent Prog Horm Res 57 (2002): 1–18. https://doi.org/10.1210/rp.57.1.1.Full Text Link to Item
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Yao, Humphrey Hung-Chang, Christopher Tilmann, Guang-Quan Zhao, and Blanche Capel. “The battle of the sexes: opposing pathways in sex determination.” Novartis Found Symp 244 (2002): 187–98.Link to Item
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Colvin, J. S., R. P. Green, J. Schmahl, B. Capel, and D. M. Ornitz. “Male-to-female sex reversal in mice lacking fibroblast growth factor 9.” Cell 104, no. 6 (March 23, 2001): 875–89. https://doi.org/10.1016/s0092-8674(01)00284-7.Full Text Link to Item
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Albrecht, K. H., B. Capel, L. L. Washburn, and E. M. Eicher. “Defective mesonephric cell migration is associated with abnormal testis cord development in C57BL/6J XY(Mus domesticus) mice.” Dev Biol 225, no. 1 (September 1, 2000): 26–36. https://doi.org/10.1006/dbio.2000.9819.Full Text Link to Item
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Capel, B. “The battle of the sexes.” Mech Dev 92, no. 1 (March 15, 2000): 89–103. https://doi.org/10.1016/s0925-4773(99)00327-5.Full Text Link to Item
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Schmahl, J., E. M. Eicher, L. L. Washburn, and B. Capel. “Sry induces cell proliferation in the mouse gonad.” Development 127, no. 1 (January 2000): 65–73. https://doi.org/10.1242/dev.127.1.65.Full Text Link to Item
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Tilmann, C., and B. Capel. “Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad.” Development 126, no. 13 (July 1999): 2883–90. https://doi.org/10.1242/dev.126.13.2883.Full Text Link to Item
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Capel, B., K. H. Albrecht, L. L. Washburn, and E. M. Eicher. “Migration of mesonephric cells into the mammalian gonad depends on Sry.” Mech Dev 84, no. 1–2 (June 1999): 127–31. https://doi.org/10.1016/s0925-4773(99)00047-7.Full Text Link to Item
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Karl, J., and B. Capel. “Sertoli cells of the mouse testis originate from the coelomic epithelium.” Dev Biol 203, no. 2 (November 15, 1998): 323–33. https://doi.org/10.1006/dbio.1998.9068.Full Text Link to Item
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Brennan, J., J. Karl, J. Martineau, K. Nordqvist, J. Schmahl, C. Tilmann, K. Ung, and B. Capel. “Sry and the testis: molecular pathways of organogenesis.” J Exp Zool 281, no. 5 (August 1, 1998): 494–500. https://doi.org/10.1002/(sici)1097-010x(19980801)281:5<494::aid-jez14>3.0.co;2-9.Full Text Link to Item
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Capel, B. “Sex in the 90s: SRY and the switch to the male pathway.” Annu Rev Physiol 60 (1998): 497–523. https://doi.org/10.1146/annurev.physiol.60.1.497.Full Text Link to Item
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Martineau, J., K. Nordqvist, C. Tilmann, R. Lovell-Badge, and B. Capel. “Male-specific cell migration into the developing gonad.” Curr Biol 7, no. 12 (December 1, 1997): 958–68. https://doi.org/10.1016/s0960-9822(06)00415-5.Full Text Link to Item
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Capel, B., J. R. Hawkins, E. Hirst, D. Kioussis, and R. Lovell-Badge. “Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge.” J Cell Sci 109 ( Pt 5) (May 1996): 899–909. https://doi.org/10.1242/jcs.109.5.899.Full Text Link to Item
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Capel, B. “The role of Sry in cellular events underlying mammalian sex determination.” Curr Top Dev Biol 32 (1996): 1–37. https://doi.org/10.1016/s0070-2153(08)60423-8.Full Text Link to Item
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Karl, J., and B. Capel. “Three-dimensional structure of the developing mouse genital ridge.” Philos Trans R Soc Lond B Biol Sci 350, no. 1333 (November 29, 1995): 235–42. https://doi.org/10.1098/rstb.1995.0157.Full Text Link to Item
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Capel, B., P. S. Burgoyne, and U. Mittwoch. “The genetic basis of XX-XY differences present before gonadal sex differentiation in the mouse - Discussion.” Philosophical Transactions of the Royal Society of London Series B Biological Sciences 350, no. 1333 (November 29, 1995): 260–61.Link to Item
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Graves, J. A. M., P. T. Sharpe, M. B. Renfree, B. Capel, and D. Mireille. “The molecular biology of temperature-dependent sex determination - Discussion.” Philosophical Transactions of the Royal Society of London Series B Biological Sciences 350, no. 1333 (November 29, 1995): 303–4.Link to Item
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Hacker, A., B. Capel, P. Goodfellow, and R. Lovell-Badge. “Expression of Sry, the mouse sex determining gene.” Development 121, no. 6 (June 1995): 1603–14. https://doi.org/10.1242/dev.121.6.1603.Full Text Link to Item
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Capel, B. “New bedfellows in the mammalian sex-determination affair.” Trends Genet 11, no. 5 (May 1995): 161–63. https://doi.org/10.1016/S0168-9525(00)89031-9.Full Text Link to Item
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Conway, S. J., S. K. Mahadevaiah, S. M. Darling, B. Capel, A. M. Rattigan, and P. S. Burgoyne. “Y353/B: a candidate multiple-copy spermiogenesis gene on the mouse Y chromosome.” Mamm Genome 5, no. 4 (April 1994): 203–10. https://doi.org/10.1007/BF00360546.Full Text Link to Item
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Capel, B., C. Rasberry, J. Dyson, C. E. Bishop, E. Simpson, N. Vivian, R. Lovell-Badge, S. Rastan, and B. M. Cattanach. “Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal.” Nat Genet 5, no. 3 (November 1993): 301–7. https://doi.org/10.1038/ng1193-301.Full Text Link to Item
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Capel, B., A. Swain, S. Nicolis, A. Hacker, M. Walter, P. Koopman, P. Goodfellow, and R. Lovell-Badge. “Circular transcripts of the testis-determining gene Sry in adult mouse testis.” Cell 73, no. 5 (June 4, 1993): 1019–30. https://doi.org/10.1016/0092-8674(93)90279-y.Full Text Link to Item
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Capel, B., and R. Lovell-Badge. “The sry gene and sex determination in mammals.” Advances in Developmental Biology (1992) 2, no. C (January 1, 1993): 1–35. https://doi.org/10.1016/s1566-3116(08)60025-0.Full Text
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Koopman, P., A. Münsterberg, B. Capel, N. Vivian, and R. Lovell-Badge. “Expression of a candidate sex-determining gene during mouse testis differentiation.” Nature 348, no. 6300 (November 29, 1990): 450–52. https://doi.org/10.1038/348450a0.Full Text Link to Item
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Gubbay, J., J. Collignon, P. Koopman, B. Capel, A. Economou, A. Münsterberg, N. Vivian, P. Goodfellow, and R. Lovell-Badge. “A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.” Nature 346, no. 6281 (July 19, 1990): 245–50. https://doi.org/10.1038/346245a0.Full Text Link to Item
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Capel, B., R. G. Hawley, and B. Mintz. “Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers.” Blood 75, no. 12 (June 15, 1990): 2267–70.Link to Item
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Capel, B., and B. Mintz. “Neonatal W-mutant mice are favorable hosts for tracking development of marked hematopoietic stem cells.” Exp Hematol 17, no. 8 (September 1989): 872–76.Link to Item
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Capel, B., R. Hawley, L. Covarrubias, T. Hawley, and B. Mintz. “Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice.” Proc Natl Acad Sci U S A 86, no. 12 (June 1989): 4564–68. https://doi.org/10.1073/pnas.86.12.4564.Full Text Link to Item
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Falmagne, P., C. Capiau, B. Capel, P. Lambotte, and J. Dirkx. “Complete and N-terminal amino-acid sequences of CNBr-peptides CB5 and CB3 from diphteria toxin fragment B [proceedings].” Arch Int Physiol Biochim 87, no. 4 (October 1979): 812–13.Link to Item
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Book Sections
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Capel, Blanche. “Sex Determination in Vertebrates Preface.” In SEX DETERMINATION IN VERTEBRATES, edited by B. Capel, 134:XIII–XVII. ELSEVIER ACADEMIC PRESS INC, 2019.Link to Item
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Conference Papers
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Weber, C. J., Y. Zhou, J. G. Lee, L. Looger, G. Qian, G. Ge, and B. Capel. “Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b.” In Integrative and Comparative Biology, 60:E249–E249, 2020.Link to Item
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Lin, Yi-Tzu, Lindsey Barske, Tony DeFalco, and Blanche Capel. “Numb regulates somatic cell lineage commitment during early gonadogenesis in mice.” In Development, 144:1607–18, 2017. https://doi.org/10.1242/dev.149203.Full Text Link to Item
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Weber, C., M. Czerwinski, and B. Capel. “Germ cell dynamics during gonad development in the turtle T. scripta.” In Integrative and Comparative Biology, 56:E390–E390. OXFORD UNIV PRESS INC, 2016.Link to Item
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Capel, Blanche, Tony DeFalco, and Jonah Cool. “Fetal macrophages mediate vascularization and cord formation during testis organogenesis.” In Faseb Journal, Vol. 29. FEDERATION AMER SOC EXP BIOL, 2015.Link to Item
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Capel, B., L. Mork, D. M. Maatouk, J. A. McMahon, A. P. McMahon, and P. Zhang. “Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates.” In Human Reproduction, Vol. 27, 2012.Link to Item
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Cool, Jonah, and Blanche Capel. “Endothelial migration initiates SF1− proliferation and testis morphogenesis.” In Developmental Biology, 344:486–486. Elsevier BV, 2010. https://doi.org/10.1016/j.ydbio.2010.05.291.Full Text
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Capel, Blanche, Jonah Cool, Hao Tang, Doug Coveney, and Tony DeFalco. “Patterning the Gonad in Four Dimensions.” In Biology of Reproduction, 74–74. SOC STUDY REPRODUCTION, 2009.Link to Item
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Tevosian, Sergei G., Fatima O. Smagulova, Danielle Maatouk, Lyndsay L. Leach, Blanche Capel, and Nikolay L. Manuylov. “Ovarian development in mice requires GATA4/FOG2 transcriptional complex.” In Developmental Biology, 319:549–549. Elsevier BV, 2008. https://doi.org/10.1016/j.ydbio.2008.05.295.Full Text
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Maatouk, Danielle M., Leo DiNapoli, Makoto M. Taketo, and Blanche Capel. “Investigating the Role of Beta-Catenin in Sex Determination.” In Biology of Reproduction, 78:189–90. Oxford University Press (OUP), 2008. https://doi.org/10.1093/biolreprod/78.s1.189c.Full Text
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Capel, Blanche, Danielle Maatouk, Yuna Kim, Leo DiNapoli, and Lindsey Barske. “The Battle of Sexes: Patterning the Gonad.” In Sexual Development, 2:280–280. KARGER, 2008.Link to Item
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Kim, Yuna, Leo DiNapoli, and Blanche Capel. “The battle of the sexes: Patterning the gonad.” In Zoological Science, 23:1133–1133. ZOOLOGICAL SOC JAPAN, 2006.Link to Item
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Page, D. C., A. Baltus, J. Koubova, D. Menke, M. Goodheart, and B. Capel. “Evidence of retinoid regulation of meiotic prophase initiation and germ cell sex differentiation in mice.” In Journal of Experimental Zoology Part a Comparative Experimental Biology, 305A:167–167. WILEY-LISS, 2006.Link to Item
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Kim, Yuna, Akio Kobayashi, Ryohei Sekido, Leo DiNapoli, Jennifer Brennan, Marie-Christine Chaboissier, Francis Poiulat, Richard Behringer, Robin Lovell-Badge, and Blanche Capel. “Paracrine regulation of fetal gonad differentiation.” In Biology of Reproduction, 66–66. OXFORD UNIV PRESS INC, 2006.Link to Item
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DiNapoli, L., and B. Capel. “FGF9 is required for male germ cell survival.” In Developmental Biology, 283:649–649. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005.Link to Item
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Kim, Y., A. Kobayashi, R. Sekido, B. Capel, R. R. Behringer, and R. Lovell-Badge. “Fgf9 signaling is required for Sertoli precursor cells to establish the male pathway.” In Developmental Biology, 283:638–638. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005.Link to Item
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Capel, B., C. Tilmann, J. Schmahl, J. Brennan, and H. H. C. Yao. “Competing pathways in testis organogenesis.” In Developmental Biology, 235:209–209. ACADEMIC PRESS INC, 2001.Link to Item
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Yao, H. H. C., and B. Capel. “Decisive roles of meiotic germ cells in sex determination of mammalian gonads.” In Developmental Biology, 235:210–210. ACADEMIC PRESS INC, 2001.Link to Item
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Brennan, J., and B. Capel. “Sex-specific mechanisms of vascular development in the mouse gonad.” In Developmental Biology, 222:249–249. ACADEMIC PRESS INC, 2000.Link to Item
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Capel, B., J. Karl, C. Tilmann, J. Schmahl, J. Brennan, and J. Guille. “Sry and the control of testis organogenesis.” In Developmental Biology, 222:250–250. ACADEMIC PRESS INC, 2000.Link to Item
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Schmahl, J. P., and B. Capel. “Cell proliferation is necessary for the induction of the testis pathway in the XY gonad.” In Developmental Biology, 222:250–250. ACADEMIC PRESS INC, 2000.Link to Item
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Capel, B. “Sry and the testis: Molecular pathways of organogenesis.” In Testis: From Stem Cell to Sperm Function, edited by E. Goldberg, 21–29. SPRINGER, 2000.Link to Item
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Capel, B., J. Karl, C. Tilmann, J. Schmahl, J. Brennan, H. H. C. Yao, and J. Guille. “SRY and early mechanisms of testis organogenesis.” In Biology of Reproduction, 62:82–82. SOC STUDY REPRODUCTION, 2000.Link to Item
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Brennan, J., and B. Capel. “Vascular patterning in the developing mouse gonad.” In Developmental Biology, 198:208–208. ACADEMIC PRESS INC, 1998.Link to Item
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Karl, J., and B. Capel. “Sertoli cells of the mouse testis originate from the coelomic epithelium.” In Developmental Biology, 198:181–181. ACADEMIC PRESS INC, 1998.Link to Item
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Schmahl, J., and B. Capel. “Cell division in the mouse gonad.” In Developmental Biology, 198:208–208. ACADEMIC PRESS INC, 1998.Link to Item
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Tilmann, C., and B. Capel. “The role of cell migration in the developing mouse gonad.” In Developmental Biology, 198:208–208. ACADEMIC PRESS INC, 1998.Link to Item
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Karl, J., and B. Capel. “Fate of the coelomic epithelium during mouse gonadogenesis.” In Developmental Biology, 186:A267–A267. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 1997.Link to Item
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Schmahl, J., and B. Capel. “Proliferation in the early gonad.” In Developmental Biology, 186:A265–A265. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 1997.Link to Item
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Tilmann, C., and B. Capel. “Signals for cell migration downstream of the testis determining gene, Sry.” In Developmental Biology, 186:A264–A264. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 1997.Link to Item
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Capel, B., K. Nordqvist, J. Karl, R. LovellBadge, and J. Martineau. “Sry expression and the differentiation of the mouse fetal gonad.” In Developmental Biology, 175:45–45. ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 1996.Link to Item
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Recent Courses
- CELLBIO 493: Research Independent Study 2023
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- CMB 710D: Cell & Molecular Biology Module IV 2022
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