Journal articleCancer Immunol Immunother · August 23, 2025
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by exceedingly high rates of metastatic progression, with the liver representing the most common site of distant spread. Here, we established a platform for multisite immune profiling of ...
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Journal articleAm J Geriatr Psychiatry · July 2025
Frequent questions arise from residents and their families/friends in long term care regarding their care and comfort. These questions are usually, though not always, directed primarily to the nursing staff and therefore are not available to geriatric psyc ...
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Journal articleJ Natl Compr Canc Netw · June 2025
BACKGROUND: The benefit of adjuvant chemotherapy (AC) for ampullary adenocarcinoma is unclear. The Hidden Genome model classifies prognostic subtypes with greater accuracy than standard histologic classification (intestinal [INT] vs pancreatobiliary [PB]), ...
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Journal articleAnnu Rev Clin Psychol · May 2025
As the numbers of older adults continue to increase globally, the need for facilitating healthy aging has become critical. While a physically healthy lifestyle, including exercise and diet, is important, recent research has highlighted a major impact of ps ...
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Journal articleAnn Surg Oncol · November 2024
BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) price transparency rule tries to facilitate cost-conscious decision-making. For surgical services, such as pancreaticoduodenectomy (PD), factors mediating transparency and real-world reimburs ...
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Journal articleSurgical Oncology Insight · September 1, 2024
Introduction: Approximately 5 % of patients with new breast cancer diagnoses have stage IV disease and 10 % of these patients have liver-confined metastases. The surgical management of synchronous liver metastases remains controversial. Methods: The Nation ...
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Journal articleSurgical Oncology Insight · March 1, 2024
Objective: Patients with gastrointestinal malignancies represent a heterogenous population, even among those with similar stage and treatment pathways. Here, we used dimensionality reduction in the National Cancer Database (NCDB) to inform unsupervised clu ...
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Journal articleLancet Diabetes Endocrinol · October 2023
BACKGROUND: The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with diabetes die, on average, 6 years earlier than people without diabetes. We aimed to provide reliable estimates of ...
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Journal articleWorld Psychiatry · October 2022
The world's population is aging, bringing about an ever-greater burden of mental disorders in older adults. Given multimorbidities, the mental health care of these people and their family caregivers is labor-intensive. At the same time, ageism is a big pro ...
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Journal articleAm J Geriatr Psychiatry · July 2022
Religion and spirituality have long been considered important social determinants of human health, and there exists an extensive body of research to support such. End-of-life (EOL) may raise complex questions for individuals about religious and spiritual ( ...
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Journal articleJ Am Geriatr Soc · May 2022
BACKGROUND: The ability to rate delirium severity is key to providing optimal care for persons with Alzheimer's Disease and Related Dementias (ADRD). Such ratings would allow clinicians to assess response to treatment, recovery time and prognosis, nursing ...
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Journal articleAcad Med · April 1, 2022
The great health paradox is that the least expensive and most effective public health measures available for addressing the COVID-19 pandemic-and other society-wide health challenges-have long been ignored and rejected in the United States in favor of more ...
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Journal articleInt Psychogeriatr · January 2022
OBJECTIVES: Work in occupations with higher levels of occupational stress can bring mental health costs. Many older adults worldwide are continuing to work past traditional retirement age, raising the question whether older adults experience depression, an ...
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Journal articleJ Interpers Violence · August 2021
Sexual harassment (SH) and sexual assault (SA) continue to be a focus of prevention efforts in the U.S. military because of the prevalence and potential to affect the health and readiness of service members. Limited research exists on the association of SH ...
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Journal articleJAMA · December 15, 2020
IMPORTANCE: It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs). OBJECTIVE: To characterize the association between depressive symptoms and CVD incidence across the spectrum of low ...
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Journal articleAm J Geriatr Psychiatry · December 2020
The authors of this review both served on the National Academy of Science, Engineering, and Medicine Committee that produced the report, "Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System." In 2018, the AARP Foundati ...
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Journal articleAcad Med · August 2020
The coronavirus (COVID-19) pandemic is having profound effects on the lives and well-being of the world's population. All levels of the nation's public health and health care delivery systems are rapidly adjusting to secure the health infrastructure to man ...
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Journal articleClin Geriatr Med · May 2020
Hearing loss is among the most frequent problems experienced by older adults, yet psychiatrists and other clinicians often ignore the problem as an aggravation rather than recognizing that the problem might benefit from appropriate hearing health care. Man ...
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Journal articleLancet Glob Health · October 2019
BACKGROUND: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illu ...
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Journal articlePsychol Med · April 2019
Hearing loss is one of the most common yet unrecognized impairments experienced by adults, especially as they age. Mental health investigators and practitioners require better understanding of hearing loss, its association with psychiatric disorders, and t ...
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Journal articleJ Am Geriatr Soc · April 2019
BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ...
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Journal articleEur Heart J · February 14, 2019
AIMS: There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after 'recalibration', a method that adapt ...
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Journal articlePerspect Biol Med · 2019
Wisdom has been discussed for centuries in religious and philosophical texts. It is often viewed as a fuzzy psychological construct analogous to consciousness, stress, and resilience. This essay provides an understanding of wisdom as a scientific construct ...
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Journal articleJ Psychiatr Pract · November 2018
Religious participation and spirituality are linked to good mental health. However, clergy may experience more depression than is observed in the general population, which may be due in part to high job strain. The objectives of this study were to identify ...
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Journal articleCurr Opin Psychiatry · July 2018
PURPOSE OF REVIEW: Academic recognition of the implications of religion/spirituality (R/S) for mental health is increasing, with a growing number of studies involving older adults. The present review provides an overview of these studies, highlighting the ...
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Journal articleLancet · April 14, 2018
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant ...
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Journal articleInt Psychogeriatr · April 2018
Delirium is one of the most prevalent and disabling conditions impacting older adults in hospitals and long-term care settings. The estimates of frequency of delirium in hospitals and nursing homes among older adults range widely, yet it is safe to assume ...
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Journal articlePsychiatr Clin North Am · March 2018
Hearing loss is among the most frequent problems experienced by older adults, yet psychiatrists and other clinicians often ignore the problem as an aggravation rather than recognizing that the problem might benefit from appropriate hearing health care. Man ...
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Journal articleAnticancer Res · February 2018
Appendiceal neuroendocrine neoplasms (ANENs) comprise rare tumors of the appendix, mainly affecting young populations and characterized by a rather favorable prognosis. The aim of this review was to summarize the current knowledge on these neoplasms, focus ...
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Journal articleAm J Geriatr Psychiatry · January 2018
Is depression among older adults symptomatically different than younger adults? Is it more common or chronic or difficult to treat? Is depression in late life more likely to be attributed to psychological problems? Twenty-years ago, Dan Blazer, a pioneer k ...
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Journal articlePerspect Biol Med · 2017
Advances in the scientific understanding of the aging brain have led to the concept of cognitive aging. Physicians lag in their understanding of cognitive aging, and the public fear of mental deterioration is disproportionate to its true risk. Understandin ...
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Journal articleAm J Geriatr Psychiatry · December 2016
Older adults consistently prefer aging in place, which requires a high level of community support and services that are currently lacking. With a rapidly aging population, the present infrastructure for healthcare will prove even more inadequate to meet se ...
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Journal articleAm J Geriatr Psychiatry · September 2016
The authors of this review both served on the Institute of Medicine Committee, which produced the report "Cognitive Aging: Progress in Understanding and Opportunities for Action." In this review, the authors summarize portions of the report that are especi ...
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Journal articleInt J Geriatr Psychiatry · July 2016
OBJECTIVE: The objective of this research was to identify distinct trajectories of recovery in older depressed patients in order to identify optimal samples and points for interventions. METHODS: The sample was 368 patients ages 60 years and older diagnose ...
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Journal articlePsychological Medicine · February 12, 2015
Background Asian Americans (AAs) and Native Hawaiians/Pacific Islanders (NHs/PIs) are the fastest growing segments of the US population. However, their population sizes are small, and thus AAs and NHs/PIs are often aggregated into a single racial/ethnic gr ...
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Journal articlePsychol Med · February 2015
BACKGROUND: Asian Americans (AAs) and Native Hawaiians/Pacific Islanders (NHs/PIs) are the fastest growing segments of the US population. However, their population sizes are small, and thus AAs and NHs/PIs are often aggregated into a single racial/ethnic g ...
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Journal articleAging Ment Health · January 2015
The Diagnostic Statistical Manual-5 (DSM-5) has included a category named the neurocognitive disorder which was formally known in DSM-IV as 'dementia, delirium, amnestic, and other cognitive disorders'. The DSM-5 distinguishes between 'mild' and 'major' ne ...
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Journal articleAnnu Rev Clin Psychol · 2015
This review provides an overview of the relationship between depression and cognition in the elderly, with an emphasis on psychotherapies and nonpharmacologic approaches. We first review the clinical presentation of late-life depression and comorbid cognit ...
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Journal articleJ Psychiatr Res · December 2014
There are concerns over nonmedical use of prescription stimulants among youths, but little is known about the extent of use among young Asian-Americans, Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race individuals-the fastest growing segments o ...
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Journal articleNat Rev Neurol · November 2014
Neurocognitive disorders--including delirium, mild cognitive impairment and dementia--are characterized by decline from a previously attained level of cognitive functioning. These disorders have diverse clinical characteristics and aetiologies, with Alzhei ...
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Journal articleAging Ment Health · September 2014
OBJECTIVE: To determine whether the increased risk of suicide for individuals with cancer may be explained by functional limitations, lack of social support, or other factors. METHOD: In this population-based case-control study, interviews of primary infor ...
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Journal articleClin Geriatr Med · August 2014
Although the myth that older adults do not use mood-altering substances persists, evidence suggests that substance use among older adults has been underidentified for decades. The baby boom generation is unique in its exposure to, attitudes toward, and pre ...
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Journal articleJ Aging Health · June 2014
OBJECTIVE: The aim of this study was to examine inflammation and coagulation, which are positively linked to disability and inversely linked to increased religious attendance, as mediators in the cross-sectional relationships between religious attendance a ...
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Journal articleAm J Geriatr Psychiatry · June 2014
OBJECTIVES: Either dysphoria (sadness) or anhedonia (loss of interest in usually pleasurable activities) is required for a diagnosis of major depression. Although major depression is a known risk factor for disability in older persons, few studies have exa ...
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Journal articleJ Gerontol A Biol Sci Med Sci · May 2014
BACKGROUND: Depressive symptoms and cognitive outcomes are strongly interrelated. Despite that rates of depressive symptoms fluctuate during late life, little is known about the impact of long-term cumulative depressive symptom burden on cognitive decline ...
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Journal articleInt J Epidemiol · April 2014
BACKGROUND: Globally, adults aged 65 years or older will increase from 516 million in 2009 to an estimated 1.53 billion in 2050. Due to substance use at earlier ages that may continue into later life, and ageing-related changes in medical conditions, older ...
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Journal articleJAMA · March 26, 2014
IMPORTANCE: The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain. OBJECTIVE: To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is assoc ...
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Journal articleAlzheimer Dis Assoc Disord · 2014
BACKGROUND: Several sets of diagnostic criteria have been published for vascular dementia since the 1960s. The continuing ambiguity in vascular dementia definition warrants a critical reexamination. METHODS: Participants at a special symposium of the Inter ...
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Journal articleGerontologist · December 2013
A large volume of empirical research has accumulated on the relationship between religion/spirituality (R/S) and health since the year 2000, much of it involving older adults. The purpose of this article is to discuss how this body of existing research fin ...
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Journal articleDrug Alcohol Depend · December 1, 2013
BACKGROUND: The racial/ethnic composition of the United States is shifting rapidly, with non-Hispanic Asian-Americans, Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race individuals the fastest growing segments of the population. We determined ne ...
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Journal articleJ Psychiatr Res · December 2013
Little is known about behavioral healthcare needs of Asian Americans (AAs), Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race people (MRs)-the fastest growing segments of the U.S. population. We examined substance use disorder (SUD) prevalences ...
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Journal articleJ Psychiatr Res · October 2013
Identifying sources of heterogeneity in late life depression remains an important focus of psychiatric investigation. Community samples are particularly informative since many older adults have clinically significant depressive symptoms but fail to meet cr ...
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Journal articleDrug Alcohol Depend · September 1, 2013
BACKGROUND: Non-Hispanic Asian Americans, Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race individuals are the fastest growing segments of the US population. We examined prevalences and correlates of tobacco use among these understudied groups. ...
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Journal articleJ Gerontol A Biol Sci Med Sci · June 2013
BACKGROUND: It is unclear whether distinct weight-related trajectory classes, differing in course, demographics, and health characteristics, exist in the elderly population. METHODS: Data came from the 10-year (1986-1996) Duke Established Populations for E ...
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Journal articleJ Psychiatr Res · April 2013
OBJECTIVE: To examine prevalences of substance use disorders (SUD) and comprehensive patterns of comorbidities among psychiatric patients ages 18-64 years (N = 40,099) in an electronic health records (EHR) database. METHOD: DSM-IV diagnoses among psychiatr ...
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Journal articleJ Gerontol A Biol Sci Med Sci · April 2013
BACKGROUND: A comparative analysis between centenarians' children and neighborhood controls is an efficient approach to learn how familial longevity influence and its interaction with environmental factors affect healthy aging. Yet, there are few extant st ...
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Journal articleAm J Geriatr Psychiatry · February 2013
OBJECTIVE: To review systematically, for the first time, the effectiveness of all pharmacologic interventions to improve quality of life and well-being in people with dementia. DESIGN: Systematic review and meta-analysis. METHODS: We systematically reviewe ...
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Journal articlePLoS One · 2013
BACKGROUND: The effects of systolic blood pressure (SBP), serum total cholesterol (TC), fasting plasma glucose (FPG), and body mass index (BMI) on the risk of cardiovascular diseases (CVD) have been established in epidemiological studies, but consistent es ...
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Journal articleGen Hosp Psychiatry · 2013
OBJECTIVE: The objective was to identify a potential core set of brief screeners for the detection of individuals with a substance use disorder (SUD) in medical settings. METHOD: Data were from two multisite studies that evaluated stimulant use outcomes of ...
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Journal articleAnn Epidemiol · November 2012
PURPOSE: Preterm birth (PTB) is a major problem in the United States, and black women have greater risk of PTB than white women. The etiology of PTB and the racial disparity in preterm outcomes are poorly understood. Diminished life satisfaction is associa ...
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Journal articleArch Gen Psychiatry · October 2012
CONTEXT: Despite the frequent occurrence of depressive symptoms among older adults, especially women, little is known about the long-term course of late-life depressive symptoms. OBJECTIVE: To characterize the natural course of depressive symptoms among ol ...
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Journal articleGerontologist · October 2012
PURPOSE OF THE STUDY: To examine the longitudinal associations between 3 dimensions of religious involvement-religious attendance, use of religious media, and private religious activities-and 3 domains of functional status-limitations in basic activities o ...
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Journal articleInt J Epidemiol · October 2012
BACKGROUND: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. METHODS: We calculated hazard ratios (HRs) for height, assessed in ...
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Journal articleAnn Emerg Med · August 2012
STUDY OBJECTIVE: Improving identification and treatment for substance use disorders is a national priority, but data about various drug use disorders encountered in emergency departments (EDs) are lacking. We examine past-year substance use and substance u ...
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Journal articleMatern Child Health J · July 2012
Maternal smoking is a key preventable cause of poor pregnancy outcomes, such as low birthweight. In many areas of the United States, including Eastern North Carolina, rates of prenatal smoking are high. Prenatal depressive symptoms are associated with mate ...
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Journal articleInt J Geriatr Psychiatry · June 2012
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OBJECTIVE: The aim of the study was to compare symptom expression in primarily middle-aged (<60) and older (60+) patients who were depressed and determine if symptom profiles differed by age. METHODS: Patients diagnosed with major depression (N = 664) were ...
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Journal articleActa Psychiatr Scand · June 2012
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OBJECTIVE: To identify trajectories of depressive symptoms in older community residents. METHOD: Depressive symptomatology, based on a modified Center for Epidemiological Studies-Depression scale, was obtained at years 0, 3, 6, and 10, in the Duke Establis ...
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Journal articleInt J Methods Psychiatr Res · June 2012
While item response theory (IRT) research shows a latent severity trait underlying response patterns of substance abuse and dependence symptoms, little is known about IRT-based severity estimates in relation to clinically relevant measures. In response to ...
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Journal articleInt J Epidemiol · June 2012
BACKGROUND: For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analys ...
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Journal articleInt Psychogeriatr · June 2012
BACKGROUND: People with dementia report lower quality of life, but we know little about what interventions might improve it. METHODS: We systematically reviewed 20 randomized controlled trials reporting the effectiveness of non-pharmacological intervention ...
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Journal articleCurr Opin Psychiatry · May 2012
PURPOSE OF REVIEW: Since the publication of DSM-III in 1980, the essential criteria for delirium have been reduced progressively through DSM-III-R to DSM-IV. As the field moves toward DSM-V and ICD-11, new data can shed light on the nosological changes tha ...
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Journal article · March 12, 2012
Depression is the most frequent cause of emotional suffering in later life and is associated with significant losses in one's quality of life, often occurring in the context of physical or cognitive impairment. Several theories of depression in the elderly ...
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Journal articleJ Psychiatr Res · March 2012
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AIM: To address an urgent need for screening of substance use problems in medical settings, we examined substance-specific dependence criteria as potential brief screeners for the detection of patients with a substance use disorder (SUD). METHODS: The samp ...
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Journal articleJ Am Geriatr Soc · February 2012
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OBJECTIVES: To compare outcomes and the use of multimodality therapy in young and elderly people with pancreatic cancer undergoing surgical resection. DESIGN: Retrospective, single-institution study. SETTING: National Cancer Institute/National Comprehensiv ...
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Journal articleStat Med · January 30, 2012
New prognostic models are traditionally evaluated using measures of discrimination and risk reclassification, but these do not take full account of the clinical and health economic context. We propose a framework for comparing prognostic models by quantify ...
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Journal articleAmerican Journal of Geriatric Psychiatry · January 12, 2012
OBJECTIVE: To review systematically, for the first time, the effectiveness of all pharmacologic interventions to improve quality of life and well-being in people with dementia. DESIGN: Systematic review and meta-analysis. METHODS: We systematically reviewe ...
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Journal articleAge of Melancholy Major Depression and Its Social Origins · January 1, 2012
Depression has become the most frequently diagnosed chronic mental illness, and is a disability encountered almost daily by mental health professionals of all trades. “Major Depression” is a medical disease, which some would argue has reached epidemic prop ...
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Journal articleAging Ment Health · 2012
OBJECTIVES: To examine prevalence of tobacco use and identify psychiatric symptoms and substance use correlates of tobacco use comparing adults 50-64 years of age with those 65+ years of age (N = 10,891). METHODS: Data were from the 2008-2009 US National S ...
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Journal articleAddict Behav · December 2011
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BACKGROUND: This study examined national trends, patterns, correlates, and barriers to substance abuse treatment use by adolescents aged 12-17 years who met at least one of the past-year criteria for prescription opioid abuse or dependence (N=1788). METHOD ...
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Journal articleJ Psychiatr Res · November 2011
This study examined the prevalence of substance use disorders (SUDs) among psychiatric patients aged 2-17 years in an electronic health records database (N=11,457) and determined patterns of comorbid diagnoses among patients with a SUD to inform emerging c ...
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Journal articleArch Gen Psychiatry · November 2011
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CONTEXT: While young racial/ethnic groups are the fastest growing population in the United States, data about substance-related disorders among adolescents of various racial/ethnic backgrounds are lacking. OBJECTIVE: To examine the magnitude of past-year D ...
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Journal articleDrug Alcohol Depend · November 1, 2011
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BACKGROUND: This study applied item response theory (IRT) and latent class analysis (LCA) procedures to examine the dimensionality and heterogeneity of comorbid substance use disorders (SUDs) and explored their utility for standard clinical assessments, in ...
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Journal articleInt Psychogeriatr · August 2011
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BACKGROUND: Late-life depression may be undiagnosed due to symptom expression. These analyses explore the structure of depressive symptoms in older patients diagnosed with major depression by identifying clusters of patients based on their symptom profiles ...
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Journal articleAm J Geriatr Psychiatry · August 2011
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OBJECTIVE: To estimate 1-year prevalence and correlates of alcohol abuse, dependence, and subthreshold dependence (diagnostic orphans) among middle-aged and elderly persons in the United States. DESIGN: 2005-2007 National Surveys on Drug Use and Health. ME ...
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Journal articleAm J Psychiatry · July 2011
OBJECTIVE: The authors systematically reviewed the management of treatment-refractory depression in older people (defined as age 55 or older). METHOD: The authors conducted an electronic database search and reviewed the 14 articles that fit predetermined c ...
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Journal articleSubst Abuse Rehabil · May 2011
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OBJECTIVES: To examine patterns of onset and abuse/dependence episodes of prescription opioid (PO) and heroin use disorders in a national sample of adults, and to explore differences by gender and substance abuse treatment status. METHODS: Analyses of data ...
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Journal articleJ Aging Health · April 2011
OBJECTIVE: Substance abuse among older adults is a looming public health concern. The number of Americans aged 50+ years with a substance use disorder is projected to double from 2.8 million in 2002-2006 to 5.7 million in 2020. The authors provide a review ...
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Journal articleSubst Abuse Rehabil · April 2011
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CONTEXT: Media and scientific reports have indicated an increase in recreational use of Salvia divinorum. Epidemiological data are lacking on the trends, prevalence, and correlates of S. divinorum use in large representative samples, as well as the extent ...
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Journal articleLancet · March 26, 2011
BACKGROUND: Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI), w ...
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Journal articlePsychol Med · March 2011
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BACKGROUND: For the emerging DSM-V, it has been recommended that dimensional and categorical methods be used simultaneously in diagnostic classification; however, little is known about this combined approach for abuse and dependence. METHOD: Using data (n= ...
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Journal articleJ Addict Med · March 2011
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OBJECTIVES: To study substance use and psychiatric disorders among prescription opioid users, heroin users, and non-opioid drug users in a national sample of adults. METHODS: Analyses of data from the 2001-2002 National Epidemiologic Survey on Alcohol and ...
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Journal articleSubst Use Misuse · 2011
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The sample included 343 opioid-dependent adults enrolled in two national multisite studies of the National Drug Abuse Treatment Clinical Trials Network (CTN001-002). Opioid-dependent individuals were recruited from 12 sites across the United States from Ja ...
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Journal articleSubst Abuse Rehabil · January 1, 2011
BACKGROUND: In response to the rising rate of treatment admissions related to illicit use of amphetamines (eg, methamphetamine), we examined the prevalence of amphetamine use among treatment-seeking, opioid-dependent adults, explored whether amphetamine us ...
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Journal articleInt J Psychiatry Med · 2011
Patients and family members often turn to prayer in response to serious, life-threatening illness. Prayer for a miraculous cure is often the request. While prayer can keep hope alive, it may also promote unrealistic expectations that fuel demands for life- ...
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Journal article · December 2, 2010
Mood disorders in DSM-IV and ICD-10 are classified into a number of different categories, including manic episode, depressive episode, bipolar disorder, unipolar disorder, dysthymia, adjustment disorder with depressed mood, and depressed mood associated wi ...
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Journal articleSubst Abuse Rehabil · December 2010
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PURPOSE: Detoxification often serves as an initial contact for treatment and represents an opportunity for engaging patients in aftercare to prevent relapse. However, there is limited information concerning clinical profiles of individuals seeking detoxifi ...
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Journal articleDrug Alcohol Depend · November 1, 2010
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AIMS: To identify subtypes of nonmedical opioid users, gender variations in psychiatric disorders, and quality of life in a representative sample of adults. METHODS: Analyses of data from the 2001-2002 National Epidemiologic Survey on Alcohol and Related C ...
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Journal articleInt J Epidemiol · October 2010
BACKGROUND: Meta-analysis of individual participant time-to-event data from multiple prospective epidemiological studies enables detailed investigation of exposure-risk relationships, but involves a number of analytical challenges. METHODS: This article de ...
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Journal articleInt J Geriatr Psychiatry · October 2010
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OBJECTIVES: Physical symptoms are known to be associated with late life depression both cross-sectionally and over time. We attempted to determine if self-reported shortness of breath (SoB) is associated with depressive symptoms at long-term (3-year) follo ...
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Journal articleJ Gerontol A Biol Sci Med Sci · October 2010
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BACKGROUND: To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age. METHOD: The sample consisted of cognitively intact participants at the third in-person wav ...
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Journal articleGerontologist · October 2010
PURPOSE: Wisdom has received increasing attention in empirical research in recent years, especially in gerontology and psychology, but consistent definitions of wisdom remain elusive. We sought to better characterize this concept via an expert consensus pa ...
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Journal articleAging Ment Health · August 2010
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OBJECTIVE: The apolipoprotein (APOE) epsilon4 allele genotype is a risk factor for dementia, but not all people with the APOE epsilon4 allele develop cognitive impairment (CI). Among participants with the APOE epsilon4 allele (N = 664), we identified biolo ...
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Journal articleBiochim Biophys Acta · August 2010
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The neurosteroid allopregnanolone has pronounced neuroprotective actions, increases myelination, and enhances neurogenesis. Evidence suggests that allopregnanolone dysregulation may play a role in the pathophysiology of Alzheimer's disease (AD) and other n ...
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Journal articleLancet · June 26, 2010
BACKGROUND: Uncertainties persist about the magnitude of associations of diabetes mellitus and fasting glucose concentration with risk of coronary heart disease and major stroke subtypes. We aimed to quantify these associations for a wide range of circumst ...
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Journal articleJ Subst Abuse Treat · June 2010
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This study applies a latent variable approach to examine gender and racial/ethnic differences in cocaine dependence, to determine the presence of differential item functioning (DIF) or item-response bias to diagnostic questions of cocaine dependence, and t ...
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Journal articleLancet · May 8, 2010
BACKGROUND: Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality. METHODS: We assessed the -1131T>C ...
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Journal articleAging Ment Health · March 2010
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OBJECTIVES: The ApolipoproteinE epsilon4 (APOE epsilon4) allele influences cognitive decline (CD) in some but not in all individuals. The purpose of this study was to investigate whether problems meeting basic needs (BN) (e.g., having enough money to meet ...
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Journal articleAddict Behav · March 2010
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AIM: This study applied both item response theory (IRT) and multiple indicators-multiple causes (MIMIC) methods to evaluate item-level psychometric properties of diagnostic questions for hallucinogen use disorders (HUDs), differential item functioning (DIF ...
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Journal articleJ Am Geriatr Soc · March 2010
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OBJECTIVES: To determine whether middle-aged persons with depressive symptoms are at higher risk for developing activity of daily living (ADL) and mobility limitations as they advance into older age than those without. DESIGN: Prospective cohort study. SET ...
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Journal articleLancet · January 9, 2010
BACKGROUND: Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up of large numbers of people. We assessed the associations of CRP concentration with risk of vascular and n ...
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Journal articleHealth Aff (Millwood) · 2010
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A genetic marker known as apolipoprotein E provides a clear signal of a person's risk of developing Alzheimer's disease and thus that person's future need for long-term care. People who find that they have the variant of the trait that increases Alzheimer' ...
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Journal articleInt J Geriatr Psychiatry · January 2010
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OBJECTIVE: Research has shown an association between depression and functional limitations in older adults. Our aim was to explore the latent traits of trajectories of limitations in mobility and instrumental activities of daily living (IADL) tasks in a sa ...
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Journal articleAmerican Journal of Geriatric Psychiatry · 2010
OBJECTIVE: To estimate 1-year prevalence and correlates of alcohol abuse, dependence, and subthreshold dependence (diagnostic orphans) among middle-aged and elderly persons in the United States. DESIGN: 2005-2007 National Surveys on Drug Use and Health. ME ...
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Journal articleAm J Public Health · January 2010
OBJECTIVE: We investigated relations between deployment and new-onset depression among US service members recently deployed to the wars in Iraq and Afghanistan. METHODS: We included 40 219 Millennium Cohort Study participants who completed baseline and fol ...
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Journal articleJ Gerontol A Biol Sci Med Sci · December 2009
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BACKGROUND: There is growing evidence that regular attendance at religious functions is associated with less cognitive decline (CD). However, little research has investigated factors that may moderate the religious attendance-CD relationship. The present s ...
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Journal articleJAMA · November 11, 2009
CONTEXT: Associations of major lipids and apolipoproteins with the risk of vascular disease have not been reliably quantified. OBJECTIVE: To assess major lipids and apolipoproteins in vascular risk. DESIGN, SETTING, AND PARTICIPANTS: Individual records wer ...
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Journal articlePsychol Med · October 2009
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BACKGROUND: Depressive symptoms above screening thresholds have been shown to predict functional decline in older adults. Less is known about the impact of subthreshold depression, and whether more symptoms confer significantly greater risk compared to few ...
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Journal articleAm J Psychiatry · October 2009
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OBJECTIVE: The purpose of this article was to estimate the prevalence, distribution, and correlates of at-risk alcohol use (especially binge drinking) among middle-aged and elderly persons in the United States and to compare at-risk alcohol use between wom ...
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Journal articleDrug Alcohol Depend · September 1, 2009
AIMS: To present the prevalence and correlates of hallucinogen use disorders (HUDs: abuse or dependence) and subthreshold dependence. METHODS: The study sample included adolescents aged 12-17 years (N=55,286) who participated in the National Survey on Drug ...
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Journal articleAm J Epidemiol · August 15, 2009
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Data from the National Death Index (NDI) are frequently used to determine survival status in epidemiologic or clinical studies. On the basis of selected information submitted by the investigator, NDI returns a file containing a set of candidate matches. Al ...
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Journal articleDrug Alcohol Depend · August 1, 2009
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INTRODUCTION: Although DSM-IV criteria are widely used in making diagnoses of substance use disorders, gaps exist regarding diagnosis classification, use of dependence criteria, and effects of measurement bias on diagnosis assessment. We examined the const ...
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Journal articleAddict Behav · August 2009
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AIM: In light of the resurgence in MDMA use and its association with polysubstance use, we investigated the 12-month prevalence of substance use disorders (SUDs) among adult MDMA users to determine whether they are at risk of other drug-related problems th ...
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Journal articlePublic Health · August 2009
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OBJECTIVES: MDMA/ecstasy use among college students has increased and reportedly leads to risky sexual behaviours. However, little is known about its association with sexually transmitted diseases (STDs). To evaluate this public health concern, this study ...
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Journal articleJAMA · July 22, 2009
CONTEXT: Circulating concentration of lipoprotein(a) (Lp[a]), a large glycoprotein attached to a low-density lipoprotein-like particle, may be associated with risk of coronary heart disease (CHD) and stroke. OBJECTIVE: To assess the relationship of Lp(a) c ...
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Journal articleJ Am Geriatr Soc · July 2009
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OBJECTIVES: To estimate the frequency, distribution, and correlates of nonprescription use of pain relievers by middle-aged and elderly persons in the United States. DESIGN: Cross-sectional data analysis of a national community survey. SETTING: The 2005 an ...
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Journal articleCancer · July 1, 2009
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BACKGROUND: The authors compared disease-specific survival (DSS) in stage-specific subgroups of patients with clear cell sarcoma, including those with lymph node metastases (N1M0) and those with distant metastases (N0M1). METHODS: Clinical data regarding s ...
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Journal articleJ Am Acad Child Adolesc Psychiatry · May 2009
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OBJECTIVE: To examine the psychometric properties of diagnostic criteria for prescription analgesic opioid use disorders (OUDs) and to identify background predictors of a latent continuum for OUD liability. METHOD: Data were drawn from the adolescent sampl ...
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Journal articleAm J Geriatr Psychiatry · May 2009
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OBJECTIVE: To explore the underlying structure of symptom presentation in older adults with major depression by identifying homogeneous clusters of individuals based on symptom profiles. DESIGN: Secondary data analysis using latent class cluster analysis. ...
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Journal articleJ Stud Alcohol Drugs · May 2009
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OBJECTIVE: The aim of this study was to examine psychometric properties of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), diagnostics criteria for alcohol and marijuana dependences among 462 alcohol users and 311 mariju ...
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Journal articleNicotine Tob Res · April 2009
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INTRODUCTION: Initial research on older smokers suggests that a subgroup of smokers with higher levels of psychological distress and health problems may be more likely to quit smoking than older smokers with fewer such problems. The present study, based on ...
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Journal articleAm J Geriatr Psychiatry · March 2009
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OBJECTIVE: To estimate the prevalence, distribution, and correlates of drug use among middle aged and elderly persons in the United States and to compare with alcohol use in this age group. SETTING: The 2005 and 2006 National Surveys on Drug Use and Health ...
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Journal articleAm J Geriatr Psychiatry · February 2009
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OBJECTIVES: The apolipoproteinE epsilon4 (APOE epsilon4) allele and a history of depression are each separate risk factors for cognitive decline (CD). However, little research has investigated whether a history of depression influences the relationship bet ...
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Journal articleAm J Addict · 2009
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This study investigates the potential heterogeneity of ecstasy or MDMA (3,4-methylenedioxy-N-methylamphetamine) users. Data came from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Latent class analysis (LCA) and mu ...
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Journal articleAm J Addict · 2009
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We investigated the presence of DSM-IV subtyping for dependence on cocaine and amphetamines (with versus without physical dependence) among outpatient stimulant users enrolled in a multisite study of the Clinical Trials Network (CTN). Three mutually exclus ...
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Journal articleGerontology · 2009
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BACKGROUND: Most, but not all, past studies have suggested that the APOE genotype is a risk factor for dementia in whites but not African Americans. This paper first describes explanations as to why some studies may have failed to detect the effect of APOE ...
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Journal articleJ Clin Oncol · November 20, 2008
PURPOSE: The primary goal of this study was to evaluate whether pathologic response to chemotherapy predicts patient survival after preoperative chemotherapy and resection of colorectal liver metastases (CLM). The secondary goal of the study was to identif ...
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Journal articleAm J Med Genet B Neuropsychiatr Genet · October 5, 2008
Although often viewed as a purely environmental construct, perception of social support may be influenced by genetic factors. This study examined the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and social support ...
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Journal articleJ Clin Endocrinol Metab · August 2008
OBJECTIVE: It is currently unknown whether cerebrospinal fluid (CSF) neurosteroid levels are related to brain neurosteroid levels in humans. CSF and brain dehydroepiandrosterone (DHEA) levels are elevated in patients with Alzheimer's disease (AD), but it i ...
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Journal articleGerontologist · August 2008
Research has shown over the years that the self-perceptions of older adults about their health and well-being may be at least as important as objective data for predicting the course of their health over time. I review a series of studies that span 30 year ...
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Journal articleSemin Intervent Radiol · June 2008
Preoperative portal vein embolization (PVE) is increasingly used to optimize the volume and function of the future liver remnant (FLR) and to reduce the risk for complications of major hepatectomy for hepatocellular carcinoma (HCC) or hilar cholangiocarcin ...
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Journal articleAm J Geriatr Psychiatry · April 2008
OBJECTIVE: To examine the course of depressive symptoms in older patients with comorbid major depression and dysthymia. DESIGN: Secondary data analysis using both proportional hazards modeling and a repeated measures mixed model. SETTING: Clinical Research ...
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Journal articleNeuropsychopharmacology · April 2008
In elderly persons, antipsychotic drugs are clinically prescribed off-label for a number of disorders outside of their Food and Drug Administration (FDA)-approved indications (schizophrenia and bipolar disorder). The largest number of antipsychotic prescri ...
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Journal articleAging Ment Health · March 2008
The current study investigated the association between lifetime major depressive disorder (MDD) and self-reported memory and cognitive problems in a general population sample. The study was based on data from the National Comorbidity Survey-Replication (n ...
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Journal articleJ Am Med Dir Assoc · February 2008
OBJECTIVES: To review the diagnosis and treatment of depressive disorders in long-term care settings. METHODS: A review of the literature on the diagnosis and treatment of depression in long-term care. RESULTS: Up to 35% of residents in long-term care faci ...
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Journal articleJOP · January 8, 2008
CONTEXT: The majority of oncological pancreatic resections involve resection of primary pancreatic tumors. Pancreatic resection for metastatic disease is rare but can produce durable palliation or even cure in carefully selected patients. Herein, we report ...
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Journal article · January 1, 2008
The science of epidemiology has much to offer in assisting clinical investigators and practicing psychiatrists to place the work on inpatient units and outpatient clinics into context. Epidemiologists first emphasize the importance of case identification a ...
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Journal articleAm J Addict · 2008
We sought to determine the prevalence, patterns, and correlates of past-month illicit methadone use and history of regular illicit use among stimulant-using methadone maintenance treatment patients. We obtained self-reported information on illicit methadon ...
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Journal articleInt J Psychiatry Med · 2008
OBJECTIVE: An increasing body of literature examines the association of religious factors with posttraumatic stress as well as posttraumatic growth. This review of selected empirical studies describes religious and spiritual factors that have been examined ...
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Journal articleBiomark Med · 2008
AIM: To examine environmental sociodemographic risks of high IL-6, a marker of chronic inflammation in older adults. METHODS: We spatially linked 1990 USA Census tract demographic and economic measures to a prospective cohort study of representative commun ...
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Journal articleJ Am Geriatr Soc · October 2007
OBJECTIVES: To use a formal decision-making strategy to reach clinically appropriate, internally consistent decisions on the application of quality indicators (QIs) to vulnerable elders (VEs) with advanced dementia (AD) or poor prognosis (PP). DESIGN: Usin ...
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Journal articleAm J Geriatr Psychiatry · September 2007
OBJECTIVE: Although the long-term health risks associated with obesity in older adults have been well documented, less is known about the psychological consequences. The current study examined the relationship between body mass index (BMI) and subsequent d ...
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Journal articleJ Trauma Stress · August 2007
In addition to cross-cultural and environmental stressors, aid workers and missionaries are frequently exposed to trauma. We explored the frequency of traumatic events, their mental health impact, and factors associated with posttraumatic stress in two gro ...
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Journal articleJ Nerv Ment Dis · August 2007
Although many studies suggest lower rates of depressive symptoms in those who report greater spirituality, few have investigated the mechanisms by which spirituality might relate to depressive symptoms. The current study aimed to elucidate potential psycho ...
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Journal articleSurgery · June 2007
BACKGROUND: With the introduction of sentinel lymph node (SLN) biopsy for melanoma, inguinal lymph node dissections (ILND) are more commonly performed for microscopic disease than for clinically palpable disease. We sought to examine the effect this change ...
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Journal articleSemin Oncol · June 2007
For most solid tumors therapy has evolved from surgery alone to a multidisciplinary approach. Malignant melanoma remains an exception, with surgery maintaining the principal role not only for treatment of the primary lesion but also staging and the managem ...
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Journal articleJ Womens Health (Larchmt) · May 2007
OBJECTIVES: Depressive symptoms are common among women, especially those who are of childbearing age or are pregnant. Prior studies have suggested that an increased burden of depressive symptoms is associated with diminished health and functional status, b ...
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Journal articleAging Ment Health · March 2007
We examined the effects of use of low charge, integrated and comprehensive health care services (Veterans Administration (VA) health care system) on health care service use and health-related outcomes. Data came from the 10-year (1986/87-1996/97) Duke Esta ...
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Journal articleJ Gerontol A Biol Sci Med Sci · February 2007
BACKGROUND: In previous studies we found that, among older adults (>64 years), perception that basic needs were not being met increased mortality risk and risk for functional decline. In this study, we determined, controlling for reported income and functi ...
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Journal articleJ Clin Epidemiol · February 2007
OBJECTIVES: The 12-month prevalence of common mental illnesses in the United States is estimated to be 26%, accounting for an increasing fraction of all disability in the general population. The U.S. military is a unique group involved in response and defe ...
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Journal articleEur J Epidemiol · 2007
Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circums ...
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Journal articlePsychosom Med · 2007
OBJECTIVE: To focus on the relationship between pregnancy-related anxiety and spontaneous preterm birth. Psychosocial factors have been the subject of inquiries about the etiology of preterm birth; a factor of recent interest is maternal prenatal pregnancy ...
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Journal articleJ Am Geriatr Soc · January 2007
OBJECTIVES: To determine whether some health behaviors of older people (e.g., obtaining cancer screens) have a limited and others (e.g., exercise) have a broad association with population-level health status 4 to 6 years later. DESIGN: Longitudinal cohort. ...
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Journal articleBiol Psychiatry · December 15, 2006
BACKGROUND: Few data are currently available investigating neurosteroids (NS) in Alzheimer's disease (AD). The NS allopregnanolone may be decreased in serum and plasma in patients with AD, but it is unclear if allopregnanolone is also reduced in brain. Bec ...
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Journal articleJ Nerv Ment Dis · December 2006
The role of spirituality in depression is understudied. We examined the relationship between one dimension of spirituality, spiritual experiences, and depressive symptoms, and evaluated whether differences in gender, race, age, and stress moderated the rel ...
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Journal articleJ Aging Health · December 2006
OBJECTIVES: The present study examined the influence of participant's perception that their basic needs were not being met on their physical functioning problems. The association between lower social economic status (SES), typically indexed by income and e ...
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Journal articleTranscult Psychiatry · September 2006
In My Name Is Legion (Leighton, 1959), the basic assumption of Alexander H. Leighton's theory of sentiment is as follows: 'A given personality exists more or less continuously throughout life in the act of striving, and interference with that striving has ...
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Journal articleJ Am Geriatr Soc · June 2006
OBJECTIVES: To determine whether the characteristics of the usual medical care providers of older antidepressant users changed between 1986 and 1997 with the introduction of selective serotonin reuptake inhibitors. DESIGN: Longitudinal study. SETTING: Five ...
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Journal articleAm J Geriatr Psychiatry · June 2006
OBJECTIVE: Neighborhood sociodemographic characteristics may be important to the mental health of older adults who have decreased mobility and fewer resources. Our objective was to examine the association between neighborhood context and level of depressiv ...
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Journal articleAnn Epidemiol · June 2006
PURPOSE: Black women have an increased risk for preterm birth compared with white women, and prior research indicated that maternal prenatal depressive symptoms are associated with increased risk for preterm outcomes among black women. Race-related differe ...
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Journal articleGeriatrics · April 2006
Major depression can affect up to 10% of older adults in clinical samples. Longitudinal studies of older adults with major depression report that a significant proportion of patients do not fully recover. Partial remission or symptoms of major depression t ...
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Journal articleJ Am Geriatr Soc · March 2006
OBJECTIVES: To determine whether metabolic syndrome is an independent predictor of decline in mobility in an elderly community sample. DESIGN: Biracial community-based prospective cohort study. SETTING: Urban and rural areas of central North Carolina. PART ...
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Journal articleAm J Geriatr Psychiatry · November 2005
OBJECTIVE: The authors examined racial differences in cognitive decline (CD) and the role of education and literacy in mediating this relationship. METHODS: The relationship between race and CD was examined over a 3-year period in a biracial community samp ...
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Journal articlePsychol Med · September 2005
BACKGROUND: Despite the burden of depression in late life, its origins present a paradox to investigators and clinicians alike. METHOD: We review biological (genetics and heredity factors, neurotransmitter dysfunction, endocrine changes, vascular disorders ...
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Journal articleBiol Psychiatry · August 15, 2005
It is commonly thought and taught that most psychiatric disorders other than dementia are much less prevalent among the elderly than among younger adults. This perception is based on a relatively small number of published epidemiologic investigations of th ...
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Journal articleAm J Geriatr Psychiatry · August 2005
OBJECTIVE: The authors studied demographic, clinical, social, and perceived health and well-being factors as predictors of partial remission in older patients treated for major depressive disorder (MDD). METHODS: The sample included 186 patients who met DS ...
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Journal articleAm J Geriatr Psychiatry · May 2005
OBJECTIVE: An association between depression and cognitive decline (CD) has been observed in cross-sectional and case/control studies of elderly populations. Whereas a handful of longitudinal community studies have found depressive symptoms to predate the ...
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Journal articleAging Ment Health · May 2005
In a biracial sample of community dwelling elders (n=4162, the Duke EPESE), African-Americans endorsed more items than Whites on a standardized depression scale, the CES-D, in unadjusted, cross-sectional analyses. However, indices of socioeconomic status ( ...
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Journal articleAm J Psychiatry · April 2005
OBJECTIVE: Antidepressant use increased substantially among older adults with the introduction of the new-generation medications such as the selective serotonin reuptake inhibitors. The authors analyzed data from two follow-up intervals-1986-1987 to 1989-1 ...
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Journal articleAm J Public Health · February 2005
OBJECTIVES: We sought to determine whether, among older adults (>65 years), a perception that their basic needs are not being met increased mortality risk and whether this risk varied by race/ethnicity. METHODS: We used Cox proportional hazards modeling to ...
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Journal articleHealth Psychol · January 2005
In a population sample (N=5,877; ages 15 to 54), the authors found childhood sexual and physical abuse to be associated with the 1-year prevalence of serious health problems for both men and women. The authors also found that participants' psychiatric diso ...
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Journal articleJ Am Geriatr Soc · December 2004
OBJECTIVES: To determine whether self-reports of delayed care predict increased mortality and functional decline in community-dwelling elderly. DESIGN: Longitudinal cohort study. SETTING: Five counties in North Carolina. PARTICIPANTS: A total of 4,162 rand ...
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Journal articleJ Am Geriatr Soc · December 2004
OBJECTIVES: To determine which symptoms of depression are most likely to increase the risk of mortality in a biracial sample of older adults. DESIGN: Cross-sectional and longitudinal study. SETTING: Baseline and mortality follow-up in urban and rural North ...
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Journal articleJournal of Applied Gerontology · September 1, 2004
This study uses Lawton's model of "the good life " to examine whether the Apolipoprotein E-ε4 genotype functions as a risk factor not only for specific diseases but also for a misfit between elders' personal needs and their physical and social environments ...
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Journal articleJ Transl Med · June 25, 2004
With the role of angiogenesis in tumor growth and progression firmly established, considerable effort has been directed to antiangiogenic therapy as a new modality to treat human cancers. Antiangiogenic agents have recently received much widespread attenti ...
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Journal articleAm J Geriatr Psychiatry · 2004
OBJECTIVE: The authors examined whether older adults respond comparably to two standard depression instruments rating symptoms by frequency/duration or degree of severity/"bother." METHODS: Data for this cross sectional analysis of a prospective cohort cam ...
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Journal articleClin Geriatr Med · November 2003
This article reviews the prevalence and incidence of mental disorders in older adults. The authors outline the epidemiologic challenges in determining the frequency of mental disorders in late-life and discuss issues that are critical for understanding the ...
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Journal articleSurg Oncol · November 2003
Is there a role for sentinel lymph node (SLN) biopsy in the management of sarcoma? Sentinel node biopsy has dramatically changed the management of melanoma and breast cancer, helping surgeons avoid radical lymphadenectomies in node negative patients who wo ...
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Journal articleJ Aging Health · November 2003
UNLABELLED: The epsilon4 allele of apolipoprotein E (APOE) has been associated with health-related outcomes that may adversely affect quality of life (QOL) in older adults. In the absence of published information, we sought to determine whether the epsilon ...
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Journal articleArch Gen Psychiatry · July 2003
OBJECTIVES: To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research. PARTICIPANTS: The Consensus Development Panel consisted of experts in late-life mood disorders, ...
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Journal articleJ Am Geriatr Soc · July 2003
OBJECTIVES: To evaluate the applicability of process-of-care quality indicators (QIs) to vulnerable elders and to measure the effect of excluding indicators based on patients' preferences and for advanced dementia and poor prognosis. DESIGN: The Assessing ...
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Journal articleAm J Med Genet A · June 1, 2003
We have tried, with only partial success, to confirm findings in a recently reported study in this journal on the relationship of APOE genotype to mortality in community representative Hispanics (n = 659), Whites (n = 272), and African-Americans (n = 450), ...
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Journal articleJ Gerontol A Biol Sci Med Sci · March 2003
Depression is perhaps the most frequent cause of emotional suffering in later life and significantly decreases quality of life in older adults. In recent years, the literature on late-life depression has exploded. Many gaps in our understanding of the outc ...
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Journal articleAm J Geriatr Psychiatry · 2003
OBJECTIVE: The apolipoprotein epsilon4 (APOE epsilon4) genotype is associated with a number of adverse health outcomes. The authors assessed whether the epsilon4 genotype was associated with higher hospital costs on the basis of data from 1,999 white or bl ...
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Journal articleAging Ment Health · November 2002
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Feelings of sadness and loneliness are ubiquitous in late life and a risk factor for depression and perhaps other mental illnesses in late life. Targeting sadness and loneliness for an intervention addresses both primary risk reduction for depressive disor ...
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Journal articleJ Psychosom Res · October 2002
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OBJECTIVES: This study focuses on the comorbidity between depression and diabetes, as well as depression and obesity, in a biracial community sample of older adults. METHODS: The data are drawn from a cross-sectional survey of five counties in North Caroli ...
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Journal articleGerontologist · June 2002
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PURPOSE: The goal of this study was to determine whether the epsilon4 allele of apolipoprotein E is predictive of mortality in a community-based sample. DESIGN AND METHODS: Of the stratified random household sample of 4,162 participants age 65 years and ol ...
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Journal articleMil Med · June 2002
Does military service, in particular operational deployment, result in a higher risk of chronic illness among military personnel and veterans? The Millennium Cohort Study, the largest Department of Defense prospective cohort study ever conducted, will atte ...
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Journal articleJ Am Geriatr Soc · March 2002
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OBJECTIVES: To determine whether there are racial/ethnic differences regarding the relationship of level of blood pressure to change in cognitive function in older people. DESIGN: Longitudinal data 1986 to 1989 on representative, older, community-residing ...
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Journal articleAging Ment Health · February 2002
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Reference groups, such as religious groups, are thought to provide individuals with normative frameworks which set and maintain standards for them. Persons who belong to a reference group, yet do not comply with the standards of that group, i.e. non-confor ...
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Journal articleAm J Geriatr Psychiatry · 2002
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The authors investigated the increased risk of mortality from subthreshold depression and examined differences in risk by gender. Data from the Duke University Established Populations for Epidemiologic Studies of the Elderly (EPESE) longitudinal study of 4 ...
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Journal articleCompr Psychiatry · 2002
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This study examines impairment and health status and resource utilization among individuals with and without borderline personality disorder (BPD), all of whom had post-traumatic stress symptoms (PTSS). Using data from the community-based Piedmont Health S ...
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Journal articleAm J Geriatr Psychiatry · 2002
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OBJECTIVE: The epsilon4 allele of apolipoprotein (APOE) is known to be associated with a number of adverse health outcomes, yet the association of the allele with depression has not been conclusively determined. The authors explored the hypothesis that the ...
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Journal articleJ Gerontol A Biol Sci Med Sci · December 2001
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BACKGROUND: Given previous findings of adverse health outcomes associated with the E4 allele, data from a biracial community sample of older adults were used to determine whether functional decline is associated with the apolipoprotein E (APOE) E4 allele. ...
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Journal articleJ Am Geriatr Soc · September 2001
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OBJECTIVES: To determine whether cognitive decline associated with the apolipoprotein E (APOE) epsilon4 allele is different in older African Americans than it is in Caucasians. DESIGN: Performance on a brief screen of cognitive functioning was examined at ...
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Journal articleJ Gerontol A Biol Sci Med Sci · August 2001
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BACKGROUND: The evidence for an association between depression and mortality among community-dwelling elderly persons remains inconclusive, although it is well established for younger individuals. Extant studies suggest that this association weakens when a ...
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Journal articleAging Ment Health · August 2001
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The objective was to use secondary analysis of prevalence data from a prospective cohort study to ascertain the accuracy of self-reported stroke among veterans. The study comprised a community-dwelling population of 88 elderly veterans (from five counties ...
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Journal articleGerontologist · June 2001
PURPOSE: The prevalence of depressive symptoms in elderly adults is high, yet the criteria to identify clinically significant depression may leave many elders undiagnosed and untreated. We explored the demographic and risk factor profiles of two groups, on ...
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Journal articleJ Am Geriatr Soc · April 2001
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OBJECTIVES: To determine the risk from hypertension for all-cause mortality in a racially mixed sample of community-dwelling older adults. DESIGN: Baseline blood pressure was assessed between 1985 and 1986 in a sample of persons 65 years of age and older f ...
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Journal articleTeach Learn Med · 2001
PURPOSE: Our purpose was to review and evaluate Duke University School of Medicine's 3rd year. SUMMARY: Duke University School of Medicine instituted a dramatic change in its curriculum 35 years ago by restructuring the 1st, 2nd, and 4th years of medical s ...
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Journal articleAm J Psychiatry · December 2000
OBJECTIVE: This article reviews the assessment and management of psychiatric problems among the oldest old. METHOD: The author reviewed the English-language literature pertinent to the characteristics of people 85 years old or older and the assessment and ...
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Journal articleArch Intern Med · November 27, 2000
BACKGROUND: High rates of low health literacy among elderly populations along with a high prevalence of chronic conditions may lead to increased levels of depression symptomatology. We sought to determine whether older adults with inadequate health literac ...
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Journal articleJ Am Geriatr Soc · October 2000
OBJECTIVE: To determine whether depressive symptoms in older adults are associated with an increased risk for hospitalization. DESIGN: A 6 month cohort study. SETTING: Five counties in the northern Piedmont of North Carolina from the Duke University site o ...
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Journal articleJ Am Geriatr Soc · September 2000
OBJECTIVES: Prescriptions of sedatives, hypnotics, and antianxiety medications have decreased over the past 15 years. However, racial differences have not been well investigated in controlled analyses. DESIGN: A prospective cohort study. SETTINGS AND PARTI ...
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Journal articleAm J Psychiatry · July 2000
OBJECTIVE: Prescriptions of antidepressant medications have increased significantly over the past 15 years across the life cycle. One overall correlate of medication use in older adults is race, with African Americans using fewer medications than whites. G ...
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Journal articleJ Gerontol A Biol Sci Med Sci · July 2000
BACKGROUND: Previous studies have linked higher religious attendance and longer survival. In this study, we examine the relationship between survival and private religious activity. METHODS: A probability sample of elderly community-dwelling adults in Nort ...
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Journal articlePsychol Med · May 2000
BACKGROUND: Phobic disorder is one of the most prevalent psychiatric disorders in community populations and much attention has focused on the association of sociodemographic factors and social resources with the disorder. There has been little investigatio ...
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Journal articleJ Aging Health · February 2000
OBJECTIVES: The purpose of the analyses was to examine the impact of health-related variables on race differences in neuropsychological functioning (Boston Naming Task). METHODS: Using cross-sectional data from the MacArthur Successful Aging Study, the aut ...
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Journal articleResearch on Aging · January 1, 2000
Recent research has shown the beneficial effects of religious activity for individual health and well-being among older adults. The purpose of this article is to determine whether breaking the norms of the religious group can have deleterious consequences ...
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Journal articleMol Carcinog · January 2000
Prostate cancer is a common disease, yet determinants of prostate cancer risk remain largely unidentified. Low circulating levels of 1, 25-dihydroxy vitamin D (1,25-D) have been implicated as a risk factor for prostate cancer. In addition, 1,25-D exhibits ...
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Journal articleAcad Med · December 1999
Because of changes in the health care environment, it is likely that strategic planning and management will become much more important to academic health centers (AHCs) than in the past. One approach to strategic planning and management that is gaining the ...
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Journal articleJ Affect Disord · November 1999
BACKGROUND: Previous research has demonstrated that suicidal ideation often predicts suicide completion. METHODS: The present study examined clinical and phenomenological variables associated with the presence, development and remission of suicidal ideatio ...
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Journal articleJ Affect Disord · November 1999
BACKGROUND: Suicidal ideation has been shown to be strongly associated with suicide completion and elders take their own lives more than any other age group. METHODS: The present study examined clinical and phenomenological correlates of suicidal ideation ...
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Journal articleJ Psychosom Res · October 1999
Since the discovery and successful treatment of sleep apnea, researchers seem to believe that the association between sleep disturbance and coronary heart disease (CHD) has been explained. To determine whether subjective nighttime sleep complaints (trouble ...
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Journal articleJ Trauma Stress · October 1999
This study describes social functioning and service utilization patterns associated with posttraumatic stress symptoms relative to nonpsychiatric controls and depressive disorder controls in a cross-sectional epidemiological survey. Data from 49 cases and ...
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Journal articleJ Affect Disord · October 1999
BACKGROUND: A number of studies have concluded that the perceived quality of support is more strongly associated with mental health than with the actual structure of personal networks. This study examined clinical, historical, and phenomenological variable ...
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Journal articleMed Clin North Am · September 1999
Older women report more depressive symptoms in community samples and are also more likely to seek medical care, although the frequency of suicide is more common among older men. Depression in the older man has been neglected by both investigators and clini ...
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Journal articleJ Gerontol A Biol Sci Med Sci · July 1999
METHODS: A probability sample of 3,968 community-dwelling adults aged 64-101 years residing in the Piedmont of North Carolina was surveyed in 1986 as part of the Established Populations for the Epidemiologic Studies of the Elderly (EPESE) program of the Na ...
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Journal articleSleep · May 1, 1999
To determine incidence and remission rates of insomnia in older adults and associated risk factors. Three-year longitudinal study, 1982-198--East Boston, MA; New Haven, CT; Iowa and Washington counties, IA. Participants were 6,899 men and women aged 65 yea ...
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Journal articleSleep · May 1, 1999
OBJECTIVES: To determine the incidence and remission rates of insomnia in older adults according to race and associated risk factors in a three-year longitudinal study. METHODS: 2,971 men and women, aged 65 years and older, completed questionnaires adminis ...
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Journal articleInt J Aging Hum Dev · 1999
This article explores the buffering effect of social support on depressive symptoms in a community sample of elderly with varying levels of disability. Baseline interviews were conducted in respondents' homes. Results show that higher levels of disability ...
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Journal articleJ Am Geriatr Soc · January 1999
OBJECTIVES: The prevalence of depression increases with age, as does the prevalence of higher levels of the cytokine interleukin-6 (IL-6). This analysis was performed to determine the association between increased levels of this cytokine and depression in ...
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Journal articleClin Pharmacol Ther · December 1998
OBJECTIVE: To evaluate the relation between benzodiazepine use and cognitive function among community-dwelling elderly. METHODS: This prospective cohort study included 2765 self-reporting subjects from the Duke Established Populations for Epidemiologic Stu ...
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Journal articlePsychol Med · November 1998
BACKGROUND: Few studies have explored the variance in individual symptoms by race in older adults. METHODS: Data were analysed from the Duke site of the Established Populations for Epidemiologic Studies of the Elderly (EPESE), a community sample of persons ...
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Journal articleJ Aging Health · November 1998
We tested whether elders substitute religious media use for church attendance when health declines (using multidimensional disengagement theory) with data from a multiracial, population-based sample in the Bible Belt (N = 2,971). In adjusted models, 3-year ...
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Journal articleJ Gerontol A Biol Sci Med Sci · November 1998
BACKGROUND: The objective of this study was to examine the relationship between religious activities and cigarette smoking in community-dwelling older adults. METHODS: Cigarette smoking and religious activities were assessed in a probability sample of 3968 ...
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Journal articleAnn Epidemiol · August 1998
PURPOSE: To investigate whether subjective sleep complaints are an independent predictor of myocardial infarction (MI) in a community of older adults and to gain clues as to why the association between sleep complaints and incident MI exists. METHODS: Usin ...
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Journal articlePatient Care · May 15, 1998
Depression is prevalent in elderly patients but frequently missed or undertreated. A practical, systematic approach can help you improve quality of life for the depressed elderly and reduce disability, suicide rates, and unnecessary health care costs in th ...
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Journal articleBr J Psychiatry · February 1998
BACKGROUND: Previous estimates of the prevalence of seasonal affective disorder (SAD) in community samples have been in the range 2-10%, using methods not derived from DSM algorithms. We report the first community-based study to estimate major and minor de ...
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Journal articleAging and Mental Health · January 1, 1998
Effects of impaired social support and stressful life events on non-lethal suicidal behaviors were examined in a clinical sample of high-risk patients: depressed adult men with a family history of suicide or attempted suicide. All subjects (N = 79) were pa ...
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Journal articleJ Gerontol B Psychol Sci Soc Sci · January 1998
Few investigations of the social correlates of depressive symptomatology have addressed variation in the correlates across multiple dimensions of depression scales. We examined the relationships of selected social, clinical, and demographic correlates with ...
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Journal articleDepress Anxiety · 1998
The literature suggests that bipolar elders with early and late onset of the disorder present with different demographic, family history, and psychosocial profiles, which are less well characterized than those for elderly unipolar patients. In this cross-s ...
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Journal articleInt J Psychiatry Med · 1998
OBJECTIVE: To examine the relationship between religious activities and blood pressure in community-dwelling older adults. METHOD: Blood pressure and religious activities were assessed in a probability sample of 3,963 persons age sixty-five years or older ...
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Journal articleDepress Anxiety · 1998
The purpose of this paper is to estimate the relative probabilities of 6-month recovery from an index episode of major depression for subjects with and without MRI-confirmed vascular brain changes. In this cohort study, 57 depressed subjects from the Duke ...
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Journal articleArchives of Gerontology and Geriatrics · January 1, 1998
Late life mood disorders are subject to many misconceptions. In this paper, misconceptions about the symptomatology, frequency and treatment of late life depression are reviewed. If late life depression is not complicated by comorbid physical illness or de ...
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Journal articlePsychiatry Res · October 10, 1997
This study used a case-control design to address differences in psychosocial, physical and clinical profiles between subjects who presented with a chronic index episode of major depression and those who presented with a non-chronic index episode. Subjects ...
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Journal articleJ Affect Disord · August 1997
Data from the National Comorbidity Survey are used to study the lifetime prevalences, correlates, course and impairments associated with minor depression (mD), major depression 5-6 symptoms (MD 5-6), and major depression with seven or more symptoms (MD 7-9 ...
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Journal articleJ Aging Health · May 1997
Of a representative, racially mixed community sample of older adults in North Carolina, 59% of Whites and 49% of African Americans reported worsening memory. The complaint about memory was positively correlated with age, depressive symptomatology, and phys ...
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Journal articleAm J Psychiatry · April 1997
OBJECTIVE: The authors' goal was to characterize the clinical and demographic features of vascular depression. METHOD: They classified 89 depressed patients into two groups-those with vascular (N = 32) and nonvascular (N = 57) depression-on the basis of ex ...
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Journal articlePsychiatr Clin North Am · March 1997
Despite myths to the contrary, existing evidence suggests that depression in the elderly is not different in its symptoms, more frequent, more chronic, more difficult to treat, or more attributable to psychosocial factors than depression in younger persons ...
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Journal articleAging and Mental Health · January 1, 1997
Poor physical function status in elders is a robust predictor of not only medical service use and institutionalization but also mortality. We assessed whether depressive symptoms and low social support would predict deficits in three domains of physical fu ...
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Journal articleInt J Psychiatry Med · 1997
OBJECTIVE: First, to examine and explain the relationship between religious service attendance and plasma Interleukin-6 (IL-6) levels, and second, to examine the relationship between religious attendance and other immune-system regulators and inflammatory ...
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Journal articleJ Immunother · January 1997
Ex vivo genetically engineered cytokine-secreting tumor cell vaccines have been shown to prevent metastatic disease in animal models of lung and breast cancer. Because of the inefficiency of existing modes of gene delivery in transducing primary human tumo ...
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Journal articleHarv Rev Psychiatry · 1997
Practicing psychiatrists frequently encounter elderly patients with generalized anxiety disorder or panic disorder. Unfortunately, the empirical literature regarding the assessment, diagnosis, and treatment of these illnesses in older individuals is sparse ...
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Journal articleCancer Gene Ther · 1997
Pancreatic cancer has a poor prognosis even when complete resection can be accomplished. Recent studies have demonstrated that the immune system is capable of mounting effective tumor-specific immune responses even against "nonimmunogenic" tumors. The stud ...
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Journal articleAm J Geriatr Psychiatry · 1997
The authors examined models of the relationships between religious activities, physical health, social support, and depressive symptoms in a sample of 4,000 persons age 65 and over. Religious activity was examined first as a single composite construct and ...
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Journal articleEthn Dis · 1997
Using cross-sectional and longitudinal data from the MacArthur Successful Aging Study, this paper examines associations between cognition and indices of health in 224 elderly African Americans 70 to 79 years of age at initial interview. The results indicat ...
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Journal articleJ Clin Epidemiol · September 1996
We analyzed the first 5 years of surveillance data from the Established Population for the Epidemiologic Studies of the Elderly (EPESE) in the Piedmont of North Carolina (n = 4162) to estimate the effect of a global self-rating of health on survival. Covar ...
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Journal articleAmerican Journal of Geriatric Psychiatry · September 1, 1996
Minor depression is a type of depressive disorder that does not fulfill the duration criteria or show the number of symptoms necessary to make the diagnosis of major depression. Defining minor depression, therefore, is difficult because of the many differe ...
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Journal articleSurgery · August 1996
BACKGROUND: Vaccination of tumor-bearing animals with tumor cells genetically engineered to secrete cytokines including interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) has been shown to induce effective tumor-specific immune responses capable of inhi ...
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Journal articleJ Affect Disord · July 8, 1996
Age of onset has been used as a correlate of depressive symptomatology in the elderly. Examining frequency of episodes may improve our ability to make such correlations. The authors studied variations in an index presentation of depression in late life bas ...
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Journal articleArch Gen Psychiatry · June 1996
BACKGROUND: Lifetime community rates of attempted suicide were compared between those who reported a history of sexual assault and a control group without such a history. METHODS: The 2918 respondents in the Duke University Epidemiological Catchment Area S ...
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Journal articleJ Am Geriatr Soc · June 1996
OBJECTIVE: To describe the demographic and health-related factors related to excessive daytime sleepiness. To estimate the risk of mortality associated with excessive daytime sleepiness independent of nightime sleep problems and other factors that limit su ...
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Journal articleAm J Hypertens · June 1996
In order to determine the adequacy of blood pressure treatment in black and white elderly men and women, the authors performed a cross-sectional population survey in Central North Carolina in 1986-1987. Participants included a random sample of noninstituti ...
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Journal articleBr J Psychiatry Suppl · June 1996
General population data are presented on the prevalence and correlates of comorbidity between DSM-III-R major depressive disorder (MDD) and other DSM-III-R disorders. The data come from the US National Comorbidity Survey, a large general population survey ...
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Journal articleThe British journal of psychiatry. Supplement · June 1, 1996
General population data are presented on the prevalence and correlates of comorbidity between DSM-III-R major depressive disorder (MDD) and other DSM-III-R disorders. The data come from the US National Comorbidity Survey, a large general population survey ...
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Journal articleJ Aging Health · May 1996
The objective of this study was to determine whether racial differences in hypertension in a random sample of community-dwelling older adults also remained significant in a sample of successful agers. Data for the random sample of community-dwelling older ...
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Journal articleAge Ageing · May 1996
To determine whether medication use differs by cognitive status among community dwelling elderly, a survey was made of a stratified random sample of 4110 black and white participants, aged 65 or older from the Duke Established Populations for Epidemiologic ...
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Journal articleGerontologist · February 1996
Symptoms of paranoia were found in 9.5% of a community sample of older adults in North Carolina. In cross-sectional analyses, these symptoms were associated most strongly with black race, lower income and education, less exercise, and more depressive sympt ...
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Journal articlePsychol Aging · December 1995
This study used a linear structural relations modeling technique (LISREL) to examine longitudinal data for 1,192 persons from a community-based population. The goal was to test the ability of an a priori model to predict cognitive change over a 2.0- to 2.5 ...
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Journal articleJ Gerontol A Biol Sci Med Sci · November 1995
BACKGROUND: Peak expiratory flow rate (PEFR) is correlated with several measures of health in the elderly, including physical and cognitive function. It is unclear, however, whether these relationships persist among the non-frail. METHODS: The Community-ba ...
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Journal articleAm J Public Health · October 1995
OBJECTIVES: This study compared health service use and satisfaction with health care among older adults living in urban vs rural counties in North Carolina. METHODS: A stratified random sample of 4162 residents of one urban and four rural counties of North ...
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Journal articleJ Gerontol A Biol Sci Med Sci · September 1995
BACKGROUND: Sleep complaints have been reported in epidemiologic studies to be more frequent in late life, among females, among the physically impaired, and among persons experiencing psychiatric disorders. To date, however, no studies have reported a raci ...
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Journal articleJ Gerontol B Psychol Sci Soc Sci · September 1995
The dynamic nature of household composition in a population of elderly persons, with particular focus on Black-White and urban-rural differences, is described in this study. The Duke EPESE is a stratified, random household sample (N = 4,162) of elderly per ...
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Journal articleProg Neuropsychopharmacol Biol Psychiatry · September 1995
1. The white blood cell (WBC) count in those with high depressive symptoms and non-depressed participants in the Established Populations for Epidemiologic Studies of the Elderly (EPESE) were compared. 2. Of 3769 participants 10.8% had high depressive sympt ...
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Journal articleSleep · July 1995
The frequencies of five common sleep complaints--trouble falling asleep, waking up, awaking too early, needing to nap and not feeling rested--were assessed in over 9,000 participants aged 65 years and older in the National Institute on Aging's multicentere ...
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Journal articleJ Gerontol A Biol Sci Med Sci · July 1995
BACKGROUND: Performance-based measures of physical performance are examined for an older cohort of relatively high-functioning men and women. The influences of baseline behavioral, social, and psychological characteristics on patterns of change in performa ...
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Journal articleAm J Psychiatry · May 1995
OBJECTIVE: The authors examined the relationship between age at onset of first depressive episode and clinical features in elderly depressed patients. METHOD: They used data on age at onset and clinical features in 246 elderly depressed patients treated at ...
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Journal articleAnn Pharmacother · April 1995
OBJECTIVE: To describe and compare medication-taking behaviors in the high- and low-functioning elderly living in the community. DESIGN: A cross-sectional design with data collected by interview. SETTING: The study included 5 counties in the southern Piedm ...
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Journal articleJ Clin Epidemiol · March 1995
The characteristics of antidepressant use and its correlates were assessed in the four Established Populations for Epidemiologic Study of the Elderly (EPESE) communities (n = 13,074). Women were significantly more likely to be treated with an antidepressan ...
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Journal articleAm J Epidemiol · February 15, 1995
The authors examined body mass index at middle age, body mass index in old age, and weight change between age 50 years and old age in relation to mortality in old age. The study population from the Established Populations for Epidemiologic Studies of the E ...
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Journal articlePsychosom Med · 1995
This study determines, in a population of older adults with diagnosed hypertension, the concurrent association between depressive symptomatology and blood pressure control and the longitudinal association between depressive symptomatology and blood pressur ...
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Journal articlePsychosomatics · 1995
The investigators examined associations between depressive symptom type and religious coping in 832 consecutively admitted older medical inpatients. Cognitive symptoms of depression, but not somatic symptoms, were related to religious coping. Boredom, loss ...
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Journal articleArch Gen Psychiatry · December 1994
BACKGROUND: Individuals with subthreshold social phobia (SSP) in the community are characterized relative to nonphobic, healthy controls (C), and diagnosed social phobics (SP). METHODS: Data from 1488 subjects from the Duke University Epidemiological Catch ...
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Journal articleAm J Public Health · November 1994
OBJECTIVES: The purpose of these analyses was to test the hypothesis that depressive symptomatology affects the risk of onset of physical disability in high-functioning elderly adults. METHODS: The data come from the MacArthur Study of Successful Aging, a ...
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Journal articleToxicol Appl Pharmacol · August 1994
Chronic exposure of female B6C3F1 mice to a high concentration of unleaded gasoline (UG) vapor induced liver tumors and caused uterine changes suggestive of estrogen antagonism. These effects of UG may be related, since estrogens inhibit hepatocarcinogenes ...
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Journal articleHosp Pract (Off Ed) · July 15, 1994
Presentation differs from that in the young, as does choice of therapy, which tends to be empiric. The tricyclics are considered the best treatment, although electroconvulsive therapy may be preferable in severe delusional depression. ...
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Journal articleAm J Psychiatry · July 1994
OBJECTIVE: Major depression is a frequent and disabling psychiatric disorder in the United States. This report examines the prevalence and risk factor profile of both pure and comorbid major depression according to data from the National Comorbidity Survey ...
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Journal articleJ Am Geriatr Soc · July 1994
OBJECTIVE: To measure markers of inflammation in a cohort of young and old subjects and relate these findings to the functional level of the individuals. DESIGN: For the pilot study, blood samples were obtained from 18 young (age 20-35 years) and 18 old (a ...
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Journal articleHosp Community Psychiatry · June 1994
OBJECTIVE: The authors examined the relationship between religious affiliation and psychiatric disorder among Protestant members of the baby-boom generation (those born between 1945 and 1966) who resided in the Piedmont area of North Carolina. METHODS: Dat ...
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Journal articleDemography · May 1994
A fundamental limitation of current multistate life table methodology-evident in recent estimates of active life expectancy for the elderly-is the inability to estimate tables from data on small longitudinal panels in the presence of multiple covariates (s ...
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Journal articleJ Gerontol · May 1994
BACKGROUND: This study tested the predictive value of self-rated health on 3-year mortality, with attention focused on healthy, high-functioning elders. METHODS: Data from the MacArthur Field Study of Successful Aging were utilized. Subjects were 70-79-yea ...
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Journal articleJ Gerontol · May 1994
BACKGROUND: Performance-based measures of physical performance were examined for an older cohort of relatively high-functioning men and women. Relationships between baseline physical performance and sociodemographic and health status characteristics were a ...
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Journal articleHosp Community Psychiatry · March 1994
OBJECTIVE: The study examined associations between religious variables and alcohol abuse and dependence among 2,969 North Carolina residents aged 18 to 97 who participated in the 1983-1984 National Institute of Mental Health Epidemiologic Catchment Area su ...
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Journal articleJ Gerontol · March 1994
BACKGROUND: A short battery of physical performance tests was used to assess lower extremity function in more than 5,000 persons age 71 years and older in three communities. METHODS: Balance, gait, strength, and endurance were evaluated by examining abilit ...
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Journal articleNeuropsychopharmacology · February 1994
To investigate the dopaminergic correlates of the aging-related motor and cognitive deficits, the dopamine metabolite homovanillic acid (HVA) in plasma was studied in a community-dwelling elderly cohort (n = 141). The results showed that hand-signature tim ...
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Journal articleJournal of Personality Disorders · January 1, 1994
Data from the Duke Epidemiologic Catchment Area (ECA) study were used to determine if persons reporting a pervasive pattern of severe adult antisocial behavior always report a similar pattern of antisocial behavior in childhood. Roughly half of persons rep ...
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Journal articleJ Affect Disord · January 1994
Data from a nationally representative sample of the general population are used to study cohort differences in the prevalence of DSM-III-R Major Depressive Episode (MDE). We document increasing lifetime prevalence of MDE among both men and women in more re ...
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Journal articlePublic Health Rep · 1994
Although diabetes is a common health problem of the elderly, the impact of diabetes on health and functioning in older persons is not well established. The purpose of this analysis was to identify health conditions accompanying diabetes in four samples of ...
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Journal articleAnnals of Behavioral Medicine · January 1, 1994
Data from a community-based, relatively high-functioning cohort of men and women, aged 70-79, were used to test hypotheses relating the quantity and quality of social relationships to levels of urinary norepinephrine, epinephrine, and cortisol. For men, mu ...
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Journal articleJ Am Geriatr Soc · December 1993
OBJECTIVE: To explore the relationship of smoking cessation and depression. DESIGN: Cohort study with 3 years of follow-up. SETTING: North Carolina community of the Established Populations for the Epidemiologic Studies of the Elderly. PARTICIPANTS: Stratif ...
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Journal articleJ Am Geriatr Soc · November 1993
OBJECTIVE: To examine and compare the profile of cognitive symptoms, somatic symptoms, and somatic complaints in younger and older medical inpatients diagnosed with major depressive disorder (MDD). DESIGN: Cross-sectional cohort. PATIENTS AND SETTING: Male ...
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Journal articleJ Clin Epidemiol · October 1993
The objective of this study is to determine the range of complex physical and cognitive abilities of older men and women functioning at high, medium and impaired ranges and to determine the psychosocial and physiological conditions that discriminate those ...
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Journal articlePsychol Med · August 1993
Social phobia was studied in a North Carolina community, using DSM-III criteria. Two kinds of comparison were made: social phobia v. non-social phobia, and comorbid social phobia v. non-comorbid social phobia. Six-month and lifetime prevalence rates were 2 ...
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Journal articleN Engl J Med · July 8, 1993
BACKGROUND AND METHODS: Persons of low socioeconomic status are known to have reduced life expectancy. In a study of the relation of socioeconomic status to disability-free or active life expectancy among older persons, we analyzed prospectively gathered d ...
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Journal articleJ Am Geriatr Soc · July 1993
OBJECTIVE: To assess the validity of several equations for estimating creatinine clearance in a large sample of high-functioning, community-dwelling elderly. DESIGN: Serum and 12-hour urine samples were collected and assayed for creatinine using the Jaffe ...
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Journal articleAnn Epidemiol · July 1993
Identical measures of social ties obtained from three community-based cohorts aged 65 and over from East Boston, MA; New Haven, CT; and two rural counties in Iowa permit the first direct cross-community comparison of the hypothesis that social isolation in ...
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Journal articleAm J Psychiatry · May 1993
OBJECTIVE: The authors examined the effects of physical health and social support on 6-month outcome of a major depressive episode in 67 patients who were less than 60 years old and 46 patients who were 60 years old or older. They hypothesized that despite ...
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Journal articleAm J Psychiatry · May 1993
OBJECTIVE: The authors examined differences in the prevalence of psychiatric disorders in individuals who did or did not have alcoholic parents. METHOD: They used data from the National Institute of Mental Health Epidemiologic Catchment Area project, speci ...
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Journal articleArch Intern Med · March 22, 1993
OBJECTIVE: In the United States, 20% or more of nursing home residents receive antipsychotic drugs, primarily for the behavioral manifestations of dementia. This high level of use of drugs with substantial toxicity has engendered a strong and persistent co ...
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Journal articleAging (Milano) · February 1993
A project initiated by the intramural Epidemiology, Demography and Biometry Program of the National Institute on Aging, entitled "Established Populations for Epidemiologic Studies of the Elderly" (EPESE), has developed information on death, chronic conditi ...
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Journal articleJournal of Anxiety Disorders · January 1, 1993
We examined and compared associations between religious variables and anxiety disorders in 1025 young (ages 18 to 39), 645 middle-aged (ages 40 to 59), and 1299 elderly (ages 60 to 97) community-dwelling adults who participated in Wave II of the Piedmont N ...
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Journal articlePsychosomatics · 1993
The 35-item Duke Social Support Index (DSSI) measures multiple dimensions of social support and has been used extensively in cross-sectional and longitudinal studies of aging. Epidemiological studies of chronically ill, frail elderly individuals often wish ...
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Journal articleAm J Epidemiol · January 1, 1993
Hypertension in blacks, compared with whites, occurs at higher prevalence rates, is more severe, and carries a worse prognosis for cardiovascular morbidity and mortality. The authors examined the degree to which black/white differences in hypertension in t ...
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Journal articleInt J Psychiatry Med · 1993
OBJECTIVE: We wish to determine whether or not elderly medical inpatients should be screened for depressive disorder using either 1) a self-rated depression scale (Geriatric Depression Scale), 2) "usual clinical assessment," or 3) neither, assuming that tr ...
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Journal articleNeurobiol Aging · 1993
Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in el ...
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Journal articleJ Affect Disord · 1993
Basic epidemiologic prevalence data are presented on sex differences in DSM-III-R major depressive episodes (MDE). The data come from the National Comorbidity Survey (NCS), the first survey in the U.S. to administer a structured psychiatric interview to a ...
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Journal articlePsychopharmacol Bull · 1993
The National Institutes of Health Consensus Development Conference on Diagnosis and Treatment of Depression in Late Life brought together biomedical and behavioral scientists, surgeons, and other health care professionals as well as the public to address t ...
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Journal articleAm J Psychiatry · December 1992
OBJECTIVE: The investigators examined the frequency of religious coping among older medical inpatients, the characteristics of those who use it, and the relation between this behavior and depression. METHOD: The subjects were 850 men aged 65 years and over ...
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Journal articleHosp Community Psychiatry · December 1992
Data from the Duke Epidemiologic Catchment Area survey were used to examine the relationship between religious affiliation and major depression among 2,850 adults in the community. Religious affiliations were categorized into six groups: mainline Protestan ...
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Journal articleJ Am Geriatr Soc · October 1992
OBJECTIVE: To re-examine the test characteristics of the Geriatric Depression Scale (GDS) and the Brief Carroll Depression Rating Scale (BCDRS) in elderly medical inpatients, simulating the procedure followed by clinicians when using screening instruments. ...
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Journal articleJ Affect Disord · July 1992
We examined effects of two risk factors for depression, family psychiatric history and Low Self-Confidence, on (1) baseline characteristics of major depression and (2) depressive symptoms one year later. Subjects (N = 104) in the midst of a depressive epis ...
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Journal articleClin Geriatr Med · May 1992
Recent Epidemiologic Catchment area studies found the prevalence of major depression to be only about 1% in community-dwelling elders; other less severe depressive disorders, however, may be present in over 25% of this population. Furthermore, at least 800 ...
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Journal articleAnn Pharmacother · May 1992
OBJECTIVE: To describe and compare drug-use patterns among black and nonblack community-dwelling elderly. DESIGN: Survey. SETTING: Five-county urban and rural region in Piedmont, NC. PARTICIPANTS: Stratified probability household sample of 4164 community r ...
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Journal articleJournal of Social Issues · April 1992
In previous research, the lifetime prevalence of sexual assault among U.S. women ranges from less than 15% to more than 50%. Much of this variability is due to methodological differences across studies, but some of the inconsistency may be substant ...
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Journal articleJ Nerv Ment Dis · March 1992
We followed a cohort of subjects (predominantly inpatients) suffering a major depressive episode in midlife and late-life for 1 year (N = 118). In this follow-up study, we examined three hypotheses. a) Elder subjects suffering major depression, compared wi ...
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Journal articleClin Geriatr Med · February 1992
Limited information is available regarding the relationship between elderly individuals and depression; but the clinician can anticipate problems in those who have had depression in the past, in those who are bereaved, in caretakers, and in patients with a ...
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Journal articleInt J Psychiatry Med · 1992
OBJECTIVE: Using items from two existing depression scales, we have sought to develop a brief self-rated instrument for detecting major depressive disorder (M.D.D.) in medically ill, hospitalized patients. METHOD: Forty-two items from the Geriatric Depress ...
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Journal articleInt J Psychiatry Med · 1992
One thousand and eleven men under age forty (n = 161) or over age sixty-four (n = 850) admitted to medical and neurological services of an acute care hospital were screened for depressive symptoms as part of the Durham VA Mental Health Survey. Thirty-three ...
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Journal articleWomen and Health · 1992
This study examines the prevalence of Major Depressive Disorder; missed work; and mental health services use among secretaries and other women employed full-time. In a random sample of 3,484 women employed full-time, women employed as secretaries were sign ...
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Journal articleInternational Journal of Geriatric Psychiatry · January 1, 1992
Fifty‐three hospitalized elderly men with medical illness were diagnosed with major depressive disorder and followed up for a mean of 2.3 months. Documentation and management of the depression by medical housestaff during the followup period were examined. ...
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Journal articlePsychiatry Res · December 1991
In a retrospective study, brain magnetic resonance images of 12 patients with the onset of manic symptoms after the age of 50 years were compared to age- and sex-matched control subjects for the incidence, size, and location of subcortical hyperintensities ...
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Journal articleJ Gerontol · November 1991
Advanced age among the elderly has been hypothesized to be a risk factor for depression, yet extant data do not uniformly support this hypothesis. The paucity of sufficiently large and representative samples of both the young-old and old-old and the failur ...
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Journal articleJ Nerv Ment Dis · November 1991
The effects of negative childhood experiences on adult psychiatric status remain unclear because of inconsistent findings in previous studies. In this study, we examine the extent to which parental separation/divorce before the age of 10, parental death be ...
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Journal articleJ Am Geriatr Soc · September 1991
OBJECTIVE: To study the epidemiology of depressive disorder in younger and older medical inpatients. DESIGN, PATIENTS, & SETTING: Depressive disorders were examined using the Diagnostic Interview Schedule in 116 young and 332 elderly medically ill men hosp ...
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Journal articlePsychol Med · August 1991
Post-traumatic stress disorder (PTSD) was studied in the Piedmont region of North Carolina. Among 2985 subjects, the lifetime and six month prevalence figures for PTSD were 1.30 and 0.44% respectively. In comparison to non-PTSD subjects, those with PTSD ha ...
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Journal articleJ Fam Pract · July 1991
BACKGROUND: Primary care physicians often do not document a psychiatric diagnosis when prescribing psychotropic medications. Recent literature suggests the potential benefit of tricyclic antidepressants (TCAs) in a number of nonpsychiatric conditions (low ...
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Journal articleAm J Public Health · May 1991
BACKGROUND: Benzodiazepine anti-anxiety agents are the most widely prescribed psychotherapeutic drugs in the United States today. Recent evidence, however, suggests that their use may be decreasing. METHODS: We examine the population prevalence and correla ...
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Journal articleAcademic Psychiatry · January 1, 1991
The objective of this study was to determine the extent and the barriers to expansion of geriatric psychiatry training in psychiatry training programs in the United States. We mailed a questionnaire to the training directors of all 216 psychiatry residency ...
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Journal articleSoc Psychiatry Psychiatr Epidemiol · January 1991
The Epidemiologic Catchment Area Program (ECA) is the most comprehensive community and institutionalized epidemiologic data base currently available for mental health service planning. In this report, the authors compare the ECA with a previous community s ...
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Journal articleCurrent Opinion in Psychiatry · January 1, 1991
An epidemiologic dilemma exists in the study of the prevalence of depression in late life. Though depressive symptoms are frequent, the diagnosis of major depression in both community and clinical populations is relatively rare. Minor depression, a subsynd ...
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Journal articleJ Psychiatr Res · 1991
One hundred and twenty-five middle-aged and elderly adults suffering from a major depressive episode were evaluated during the index episode and at six and twelve month follow-up. Subjective (emotional) social support and depressive symptoms (CES-D) were e ...
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Journal articleJ Consult Clin Psychol · December 1990
Analyses are presented that examine the impact of a diagnosis of affective disorder, anxiety disorder, and substance abuse before and after age 20 on multiple measures of education, socioeconomic and employment status, childbearing, marital status, and ins ...
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Journal articleJAMA · November 21, 1990
We describe the relationship of depression and depressive symptoms to disability days and days lost from work in 2980 participants in the Epidemiologic Catchment Area Study in North Carolina after 1 year of follow-up. Compared with asymptomatic individuals ...
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Journal articleArch Gen Psychiatry · April 1990
The plasma concentration of alpha 1-acid glycoprotein, a putative endogenous inhibitor of the site labeled by tritiated imipramine, was measured by a radial immunodiffusion assay in 36 normal human volunteers and 51 drug-free patients who fulfilled DSM-III ...
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Journal articleAm J Psychiatry · March 1990
The authors examined the relationships between sexual assault and psychiatric disorders in a sample of 1,157 women 18-64 years old in the North Carolina site of the NIMH Epidemiologic Catchment Area Program. The results suggest that sexual assault is a ris ...
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Journal articleJournal of Personality Disorders · January 1, 1990
The authors use a new diagnostic algorithm derived from the Diagnostic Interview Schedule (the DIS/Borderline Index) to identify a borderline personality disorder among 19- to 55-year-olds at the Duke site of the Epidemiologic Catchment Area project. A cri ...
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Journal articleJ Public Health Dent · 1990
As in all of medicine, there are basic assumptions underlying the present system of dental education and delivery. These basic assumptions are facing challenges due in part to the marked reduction in the incidence of caries and the development of more effe ...
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Journal articleAm J Prev Med · 1990
Although smoking has been shown to be associated with excess morbidity and mortality, most studies have focused on young and middle-aged rather than elderly smokers. We examined the demographic characteristics and physical and psychological health of elder ...
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Journal articleAm J Community Psychol · October 1989
The interactive effects of life events and social support on a DSM-III diagnosis of major depressive episode and on number of depressive symptoms were examined. Data are from a stratified random sample of 3,732 community-dwelling adults. The paper focuses ...
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Journal articleAm J Epidemiol · October 1989
There have been inconsistent findings on race differences in the rates and nature of depression, which are probably due to methodological differences between studies. Data are presented on the prevalence of major depression in white and black adults from t ...
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Journal articleJ Nerv Ment Dis · September 1989
Symptoms of antisocial personality disorder (ASPD) and of psychiatric conditions reported to be related to ASPD were subjected to grade of membership analysis, a relatively new procedure for medical classification, to identify the pure types that would emp ...
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Journal articleJ Gerontol · July 1989
The association between depression and two-year mortality risk was assessed in 1,606 elderly community participants in the 1982-83 Epidemiologic Catchment Area-Piedmont Health Survey. Two depression measures were formed from the Diagnostic Interview Schedu ...
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Journal articleJ Am Geriatr Soc · July 1989
Forty-one elderly medical inpatients with active major depression were matched with nondepressed controls from the same population. Survival and health care utilization were examined during a mean follow-up period of five months. Cases and controls were ma ...
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Journal articleBr J Psychiatry · June 1989
Duke Epidemiologic Catchment Area (ECA) data were used to examine the relationships between: (a) early childhood maternal death, paternal death, and parental separation/divorce, and (b) six-month DIS/DSM-III diagnoses of agoraphobia with and without panic ...
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Journal articleBr J Psychiatry · April 1989
One hundred and fifty middle-aged and elderly adults with a diagnosis of major depression were assessed initially as in-patients, and were reinterviewed 6-32 months later. Both size of social network and subjective social support were significant predictor ...
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Journal articleBiol Psychiatry · March 15, 1989
Tritiated imipramine binding, uptake of radiolabeled serotonin, and inhibition of uptake by imipramine in vitro were studied in platelets obtained from four groups of subjects: (1) normal controls 50 years of age or younger, (2) patients with major depress ...
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Journal articleJ Am Geriatr Soc · February 1989
Dizziness was studied in 1,622 community-dwelling adults aged 60 and older who were interviewed as part of the Duke Epidemiologic Catchment Area study. The lifetime prevalence of dizziness (defined as severe enough to see a physician, to take a medication, ...
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Journal articleAm J Psychiatry · February 1989
No lay-administered interviews are currently available to identify persons with borderline personality disorder. The authors studied 79 subjects with the NIMH Diagnostic Interview Schedule (DIS), a lay-administered interview, and the Diagnostic Interview f ...
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Journal articleJ Nerv Ment Dis · February 1989
Religious affiliations of patients in research samples in four major psychiatric journals for the years 1978-1982 were compared with those reported in national samples. Protestants and the unaffiliated were underrepresented, whereas Jewish persons were ove ...
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Journal articlePsychosomatics · 1989
Somatization is conceptualized as a bodily or somatic expression of psychic distress. Unexplained somatic symptomatology was assessed by use of the National Institute of Mental Health Diagnostic Interview Schedule among community respondents in the Piedmon ...
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Journal articleJ Gen Intern Med · 1989
The authors conducted a clinical trial to examine the efficacy and safety of nortriptyline in the treatment of major depression in elderly medical inpatients. The diagnosis of major depression was made by a psychiatrist in 41 of 680 patients 65 years of ag ...
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Journal articleInt J Psychiatry Med · 1989
The authors validate the usefulness of the Diagnostic Interview Schedule (DIS) in prevalence studies of major depression (MD) in medically ill male veterans. The affective disorders portion of the DIS was administered by a trained interviewer to a represen ...
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Journal articleJ Neuropsychiatry Clin Neurosci · 1989
Two hundred forty-one nursing home patients from the National Nursing Home Survey Pretest were assessed using the Ischemic Score of Hachinski. Medical chart diagnoses were used to classify those with and without dementia. The Mini-Mental State Examination ...
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Journal articleAnnu Rev Gerontol Geriatr · 1989
Clinical and basic research units depressive disorders in late life have expanded our knowledge base appreciably in recent years. In the process, some clinical impressions have been confirmed (e.g., the association of depression and physical disorders); ot ...
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Journal articleJ Geriatr Psychiatry · 1989
In contrast to previous observations, which had indicated an increased prevalence of depressive symptoms among the elderly, recent epidemiological studies have shown a decreasing current and lifetime prevalence after age 20 or 30. The question whether depr ...
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Journal articleJ Affect Disord · 1989
Depressive symptoms in three samples are assessed using grade-of-membership analysis to clarify the distribution of depressive symptoms across traditional affective diagnoses. The technique is used to examine whether depressive symptoms and symptoms freque ...
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Journal articleInternational Journal of Geriatric Psychiatry · January 1, 1989
Early morning anxiety was reported as a symptom in 32.1% of 131 elderly and middle‐aged patients hospitalized for depression one to two years following hospitalization. Two‐thirds of those patients complaining of early morning anxiety also complained of an ...
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Journal articleArch Gen Psychiatry · December 1988
A multivariate classification technique was used to examine whether depressive symptoms and symptoms frequently associated with depressive disorders would cluster into recognizable syndromes that parallel traditional DSM-III psychiatric diagnoses. An analy ...
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Journal articlePsychol Med · November 1988
Alternative procedures for coding nonresponse on the Mini-Mental State Examination as error or as correct) results in different classification of 13% of a random sample of 1931 subjects aged 60 and over. Comparison of responders' and nonresponders' ability ...
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Journal articleArch Gen Psychiatry · October 1988
The number (Bmax) and affinity (Kd) of platelet-tritiated imipramine binding sites was determined in young and middle-aged controls 50 years of age and younger (n = 25), elderly normal controls over 60 years of age (n = 18), patients who fulfilled DSM-III ...
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Journal articleArch Intern Med · September 1988
Depressive symptoms and disorders were identified by structured psychiatric interview in 130 consecutively admitted male inpatients aged 70 years and over. Major depression was found in 11.5% and other depressive syndromes in 23%. While depressive symptoms ...
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Journal articleJ Am Geriatr Soc · August 1988
Until now, no self-rated depression scale had been validated as a screening measure for major depression in the older patient hospitalized with medical illness. The present report establishes the validity of two brief, easily administered depression screen ...
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Journal articlePsychol Med · August 1988
Mini-Mental State findings from an age 60+ random community sample (N = 1681) indicate that score is related to education, age and race (but not sex) and to functional status, but not to selected aspects of physical or mental health. Adjustment for demogra ...
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Journal articleInt J Epidemiol · June 1988
Interest has recently emerged in increases in suicide among US teenagers. Nonetheless suicide remains one of the major causes of death among the fastest growing components of the US population--the elderly. We examine the trends in US age-specific suicide ...
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Journal articleCompr Ther · April 1988
The diagnosis and therapy of the depressive disorders has entered a new era in the 80s. Though primarily driven by breakthroughs in the neurosciences, such as neuroendocrinology, neurochemistry, and psychopharmacology, the increased sophistication of our d ...
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Journal articlePsychol Med · February 1988
Results on the age/sex specific prevalence of DSM-III affective disorders from the NIMH Epidemiologic Catchment Area Study (ECA), a probability sample of over 18,000 adults from five United States communities, are presented. The cross-site means for bipola ...
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Journal articleInt J Psychiatry Med · 1988
While major depression is common among medically ill older inpatients, little is known about the frequency of detection or appropriate treatment in this population. In the present study, 171 consecutive men age seventy and over admitted to the medical and ...
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Journal articleInt J Aging Hum Dev · 1988
Effects of age on the distribution of specific life events experienced during the past year by community-based adults were examined controlling for sex, race, education, marital status, and place of residence. The controlled analyses were done using logist ...
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Journal articleAm J Public Health · November 1987
We conducted a statewide, controlled trial of the efficacy of an educational visit in reducing antipsychotic drug prescribing for nursing home patients. Frequent antipsychotic drug prescribers were visited by a trained physician counselor who stressed know ...
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Journal articleJ Am Geriatr Soc · October 1987
Patients admitted to an inpatient psychiatric service were screened to identify middle-aged (35 to 50 years of age) and elderly (60 years of age and over) patients suffering from a major depressive episode with melancholia. Thirty-seven subjects (18 middle ...
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Journal articleAm J Psychiatry · September 1987
In a study of 2,902 subjects from the National Institute of Mental Health Epidemiologic Catchment Area Project in North Carolina, the association between life events and the onset of new cases of generalized anxiety syndrome varied across demographic subgr ...
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Journal articleArch Gen Psychiatry · August 1987
We studied rural-urban differences in the prevalence of Diagnostic Interview Schedule (DIS)-DSM-III alcohol abuse or dependence from a community survey (part of the Epidemiologic Catchment Area program) of 3921 adults living in the Piedmont of North Caroli ...
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Journal articleJ Gerontol · March 1987
Cross-temporal data on suicide for the period 1962 to 1981 from the National Center for Health Statistics were analyzed. These data were used to estimate period and cohort suicide rates for the four middle-aged and elderly groups (ages 45 to 64, 65 to 74, ...
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Journal articleJ Nerv Ment Dis · January 1987
Somatization disorder, the presentation of multiple somatic complaints in multiple organ systems, can be diagnosed by three roughly comparable diagnostic systems: the Washington University Feighner criteria, the Research Diagnostic Criteria, and DSM-III cr ...
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Journal articlePsychiatr Dev · 1987
A new multivariate analytical technique for the analysis of medical classification, Grade of Membership analysis, is utilized to examine somatization disorder in a community population. The authors examine whether somatic symptoms will cluster into a clini ...
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Journal articleInternational Journal of Eating Disorders · January 1, 1987
In order to characterize changes in the presenting symptomatology and treatment of anorexia nervosa (AN), the hospital charts of 76 anorexia nervosa patients were reviewed from three time periods: (1) 1958‐1962, (II) 1968‐1972, and (III) 1978‐1982. In peri ...
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Journal articleJAMA · November 14, 1986
We conducted a controlled, statewide trial of the efficacy of an educational visit by a physician counselor in the reduction of diazepam prescribing in outpatient practice. A novel aspect of this trial was the provision of a schedule for gradual withdrawal ...
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Journal articleAm J Psychiatry · November 1986
The data recently collected in the Piedmont region of North Carolina as part of the National Institute of Mental Health Epidemiologic Catchment Area Program were used to examine somatization disorder in a community population. The authors found an adjusted ...
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Journal articleAm J Psychiatry · November 1986
Premenstrual syndrome specialty clinics are reported to be almost exclusively attended by white women. This racial discrepancy has raised the question of whether there is a lower prevalence or severity of symptoms during the premenstruum among black women. ...
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Journal articleGen Hosp Psychiatry · November 1986
This article provides estimates of direct treatment costs and indirect costs from lost productivity associated with the morbidity and mortality of depression. Data are based on epidemiologic estimates of the prevalence of major depressive illness and on th ...
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Journal articleBr J Psychiatry · September 1986
The Piedmont Health Survey interviewed 3798 adult community residents in a region of North Carolina. Current major depression was nearly three times more common in the urban than in the rural counties; rural residence decreased the risk of major depression ...
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Journal articleJ Nerv Ment Dis · September 1986
The purpose of this investigation was to obtain information about lifetime psychiatric diagnoses of women seeking treatment for premenstrual syndrome. The National Institute for Mental Health Diagnostic Interview Schedule (DIS) was administered to 223 wome ...
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Journal articlePsychol Med · August 1986
The authors examine somatization disorder in a community population, using grade of membership analysis, a new multivariate analytical technique for the analysis of medical classification. The technique is used to examine whether somatic symptoms will clus ...
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Journal articleJ Am Geriatr Soc · July 1986
Increasing attention has been directed to recent increases in suicide rates for children, adolescents, and young adults. Nevertheless, persons 65 years and older continue to commit suicide at a higher rate than any other age group in the United States. In ...
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Journal articleAm J Psychiatry · March 1986
The authors conducted a systematic analysis of quantitative research on religious variables found in four psychiatric journals between 1978 and 1982. Of the 2,348 psychiatric articles reviewed, 59 included a quantified religious variable. In this research, ...
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Journal articleJ Psychiatr Res · 1986
Despite the low prevalence of somatization disorder in the community, the section of the Diagnostic Interview Schedule used to make the diagnosis--as well as previous diagnostic interviews for the related diagnoses of hysteria, and Briquet's syndrome--is q ...
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Journal articleArch Gen Psychiatry · July 1985
We studied rural/urban differences in the prevalence of nine psychiatric disorders from a community survey (part of the Epidemiologic Catchment Area Program) of 3,921 adults living in the Piedmont of North Carolina. Crude comparisons disclosed that major d ...
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Journal articleArch Gen Psychiatry · October 1984
The National Institute of Mental Health multisite Epidemiologic Catchment Area (ECA) program is described in the context of four previous psychiatric epidemiologic surveys that included a combined total of 4,000 subjects from Stirling County, the Baltimore ...
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Journal articleAm J Psychiatry · September 1984
Of 997 elderly people living in the community, 40 (4%) were found to have generalized persecutory ideation. Sensory deficits and cognitive impairment were significant risk factors for the development of this symptom complex. Generalized persecutory ideatio ...
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Journal articleAm Fam Physician · May 1984
Caring for a relative with senile dementia often results in family problems. In this situation, the family usually turns to the physician for evaluation, advice, treatment and support. A specific strategy for family intervention is helpful and does not req ...
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Journal articleArchives of General Psychiatry · 1984
The National Institute of Mental Health multisite Epidemiologic Catchment Area (ECA) program is described in the context of four previous psychiatric epidemiologic surveys that included a combined total of 4,000 subjects from Stirling County, the Baltimore ...
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Journal articleJ Clin Psychol · March 1983
Community adjustment among older schizophrenics is a virtually unresearched area. This study addressed two questions related to this problem: Does the community adjustment of older schizophrenics differ from that of younger schizophrenics?, and Do "older" ...
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Journal articleAm J Psychiatry · February 1983
The author tested the hypothesis that a major depressive disorder contributes to a decline in social support by studying data from 331 subjects 65 years of age and older who had been selected at random from a larger community group and screened for a major ...
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Journal articleJ Gerontol · January 1983
The potential for anticholinergic toxicity due to concurrent use of medications was assessed among 5,902 continuous nursing home residents and a comparable group of ambulatory patients. During the study year nearly 60% of the nursing home residents and 23% ...
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Journal articleAm J Epidemiol · May 1982
A community sample made in the fall of 1972 in Durham County, North Carolina, and that consisted of 331 persons 65 years of age and older was assessed for adequacy of social support along three parameters: roles and available attachments, perceived social ...
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Journal articleHosp Community Psychiatry · January 1982
A university medical center and a community mental health center undertook an epidemiologic survey of elderly residents of a county in North Carolina and used the data to plan a geriatric mental health program. The survey team assessed the rate and distrib ...
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Journal articleSouth Med J · February 1981
With the advent of new and improved psychiatric treatment of chronic pain, increased interest has been directed toward psychosocial factors that contribute to chronic pain. Attention has been focused on assessing chronic pain and selecting therapy accordin ...
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Journal articleAm J Public Health · November 1980
The association of life events and mental health impairment was studied in a community-based population of the elderly (n = 986). A crude estimate of the relative risk for mental health impairment given life events larger than or equal to 150 (as measured ...
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Journal articleHosp Community Psychiatry · May 1980
Clinicians at a geriatric evaluation and treatment clinic include the patient's family in all stages of assessment and intervention so that the family can ultimately assume much of the responsibility for care. The family's strengths and weaknesses and its ...
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Journal articleAm J Psychiatry · April 1980
The authors surveyed 997 elderly people living in the community and found that the rate of significant dysphoric symptomatology was 14.7%. Forty-five (4.5%) of these individuals suffered from dysphoric symptoms only, and 37 (3.7%) had symptoms of a major d ...
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Journal articleJ Am Geriatr Soc · February 1980
The reported prevalence of depressive symptomatology among the elderly ranges from 5 to 65 percent in hospital and community populations. Depression is considered the most common emotional disorder of advanced age. One of the chief diagnostic problems has ...
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Journal articleInt J Psychiatry Med · 1980
Thirteen patients were selected for study from a population of patients undergoing routine psychiatric evaluation in a Pain Clinic. These patients demonstrated consistent character traits (traits typically seen in the narcissistic personality) and appeared ...
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Journal articleAm Fam Physician · November 1979
The depressed elderly have the highest suicide risk of any group in our society. Thus, depression in late life is a serious mental health problem. The essential goal of the diagnostic work-up is to distinguish a major depressive episode from less severe dy ...
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Journal articleJ Am Geriatr Soc · July 1979
A survey of 977 community subjects aged 65 or older identified 719 of them as not impaired in physical health. Of these, 104 (14 percent) perceived their physical status to be poor, whereas 615 (86 percent) accurately perceived it to be unimpaired. There w ...
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Journal articleGeriatrics · November 1978
A physician can best treat elderly patients if he or she understands their unique problems and employs effective techniques of communication. Be aware how your patient's anxiety or your own view about the elderly can erect a barrier to communication. Your ...
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Journal articleSouth Med J · April 1977
Ten female patients with a diagnosis of anorexia nervosa were treated with a combination of behavior modification and psychotherapy and, when appropriate, psychotropic medication. All patients had favorable weight gain and improvement in adjustment during ...
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Journal articleDis Nerv Syst · December 1976
Six patients who developed affective psychoses following renal transplantation ae reported. Each patient was treated, with careful management, with an appropriate somatic therapy (including phenothiazines, tricyclic antidepressants, electroconvulsive treat ...
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Journal articleDis Nerv Syst · July 1975
A case of psychosis secondary to pentazocine is presented. The patient demonstrated hallucinations, preceptual aberrations, a distorted body image and delusional thinking. The delusional ideation persisted for a period of three weeks. Such a case of persis ...
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Journal articleAm J Geriatr Psychiatry
The authors examined the determinants of poor self-rated health by use of data from the Duke University site of the Established Populations for Epidemiologic Studies of the Elderly (EPESE). Study participants were community residents, 65 years of age or ol ...
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