Scholars@Duke
Barbara D Lipes

Barbara D Lipes

Assistant Professor in Medicine
Medicine, Cardiology
blipes@duke.edu
Box 102143 Med Ctr, Durham, NC 27710
198A CARL Building, Durham, NC 27710

Scholarly Works - Conferences

Abstract 5191: Multiscale engineering of PTPRZ1 CAR T cells through affinity-tuned binders and modular architecture optimization

Conference Cancer Research · April 3, 2026 AbstractGlioblastoma remains universally lethal, with rapid recurrence and a median survival of less than two years. Current CAR T approaches in glioblastoma have been limited by a lack of uniformly expre ... Full text Cite

EXTH-68. Targeting Tumor Heterogeneity And Plasticity in Glioblastoma With Novel CAR T Cells Targeting PTPRZ1

Conference Neuro-Oncology · November 11, 2025 AbstractGlioblastoma (GBM) remains among the most aggressive and intractable human cancers, driven by profound intratumoral heterogeneity, dynamic cellular plasticity, and robust mechanisms of immune esca ... Full text Cite

Abstract 3193: Overcoming glioblastoma heterogeneity and plasticity through the development of novel chimeric antigen receptor (CAR)-T cells targeting PTPRZ1

Conference Cancer Research · April 21, 2025 AbstractGlioblastoma (GBM) is an aggressive and heterogeneous brain tumor characterized by extensive plasticity, which contributes to resistance against conventional therapies. To address this challenge, we ... Full text Cite