Scholars@Duke
Bo Wang

Bo Wang

Adjunct Assistant Professor in the Department of Ophthalmology
Ophthalmology

Scholarly Works - Journal articles

Comparison of 360-Degree Trabeculotomy Versus Traditional Angle Surgery in Primary Congenital Glaucoma: A Systematic Review and Meta-Analysis.

Journal article J Glaucoma · July 1, 2026 PRCIS: Systematic Meta-Analysis demonstrates greater IOP reduction, fewer glaucoma medication uses, and a higher surgical success rate with 360-degree trabeculotomy compared with traditional angle surgery in primary congenital glaucoma. PURPOSE: Primary co ... Full text Link to item Cite

Micropulse Cyclophotocoagulation Versus Continuous Wave Cyclophotocoagulation: A Meta-Analysis.

Journal article J Glaucoma · April 1, 2026 PRÉCIS: In this systematic review, we find that CW-CPC produces more sustained IOP lowering in children compared with MP-CPC. PURPOSE: Micropulse cyclophotocoagulation (MP-CPC) and continuous cyclophotocoagulation (CW-CPC) are both surgical interventions u ... Full text Link to item Cite

Evaluating the Role of Virtual Reality Visual Fields (VRF) in the Diagnosis and Management of Pediatric Neuro-Ophthalmic Conditions.

Journal article Am J Ophthalmol · January 2026 OBJECTIVE: Virtual reality field testing (VRF) is feasible and reliable in adults and in children with normal and glaucomatous eyes, but its role in pediatric neuro-ophthalmic conditions remains unexplored. PURPOSE: To evaluate the feasibility of using VRF ... Full text Link to item Cite

A comparison of general anesthesia versus local anesthesia in open globe injuries: A systematic review and meta-analysis.

Journal article Eur J Ophthalmol · January 2026 ObjectiveLocal anesthesia represents an alternative to general anesthesia in selected patients undergoing repair for open globe injuries. This study aimed to evaluate and compare visual acuity and clinical outcomes in such patients.MethodsA systematic lite ... Full text Link to item Cite

Pilot comparison of monocular and binocular modes of virtual reality field testing in strabismus.

Journal article Sci Rep · December 26, 2025 Virtual reality field (VRF) perimetry is a promising new tool for visual field assessments, offering both monocular and binocular testing modes. We aimed to examine whether ocular misalignment, known as strabismus, influences VRF outcomes between monocular ... Full text Link to item Cite

Virtual reality field testing in children with normal eyes and glaucoma: comparison of game-based versus Humphrey visual field-equivalent algorithms.

Journal article J AAPOS · December 2025 BACKGROUND: Virtual reality-based field (VRF) perimetry presents an alternative to standard automated perimetry, offering both game-based and Humphrey-equivalent algorithms. Comparative performance of these two algorithms is not well-documented. We evaluat ... Full text Link to item Cite

Lamina cribrosa shape in non-human primates is different from that of humans.

Journal article Exp Eye Res · December 2025 Non-human primates (NHPs) are a crucial model for studying glaucoma because of their similarities to humans in anatomy, physiology and pathology. Our goal in this study was to quantify in vivo NHP lamina cribrosa (LC) shapes at low, normal, and elevated in ... Full text Link to item Cite

Anterior segment structure after angle-based surgery in childhood glaucoma: descriptive findings using overhead-mounted optical coherence tomography.

Journal article J AAPOS · August 2025 Despite the importance of the iridocorneal angle in childhood glaucoma, relatively few studies have been published on the outflow system in children and how surgery affects the iridocorneal angle. Using overhead-mounted optical coherence tomography, we inv ... Full text Link to item Cite

Semi-automated evaluation of trabecular meshwork and schlemm canal imaged with OCT in children with normal eyes vs. primary congenital glaucoma.

Journal article Sci Rep · April 12, 2025 Maldevelopment of Schlemm canal (SC) and trabecular meshwork (TM) is proposed in the pathogenesis of primary congenital glaucoma (PCG). This study aims to evaluate a semi-automated segmentation algorithm of SC and TM in pediatric patients scanned using ove ... Full text Link to item Cite

In Vivo Assessment of the Pediatric Trabecular Meshwork, Schlemm Canal, and Iridocorneal Angle Using Overhead-Mounted Optical Coherence Tomography.

Journal article Am J Ophthalmol · January 2025 PURPOSE: To describe the in vivo morphologic characteristics of the trabecular meshwork (TM), Schlemm canal (SC), and iridocorneal angle in pediatric patients with normal eyes, glaucoma, and cataract. DESIGN: Prospective cohort study. STUDY POPULATION: A t ... Full text Link to item Cite

Endogenous Endophthalmitis in Children: A 5-Year Retrospective Study in Vietnam.

Journal article J Pediatr Ophthalmol Strabismus · 2025 PURPOSE: To describe the findings and outcomes in pediatric endogenous endophthalmitis cases over a 5-year period in Vietnam. METHODS: All cases of pediatric endogenous endophthalmitis seen at Vietnam National Eye Hospital from 2016 to 2020 (n = 157) were ... Full text Link to item Cite

Accuracy of an artificial intelligence chatbot in identifying congenital glaucoma from other ocular etiologies.

Journal article Digit J Ophthalmol · 2025 PURPOSE: To evaluate the accuracy and appropriateness of responses provided by ChatGPT in identifying congenital glaucoma from a series of written and image-based prompts. METHODS: A series of questions regarding common signs and symptoms of congenital gla ... Full text Link to item Cite

Performance of VisuALL virtual reality visual field testing in healthy children.

Journal article J AAPOS · February 2024 BACKGROUND: Virtual reality field testing may provide an alternative to standard automated perimetry. This study evaluates a virtual reality game-based automated perimetry in a healthy pediatric population. METHODS: A prospective series of pediatric patien ... Full text Link to item Cite

Micropulse cyclophotocoagulation compared to continuous wave cyclophotocoagulation for the management of refractory pediatric glaucoma.

Journal article PLoS One · 2024 INTRODUCTION: Micropulse cyclophotocoagulation (MPCPC) has been shown in adults to offer a favorable post-operative safety profile compared to continuous wave transscleral cyclophotocoagulation (CWCPC) in the management of glaucoma. The purpose of this stu ... Full text Link to item Cite

Bioptigen Oct (Leica Microsystems)

Journal article Everyday Oct A Handbook for Clinicians and Technicians Second Edition · January 1, 2024 Cite

Performance of virtual reality game-based automated perimetry in patients with childhood glaucoma.

Journal article J AAPOS · December 2023 PURPOSE: To evaluate VisuALL, a game-based automated perimetry device, utilizing virtual reality (VR) goggles, in a cohort of patients with childhood glaucoma. METHODS: In this prospective series, the results of consecutive patients with childhood glaucoma ... Full text Link to item Cite

Netarsudil in the management of refractory pediatric glaucoma.

Journal article J AAPOS · October 2023 We performed a retrospective review of patients with refractory pediatric glaucoma who were started on netarsudil at the Wilmer Eye Institute. We found minimally sustained IOP lowering over a 6-month period in 29 eyes of 23 patients. Our results suggest th ... Full text Link to item Cite

Under Pressure: Lamina Cribrosa Pore Path Tortuosity in Response to Acute Pressure Modulation.

Journal article Transl Vis Sci Technol · April 3, 2023 PURPOSE: Lamina cribrosa (LC) deformation is hypothesized to play a major role in glaucoma pathogenesis. The purpose of this study was to determine in vivo how varying intraocular pressure (IOP) under fixed intracranial pressure (ICP), and vice versa, defo ... Full text Link to item Cite

Comparing Acute IOP-Induced Lamina Cribrosa Deformations Premortem and Postmortem.

Journal article Transl Vis Sci Technol · December 1, 2022 PURPOSE: Lamina cribrosa (LC) deformations caused by elevated intraocular pressure (IOP) are believed to contribute to glaucomatous neuropathy and have therefore been extensively studied, in many conditions, from in vivo to ex vivo. We compare acute IOP-in ... Full text Link to item Cite

Vision Therapy: A Primer and Caution for Pediatricians.

Journal article Children (Basel) · November 30, 2022 Vision therapy, also known as behavioral therapy, is theorized by its practitioners to treat a variety of visual disorders, including learning disability in children. However, the utility of vision therapy to treat various learning disabilities is challeng ... Full text Link to item Cite

Microstructural Deformations Within the Depth of the Lamina Cribrosa in Response to Acute In Vivo Intraocular Pressure Modulation.

Journal article Invest Ophthalmol Vis Sci · May 2, 2022 PURPOSE: The lamina cribrosa (LC) is a leading target for initial glaucomatous damage. We investigated the in vivo microstructural deformation within the LC volume in response to acute IOP modulation while maintaining fixed intracranial pressure (ICP). MET ... Full text Link to item Cite

A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography.

Journal article Acta Biomater · April 15, 2022 In-vivo optic nerve head (ONH) biomechanics characterization is emerging as a promising way to study eye physiology and pathology. We propose a high-accuracy and high-efficiency digital volume correlation (DVC) method to characterize the in-vivo ONH deform ... Full text Link to item Cite

Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo.

Journal article Exp Eye Res · December 2021 Intracranial pressure (ICP) has been proposed to play an important role in the sensitivity to intraocular pressure (IOP) and susceptibility to glaucoma. However, the in vivo effects of simultaneous, controlled, acute variations in ICP and IOP have not been ... Full text Link to item Cite

Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa.

Journal article Sci Rep · May 8, 2018 The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribros ... Full text Link to item Cite

Integrating images from a moveable tracked display of three-dimensional data

Journal article Cognitive Research Principles and Implications · December 1, 2017 This paper describes a novel method for displaying data obtained by three-dimensional medical imaging, by which the position and orientation of a freely movable screen are optically tracked and used in real time to select the current slice from the data se ... Full text Cite

Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes.

Journal article Sci Rep · August 30, 2017 Glaucoma is a leading cause of blindness that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of vessels. It is unknown whether the spatial location of this vessel shift inside the ONH occurs within the lamina cri ... Full text Link to item Cite

Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility.

Journal article Invest Ophthalmol Vis Sci · March 1, 2017 PURPOSE: Evaluation of the effect of prelaminar tissue thickness on visualization of the lamina cribrosa (LC) using optical coherence tomography (OCT). METHODS: The optic nerve head (ONH) region was scanned using OCT. The quality of visible LC microstructu ... Full text Link to item Cite

Adaptive optics optical coherence tomography in glaucoma.

Journal article Prog Retin Eye Res · March 2017 Since the introduction of commercial optical coherence tomography (OCT) systems, the ophthalmic imaging modality has rapidly expanded and it has since changed the paradigm of visualization of the retina and revolutionized the management and diagnosis of ne ... Full text Link to item Cite

In-vivo effects of intraocular and intracranial pressures on the lamina cribrosa microstructure.

Journal article PLoS One · 2017 There is increasing clinical evidence that the eye is not only affected by intraocular pressure (IOP), but also by intracranial pressure (ICP). Both pressures meet at the optic nerve head of the eye, specifically the lamina cribrosa (LC). The LC is a colla ... Full text Link to item Cite

Retinal Structures and Visual Cortex Activity are Impaired Prior to Clinical Vision Loss in Glaucoma.

Journal article Sci Rep · August 11, 2016 Glaucoma is the second leading cause of blindness worldwide and its pathogenesis remains unclear. In this study, we measured the structure, metabolism and function of the visual system by optical coherence tomography and multi-modal magnetic resonance imag ... Full text Link to item Cite

Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk.

Journal article Invest Ophthalmol Vis Sci · June 1, 2016 PURPOSE: To investigate how the lamina cribrosa (LC) microstructure changes with distance from the central retinal vessel trunk (CRVT), and to determine how this change differs in glaucoma. METHODS: One hundred nineteen eyes (40 healthy, 29 glaucoma suspec ... Full text Link to item Cite

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye.

Journal article J Vis Exp · June 20, 2015 The mechanical characteristics of the trabecular meshwork (TM) are linked to outflow resistance and intraocular pressure (IOP) regulation. The rationale behind this technique is the direct observation of the mechanical response of the TM to acute IOP eleva ... Full text Link to item Cite

In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT.

Journal article Invest Ophthalmol Vis Sci · June 2015 PURPOSE: Excitotoxicity has been linked to the pathogenesis of ocular diseases and injuries and may involve early degeneration of both anterior and posterior visual pathways. However, their spatiotemporal relationships remain unclear. We hypothesized that ... Full text Link to item Cite

Treatment of severe hemifacial atrophy with dorsal thoracic adipofascial free flap and concurrent lipoinjection.

Journal article J Craniofac Surg · March 2015 BACKGROUND: Parry-Romberg syndrome is an infrequent, acquired disorder characterized by progressive facial atrophy of the skin and soft tissue of the face and, in some cases, results in atrophy of muscles, cartilage, and the underlying bony structures. We ... Full text Link to item Cite

In vivo three-dimensional characterization of the healthy human lamina cribrosa with adaptive optics spectral-domain optical coherence tomography.

Journal article Invest Ophthalmol Vis Sci · September 16, 2014 PURPOSE: To characterize the in vivo three-dimensional (3D) lamina cribrosa (LC) microarchitecture of healthy eyes using adaptive optics spectral-domain optical coherence tomography (AO-SDOCT). METHODS: A multimodal retinal imaging system with a light sour ... Full text Link to item Cite

Recent advances in OCT imaging of the lamina cribrosa.

Journal article Br J Ophthalmol · July 2014 The lamina cribrosa (LC) is believed to be the site of injury to retinal ganglion cell axons in glaucoma. The ability to visualise this structure has the potential to help increase our understanding of the disease and be useful in the early detection of gl ... Full text Link to item Cite

Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography

Journal article Biomedical Optics Express · April 1, 2014 We demonstrate the repeatability of lamina cribrosa (LC) microarchitecture for in vivo 3D optical coherence tomography (OCT) scans of healthy, glaucoma suspects, and glaucomatous eyes. Eyes underwent two scans using a prototype adaptive optics spectral dom ... Full text Cite

IOP elevation reduces Schlemm's canal cross-sectional area.

Journal article Invest Ophthalmol Vis Sci · March 25, 2014 PURPOSE: Previously, we demonstrated reduced Schlemm's canal cross-sectional area (SC-CSA) with increased perfusion pressure in a cadaveric flow model. The purpose of the present study was to determine the effect of acute IOP elevation on SC-CSA in living ... Full text Link to item Cite

Reproducibility of in-vivo OCT measured three-dimensional human lamina cribrosa microarchitecture.

Journal article PLoS One · 2014 PURPOSE: To determine the reproducibility of automated segmentation of the three-dimensional (3D) lamina cribrosa (LC) microarchitecture scanned in-vivo using optical coherence tomography (OCT). METHODS: Thirty-nine eyes (8 healthy, 19 glaucoma suspects an ... Full text Link to item Cite

Gold nanorods as a contrast agent for Doppler optical coherence tomography.

Journal article PLoS One · 2014 PURPOSE: To investigate gold nanorods (GNRs) as a contrast agent to enhance Doppler optical coherence tomography (OCT) imaging of the intrascleral aqueous humor outflow. METHODS: A serial dilution of GNRs was scanned with a spectral-domain OCT device (Biop ... Full text Link to item Cite

In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as assessed by optical coherence tomography.

Journal article Invest Ophthalmol Vis Sci · December 19, 2013 PURPOSE: The lamina cribrosa (LC) is a prime location of glaucomatous damage. The purpose of this study was to compare LC 3-dimensional micro-architecture between healthy and glaucomatous eyes in vivo by using optical coherence tomography (OCT). METHODS: S ... Full text Link to item Cite

Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes

Journal article Biomedical Optics Express · November 1, 2013 We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of th ... Full text Cite

Morphometric analysis of aqueous humor outflow structures with spectral-domain optical coherence tomography.

Journal article Invest Ophthalmol Vis Sci · August 7, 2012 PURPOSE: To describe morphometric details of the human aqueous humor (AH) outflow microvasculature visualized with 360-degree virtual castings during active AH outflow in cadaver eyes and to compare these structures with corrosion casting studies. METHODS: ... Full text Link to item Cite