Scholars@Duke
Bradley Marino

Bradley Marino

Instructor in the Department of Pediatrics
Pediatrics, Cardiology

Scholarly Works

Artificial Intelligence in Pediatric Cardiac Intensive Care: Clinical Applications, Implementation Challenges, and Future Directions

Journal article Current Treatment Options in Pediatrics · December 1, 2026 Purpose of Review: Pediatric cardiac intensive care units manage high risk, rapidly evolving physiology in children with congenital heart disease within a data dense environment shaped by continuous monitoring, device-based therapies, and time constrained ... Full text Cite

Psychosocial and Functional Outcomes Among Tetralogy of Fallot Survivors in the Congenital Heart Disease Project to Understand Lifelong Survivor Experience.

Journal article Am J Cardiol · July 1, 2026 As survival improves for adults with tetralogy of Fallot (TOF), long-term outcomes have taken on greater importance. We aimed to compare the long-term health, socioeconomic, and quality of life (QOL) outcomes between adult survivors and sibling controls. C ... Full text Link to item Cite

Use of and Experience With Wearable Biosensors in Congenital Heart Disease: A Survey Study.

Journal article CJC Pediatr Congenit Heart Dis · April 2026 Wearable biosensors ("wearables") are increasingly used by consumers to monitor their health, but their use in congenital heart disease is understudied. This survey study aimed to define wearable use in congenital heart disease. We found that patients and ... Full text Link to item Cite

Reproductive health outcomes of congenital heart disease survivors: A report from the congenital heart disease project to understand lifelong survivor experience (CHD PULSE study).

Journal article Am Heart J · April 2026 BACKGROUND: Improved survival of individuals with congenital heart disease (CHD) into adulthood has made reproductive health a crucial aspect of CHD care. Despite existing guidelines on heritability, contraception, pregnancy, and postpartum care, little is ... Full text Link to item Cite

Perioperative Care of Children with Congenital and Acquired Heart Disease Undergoing Non-Cardiac Surgical Procedures.

Journal article Pediatr Clin North Am · April 2026 Children with congenital and acquired heart disease are at elevated risk for perioperative morbidity and mortality. These patients have high rates of coexisting conditions that necessitate noncardiac surgical procedures, some of which may occur outside of ... Full text Link to item Cite

Association of Pre-Fontan Hemodynamics With Long-Term Outcomes After Fontan Palliation: A Study From the Pediatric Cardiac Care Consortium.

Journal article Circulation · February 10, 2026 BACKGROUND: Long-term outcomes after Fontan vary widely. Although pre-Fontan hemodynamics predict early failure, their association with long-term outcomes remains unclear. We hypothesized that pre-Fontan hemodynamics predict long-term risk of death or tran ... Full text Link to item Cite

Impact of Peak Donor Troponin and Donor Troponin Trends on Pediatric Heart Transplant Outcomes.

Journal article J Am Heart Assoc · February 3, 2026 BACKGROUND: Donor discard rates for pediatric heart transplant (HT) remain high (≈40%), often driven by concerns about elevated donor troponin levels. This study evaluated the association between peak donor troponin levels, donor troponin trends, and post ... Full text Link to item Cite

Hybrid rule-based and on-premises LLM pipeline for extracting CMR and CPET metrics from free-text reports in repaired tetralogy of Fallot.

Journal article medRxiv · January 23, 2026 BACKGROUND: Patients with repaired tetralogy of Fallot (rTOF) require lifelong surveillance with cardiovascular magnetic resonance (CMR) and cardiopulmonary exercise testing (CPET). However, results are frequently stored as unstructured free-text reports, ... Full text Link to item Cite

Performance of Supervised Machine Learning Models for Cardiac Surgery-Associated Acute Kidney Injury in Children: Multicenter Retrospective Cohort Study, 2019-2022.

Journal article Pediatr Crit Care Med · January 1, 2026 OBJECTIVES: To derive and externally validate supervised machine learning (ML) models predictive of cardiac surgery-associated acute kidney injury (CS-AKI). DESIGN: Retrospective cohort analysis. SETTING: Multicenter (4), cardiac surgical centers from Janu ... Full text Link to item Cite

Preoperative, operative, and immediate postoperative predictors of the onset of low cardiac output syndrome in CHD

Journal article Cardiology in the Young · January 1, 2026 Background: Low cardiac output syndrome is a leading cause of morbidity and mortality after CHD surgery. Early, transparent risk estimation at paediatric cardiac ICU admission could guide monitoring and resource allocation. Objectives: To develop and evalu ... Full text Cite

Arrhythmia burden in congenitally corrected transposition of the great arteries: Does treatment pathway matter?

Journal article Heart Rhythm · December 2025 BACKGROUND: There are limited data comparing arrhythmia burden of patients with congenitally corrected transposition of the great arteries (cc-TGA) undergoing anatomic repair, physiologic repair, and nonsurgical management. OBJECTIVE: We aimed to examine t ... Full text Link to item Cite

Supervised Machine Learning Models Predicting Postoperative Low Cardiac Output Syndrome In Neonates.

Journal article Crit Care Explor · October 1, 2025 OBJECTIVE: To train and test supervised machine learning (ML) models to predict low cardiac output syndrome (LCOS) within the first 48 postoperative hours in neonates undergoing cardiothoracic surgery. DESIGN: Retrospective observational study. An efficien ... Full text Link to item Cite

Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.

Journal article J Am Heart Assoc · August 5, 2025 BACKGROUND: In 2010, the American Heart Association introduced Life's Simple 7, a construct to measure, monitor, and modify cardiovascular health (CVH) across the lifespan. We aimed to summarize the knowledge on outcomes, prevalence, determinants, and mech ... Full text Link to item Cite

Safeguarding Biomedical Research Investments.

Journal article Circulation · July 22, 2025 Full text Link to item Cite

The novel associations between frailty and neurodevelopmental outcomes in CHD.

Journal article Cardiol Young · July 2025 OBJECTIVES: "Frailty" is associated with worse outcomes in adult cardiology. There is limited data on the associations between frailty and outcomes in paediatric cardiology. We aimed to define the prevalence of frailty and identify associations between fra ... Full text Link to item Cite

Dual-Phase Increase in Atrial Arrhythmia Prevalence Following Percutaneous Atrial Septal Defect Closure.

Journal article J Soc Cardiovasc Angiogr Interv · July 2025 BACKGROUND: Conflicting data surround the relationship between age at percutaneous atrial septal defect (ASD) closure and subsequent burden of atrial arrhythmias (AA), particularly in adults. This study aimed to determine the effect of age at ASD closure a ... Full text Link to item Cite

Outcomes for Children With Congenital Heart Disease Undergoing Ventricular Assist Device Implantation: An ACTION Registry Analysis.

Journal article J Am Coll Cardiol · March 4, 2025 BACKGROUND: There are no contemporary reports that highlight the national outcomes for children with congenital heart disease (CHD) undergoing ventricular assist device (VAD) implantation. OBJECTIVES: This study sought to evaluate differences in VAD outcom ... Full text Link to item Cite

Motor proficiency in school-aged children with CHD.

Journal article Cardiol Young · January 2025 OBJECTIVES: To evaluate the motor proficiency, identify risk factors for abnormal motor scores, and examine the relationship between motor proficiency and health-related quality of life in school-aged patients with CHD. STUDY DESIGN: Patients ≥ 4 years old ... Full text Link to item Cite

Preoperative, Operative, and Immediate Postoperative Predictors of Onset of Low Cardiac Output Syndrome in Congenital Heart Disease

Preprint · 2025 AbstractBackground Low cardiac output syndrome (LCOS) is a leading cause of morbidity and mortality after congenital heart disease (CHD) surgery. Early, transparent risk estimation at pediatric cardiac intensive care uni ... Full text Cite

Quality of life, neurodevelopmental and psychosocial outcomes in pediatric heart failure

Book section · January 1, 2025 Children living with cardiovascular disease continue to suffer from morbidity which significantly impacts their neurodevelopmental, psychosocial, and physical functioning and diminishes their quality of life (QOL). QOL may be described as the child's abili ... Full text Cite

Optimizing Quality of Life in Children with Complex Congenital Heart Disease

Journal article Current Treatment Options in Pediatrics · December 1, 2024 Purpose of Review: Individuals with congenital heart disease (CHD) can experience long-term morbidities related to physical, neurodevelopmental, and psychosocial functioning. These long-term sequelae are more likely to occur for patients who meet the high- ... Full text Cite

Rationale and design of CHD PULSE: Congenital Heart Disease Project to Understand Lifelong Survivor Experience.

Journal article Am Heart J · December 2024 BACKGROUND: With improved survival of adults with congenital heart disease (CHD) comes a need to understand the lifelong outcomes of this population. The aim of this paper is to describe the rationale and design of Congenital Heart Disease Project to Under ... Full text Link to item Cite

External validation of a clinical mathematical model estimating post-operative urine output following cardiac surgery in children.

Journal article Pediatr Nephrol · November 2024 BACKGROUND: This study aims to externally validate a clinical mathematical model designed to predict urine output (UOP) during the initial post-operative period in pediatric patients who underwent cardiac surgery with cardiopulmonary bypass (CPB). METHODS: ... Full text Link to item Cite

Living with Congenital Aortic Stenosis: Exercise Restriction, Patterns of Adherence, and Quality of Life.

Journal article Pediatr Cardiol · October 2024 Modern consensus panel guidelines recommend restriction from most organized sports for patients with moderate or severe aortic stenosis (AS). However, there is little published data on how frequently physicians deviate from guidelines, how well patients ad ... Full text Link to item Cite

The Society of Thoracic Surgeons Clinical Practice Guidelines on the Management of Neonates and Infants With Coarctation.

Journal article Ann Thorac Surg · September 2024 BACKGROUND: Although coarctation of the aorta without concomitant intracardiac pathology is relatively common, there is lack of guidance regarding aspects of its management in neonates and infants. METHODS: A panel of experienced congenital cardiac surgeon ... Full text Open Access Link to item Cite

Demonstrating responsiveness of the pediatric cardiac quality of life inventory in children and adolescents undergoing arrhythmia ablation, heart transplantation, and valve surgery.

Journal article Qual Life Res · September 2024 PURPOSE: Pediatric Cardiac Quality of Life Inventory (PCQLI) is a disease-specific pediatric cardiac health-related quality of life (HRQOL) instrument that is reliable, valid, and generalizable. We aim to demonstrate PCQLI responsiveness in children underg ... Full text Link to item Cite

Perceived family-centered care and post-traumatic stress in parents of infants cared for in the paediatric cardiac intensive care unit.

Journal article Nurs Crit Care · September 2024 BACKGROUND: Family-centred care (FCC), while a core value of paediatric hospitals, has not been well-studied in the paediatric cardiac intensive care unit (PCICU). AIM: To describe parents' perceptions of FCC provided by nurses in the PCICU during their in ... Full text Link to item Cite

Vigorous Exercise in Patients With Congenital Long QT Syndrome: Results of the Prospective, Observational, Multinational LIVE-LQTS Study.

Journal article Circulation · August 13, 2024 BACKGROUND: Whether vigorous exercise increases risk of ventricular arrhythmias for individuals diagnosed and treated for congenital long QT syndrome (LQTS) remains unknown. METHODS: The National Institutes of Health-funded LIVE-LQTS study (Lifestyle and E ... Full text Link to item Cite

Can perioperative electroencephalogram and adverse hemodynamic events predict neurodevelopmental outcomes in infants with congenital heart disease?

Journal article J Thorac Cardiovasc Surg · August 2024 OBJECTIVE: The study objective was to characterize preoperative and postoperative continuous electroencephalogram metrics and hemodynamic adverse events as predictors of neurodevelopment in congenital heart disease infants undergoing cardiac surgery. METHO ... Full text Link to item Cite

Periods of low renal perfusion pressure are associated with acute kidney injury following paediatric cardiac surgery.

Journal article Cardiol Young · May 16, 2024 INTRODUCTION: Acute kidney injury is associated with worse outcomes after cardiac surgery. The haemodynamic goals to ameliorate kidney injury are not clear. Low post-operative renal perfusion pressure has been associated with acute kidney injury in adults. ... Full text Link to item Cite

Impact of center volume on outcomes after ventricular assist device implantation in pediatric patients: An analysis of the STS-Pedimacs database.

Journal article J Heart Lung Transplant · May 2024 BACKGROUND: To date, no pediatric studies have highlighted the impact of center's ventricular assist device (VAD) volumes on post implant outcomes. METHODS: Children (age <19) enrolled in Pedimacs undergoing initial left ventricular assist device implantat ... Full text Link to item Cite

Neurocognitive function and health-related quality of life in adolescents and young adults with CHD with pulmonary valve dysfunction.

Journal article Cardiol Young · May 2024 BACKGROUND: Neurocognitive impairment and quality of life are two important long-term challenges for patients with complex CHD. The impact of re-interventions during adolescence and young adulthood on neurocognition and quality of life is not well understo ... Full text Link to item Cite

Neurodevelopmental Outcomes for Individuals With Congenital Heart Disease: Updates in Neuroprotection, Risk-Stratification, Evaluation, and Management: A Scientific Statement From the American Heart Association.

Journal article Circulation · March 26, 2024 Over the past decade, new research has advanced scientific knowledge of neurodevelopmental trajectories, factors that increase neurodevelopmental risk, and neuroprotective strategies for individuals with congenital heart disease. In addition, best practice ... Full text Link to item Cite

A Proposed Pediatric Clinical Cardiovascular Health Reference Standard.

Journal article Am J Prev Med · February 2024 INTRODUCTION: Clinical cardiovascular health is a construct that includes 4 health factors-systolic and diastolic blood pressure, fasting glucose, total cholesterol, and body mass index-which together provide an evidence-based, more holistic view of cardio ... Full text Open Access Link to item Cite

Developmental Delay in Children with Congenital Heart Disease

Book section · January 1, 2024 Children with congenital heart disease, particularly congenital heart surgery survivors, are known to face important neurodevelopmental and psychosocial challenges throughout thei life span. These difficulties are multifactorial in etiology and often affec ... Full text Cite

Development of the data registry for the Cardiac Neurodevelopmental Outcome Collaborative.

Journal article Cardiol Young · January 2024 Children with congenital heart disease (CHD) can face neurodevelopmental, psychological, and behavioural difficulties beginning in infancy and continuing through adulthood. Despite overall improvements in medical care and a growing focus on neurodevelopmen ... Full text Link to item Cite

Non-invasive Cardiac Output Monitoring in Congenital Heart Disease

Journal article Current Treatment Options in Pediatrics · December 1, 2023 Purpose of review: Cardiac output (CO) is a fundamental physiological parameter that measures the volume of blood that is pumped by the heart per unit of time, and helps define how oxygen is delivered to the tissues of the human body. In this paper, we dis ... Full text Cite

Differences in Quality of Life in Children Across the Spectrum of Congenital Heart Disease.

Journal article J Pediatr · December 2023 OBJECTIVE: To create complexity groups based upon a patient's cardiac medical history and to test for group differences in health-related quality of life (HRQOL). METHODS: Patients 8-18 years with congenital heart disease (CHD) and parent-proxies from the ... Full text Link to item Cite

Recommendations for centers performing pediatric heart surgery in the United States.

Journal article J Thorac Cardiovasc Surg · December 2023 Care and outcomes for the more than 40,000 patients undergoing pediatric and congenital heart surgery in the United States annually are known to vary widely. While consensus recommendations have been published across numerous fields as one mechanism to pro ... Full text Link to item Cite

Recommendations for Centers Performing Pediatric Heart Surgery in the United States.

Journal article Ann Thorac Surg · November 2023 Care and outcomes for the more than 40,000 patients undergoing pediatric and congenital heart surgery in the United States annually are known to vary widely. While consensus recommendations have been published across numerous fields as one mechanism to prom ... Full text Link to item Cite

Recommendations for Centers Performing Pediatric Heart Surgery in the United States.

Journal article World J Pediatr Congenit Heart Surg · September 2023 Care and outcomes for the more than 40,000 patients undergoing pediatric and congenital heart surgery in the United States annually are known to vary widely. While consensus recommendations have been published across numerous fields as one mechanism to pro ... Full text Link to item Cite

Factors Associated With Attendance for Cardiac Neurodevelopmental Evaluation.

Journal article Pediatrics · September 1, 2023 BACKGROUND AND OBJECTIVES: Neurodevelopmental evaluation of toddlers with complex congenital heart disease is recommended but reported frequency is low. Data on barriers to attending neurodevelopmental follow-up are limited. This study aims to estimate the ... Full text Link to item Cite

The Academic Impact of Congenital Heart Surgeons' Society (CHSS) Studies.

Journal article World J Pediatr Congenit Heart Surg · September 2023 PURPOSE: We reviewed all 64 articles ever published by The Congenital Heart Surgeons' Society (CHSS) Data Center to estimate the academic impact of these peer-reviewed articles. MATERIALS AND METHODS: The Congenital Heart Surgeons' Society has performed re ... Full text Link to item Cite

Behavioral and Emotional Outcomes in Children with Congenital Heart Disease: Effects of Disease Severity, Family Life Stress, Disease-Related Chronic Stress, and Psychosocial Adaptation.

Journal article J Pediatr · August 2023 OBJECTIVE: To evaluate whether effects of congenital heart disease (CHD) severity and family life stress on behavioral and emotional functioning are mediated by disease-related chronic stress and psychosocial adaptation. STUDY DESIGN: A cross-sectional ana ... Full text Link to item Cite

Advocacy at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery.

Journal article Cardiol Young · August 2023 The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery (WCPCCS) will be held in Washington DC, USA, from Saturday, 26 August, 2023 to Friday, 1 September, 2023, inclusive. The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery ... Full text Link to item Cite

Cardiovascular health trajectories from age 2-12: a pediatric electronic health record study.

Journal article Ann Epidemiol · July 2023 PURPOSE: Many children have non-ideal cardiovascular health (CVH), but little is known about the course of CVH in early childhood. We identified CVH trajectories in children and assess the generalizability of these trajectories in an external sample. METHO ... Full text Link to item Cite

Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy.

Journal article JAMA Cardiol · June 1, 2023 IMPORTANCE: Whether vigorous intensity exercise is associated with an increase in risk of ventricular arrhythmias in individuals with hypertrophic cardiomyopathy (HCM) is unknown. OBJECTIVE: To determine whether engagement in vigorous exercise is associate ... Full text Link to item Cite

A Randomized Trial of an Exclusive Human Milk Diet in Neonates with Single Ventricle Physiology.

Journal article J Pediatr · May 2023 OBJECTIVE: To determine whether weight gain velocity (g/kg/day) 30 days after the initiation of feeds after cardiac surgery and other clinical outcomes improve in infants with single ventricle physiology fed an exclusive human milk diet compared with a mix ... Full text Link to item Cite

Long-Term Quality of Life in Congenital Heart Disease Surgical Survivors: Multicenter Retrospective Study of Surgical and ICU Explanatory Factors.

Journal article Pediatr Crit Care Med · May 1, 2023 OBJECTIVES: Greater congenital heart disease (CHD) complexity is associated with lower health-related quality of life (HRQOL). There are no data on the association between surgical and ICU factors and HRQOL in CHD survivors. This study assess the associati ... Full text Link to item Cite

American Heart Association's Children's Strategically Focused Research Network Experience.

Journal article J Am Heart Assoc · April 4, 2023 The American Heart Association's Strategically Focused Children's Research Network started in July 2017 with 4 unique programs at Children's National Hospital in Washington, DC; Duke University in Durham, North Carolina; University of Utah in Salt Lake Cit ... Full text Link to item Cite

'Are Routine Post-discharge Diuretics Necessary After Pediatric Cardiac Surgery?'.

Journal article Pediatr Cardiol · April 2023 A prospective, one-armed, safety non-inferiority trial with historical controls was performed at a single-center, quaternary, children's hospital. Inclusion criteria were children aged 3 months-18 years after pediatric cardiac surgery resulting in a two-ve ... Full text Link to item Cite

Edoxaban for Thromboembolism Prevention in Pediatric Patients With Cardiac Disease.

Journal article J Am Coll Cardiol · December 13, 2022 BACKGROUND: Standard of care (SOC) anticoagulation for thromboembolism (TE) prevention in children with cardiac disease includes low molecular weight heparins or vitamin K antagonists. Limited data exists for alternate use of direct oral anticoagulants in ... Full text Link to item Cite

Social Determinants of Cardiovascular Health in US Adolescents: National Health and Nutrition Examination Surveys 1999 to 2014.

Journal article J Am Heart Assoc · November 15, 2022 Background Cardiovascular health (CVH) is suboptimal in US adolescents. Social determinants of health (SDOH) may affect CVH. We examined SDOH by race and ethnicity and assessed for associations between SDOH and CVH among US adolescents. Methods and Results ... Full text Link to item Cite

Optimizing Neurodevelopmental Outcomes in Neonates With Congenital Heart Disease.

Journal article Pediatrics · November 1, 2022 Neurodevelopmental impairment is a common and important long-term morbidity among infants with congenital heart disease (CHD). More than half of those with complex CHD will demonstrate some form of neurodevelopmental, neurocognitive, and/or psychosocial dy ... Full text Link to item Cite

Development of a Model for the Pediatric Survival After Veno-Arterial Extracorporeal Membrane Oxygenation Score: The Pedi-SAVE Score.

Journal article ASAIO J · November 1, 2022 Pediatric cardiac extracorporeal membrane oxygenation (ECMO) patients have high mortality rates. The purpose of our study was to develop and validate the Pediatric Survival After Veno-arterial ECMO (Pedi-SAVE) score for predicting survival at hospital disc ... Full text Link to item Cite

Assessment of physician training and prediction of workforce needs in paediatric cardiac intensive care in the United States.

Journal article Cardiol Young · November 2022 OBJECTIVE: To assess the training and the future workforce needs of paediatric cardiac critical care faculty. DESIGN: REDCap surveys were sent May-August 2019 to medical directors and faculty at the 120 US centres participating in the Society of Thoracic S ... Full text Link to item Cite

Workforce demographics and unit structure in paediatric cardiac critical care in the United States.

Journal article Cardiol Young · October 2022 OBJECTIVE: To assess current demographics and duties of physicians as well as the structure of paediatric cardiac critical care in the United States. DESIGN: REDCap surveys were sent by email from May till August 2019 to medical directors ("directors") of ... Full text Link to item Cite

Provider insights on shared decision-making with families affected by CHD.

Journal article Cardiol Young · September 2022 BACKGROUND AND OBJECTIVES: Little data exist on provider perspectives about counselling and shared decision-making for complex CHD, ways to support and improve the process, and barriers to effective communication. The goal of this qualitative study was to ... Full text Link to item Cite

Fontan Geometry and Hemodynamics Are Associated With Quality of Life in Adolescents and Young Adults.

Journal article Ann Thorac Surg · September 2022 BACKGROUND: Despite favorable short-term outcomes, Fontan palliation is associated with comorbidities and diminished quality of life (QOL) in the years after completion. We hypothesized that poor Fontan hemodynamics and ventricular function are associated ... Full text Link to item Cite

Magnetic Resonance Imaging in Pediatric Myocarditis: Trends and Associations With Cost and Outcome.

Journal article JACC Cardiovasc Imaging · July 2022 BACKGROUND: Cardiac magnetic resonance (CMR) provides tissue characterization and structural and functional data. CMR has high sensitivity and specificity for myocarditis in adults and children. The relationship between pediatric CMR use, cost, and clinica ... Full text Link to item Cite

Burden of Pediatric Heart Failure in the United States.

Journal article J Am Coll Cardiol · May 17, 2022 BACKGROUND: There are currently limited accurate national estimates for pediatric heart failure (HF). OBJECTIVES: This study aims to describe the current burden of primary and comorbid pediatric HF in the United States. METHODS: International Classificatio ... Full text Link to item Cite

Quality of Life of Mothers of Infants Subjected to Neonatal Cardiac Surgery: The Importance of Psychosocial Factors.

Journal article World J Pediatr Congenit Heart Surg · May 2022 Background: The World Health Organization acknowledges quality of life (QOL) as subjectively perceived overall well-being by the individual and recognizes it as an essential construct for overall health and wellness. The purpose of this study was to examin ... Full text Link to item Cite

Contemporary Provider Management Practices and Attitudes Toward Referral for Advanced Heart Failure Therapies in Fontan Patients Across North America.

Journal article J Card Fail · April 2022 BACKGROUND: To date, no reports have described clinicians' management practices for patients with Fontan circulatory failure or their understanding of risk factors for mortality and transplant outcomes in these patients. METHODS AND RESULTS: A cross-sectio ... Full text Link to item Cite

Outcomes of Multiple Runs of Extracorporeal Membrane Oxygenation: An analysis of the Extracorporeal Life Support Registry.

Journal article J Intensive Care Med · February 2022 OBJECTIVE: When patients deteriorate after decannulation from extracorporeal membrane oxygenation (ECMO), a second run of extracorporeal support may be considered. However, repeat cannulation can be difficult and poor outcomes associated with multiple ECMO ... Full text Link to item Cite

Isolated Coarctation of the Aorta: Current Concepts and Perspectives.

Journal article Front Cardiovasc Med · 2022 Current management of isolated CoA, localized narrowing of the aortic arch in the absence of other congenital heart disease, is a success story with improved prenatal diagnosis, high survival and improved understanding of long-term complication. Isolated C ... Full text Link to item Cite

Incidence, Predictors, and Impact of Postoperative Acute Kidney Injury Following Fontan Conversion Surgery in Young Adult Fontan Survivors.

Journal article Semin Thorac Cardiovasc Surg · 2022 Acute kidney injury (AKI) is a common complication following single ventricle congenital heart surgery. Data regarding AKI following Fontan conversion (FC) surgery are limited. This study evaluated the incidence, predictors of, and prognostic value of AKI ... Full text Link to item Cite

‘Are Routine Post-Discharge Diuretics Necessary After Pediatric Cardiac Surgery?’

Preprint · 2022 Hypothesis: We hypothesized that a single regimen of no or limited diuretics post-discharge after pediatric cardiac surgery for patients with two ventricles is not inferior to prolonged diuretics for prevention of readmission for pleural effusion. Material ... Full text Cite

Telehealth Home Monitoring and Postcardiac Surgery for Congenital Heart Disease

Book section · January 1, 2022 OBJECTIVES: To test the effect of a 4-month telehealth home monitoring program (REACH), layered on usual care, on postdischarge outcomes in parents of infants recovering from cardiac surgery and their infants. METHODS: Randomized trial of infants discharge ... Full text Cite

Health Care Policy and Congenital Heart Disease: 2020 Focus on Our 2030 Future.

Journal article J Am Heart Assoc · October 19, 2021 The congenital heart care community faces a myriad of public health issues that act as barriers toward optimum patient outcomes. In this article, we attempt to define advocacy and policy initiatives meant to spotlight and potentially address these challeng ... Full text Link to item Cite

Does Value Vary by Center Surgical Volume for Neonates With Truncus Arteriosus? A Multicenter Study.

Conference Ann Thorac Surg · July 2021 BACKGROUND: Truncus arteriosus is a congenital heart defect with high resource use, cost, and mortality. Value assessment (outcome relative to cost) can improve quality of care and decrease cost. This study hypothesized that truncus arteriosus repair at a ... Full text Link to item Cite

Neurodevelopmental and psychosocial interventions for individuals with CHD: a research agenda and recommendations from the Cardiac Neurodevelopmental Outcome Collaborative.

Journal article Cardiol Young · June 2021 In 2018, the Neurodevelopmental and Psychosocial Interventions Working Group of the Cardiac Neurodevelopmental Outcome Collaborative convened through support from an R13 grant from the National Heart, Lung, and Blood Institute to survey the state of neurod ... Full text Link to item Cite

Optimising neurodevelopmental and psychosocial outcomes for survivors with CHD: a research agenda for the next decade.

Journal article Cardiol Young · June 2021 Neurodevelopmental and psychosocial impairments negatively impact health-related quality of life for survivors with CHD and complicate the transition to independent adulthood. Risk for neurodevelopmental and psychosocial impairments is influenced by a comp ... Full text Link to item Cite

Parent mental health and family functioning following diagnosis of CHD: a research agenda and recommendations from the Cardiac Neurodevelopmental Outcome Collaborative.

Journal article Cardiol Young · June 2021 Diagnosis of CHD substantially affects parent mental health and family functioning, thereby influencing child neurodevelopmental and psychosocial outcomes. Recognition of the need to proactively support parent mental health and family functioning following ... Full text Link to item Cite

Characterisation of neurodevelopmental and psychological outcomes in CHD: a research agenda and recommendations from the cardiac neurodevelopmental outcome collaborative.

Journal article Cardiol Young · June 2021 The Neurodevelopmental and Psychological Outcomes Working Group of the Cardiac Neurodevelopmental Outcome Collaborative was formed in 2018 through support from an R13 grant from the National Heart, Lung, and Blood Institute with the goals of identifying kn ... Full text Link to item Cite

Development of Care Curves Following the Stage 1 Palliation: A Comparison of Intensive Care Among 5 Centers.

Journal article J Am Heart Assoc · June 2021 Background Comparison of care among centers is currently limited to major end points, such as mortality, length of stay, or complication rates. Creating "care curves" and comparing individual elements of care over time may highlight modifiable differences ... Full text Link to item Cite

EARLY PSYCHOSOCIAL ADJUSTMENT AMONG PARENTS OF NEONATAL CARDIAC SURGERY SURVIVORS

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · May 11, 2021 Link to item Cite

Childhood Risk Factors and Adulthood Cardiovascular Disease: A Systematic Review.

Journal article J Pediatr · May 2021 OBJECTIVE: To conduct a comprehensive review of the literature on childhood risk factors and their associations with adulthood subclinical and clinical cardiovascular disease (CVD). STUDY DESIGN: A systematic search was performed using the MEDLINE, EMBASE, ... Full text Link to item Cite

Perspective on Cerebral Autoregulation Monitoring in Neonatal Cardiac Surgery Requiring Cardiopulmonary Bypass.

Journal article Front Neurol · 2021 The autoregulation of cerebral blood flow protects against brain injury from transient fluctuations in arterial blood pressure. Impaired autoregulation may contribute to hypoperfusion injury in neonates and infants. Monitoring cerebral autoregulation in ne ... Full text Link to item Cite

Comparison of Economic Self-Sufficiency and Educational Attainment in Adults With Congenital Heart Disease Versus Siblings Without Heart Disease and to General Population.

Journal article Am J Cardiol · November 15, 2020 Among children with congenital heart disease (CHD), there is often neurodevelopmental and behavioral impairment with unclear implications regarding adult socioeconomic achievements. We aimed to compare economic self-sufficiency and educational attainment i ... Full text Link to item Cite

The Cardiac Neurodevelopmental Outcome Collaborative: a new community improving outcomes for individuals with congenital heart disease.

Journal article Cardiol Young · November 2020 Improved survival of patients with paediatric and congenital cardiac disease has led to a heightened awareness of the cognitive, neurodevelopmental, psychosocial, and physical functioning deficits that limit health, academic functioning, adaptive functioni ... Full text Link to item Cite

Variations in practice in cardiac neurodevelopmental follow-up programs.

Journal article Cardiol Young · November 2020 Over the last two decades, heart centres have developed strategies to meet the neurodevelopmental needs of children with congenital heart disease. Since the publication of guidelines in 2012, cardiac neurodevelopmental follow-up programmes have become more ... Full text Link to item Cite

The origins and development of the cardiac neurodevelopment outcome collaborative: creating innovative clinical, quality improvement, and research opportunities.

Journal article Cardiol Young · November 2020 Compared to the general population, individuals with complex congenital heart disease are at increased risk for deficits in cognitive, neurodevelopmental, psychosocial, and physical functioning, resulting in a diminished health-related quality of life. The ... Full text Link to item Cite

Factors That Contribute to Cost Differences Based on ICU of Admission in Neonates Undergoing Congenital Heart Surgery: A Novel Decomposition Analysis.

Journal article Pediatr Crit Care Med · September 2020 OBJECTIVES: We leveraged decomposition analysis, commonly used in labor economics, to understand determinants of cost differences related to location of admission in children undergoing neonatal congenital heart surgery. DESIGN: A retrospective cohort stud ... Full text Link to item Cite

Telehealth Home Monitoring and Postcardiac Surgery for Congenital Heart Disease.

Journal article Pediatrics · September 2020 OBJECTIVES: To test the effect of a 4-month telehealth home monitoring program (REACH), layered on usual care, on postdischarge outcomes in parents of infants recovering from cardiac surgery and their infants. METHODS: Randomized trial of infants discharge ... Full text Link to item Cite

The Fontan outcomes network: first steps towards building a lifespan registry for individuals with Fontan circulation in the United States.

Journal article Cardiol Young · August 2020 The Fontan Outcomes Network was created to improve outcomes for children and adults with single ventricle CHD living with Fontan circulation. The network mission is to optimise longevity and quality of life by improving physical health, neurodevelopmental ... Full text Link to item Cite

Early characteristics of bone deficits in children with Fontan palliation.

Journal article Cardiol Young · April 2020 BACKGROUND: This is a cross-sectional study aiming to understand the early characteristics and background of bone health impairment in clinically well children with Fontan circulation. METHODS: We enrolled 10 clinically well children with Fontan palliation ... Full text Link to item Cite

Correction to: Providing Compassionate End of Life Care in the Setting of Mechanical Circulatory Support (Current Pediatrics Reports, (2019), 7, 4, (168-175), 10.1007/s40124-019-00206-4)

Journal article Current Pediatrics Reports · March 1, 2020 The original version did not include the correct affiliations as noted by the authors in their proofs which can be seen below. ... Full text Cite

Necrotizing Enterocolitis and Associated Mortality in Neonates With Congenital Heart Disease: A Multi-Institutional Study.

Journal article Pediatr Crit Care Med · March 2020 OBJECTIVE: There are scarce data about the prevalence and mortality of necrotizing enterocolitis in neonates with congenital heart disease. The purpose of this study is to provide a multi-institutional description and comparison of the overall prevalence a ... Full text Link to item Cite

Prevalence and risk factors associated with renal dysfunction in patients with single ventricle congenital heart disease after Fontan palliation

Journal article Congenital Heart Disease · January 1, 2020 Objectives: The Fontan operation has increased survival in patients with single-ventricle congenital heart defects. However, Fontan survivors are at risk of other organ dysfunctions, such as renal dysfunction (RD). The objectives of this study are to asses ... Full text Cite

Providing Compassionate End of Life Care in the Setting of Mechanical Circulatory Support

Journal article Current Pediatrics Reports · December 1, 2019 Purpose of Review: To outline key elements in providing compassionate end-of-life care for pediatric patients with end-stage heart failure on mechanical circulatory support (MCS) such as extracorporeal membrane oxygenation (ECMO) and ventricular assist dev ... Full text Cite

Neurologic outcomes after heart surgery.

Journal article Paediatr Anaesth · November 2019 Full text Link to item Cite

Neurodevelopmental Outcomes Among Children With Congenital Heart Disease: At-Risk Populations and Modifiable Risk Factors.

Journal article World J Pediatr Congenit Heart Surg · November 2019 As survivable outcomes among patients with complex congenital heart disease (cCHD) have continued to improve over the last several decades, more attention is being dedicated to interventions that impact not just survival but quality of life among patients ... Full text Link to item Cite

Enhancing efficiency and scientific impact of a clinical trials network: the Pediatric Heart Network Integrated CARdiac Data and Outcomes (iCARD) Collaborative.

Journal article Cardiol Young · September 2019 Recent years have seen an exponential increase in the variety of healthcare data captured across numerous sources. However, mechanisms to leverage these data sources to support scientific investigation have remained limited. In 2013 the Pediatric Heart Net ... Full text Link to item Cite

Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association.

Journal article Circulation · August 27, 2019 Significant improvements have been achieved in cardiac arrest resuscitation and postarrest resuscitation care, but mortality remains high. Most of the poor outcomes and deaths of cardiac arrest survivors have been attributed to widespread brain injury. Thi ... Full text Link to item Cite

Evaluation and Management of the Child and Adult With Fontan Circulation: A Scientific Statement From the American Heart Association.

Journal article Circulation · August 6, 2019 It has been 50 years since Francis Fontan pioneered the operation that today bears his name. Initially designed for patients with tricuspid atresia, this procedure is now offered for a vast array of congenital cardiac lesions when a circulation with 2 vent ... Full text Link to item Cite

Pediatric Acute Myocarditis: Predicting Hemodynamic Compromise at Presentation to Health Care.

Journal article Hosp Pediatr · June 2019 BACKGROUND: The clinical spectrum of pediatric acute myocarditis ranges from minimal symptoms with intact hemodynamics to rapid cardiovascular collapse and death. We sought to identify factors on initial presentation associated with subsequent hemodynamic ... Full text Link to item Cite

Cardiac Networks United: an integrated paediatric and congenital cardiovascular research and improvement network.

Journal article Cardiology in the young · February 2019 Optimising short- and long-term outcomes for children and patients with CHD depends on continued scientific discovery and translation to clinical improvements in a coordinated effort by multiple stakeholders. Several challenges remain for clinicians, resea ... Full text Cite

Long-Term Outcomes of Coarctation Repair Through Left Thoracotomy.

Journal article Ann Thorac Surg · January 2019 BACKGROUND: Optimal surgical approach for repair of coarctation of the aorta (CoA) remains controversial. This study aimed to evaluate reintervention rates and its predictors by using a strategy of resection with extended end-to-end anastomosis (REEEA) thr ... Full text Link to item Cite

Cosmetic outcomes and quality of life in children with cardiac implantable electronic devices.

Journal article Pacing Clin Electrophysiol · January 2019 BACKGROUND: Axillary implant location is an alternative implant location in patients for cardiac implantable electronic devices (CIEDs) for the purposes of improved cosmetic outcome. The impact from the patient's perspective is unknown. The purpose of this ... Full text Link to item Cite

Future Directions for Early Childhood Prevention of Mental Disorders: A Road Map to Mental Health, Earlier.

Journal article J Clin Child Adolesc Psychol · 2019 Mental disorders are the predominant chronic diseases of youth, with substantial life span morbidity and mortality. A wealth of evidence demonstrates that the neurodevelopmental roots of common mental health problems are present in early childhood. Unfortu ... Full text Link to item Cite

Psychosocial functioning of parents of children with heart disease-describing the landscape.

Journal article Eur J Pediatr · December 2018 The aim was to describe the psychological functioning of parents of school-age children with heart disease (HD) in a large-scale, transnational evaluation of parent dyads across the spectrum of cardiac diagnoses and a range of psychosocial domains. Parents ... Full text Link to item Cite

The REACH protocol: an innovative strategy for home management of infants with complex CHD.

Journal article Cardiol Young · July 2018 Approximately 32,000 infants are born with CHDs each year in the United States of America. Of every 1000 live births, 2.3 require surgical or transcatheter intervention in the first year of life. There are few more stressful times for parents than when the ... Full text Link to item Cite

Admission to dedicated pediatric cardiac intensive care units is associated with decreased resource use in neonatal cardiac surgery.

Journal article J Thorac Cardiovasc Surg · June 2018 OBJECTIVE: Neonates undergoing congenital heart surgery require highly specialized, resource-intensive care. Location of care and degree of specialization can vary between and within institutions. Using a multi-institutional cohort, we sought to determine ... Full text Link to item Cite

Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease: A Scientific Statement From the American Heart Association.

Journal article Circulation · May 29, 2018 Cardiac arrest occurs at a higher rate in children with heart disease than in healthy children. Pediatric basic life support and advanced life support guidelines focus on delivering high-quality resuscitation in children with normal hearts. The complexity ... Full text Link to item Cite

Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery.

Journal article Ther Drug Monit · April 2018 BACKGROUND: Milrinone, an inotropic agent used ubiquitously in children after cardiac surgery, accumulates in acute kidney injury (AKI). We assessed if urinary AKI biomarkers are predictive of an increase in milrinone concentrations in infants after cardia ... Full text Link to item Cite

Utilisation of early intervention services in young children with hypoplastic left heart syndrome.

Journal article Cardiology in the young · January 2018 ObjectiveChildren with hypoplastic left heart syndrome are at a risk for neurodevelopmental delays. Current guidelines recommend systematic evaluation and management of neurodevelopmental outcomes with referral for early intervention services. The ... Full text Cite

Cardiopulmonary resuscitation (CPR) in children with heart disease

Book section · January 1, 2018 Over the past two decades survival from pediatric cardiac arrest has improved dramatically, particularly in the in-hospital setting, from 15% to nearly 50%. The reasons for this are multifactorial and include but are likely not limited to the use of ECPR, ... Full text Cite

Quality of Life and Psychosocial Care in Pediatric Heart Failure

Book section · January 1, 2018 Advances in both medical and surgical management of children living with cardiovascular disease have resulted in improved survival in this population. However, children living with cardiovascular disease are often required to abide by physical activity res ... Full text Cite

First-stage palliation strategy for univentricular heart disease may impact risk for acute kidney injury.

Journal article Cardiol Young · January 2018 OBJECTIVE: Norwood palliation for patients with single ventricle heart disease is associated with a significant risk for acute kidney injury, which portends a worse prognosis. We sought to investigate the impact of hybrid stage I palliation (Hybrid) on acu ... Full text Link to item Cite

Biopsychosocial Predictors of Quality of Life Outcomes in Pediatric Congenital Heart Disease.

Journal article Pediatr Cardiol · January 2018 The purpose of this prospective multi-center cross-sectional study was to identify key biopsychosocial factors that impact quality of life (QOL) of youth with congenital heart disease (CHD). Patient-parent pairs were recruited at a regular hospital follow- ... Full text Link to item Cite

Impaired cerebral autoregulation and elevation in plasma glial fibrillary acidic protein level during cardiopulmonary bypass surgery for CHD.

Journal article Cardiol Young · January 2018 BACKGROUND: Cerebrovascular reactivity monitoring has been used to identify the lower limit of pressure autoregulation in adult patients with brain injury. We hypothesise that impaired cerebrovascular reactivity and time spent below the lower limit of auto ... Full text Link to item Cite

Fontan-Associated Liver Disease: Proceedings from the American College of Cardiology Stakeholders Meeting, October 1 to 2, 2015, Washington DC.

Journal article J Am Coll Cardiol · December 26, 2017 Over the past decade, as the majority of patients with single ventricle anatomy who have undergone the Fontan operation reach adulthood, a newly recognized disease process, Fontan-associated liver disease (FALD), has emerged. FALD is an extracardiac compli ... Full text Link to item Cite

Myocardial Infarction in Adults With Congenital Heart Disease.

Journal article Am J Cardiol · December 15, 2017 We compared the incidence and 30-day mortality of myocardial infarction (MI) in adults with congenital heart disease (CHD) relative to the general population. This cohort study used nationwide population-based medical databases to identify individuals born ... Full text Link to item Cite

Quality of Life is Diminished in Patients with Tetralogy of Fallot with Mild Residual Disease: A Comparison of Tetralogy of Fallot and Isolated Valvar Pulmonary Stenosis.

Journal article Pediatr Cardiol · December 2017 The objective of this study is to compare quality of life (QOL) in patients with mild pulmonary insufficiency (PI) after Tetralogy of Fallot (TOF) repair or after balloon dilation for isolated valvar pulmonary stenosis (VPS). A cross-sectional study of pat ... Full text Link to item Cite

Cardiovascular adaptation to the Fontan circulation.

Journal article Congenit Heart Dis · December 2017 Although medium-term survival following Fontan operations in the modern era has improved dramatically, late cardiovascular and extracardiac morbidity are common and are associated with impaired quality of life and premature late mortality. This serves as a ... Full text Link to item Cite

Effect of Fontan geometry on exercise haemodynamics and its potential implications.

Journal article Heart · November 2017 OBJECTIVE: Exercise intolerance afflicts Fontan patients with total cavopulmonary connections (TCPCs) causing a reduction in quality of life. Optimising TCPC design is hypothesised to have a beneficial effect on exercise capacity. This study investigates r ... Full text Link to item Cite

Exercise Performance and 22q11.2 Deletion Status Affect Quality of Life in Tetralogy of Fallot.

Journal article J Pediatr · October 2017 OBJECTIVE: To identify mediators of health status and quality of life (QOL) in children and adolescents aged 8-18 years old following surgical repair for tetralogy of Fallot (TOF), including resource use, exercise performance, and 22q11.2 deletion status. ... Full text Link to item Cite

National Variation in the Use of Tracheostomy in Patients With Congenital Heart Disease.

Journal article Pediatr Crit Care Med · October 2017 OBJECTIVES: The postsurgical care of children with congenital heart disease may be complicated by the need for cardiorespiratory support, including tracheostomy. The variation of the use of tracheostomy across multiple pediatric cardiac surgical centers ha ... Full text Link to item Cite

Longitudinal Outcomes of Patients With Single Ventricle After the Fontan Procedure.

Journal article J Am Coll Cardiol · June 6, 2017 BACKGROUND: Multicenter longitudinal objective data for survival into adulthood of patients who have undergone Fontan procedures are lacking. OBJECTIVES: This study sought to describe transplant-free survival and explore relationships between laboratory me ... Full text Link to item Cite

High burden of genetic conditions diagnosed in a cardiac neurodevelopmental clinic.

Journal article Cardiol Young · April 2017 BACKGROUND: There is a known high prevalence of genetic and clinical syndrome diagnoses in the paediatric cardiac population. These disorders often have multisystem effects, which may have an important impact on neurodevelopmental outcomes. Taken together, ... Full text Link to item Cite

Amiodarone Versus Lidocaine for Pediatric Cardiac Arrest Due to Ventricular Arrhythmias: A Systematic Review.

Journal article Pediatr Crit Care Med · February 2017 OBJECTIVE: We performed a systematic review as part of the International Liaison Committee on Resuscitation process to create a consensus on science statement regarding amiodarone or lidocaine during pediatric cardiac arrest for the 2015 International Liai ... Full text Link to item Cite

Quality of Life and Psychosocial Care in Pediatric Heart Failure

Book section · January 1, 2017 Advances in both medical and surgical management of children living with cardiovascular disease have resulted in improved survival in this population. However, children living with cardiovascular disease are often required to abide by physical activity res ... Full text Cite

Abnormalities in serum biomarkers correlate with lower cardiac index in the Fontan population.

Journal article Cardiol Young · January 2017 BACKGROUND: Fontan survivors have depressed cardiac index that worsens over time. Serum biomarker measurement is minimally invasive, rapid, widely available, and may be useful for serial monitoring. The purpose of this study was to identify biomarkers that ... Full text Link to item Cite

New-onset diabetes mellitus after heart transplantation in children - Incidence and risk factors.

Journal article Pediatr Transplant · November 2016 Diabetes mellitus is a recognized complication of SOT in adults and is associated with decreased graft and patient survival. Little is known about NOD in pediatric HT recipients. We aimed to characterize the incidence and describe risk factors for developm ... Full text Link to item Cite

Endothelial Function and Arterial Stiffness Relate to Functional Outcomes in Adolescent and Young Adult Fontan Survivors.

Journal article J Am Heart Assoc · September 24, 2016 BACKGROUND: Fontan survivors demonstrate diminished vascular function and functional outcomes, but the relationships between these measures have not been established. METHODS AND RESULTS: We performed a cross-sectional study of 60 Fontan survivors (52% mal ... Full text Link to item Cite

Obesity and Diabetes Mellitus Adversely Affect Outcomes after Cardiac Surgery in Children's Hospitals.

Journal article Congenit Heart Dis · September 2016 OBJECTIVE: To assess how obesity or diabetes mellitus impacts outcomes in patients undergoing cardiac surgery in pediatric hospitals. DESIGN: A multi-institutional, matched case-control study of the Pediatric Health Information System database was performe ... Full text Link to item Cite

Cardiopulmonary Resuscitation in Congenital and Acquired Heart Disease.

Journal article Pediatr Crit Care Med · August 2016 OBJECTIVES: The Pediatric Advanced Life Support recommendations were developed for otherwise healthy infants and children with normal cardiac anatomy. Patients with acquired and congenital heart disease require specific considerations that may differ from ... Full text Link to item Cite

Impact of Surgical Complexity on Health-Related Quality of Life in Congenital Heart Disease Surgical Survivors.

Journal article J Am Heart Assoc · July 22, 2016 BACKGROUND: Surgical complexity and related morbidities may affect long-term patient quality of life (QOL). Aristotle Basic Complexity (ABC) score and Risk Adjustment in Congenital Heart Surgery (RACHS-1) category stratify the complexity of pediatric cardi ... Full text Link to item Cite

Congenital Heart Disease With and Without Cyanotic Potential and the Long-term Risk of Diabetes Mellitus: A Population-Based Follow-up Study.

Journal article J Am Heart Assoc · July 8, 2016 BACKGROUND: Long-term survival for persons born with congenital heart disease (CHD) is improved, but limited knowledge exists of this growing population's acquired cardiovascular risk profile. This study's purpose was to assess CHD survivors' risk for type ... Full text Link to item Cite

Executive Functioning and School Performance among Pediatric Survivors of Complex Congenital Heart Disease.

Journal article J Pediatr · June 2016 OBJECTIVE: To investigate the presence and severity of real-world impairments in executive functioning-responsible for children's regulatory skills (metacognition, behavioral regulation)-and its potential impact on school performance among pediatric surviv ... Full text Link to item Cite

An Emergent Phenotype: A Critical Review of Neurodevelopmental Outcomes for Complex Congenital Heart Disease Survivors During Infancy, Childhood, and Adolescence

Book section · June 1, 2016 The purpose of this chapter is to describe neurodevelopmental phenotypes in complex congenital heart disease survivors across ages and across research centers in North America and Europe. ... Full text Cite

Posterior Circulation Ischemia or Occlusion in Five Adults With Failing Fontan Circulation.

Journal article Ann Thorac Surg · June 2016 BACKGROUND: Palliative procedures performed before the Fontan procedure may require ligation of the subclavian arteries, thereby affecting flow to the vertebral arteries. In adults with functionally univentricular heart disease, the implications of altered ... Full text Link to item Cite

Health-related quality of life in children with heart failure as perceived by children and parents.

Journal article Cardiol Young · June 2016 Advancements in paediatric heart failure management have resulted in improved survival and a focus on long-term outcomes including health-related quality of life. We compared health-related quality of life in children with heart failure with healthy patien ... Full text Link to item Cite

Brain in Congenital Heart Disease Across the Lifespan: The Cumulative Burden of Injury.

Journal article Circulation · May 17, 2016 The number of patients surviving with congenital heart disease (CHD) has soared over the last 3 decades. Adults constitute the fastest-growing segment of the CHD population, now outnumbering children. Research to date on the heart-brain intersection in thi ... Full text Link to item Cite

Assessment of Quality of Life in Young Patients with Single Ventricle after the Fontan Operation.

Journal article J Pediatr · March 2016 OBJECTIVES: To assess self-reported quality of life (QOL) in a large multicenter cohort of adolescent and young adults surviving Fontan. STUDY DESIGN: Cross-sectional. The Pediatric Quality of Life Inventory (PedsQL) was administered to 408 survivors of Fo ... Full text Link to item Cite

Quality of Life of Pediatric Patients With Long QT Syndrome.

Journal article Am J Cardiol · February 15, 2016 Children with long QT syndrome (LQTS) live with the risk of sudden death, activity restrictions, and the need for daily medications. We sought to evaluate the quality of life (QOL), self-perception, and behavior of patients with LQTS as perceived by both p ... Full text Link to item Cite

The Association among Feeding Mode, Growth, and Developmental Outcomes in Infants with Complex Congenital Heart Disease at 6 and 12 Months of Age.

Journal article J Pediatr · February 2016 OBJECTIVE: To assess the association between early anthropometric measurements, device-assisted feeding, and early neurodevelopment in infants with complex congenital heart diseases (CHDs). STUDY DESIGN: Bayley Scales of Infant Development II were used to ... Full text Link to item Cite

Does Congenital Heart Disease Affect Neurodevelopmental Outcomes in Children with Down Syndrome?

Journal article Congenit Heart Dis · 2016 OBJECTIVE: The impact that congenital heart disease (CHD) has on the neurodevelopment of children with Down syndrome (DS) is unknown and potentially has implications for targeted early intervention. This study assessed the relationship between CHD that req ... Full text Link to item Cite

Important knowledge for parents of children with heart disease: parent, nurse, and physician views.

Journal article Cardiol Young · January 2016 OBJECTIVES: Parental understanding of their children's heart disease is inadequate, which may contribute to poor health outcomes. The purpose of this study was to determine what parental knowledge is important in the care of children with heart disease fro ... Full text Link to item Cite

Neurodevelopmental and psychosocial outcomes across the congenital heart disease lifespan

Journal article Progress in Pediatric Cardiology · December 1, 2015 Infants, children, and adolescents with congenital heart disease are known to be at elevated risk of neurodevelopmental deficits compared to healthy children, with the risk and severity of impairment increasing with greater complexity of the cardiac lesion ... Full text Cite

Total Energy Expenditure of Infants with Congenital Heart Disease Who Have Undergone Surgical Intervention.

Journal article Pediatr Cardiol · December 2015 Growth failure is often observed in infants with congenital heart disease (CHD); it is unclear, however, whether growth failure is due to increased total energy expenditure (TEE). An observational study of infants with CHD and surgical intervention within ... Full text Link to item Cite

Perioperative feeding management of neonates with CHD: analysis of the Pediatric Cardiac Critical Care Consortium (PC4) registry.

Journal article Cardiol Young · December 2015 UNLABELLED: Introduction The optimal perioperative feeding strategies for neonates with CHD are unknown. In the present study, we describe the current feeding practices across a multi-institutional cohort. METHODS: Inclusion criteria for this study were as ... Full text Link to item Cite

Quality of life in pediatric patients affected by electrophysiologic disease.

Journal article Heart Rhythm · May 2015 BACKGROUND: Treatment of electrophysiologic (EP) disease in pediatric patients has improved; however, the effects on quality of life (QOL) are unknown. OBJECTIVE: The purpose of this study was to compare QOL within EP disease groups and to other congenital ... Full text Link to item Cite

New Onset Diabetes Mellitus After Heart Transplant in Children

Conference The Journal of Heart and Lung Transplantation · April 2015 Full text Cite

Pediatric Heart Transplantation for Anthracycline Cardiomyopathy: A UNOS Database Review

Conference The Journal of Heart and Lung Transplantation · April 2015 Full text Cite

Health-related quality of life assessment in children followed in a cardiomyopathy clinic.

Journal article Pediatr Cardiol · March 2015 As our ability to diagnosis cardiomyopathy matures and genetic testing becomes more widespread, there has been an increase in the number of children followed for cardiomyopathy. The purpose of this study was to compare health-related quality of life (HRQoL ... Full text Link to item Cite

Prediction by clinicians of quality of life for children and adolescents with cardiac disease.

Journal article J Pediatr · March 2015 OBJECTIVE: To determine whether clinicians could reliably predict health-related quality of life (HRQOL) for children with cardiac disease, the level of agreement in predicted HRQOL scores between clinician sub-types, and agreement between clinician-predic ... Full text Link to item Cite

RESTING ENERGY EXPENDITURE IN INFANTS WITH SINGLE VENTRICLE CONGENITAL HEART DISEASE

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

Survival data and predictors of functional outcome an average of 15 years after the Fontan procedure: the pediatric heart network Fontan cohort.

Journal article Congenit Heart Dis · 2015 OBJECTIVE: Multicenter longitudinal outcome data for Fontan patients surviving into adulthood are lacking. The aim of this study was to better understand contemporary outcomes in Fontan survivors by collecting follow-up data in a previously well-characteri ... Full text Link to item Cite

Quality of life: The need for a national database

Book section · January 1, 2015 Due to recent advances in pediatric cardiovascular therapy, mortality rates for children with heart disease (HD) have decreased dramatically. Despite these advances, however, survivors suffer from morbidity resulting from their circulatory abnormalities an ... Full text Cite

Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants.

Journal article J Thorac Cardiovasc Surg · December 2014 OBJECTIVE: Apolipoprotein E (APOE) genotype is a determinant of neurologic recovery after brain ischemia and traumatic brain injury. The APOE ε2 allele has been associated with worse neurodevelopmental (ND) outcome after repair of congenital heart defects ... Full text Link to item Cite

Relationship of MR elastography determined liver stiffness with cardiac function after Fontan palliation.

Journal article J Magn Reson Imaging · December 2014 PURPOSE: To use MR elastography to assess liver stiffness in patients with congenital heart disease palliated with the Fontan procedure and correlate findings with cardiac index and other functional parameters obtained during cardiac MRI. MATERIALS AND MET ... Full text Link to item Cite

Assessing the generalisability of the pediatric cardiac quality of life inventory in the United Kingdom.

Journal article Cardiol Young · April 2014 PURPOSE: To demonstrate the generalisability of the Pediatric Cardiac Quality of Life Inventory in the United Kingdom. METHODS: Children and adolescents with heart disease were recruited from three tertiary paediatric cardiac centres in the United Kingdom ... Full text Link to item Cite

Health-related quality of life outcomes in children and adolescents with congenital heart disease.

Journal article J Pediatr · April 2014 OBJECTIVES: To compare health-related quality of life (HRQOL) in a group of pediatric patients with congenital heart disease (CHD) and healthy controls and patients with other chronic diseases, and to compare HRQOL among patients with CHD of various severi ... Full text Link to item Cite

Morbidity in children and adolescents after surgical correction of interrupted aortic arch.

Journal article Pediatr Cardiol · March 2014 Previous studies of outcome after operative correction of interrupted aortic arch (IAA) have focused on mortality and rates of reintervention. We sought to investigate the clinical status of children and adolescents after surgery for IAA. A cross-sectional ... Full text Link to item Cite

Magnetic resonance elastography of the liver in patients status-post fontan procedure: feasibility and preliminary results.

Journal article Congenit Heart Dis · 2014 OBJECTIVE: The purpose of this study was to evaluate the feasibility of performing magnetic resonance elastography (MRE) as a screening tool for elevated liver stiffness in patients' status-post Fontan procedure. BACKGROUND: With greater numbers of Fontan ... Full text Link to item Cite

Long-term outcomes in congenital heart disease

Book section · January 1, 2014 The long-term survival of children with congenital heart disease (CHD) continues to improve due to advancements in cardiac surgery and perioperative care and enhancements in cardiovascular diagnostic and interventional capabilities. As the mortality rate a ... Full text Cite

Long-term outcomes in congenital heart disease

Book section · January 1, 2014 The long-term survival of children with congenital heart disease (CHD) continues to improve due to advancements in cardiac surgery and perioperative care and enhancements in cardiovascular diagnostic and interventional capabilities. As the mortality rate a ... Full text Cite

Surgical interventions for congenital heart disease

Book section · January 1, 2014 Surgery for congenital heart disease encompasses a wide variety of procedures that are often performed in combination. Not all the operations are anatomic as some are physiologic to compensate for lesions in which an anatomic repair is not possible. Over t ... Full text Cite

Surgical interventions for congenital heart disease

Book section · January 1, 2014 Surgery for congenital heart disease encompasses a wide variety of procedures that are often performed in combination. Not all the operations are anatomic as some are physiologic to compensate for lesions in which an anatomic repair is not possible. Over t ... Full text Cite

The importance of self-perceptions to psychosocial adjustment in adolescents with heart disease.

Journal article J Pediatr Health Care · 2014 INTRODUCTION: This study examined the importance of self-perceptions as determinants of psychosocial adjustment reported by adolescents with heart disease and compared adolescents with heart disease to healthy norms. METHODS: Ninety-two adolescents with he ... Full text Link to item Cite

New concepts in predicting, evaluating, and managing neurodevelopmental outcomes in children with congenital heart disease.

Journal article Curr Opin Pediatr · October 2013 PURPOSE OF REVIEW: Over the last two decades advances in congenital heart surgery, pediatric cardiology, and pediatric intensive care have dramatically increased the survival of infants with critical congenital heart disease (CHD). Survivors often experien ... Full text Link to item Cite

One hundred useful references in pediatric cardiac intensive care: the 2012 update.

Journal article Pediatr Crit Care Med · October 2013 OBJECTIVE: The specialty of pediatric cardiac critical care has undergone rapid scientific and clinical growth in the last 25 years. The Board of Directors of the Pediatric Cardiac Intensive Care Society assembled an updated list of sentinel references foc ... Full text Link to item Cite

Prevalence and patterns of retention in cardiac care in young adults with congenital heart disease.

Journal article J Pediatr · September 2013 The population with adult congenital heart disease is expanding. Cardiac care retention and follow-up patterns were assessed in 153 adults with congenital heart disease (median age, 24.5 years), previously compliant as teenagers. The majority (125; 81.7%) ... Full text Link to item Cite

Morbidity in children and adolescents after surgical correction of truncus arteriosus communis.

Journal article Am Heart J · September 2013 BACKGROUND: Studies of outcome after operative correction of truncus arteriosus communis (TA) have focused on mortality and rates of reintervention. We sought to investigate the clinical status of children and adolescents with surgically corrected TA. METH ... Full text Link to item Cite

Finding the right distribution for highly skewed zero-inflated clinical data

Journal article Epidemiology Biostatistics and Public Health · July 25, 2013 Discrete, highly skewed distributions with excess numbers of zeros often result in biased estimates and misleading inferences if the zeros are not properly addressed. A clinical example of children with electrophysiologic disorders in which many of the chi ... Full text Cite

The impact of socio-economic status on health related quality of life for children and adolescents with heart disease.

Journal article Health Qual Life Outcomes · June 18, 2013 BACKGROUND: Socioeconomic status (SES) is known to influence children's health-related quality of life. Many SES indicators assess distinct dimensions of a family's position rather than measuring the same underlying construct. Many researchers, however, se ... Full text Link to item Cite

Outcomes following extracorporeal membrane oxygenation in children with cardiac disease.

Journal article Pediatr Crit Care Med · June 2013 Extracorporeal membrane oxygenation is a commonly used form of mechanical circulatory support in children with congenital or acquired heart disease and cardiac failure refractory to conventional medical therapies. In children with heart disease who suffer ... Full text Link to item Cite

Utility of ambulatory monitoring in patients with congenital heart disease.

Journal article Am J Cardiol · March 1, 2013 Patients with congenital heart disease (CHD) are at increased risk of cardiac arrhythmias. The utility of ambulatory (Holter) monitoring in predicting these arrhythmias remains unclear. We sought to evaluate the clinical utility and cost effectiveness of H ... Full text Link to item Cite

Testing the pediatric cardiac quality of life inventory in the United kingdom.

Journal article Acta Paediatr · February 2013 AIM: To establish the validity and reliability of the Pediatric Cardiac Quality of Life Inventory (PCQLI) for children with heart disease in the United Kingdom. METHODS: Three paediatric cardiac centres recruited patients aged 8-18 years with heart disease ... Full text Link to item Cite

Resuscitation of the patient with the functionally univentricular heart.

Journal article Curr Pediatr Rev · 2013 Neonates and infants with functional single ventricle anatomy face nearly certain early mortality without cardiac transplantation or successive palliation through a pathway of staged interventions. Patients with single ventricle variants typically have mul ... Full text Link to item Cite

Resting energy expenditure at 3 months of age following neonatal surgery for congenital heart disease.

Journal article Congenit Heart Dis · 2013 OBJECTIVE: Infants with Congenital Heart Disease (CHD) often exhibit growth failure. This can affect anthropometric and neurodevelopmental outcomes well into childhood. To determine the resting energy expenditure (REE), body composition, and growth in infa ... Full text Link to item Cite

Impact of cardiac devices on the quality of life in pediatric patients.

Journal article Circ Arrhythm Electrophysiol · December 2012 BACKGROUND: Cardiac rhythm devices are increasingly used in the pediatric population, although their impact on quality of life (QOL) is poorly understood. The purpose of this study was to compare (QOL) scores among pediatric device patients, healthy contro ... Full text Link to item Cite

The effect of paediatric syncope on health-related quality of life.

Journal article Cardiol Young · October 2012 BACKGROUND: Syncope is common in children and adolescents and most commonly represents neurocardiogenic syncope. No information has been reported regarding the effect of syncope on health-related quality of life in children. METHODS: This was a retrospecti ... Full text Link to item Cite

Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association.

Journal article Circulation · August 28, 2012 BACKGROUND: The goal of this statement was to review the available literature on surveillance, screening, evaluation, and management strategies and put forward a scientific statement that would comprehensively review the literature and create recommendatio ... Full text Link to item Cite

Tetrasomy 15q25.2→qter identified with SNP microarray in a patient with multiple anomalies including complex cardiovascular malformation.

Journal article Am J Med Genet A · August 2012 We report on a male neonate with prenatally diagnosed mosaicism for a supernumerary marker chromosome and multiple congenital anomalies. Prenatal ultrasound imaging revealed a heart defect, pleural effusion, clubbed feet, and absent right kidney. Clinical ... Full text Link to item Cite

Intensive care and perioperative management of neonates with functionally univentricular hearts.

Journal article World J Pediatr Congenit Heart Surg · July 1, 2012 Although mortality rates for patients with univentricular hearts continue to fall, the course in the intensive care unit is remarkable for significant morbidity and utilization of significant resources. Preoperative patient management focuses on balancing ... Full text Link to item Cite

Impact of sildenafil on echocardiographic indices of myocardial performance after the Fontan operation.

Journal article Pediatr Cardiol · June 2012 The objective of this study was describe the impact of sildenafil on echocardiographic measures of myocardial performance in children and young adults with a functional single-ventricle physiology late after Fontan surgery. A double-blind, placebo-controll ... Full text Link to item Cite

RISK FACTORS ASSOCIATED WITH LOSS TO FOLLOW-UP IN YOUNG ADULTS WITH CONGENITAL HEART DISEASE

Conference Journal of the American College of Cardiology · March 2012 Full text Cite

Cyanosis

Book section · February 2, 2012 Cite

Chest pain

Book section · February 2, 2012 Cite

Schwartz's clinical handbook of pediatrics: Fifth edition

Book · February 2, 2012 Completely updated by expert authors from leading pediatric institutions, this pocket-sized handbook for medical students and residents covers the diagnosis and management of common problems found in children, focusing on symptoms, differential diagnosis, ... Cite

Cardiac rhythm devices in the pediatric population: utilization and complications.

Journal article Heart Rhythm · February 2012 BACKGROUND: Cardiac rhythm devices are important in the management of pediatric patients with rhythm abnormalities, although factors driving utilization are poorly understood. OBJECTIVE: This study sought to evaluate utilization trends, complication rates, ... Full text Link to item Cite

Linguistic validation of a disease-specific quality of life measure for children and teenagers with cardiac disease.

Journal article Cardiol Young · February 2012 INTRODUCTION: To anglicise an American--that is, English language--disease-specific health-related quality of life measure, using the Paediatric Cardiac Quality of Life Inventory, for children in the age group of 8-12 years and adolescents in the age group ... Full text Link to item Cite

Medical test results do not tell the whole story: health-related quality of life offers a patient perspective on outcomes.

Journal article World J Pediatr Congenit Heart Surg · October 1, 2011 Children born today with congenital heart disease (CHD) are likely to reach adulthood, even those with complex disease. As survival rates have increased, attention has focused on the longer-term morbidity associated with CHD and its treatment, but this has ... Full text Link to item Cite

Intrathoracic pressure regulation improves 24-hour survival in a pediatric porcine model of hemorrhagic shock.

Journal article Pediatr Res · September 2011 Hemorrhagic shock is a common cause of mortality and morbidity in the pediatric population. Intrathoracic pressure regulation (IPR) lowers intrathoracic pressure, thereby decreasing intracranial pressure and increasing venous return, cardiac output, and ce ... Full text Link to item Cite

Poor post-operative growth in infants with two-ventricle physiology.

Journal article Cardiol Young · August 2011 BACKGROUND: Adequate nutritional support is essential for normal infant growth and development. Infants with congenital cardiac disease are known to be at risk for growth failure. We sought to describe perioperative growth in infants undergoing surgical re ... Full text Link to item Cite

Low weight-for-age z-score and infection risk after the Fontan procedure.

Journal article Ann Thorac Surg · May 2011 BACKGROUND: Poor growth is common in infants with a single ventricle. Lower weight-for-age z-score (WAZ) is associated with worse short-term outcome after bidirectional Glenn procedure. We sought to assess growth status at the time of the Fontan procedure ... Full text Link to item Cite

Noninvasive risk stratification techniques in pediatric patients with ventricular preexcitation.

Journal article Pacing Clin Electrophysiol · May 2011 BACKGROUND: Individuals with ventricular preexcitation (VP) are known to have an increased risk of sudden death. This risk has been associated with conduction properties of the accessory pathway. METHODS: Patients with VP underwent risk stratification thro ... Full text Link to item Cite

Weight change in infants with a functionally univentricular heart: from surgical intervention to hospital discharge.

Journal article Cardiol Young · April 2011 OBJECTIVE: The purpose of this study was to assess the pattern of weight change from surgical intervention to home discharge and to determine predictors of poor growth in this population of infants with congenital cardiac disease. METHODS: Neonates with fu ... Full text Link to item Cite

SERUM BIOMARKERS CORRELATE WITH LOWER CARDIAC INDEX IN THE FONTAN POPULATION

Conference Journal of the American College of Cardiology · April 2011 Full text Cite

Impact of oral sildenafil on exercise performance in children and young adults after the fontan operation: a randomized, double-blind, placebo-controlled, crossover trial.

Journal article Circulation · March 22, 2011 BACKGROUND: Children and young adults with single-ventricle physiology have abnormal exercise capacity after the Fontan operation. A medication capable of decreasing pulmonary vascular resistance should allow improved cardiac filling and improved exercise ... Full text Link to item Cite

External validity of the pediatric cardiac quality of life inventory.

Journal article Qual Life Res · March 2011 PURPOSE: The Pediatric Cardiac Quality of Life Inventory (PCQLI) is a disease-specific, health-related quality of life (HRQOL) measure for pediatric heart disease (HD). The purpose of this study was to demonstrate the external validity of PCQLI scores. MET ... Full text Link to item Cite

One slide fits all: the versatility of slide tracheoplasty with cardiopulmonary bypass support for airway reconstruction in children.

Journal article J Thorac Cardiovasc Surg · January 2011 OBJECTIVES: This study describes results of tracheal reconstruction in children with slide tracheoplasty with cardiopulmonary bypass and identifies predictors for adverse outcomes. METHODS: Preoperative characteristics, operative variables, and outcome mea ... Full text Link to item Cite

Usefulness of left ventricular inflow index to predict successful biventricular repair in right-dominant unbalanced atrioventricular canal.

Journal article Am J Cardiol · January 2011 The outcome of biventricular (BV) repair for right-dominant unbalanced atrioventricular canal has remained poor, because it is difficult to predict left ventricular (LV) adequacy before surgery. Our aim was to determine whether preoperative echocardiograph ... Full text Link to item Cite

Clinical research careers: reports from a NHLBI pediatric heart network clinical research skills development conference.

Journal article Am Heart J · January 2011 BACKGROUND: Wyman W. Lai, MD, MPH, and Victoria L. Vetter, MD, MPH. The Pediatric Heart Network (PHN), funded under the U.S. National Institutes of Health-National Heart, Lung, and Blood Institute (NIH-NHLBI), includes two Clinical Research Skills Developm ... Full text Link to item Cite

Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the Pediatric Health Information Systems database.

Journal article Circulation · November 23, 2010 BACKGROUND: Children undergoing congenital heart surgery often receive corticosteroids with the aim of reducing the inflammatory response after cardiopulmonary bypass; however, the value of this approach is unclear. METHODS AND RESULTS: The Pediatric Healt ... Full text Link to item Cite

Linear lesion cryoablation for the treatment of atrioventricular nodal re-entry tachycardia in pediatrics and young adults.

Journal article Pacing Clin Electrophysiol · November 2010 BACKGROUND: Radiofrequency (RF) ablation is a relatively safe and effective method for treatment of atrioventricular nodal re-entry tachycardia (AVNRT), but carries a 1-2% risk of AV nodal injury. Cryothermal ablation reduces the risk of AV block, but has ... Full text Link to item Cite

Predictors of poor weight gain in infants with a single ventricle.

Journal article J Pediatr · September 2010 OBJECTIVE: To assess growth from the time of neonatal discharge to the time of performance of the bidirectional Glenn (BDG) procedure in infants with a single ventricle and determine predictors of poor growth. STUDY DESIGN: We performed a retrospective cas ... Full text Link to item Cite

Validation of the pediatric cardiac quality of life inventory.

Journal article Pediatrics · September 2010 OBJECTIVE: The purpose of this multicenter study was to confirm the validity and reliability of the Pediatric Cardiac Quality of Life Inventory (PCQLI). METHODS: Seven centers recruited pediatric patients (8-18 years of age) with heart disease (HD) and the ... Full text Link to item Cite

Evaluation of quality of life in children with heart disease

Journal article Progress in Pediatric Cardiology · August 1, 2010 Due to recent advances in pediatric cardiovascular therapy, mortality rates for children with heart disease (HD) have decreased dramatically. Despite these advances, however, survivors suffer from morbidity resulting from their circulatory abnormalities an ... Full text Cite

A fetus with hypertrophic cardiomyopathy, restrictive, and single-ventricle physiology, and a beta-myosin heavy chain mutation.

Journal article J Pediatr · July 2010 Cardiomyopathy is a significant clinical problem associated with sudden death. A molecular taxonomy is emerging that is refining the clinical classification system. We describe a patient with a pathogenic familial beta-myosin heavy chain mutation who was p ... Full text Link to item Cite

Tricuspid valve dysplasia with severe tricuspid regurgitation: fetal pulmonary artery size predicts lung viability in the presence of small lung volumes.

Journal article Fetal Diagn Ther · 2010 Congenital tricuspid valve disease (Ebstein's anomaly, tricuspid valve dysplasia) with severe tricuspid regurgitation and cardiomegaly is associated with poor prognosis. Fetal echocardiography can accurately measure right atrial enlargement, which is assoc ... Full text Link to item Cite

Following the arterial switch operation, obese children have risk factors for early cardiovascular disease.

Journal article Congenit Heart Dis · 2010 BACKGROUND: Children who have undergone the arterial switch operation (ASO) are at risk for premature coronary artery disease due to coronary re-implantation. Obesity may also pose cardiovascular risk. The purpose of this study was to evaluate comorbiditie ... Full text Link to item Cite

Adherence to treatment among children with cardiac disease.

Journal article Cardiol Young · December 2009 OBJECTIVE: Our purpose was to review the literature with respect to issues of adherence to treatment among children with congenital and acquired cardiac disease. MATERIALS AND METHODS: Databases used for this review included MEDLINE, Pub Med's Single Citat ... Full text Link to item Cite

Risk factors and comorbidities associated with obesity in children and adolescents after the arterial switch operation and Ross procedure.

Journal article Am Heart J · September 2009 BACKGROUND: Over 25% of patients with congenital heart disease are obese (OB) or overweight (OW). Unique factors such as activity restriction and early feeding practices may play a role. We evaluated a high-risk cohort predisposed to early coronary artery ... Full text Link to item Cite

Lower weight-for-age z score adversely affects hospital length of stay after the bidirectional Glenn procedure in 100 infants with a single ventricle.

Journal article J Thorac Cardiovasc Surg · August 2009 OBJECTIVE: Poor growth has been described in infants with a single ventricle; however, little is known regarding its effect on surgical outcomes. We sought to assess the effect of nutritional status at the time of the bidirectional Glenn procedure on short ... Full text Link to item Cite

Quality-of-life concerns differ among patients, parents, and medical providers in children and adolescents with congenital and acquired heart disease.

Journal article Pediatrics · April 2009 OBJECTIVES: Mortality rates in pediatric patients with heart disease have decreased dramatically in recent decades, resulting in an increasing number of survivors with morbidities that impact quality of life. The purpose of this study was to assess and com ... Full text Link to item Cite

Parachute mitral valve: morphologic descriptors, associated lesions, and outcomes after biventricular repair.

Journal article J Thorac Cardiovasc Surg · February 2009 OBJECTIVE: In "true" parachute mitral valve, mitral valve chordae insert into one papillary muscle. In parachute-like asymmetric mitral valve, most or all chordal attachments are to one papillary muscle. This study compared morphologic features, associated ... Full text Link to item Cite

Exercise performance and quality of life following surgical repair of anomalous aortic origin of a coronary artery in the pediatric population.

Journal article J Thorac Cardiovasc Surg · February 2009 OBJECTIVE: We sought to evaluate exercise performance and quality of life in children after surgical repair of anomalous aortic origin of a coronary artery with an interarterial course. METHODS: Patients who had surgery from October 2001 to January 2007 we ... Full text Link to item Cite

Off-label use of cardiovascular medications in children hospitalized with congenital and acquired heart disease.

Journal article Circ Cardiovasc Qual Outcomes · November 2008 BACKGROUND: Many barriers exist to conducting pediatric cardiovascular (CV) trials, and the majority of therapies used are not evidence based. Recent legislation has aimed to stimulate pediatric research and improve drug labeling. This study describes off- ... Full text Link to item Cite

Novel use of dexmedetomidine in a patient with pulmonary hypertension.

Journal article Paediatr Anaesth · August 2008 The presence of pulmonary arterial hypertension (PAH) is a significant predictor of major perioperative cardiovascular complications in patients undergoing cardiac diagnostic or interventional procedure or non cardiac surgery under sedation and/or anesthes ... Full text Link to item Cite

Risk factors for interstage death after stage 1 reconstruction of hypoplastic left heart syndrome and variants.

Journal article J Thorac Cardiovasc Surg · July 2008 OBJECTIVE: The risk of death during the interstage period remains high after stage 1 reconstruction for single ventricle lesions, despite improved surgical results. The purpose of this study is to identify risk factors for interstage death and to describe ... Full text Link to item Cite

Rhythm and conduction disturbances at midterm follow-up after the ross procedure in infants, children, and young adults.

Journal article Ann Thorac Surg · June 2008 BACKGROUND: To our knowledge, late electrophysiologic outcomes after the Ross procedure have not been described. The purpose of this study was to assess rhythm and conduction disturbances at midterm follow-up after the Ross procedure. METHODS: A cross-sect ... Full text Link to item Cite

The development of the pediatric cardiac quality of life inventory: a quality of life measure for children and adolescents with heart disease.

Journal article Qual Life Res · May 2008 OBJECTIVE: Mortality after surgery for congenital heart disease (CHD) has decreased. Quality of life (QOL) assessment in survivors has become increasingly important. The purpose of this project was to create the Pediatric Cardiac Quality of Life Inventory ... Full text Link to item Cite

Critical heart disease in the neonate: presentation and outcome at a tertiary care center.

Journal article Pediatr Crit Care Med · March 2008 OBJECTIVE: To define the modes of presentation, incidence of major organ dysfunction, predictors of hospital mortality, and adverse outcomes in neonates with critical heart disease admitted to a tertiary care center. DESIGN: Retrospective chart review. SET ... Full text Link to item Cite

Accuracy of intraoperative transesophageal echocardiography in the prediction of future neo-aortic valve function after the Ross procedure in children and young adults.

Journal article Congenit Heart Dis · 2008 OBJECTIVE: Neo-aortic insufficiency (neo-AI) has been noted following the Ross procedure. The purpose of this study was to evaluate the ability of intraoperative transesophageal echocardiography (TEE) to predict future neo-AI in pediatric patients undergoi ... Full text Link to item Cite

Postoperative course in the cardiac intensive care unit following the first stage of Norwood reconstruction.

Journal article Cardiol Young · December 2007 The medical records of all patients born between 1 September, 2000, and 31 August, 2002, and undergoing the first stage of Norwood reconstruction, were retrospectively reviewed for details of the perioperative course. We found 99 consecutive patients who m ... Full text Link to item Cite

Evaluation of myocardial ischemia after surgical repair of anomalous aortic origin of a coronary artery in a series of pediatric patients.

Journal article J Am Coll Cardiol · November 20, 2007 OBJECTIVES: We sought to prospectively evaluate evidence of myocardial ischemia after surgical repair of anomalous aortic origin of a coronary artery with an interarterial course (AAOCA). BACKGROUND: An AAOCA is a rare anomaly associated with increased myo ... Full text Link to item Cite

Obesity is a common comorbidity in children with congenital and acquired heart disease.

Journal article Pediatrics · November 2007 OBJECTIVES: Obesity may pose additional cardiovascular risk to children with acquired and congenital heart disease. Many children with heart disease are sedentary as a result of physician-, parent-, and/or self-imposed restrictions. The aim of this study w ... Full text Link to item Cite

Coronary artery pattern and age impact exercise performance late after the arterial switch operation.

Conference J Thorac Cardiovasc Surg · November 2007 OBJECTIVE: The impact of coronary artery pattern on exercise performance after the arterial switch operation is unknown. The purpose of this study was to evaluate the relationship between coronary artery pattern and exercise performance late after the arte ... Full text Link to item Cite

A contemporary comparison of the effect of shunt type in hypoplastic left heart syndrome on the hemodynamics and outcome at stage 2 reconstruction.

Journal article J Thorac Cardiovasc Surg · August 2007 OBJECTIVE: We compare the hemodynamics and perioperative course of shunt type in hypoplastic left heart syndrome at the time of stage 2 reconstruction and longer-term survival. METHODS: We retrospectively reviewed the echocardiograms, catheterizations, and ... Full text Link to item Cite

The relationship between neo-aortic root dilation, insufficiency, and reintervention following the Ross procedure in infants, children, and young adults.

Journal article J Am Coll Cardiol · May 1, 2007 OBJECTIVES: The purpose of this study was to describe the relationship between neo-aortic root size, neo-aortic insufficiency (AI), and reintervention at mid-term follow-up. BACKGROUND: Data on neo-aortic valve function and growth after the Ross procedure ... Full text Link to item Cite

Aortic morphometry and microcephaly in hypoplastic left heart syndrome.

Journal article Cardiol Young · April 2007 Microcephaly is a marker of abnormal fetal cerebral development, and a known risk factor for cognitive dysfunction. Patients with hypoplastic left heart syndrome have been found to have an increased incidence of abnormal neurodevelopmental outcomes. We hyp ... Full text Link to item Cite

Midterm outcomes and predictors of reintervention after the Ross procedure in infants, children, and young adults.

Conference J Thorac Cardiovasc Surg · April 2007 OBJECTIVES: This study assessed the type, time course, and risk factors for right and left ventricular outflow tract reinterventions after the Ross procedure in a population of infants, children, and young adults. METHODS: Patients who underwent the Ross p ... Full text Link to item Cite

Single-Ventricle Lesions

Book section · December 1, 2006 Full text Cite

Hypoplastic Left Heart Syndrome

Book section · December 1, 2006 Full text Cite

Neo-aortic valvar function after the arterial switch.

Journal article Cardiol Young · October 2006 OBJECTIVES: The purpose of our study was to assess the prevalence and progression, during childhood and adolescence, of dilation of the neo-aortic root, and neo-aortic valvar regurgitation, and to identify risk factors for such dilation and regurgitation, ... Full text Link to item Cite

Extracorporeal membrane oxygenation after stage I reconstruction for hypoplastic left heart syndrome.

Journal article Pediatr Crit Care Med · July 2006 OBJECTIVE: Although extracorporeal membrane oxygenation (ECMO) is an acceptable strategy for children with refractory cardiac dysfunction after cardiac surgery, its role after stage I reconstruction for hypoplastic left heart syndrome and its variants is c ... Full text Link to item Cite

Spontaneous gasping decreases intracranial pressure and improves cerebral perfusion in a pig model of ventricular fibrillation.

Journal article Resuscitation · May 2006 INTRODUCTION: Spontaneous gasping is associated with increased survival in animal models of cardiac arrest and in observational studies of humans. The potential beneficial effect of gasping on cerebral perfusion may underlie the observed survival benefit, ... Full text Link to item Cite

Rapid induction of cerebral hypothermia is enhanced with active compression-decompression plus inspiratory impedance threshold device cardiopulmonary resusitation in a porcine model of cardiac arrest.

Journal article J Am Coll Cardiol · February 21, 2006 OBJECTIVES: A rapid, ice-cold saline flush combined with active compression-decompression (ACD) plus an inspiratory impedance threshold device (ITD) cardiopulmonary resusitation (CPR) will cool brain tissue more effectively than with standard CPR (S-CPR) d ... Full text Link to item Cite

Exercise performance in children and adolescents after the Ross procedure.

Journal article Cardiol Young · February 2006 OBJECTIVES: The Ross procedure is increasingly utilized in the treatment of aortic valvar disease in children and adolescents. Our purpose was to compare pre- and post-operative exercise state in this population. METHODS: We included patients who underwent ... Full text Link to item Cite

Surgery for Congenital Heart Disease

Book section · January 1, 2006 Full text Cite

Surgery for Congenital Heart Disease

Book section · January 1, 2006 Full text Cite

Outcomes after the stage I reconstruction comparing the right ventricular to pulmonary artery conduit with the modified Blalock Taussig shunt.

Journal article Ann Thorac Surg · November 2005 BACKGROUND: Recent reports advocate that a right ventricular to pulmonary artery (RV-PA) conduit improves outcome after the stage I reconstruction. METHODS: We retrospectively compared the outcomes of all neonates who underwent a stage I reconstruction bet ... Full text Link to item Cite

Haemodynamic changes during modified ultrafiltration immediately following the first stage of the Norwood reconstruction.

Journal article Cardiol Young · February 2005 BACKGROUND: Modified ultrafiltration has been shown to reverse haemodilution and improve ventricular function following cardiopulmonary bypass. There has been concern, however, about the safety and efficacy of modified ultrafiltration after the first stage ... Full text Link to item Cite

Spontaneous breathing through an inspiratory impedance threshold device augments cardiac index and stroke volume index in a pediatric porcine model of hemorrhagic hypovolemia.

Journal article Crit Care Med · September 2004 BACKGROUND: Hemorrhagic shock secondary to trauma is associated with poor survival. The impedance threshold device (ITD) has been shown to improve blood pressure and survival rates in an adult porcine model of hemorrhagic hypovolemia. Pediatric hemodynamic ... Full text Link to item Cite

Neo-aortic root dilation and valve regurgitation up to 21 years after staged reconstruction for hypoplastic left heart syndrome.

Journal article J Am Coll Cardiol · August 6, 2003 OBJECTIVES: We sought to assess the prevalence and progression of neo-aortic root dilation and valvar regurgitation after staged reconstruction for hypoplastic left heart syndrome (HLHS). BACKGROUND: In HLHS, the pulmonary valve functions as the neo-aortic ... Full text Link to item Cite

Immediate outcomes after the Ross operation in children and adults

Journal article Progress in Pediatric Cardiology · January 1, 2003 The Ross procedure has been increasingly utilized to treat various forms of left ventricular outflow tract obstruction and aortic regurgitation. Compared with alternative valve replacement options (mechanical, porcine, homograft), benefits of the Ross proc ... Full text Cite

Outcomes after the Fontan procedure.

Journal article Curr Opin Pediatr · October 2002 Over the past two decades, advances in congenital heart surgery, pediatric cardiology, and intensive care medicine have dramatically increased the survival of infants with critical congenital heart disease. The group of patients that has perhaps benefited ... Full text Link to item Cite

Further delineation of cardiac abnormalities in Costello syndrome.

Journal article Am J Med Genet · August 1, 2002 We review the cardiac abnormalities in 94 patients (27 new, 67 literature) with Costello syndrome, an increasingly recognized syndrome consisting of increased birth weight, postnatal growth retardation, and distinctive facial, skin, and musculoskeletal fea ... Full text Link to item Cite

Diagnosis and management of the newborn with suspected congenital heart disease.

Journal article Clin Perinatol · March 2001 In critical congenital heart lesions, the ultimate outcome depends on timely and accurate diagnosis of the structural anomaly, the evaluation and resuscitation of secondary organ damage, effective lesion-specific preoperative management, and the appropriat ... Full text Link to item Cite

Early results of the Ross procedure in simple and complex left heart disease.

Journal article Circulation · November 9, 1999 BACKGROUND: The Ross procedure has been used increasingly to treat aortic valve disease in children and young adults. Benefits include the lack of anticoagulation after surgery and the potential growth and durability of the autograft. The purpose of this s ... Full text Link to item Cite