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Brenton D. Hoffman

Associate Professor in the Department of Biomedical Engineering
Biomedical Engineering

Featured Works


Dynamic molecular processes mediate cellular mechanotransduction

Journal article Nature · 2011 Featured Publication Cellular responses to mechanical forces are crucial in embryonic development and adult physiology, and are involved in numerous diseases, including atherosclerosis, hypertension, osteoporosis, muscular dystrophy, myopathies and cancer. These responses are ... Full text Cite

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

Journal article Nature · 2010 Featured Publication Mechanical forces are central to developmental, physiological and pathological processes1. However, limited understanding of force transmission within sub-cellular structures is a major obstacle to unravelling molecular mechanisms. Here we describe the dev ... Full text Cite

The consensus mechanics of cultured mammalian cells

Journal article Proceedings of the National Academy of Sciences of the United States of America · 2006 Featured Publication Although understanding cells' responses to mechanical stimuli is seen as increasingly important for understanding cell biology, how to best measure, interpret, and model cells' mechanical properties remains unclear. We determine the frequency-dependent she ... Full text Cite