Brian Chan

I work under the supervision of Professor Michael Rubinstein to model biological systems using a combination of polymer physics theory and computer simulations with a focus on 3D genome organization.

Education
Ph.D. Duke University, 2024
B.S.E. Duke University, 2018

Current Appointments & Affiliations

Postdoctoral Associate Biomedical Engineering, Pratt School of Engineering

In the News

Published August 20, 2024

How a Protein Complex Helps Organize and Compact DNA

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Recent Publications

Activity-driven chromatin organization during interphase: Compaction, segregation, and entanglement suppression.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · May 2024 In mammalian cells, the cohesin protein complex is believed to translocate along chromatin during interphase to form dynamic loops through a process called active loop extrusion. Chromosome conformation capture and imaging experiments have suggested that c ... Full text Cite

Theory of chromatin organization maintained by active loop extrusion.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · June 2023 The active loop extrusion hypothesis proposes that chromatin threads through the cohesin protein complex into progressively larger loops until reaching specific boundary elements. We build upon this hypothesis and develop an analytical theory for active lo ... Full text Cite

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