Brian Hawkins
Associate Research Professor in the Department of Electrical and Computer Engineering
Current Appointments & Affiliations
- Associate Research Professor in the Department of Electrical and Computer Engineering, Electrical and Computer Engineering, Pratt School of Engineering 2021
Contact Information
- Box 90059, Durham, NC 27708-0059
- Chesterfield Building, 701 W. Main St., Ste 400, Durham, NC 27701
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brian.hawkins@duke.edu
(919) 660-1359
- Background
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Education, Training, & Certifications
- Ph.D., University of Arizona 2004
- B.S., Georgia Institute of Technology 1999
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Previous Appointments & Affiliations
- Instructor, Temporary in Summer Academic Programs, Trinity College of Arts & Sciences, Duke University 2009
- Recognition
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In the News
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MAR 21, 2023 Duke Today -
SEP 24, 2020 Science News for Students -
FEB 20, 2020 North Carolina Health News -
FEB 17, 2020 -
NOV 23, 2018
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- Research
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Selected Grants
- iFAST Phase 2 awarded by Bill and Melinda Gates Foundation 2022 - 2024
- A compact, modular wastewater treatment system for non-potable re-use of household greywater Phase II awarded by Triangle Environmental 2023
- Zero-Waste (ZeWa) water and energy recovery system Phase II awarded by Triangle Environmental 2021 - 2023
- Smart Toilet with Artificial Intelligence for Remote Management of Inflammatory Bowel Disease awarded by Coprata LLC 2022 - 2023
- Electrodialytic Nutrient Recovery for traditional and advanced OWTS effluent polishing (EPA Phase II SBIR) awarded by Triangle Environmental 2021 - 2023
- G2RT Phase II awarded by Georgia Institute of Technology 2019 - 2022
- A compact, modular wastewater treatment system for non-potable re-use of household greywater awarded by Triangle Environmental 2021 - 2022
- Electrodialytic Nutrient Recovery from Household Wastewater awarded by Triangle Environmental 2020
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External Relationships
- Coprata Inc.
- Elefo Biotech
- The Chartered Institution of Water and Environmental Management (CIWEM)
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Hawkins, B. “Editorial.” Water and Environment Journal 37, no. 2 (May 1, 2023): 191. https://doi.org/10.1111/wej.12870.Full Text
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Vasquez, Mariana M., Kayana J. Tyson, Brian T. Hawkins, and Lena Trotochaud. “Integration of silicate minerals for ammonium and phosphate removal with an on-site wastewater treatment prototype.” Edited by Van-Huy Nguyen. Plos Water 1, no. 9 (September 19, 2022): e0000048–e0000048. https://doi.org/10.1371/journal.pwat.0000048.Full Text
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Gu, Yu-Huan, Brian T. Hawkins, Yoshikane Izawa, Yoji Yoshikawa, James A. Koziol, and Gregory J. Del Zoppo. “Intracerebral hemorrhage and thrombin-induced alterations in cerebral microvessel matrix.” Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 42, no. 9 (September 2022): 1732–47. https://doi.org/10.1177/0271678x221099092.Full Text
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Grego, Sonia, Claire M. Welling, Graham H. Miller, Peter F. Coggan, Katelyn L. Sellgren, Brian T. Hawkins, Geoffrey S. Ginsburg, Jose R. Ruiz, Deborah A. Fisher, and Brian R. Stoner. “A hands-free stool sampling system for monitoring intestinal health and disease.” Scientific Reports 12, no. 1 (June 2022): 10859. https://doi.org/10.1038/s41598-022-14803-9.Full Text
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Trotochaud, Lena, Rebecca M. Andrus, Kayana J. Tyson, Graham H. Miller, Claire M. Welling, Patrick E. Donaghy, Joseph D. Incardona, et al. “Laboratory Demonstration and Preliminary Techno-Economic Analysis of an Onsite Wastewater Treatment System.” Environmental Science & Technology 54, no. 24 (December 2020): 16147–55. https://doi.org/10.1021/acs.est.0c02755.Full Text
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Welling, Claire M., Siva Varigala, Srinivas Krishnaswamy, Antony Raj, Brendon Lynch, Jeffrey R. Piascik, Brian R. Stoner, et al. “Resolving the relative contributions of cistern and pour flushing to toilet water usage: Measurements from urban test sites in India.” The Science of the Total Environment 730 (August 2020): 138957. https://doi.org/10.1016/j.scitotenv.2020.138957.Full Text
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Welling, Claire M., Sarani Sasidaran, Prateek Kachoria, Sarah Hennessy, Brendon J. Lynch, Stephanie Teleski, Hitendra Chaudhari, et al. “Field testing of a household-scale onsite blackwater treatment system in Coimbatore, India.” The Science of the Total Environment 713 (April 2020): 136706. https://doi.org/10.1016/j.scitotenv.2020.136706.Full Text
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Sahondo, Tapuwa, Sarah Hennessy, Rebecca C. Sindall, Hitendra Chaudhari, Stephanie Teleski, Brendon J. Lynch, Katelyn L. Sellgren, Brian R. Stoner, Sonia Grego, and Brian T. Hawkins. “Field testing of a household-scale onsite blackwater treatment system in South Africa.” The Science of the Total Environment 703 (February 2020): 135469. https://doi.org/10.1016/j.scitotenv.2019.135469.Full Text
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Trotochaud, Lena, Brian Hawkins, and Brian Stoner. “Non-biological methods for phosphorus and nitrogen removal from wastewater: A gap analysis of reinvented-toilet technologies with respect to ISO 30500,” February 24, 2019. https://doi.org/10.12688/gatesopenres.12931.1.Full Text
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Hawkins, Brian T., Katelyn L. Sellgren, Enzo Cellini, Ethan J D Klem, Tess Rogers, Brendon J. Lynch, Jeffrey R. Piascik, and Brian R. Stoner. “Remediation of suspended solids and turbidity by improved settling tank design in a small-scale, free-standing toilet system using recycled blackwater.” Water and Environment Journal : The Journal 33, no. 1 (February 2019): 61–66. https://doi.org/10.1111/wej.12369.Full Text
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Trotochaud, L., B. T. Hawkins, and B. R. Stoner. “Non-biological methods for phosphorus and nitrogen removal from wastewater: A gap analysis of reinvented-toilet technologies with respect to ISO 30500.” Gates Open Research 3 (January 1, 2019). https://doi.org/10.12688/gatesopenres.12899.1.Full Text
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Trotochaud, Lena, Brian T. Hawkins, and Brian R. Stoner. “Non-biological methods for phosphorus and nitrogen removal from wastewater: A gap analysis of reinvented-toilet technologies with respect to ISO 30500.” Gates Open Research 3 (January 2019): 559. https://doi.org/10.12688/gatesopenres.12931.2.Full Text
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Hawkins, Brian, Tate Rogers, Christopher Davey, Mikayla Stoner, Ewan McAdam, and Brian Stoner. “Improving energy efficiency of electrochemical blackwater disinfection through sequential reduction of suspended solids and chemical oxygen demand,” 2019. https://doi.org/10.12688/gatesopenres.12873.2.Full Text
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Rogers, Tate W., Tess S. Rogers, Mikayla H. Stoner, Katelyn L. Sellgren, Brendon J. Lynch, Aaron A. Forbis-Stokes, Brian R. Stoner, and Brian T. Hawkins. “A granular activated carbon/electrochemical hybrid system for onsite treatment and reuse of blackwater.” Water Research 144 (November 2018): 553–60. https://doi.org/10.1016/j.watres.2018.07.070.Full Text
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Thostenson, J. O., R. Mourouvin, B. T. Hawkins, E. Ngaboyamahina, K. L. Sellgren, C. B. Parker, M. A. Deshusses, B. R. Stoner, and J. T. Glass. “Improved blackwater disinfection using potentiodynamic methods with oxidized boron-doped diamond electrodes.” Water Research 140 (September 2018): 191–99. https://doi.org/10.1016/j.watres.2018.04.022.Full Text
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Thostenson, James O., Rayane Mourouvin, Carlos Hangarter, Edgard Ngaboyamahina, Brian T. Hawkins, Katelyn L. Sellgren, Carolyn Rossman, et al. “Blackwater Disinfection Using Potentiodynamic Methods and Surface-Modified Electrochemical Packed Bed Electrode Materials.” Ecs Meeting Abstracts MA2018-01, no. 20 (April 13, 2018): 1308–1308. https://doi.org/10.1149/ma2018-01/20/1308.Full Text
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Izawa, Yoshikane, Yu-Huan Gu, Takashi Osada, Masato Kanazawa, Brian T. Hawkins, James A. Koziol, Thalia Papayannopoulou, Maria Spatz, and Gregory J. Del Zoppo. “β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.” Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 38, no. 4 (April 2018): 641–58. https://doi.org/10.1177/0271678x17722108.Full Text
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Koo, Youngmi, Brian T. Hawkins, and Yeoheung Yun. “Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening.” Scientific Reports 8, no. 1 (February 2018): 2841. https://doi.org/10.1038/s41598-018-20876-2.Full Text
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Hawkins, Brian T., Tate W. Rogers, Christopher J. Davey, Mikayla H. Stoner, Ewan J. McAdam, and Brian R. Stoner. “Improving energy efficiency of electrochemical blackwater disinfection through sequential reduction of suspended solids and chemical oxygen demand.” Gates Open Research 2 (January 2018): 50. https://doi.org/10.12688/gatesopenres.12873.2.Full Text
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Hawkins, Brian T., Katelyn L. Sellgren, Ethan J. D. Klem, Jeffrey R. Piascik, and Brian R. Stoner. “Electrochemical disinfection of repeatedly recycled blackwater in a free-standing, additive-free toilet.” Water and Environment Journal : The Journal 31, no. 4 (November 2017): 545–51. https://doi.org/10.1111/wej.12277.Full Text
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Thostenson, James O., Edgard Ngaboyamahina, Katelyn L. Sellgren, Brian T. Hawkins, Jeffrey R. Piascik, Ethan J. D. Klem, Charles B. Parker, Marc A. Deshusses, Brian R. Stoner, and Jeffrey T. Glass. “Enhanced H2O2 Production at Reductive Potentials from Oxidized Boron-Doped Ultrananocrystalline Diamond Electrodes.” Acs Applied Materials & Interfaces 9, no. 19 (May 2017): 16610–19. https://doi.org/10.1021/acsami.7b01614.Full Text
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Sellgren, Katelyn L., Brian T. Hawkins, and Sonia Grego. “An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model.” Biomicrofluidics 9, no. 6 (November 2015): 061102. https://doi.org/10.1063/1.4935594.Full Text
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Hawkins, Brian Thomas, Yu-Huan Gu, Yoshikane Izawa, and Gregory John del Zoppo. “Dabigatran abrogates brain endothelial cell permeability in response to thrombin.” Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 35, no. 6 (June 2015): 985–92. https://doi.org/10.1038/jcbfm.2015.9.Full Text
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Hawkins, Brian T., Sonia Grego, and Katelyn L. Sellgren. “Three-dimensional culture conditions differentially affect astrocyte modulation of brain endothelial barrier function in response to transforming growth factor β1.” Brain Research 1608 (May 2015): 167–76. https://doi.org/10.1016/j.brainres.2015.02.025.Full Text
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Zoppo, Gregory J. del, Yoshikane Izawa, and Brian T. Hawkins. “Hemostasis and alterations of the central nervous system.” Seminars in Thrombosis and Hemostasis 39, no. 8 (November 2013): 856–75. https://doi.org/10.1055/s-0033-1357490.Full Text
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Hawkins, Brian T., Yu-Huan Gu, Yoshikane Izawa, and Gregory J. Del Zoppo. “Disruption of dystroglycan-laminin interactions modulates water uptake by astrocytes.” Brain Research 1503 (March 2013): 89–96. https://doi.org/10.1016/j.brainres.2013.01.049.Full Text
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Cannon, Ronald E., John C. Peart, Brian T. Hawkins, Christopher R. Campos, and David S. Miller. “Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain.” Proceedings of the National Academy of Sciences of the United States of America 109, no. 39 (September 2012): 15930–35. https://doi.org/10.1073/pnas.1203534109.Full Text
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Osada, Takashi, Yu-Huan Gu, Masato Kanazawa, Yoshiaki Tsubota, Brian T. Hawkins, Maria Spatz, Richard Milner, and Gregory J. del Zoppo. “Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by β(1)-integrins.” Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 31, no. 10 (October 2011): 1972–85. https://doi.org/10.1038/jcbfm.2011.99.Full Text
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Wang, Xueqian, Brian T. Hawkins, and David S. Miller. “Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS.” Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 31, no. 6 (June 2011): 1371–75. https://doi.org/10.1038/jcbfm.2011.44.Full Text
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Wang, Xueqian, Brian T. Hawkins, and David S. Miller. “Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.” Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 25, no. 2 (February 2011): 644–52. https://doi.org/10.1096/fj.10-169227.Full Text
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Hawkins, Brian T., Robert R. Rigor, and David S. Miller. “Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay.” Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 30, no. 9 (September 2010): 1593–97. https://doi.org/10.1038/jcbfm.2010.117.Full Text
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Zoppo, Gregory J. del, and Brian T. Hawkins. “Throwing out the thromboemboli.” The New England Journal of Medicine 363, no. 13 (September 2010): 1282–84. https://doi.org/10.1056/nejmcibr1006572.Full Text
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Rigor, Robert R., Brian T. Hawkins, and David S. Miller. “Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.” Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 30, no. 7 (July 2010): 1373–83. https://doi.org/10.1038/jcbfm.2010.21.Full Text
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Hawkins, Brian T., Destiny B. Sykes, and David S. Miller. “Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 30, no. 4 (January 2010): 1417–25. https://doi.org/10.1523/jneurosci.5103-09.2010.Full Text
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Hawkins, Brian T., and Richard D. Egleton. “Pathophysiology of the blood-brain barrier: animal models and methods.” Current Topics in Developmental Biology 80 (January 2008): 277–309. https://doi.org/10.1016/s0070-2153(07)80007-x.Full Text
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Hom, Sharon, Melissa A. Fleegal, Richard D. Egleton, Christopher R. Campos, Brian T. Hawkins, and Thomas P. Davis. “Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats.” American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 292, no. 5 (May 2007): R1881–92. https://doi.org/10.1152/ajpregu.00761.2005.Full Text
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Hawkins, B. T., T. F. Lundeen, K. M. Norwood, H. L. Brooks, and R. D. Egleton. “Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases.” Diabetologia 50, no. 1 (January 2007): 202–11. https://doi.org/10.1007/s00125-006-0485-z.Full Text
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Hawkins, Brian T., Scott M. Ocheltree, Kristi M. Norwood, and Richard D. Egleton. “Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats.” Neuroscience Letters 411, no. 1 (January 2007): 1–5. https://doi.org/10.1016/j.neulet.2006.09.010.Full Text
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Hawkins, Brian T., and Richard D. Egleton. “Fluorescence imaging of blood-brain barrier disruption.” Journal of Neuroscience Methods 151, no. 2 (March 2006): 262–67. https://doi.org/10.1016/j.jneumeth.2005.08.006.Full Text
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Brooks, Tracy A., Brian T. Hawkins, Jason D. Huber, Richard D. Egleton, and Thomas P. Davis. “Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations.” American Journal of Physiology. Heart and Circulatory Physiology 289, no. 2 (August 2005): H738–43. https://doi.org/10.1152/ajpheart.01288.2004.Full Text
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Hawkins, Brian T., Richard D. Egleton, and Thomas P. Davis. “Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors.” American Journal of Physiology. Heart and Circulatory Physiology 289, no. 1 (July 2005): H212–19. https://doi.org/10.1152/ajpheart.01210.2004.Full Text
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Hawkins, Brian T., and Thomas P. Davis. “The blood-brain barrier/neurovascular unit in health and disease.” Pharmacological Reviews 57, no. 2 (June 2005): 173–85. https://doi.org/10.1124/pr.57.2.4.Full Text
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Hawkins, Brian T., Thomas J. Abbruscato, Richard D. Egleton, Rachel C. Brown, Jason D. Huber, Christopher R. Campos, and Thomas P. Davis. “Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution.” Brain Research 1027, no. 1–2 (November 2004): 48–58. https://doi.org/10.1016/j.brainres.2004.08.043.Full Text
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Abbruscato, Thomas J., Steve P. Lopez, Karen S. Mark, Brian T. Hawkins, and Thomas P. Davis. “Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells.” Journal of Pharmaceutical Sciences 91, no. 12 (December 2002): 2525–38. https://doi.org/10.1002/jps.10256.Full Text
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Hawkins, Brian T., Rachel C. Brown, and Thomas P. Davis. “Smoking and ischemic stroke: a role for nicotine?” Trends in Pharmacological Sciences 23, no. 2 (February 2002): 78–82. https://doi.org/10.1016/s0165-6147(02)01893-x.Full Text
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Book Sections
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Hawkins, B. T. “Hitting a moving target: Therapeutic delivery in the injured brain.” In Advances in Non-Invasive Drug Delivery to the Brain, 22–31, 2015. https://doi.org/10.4155/9781909453937.FSEB2013.13.47.Full Text
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Miller, D. S., and B. T. Hawkins. “Blood-Brain Barrier: Considerations in Drug Development and Delivery.” In Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease, 133–46, 2012. https://doi.org/10.1002/9781118435762.ch8.Full Text
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Del Zoppo, G. J., Y. Izawa, and B. T. Hawkins. “The neurovascular unit and possible influences on cerebral small vessel disease.” In Cerebral Small Vessel Disease, 99–115, 2011. https://doi.org/10.1017/CBO9781139382694.011.Full Text
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Conference Papers
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Grego, Sonia, Edward R. Dougherty, Francis J. Alexander, Scott S. Auerbach, Brian R. Berridge, Michael L. Bittner, Warren Casey, et al. “Systems biology for organotypic cell cultures.” In Altex, 34:301–10, 2017. https://doi.org/10.14573/altex.1608221.Full Text
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Rogers, T., B. Stoner, M. Elledge, J. Piascik, E. Klem, D. Stokes, J. Mizia, B. Hawkins, K. Sellgren, and L. Morrison. “Development and field testing of a decentralized, self-contained toilet that converts human waste into burnable fuel and disinfected, reusable liquid.” In Weftec 2016 89th Water Environment Federation Annual Technical Exhibition and Conference, 2:4466–76, 2016. https://doi.org/10.2175/193864716819706590.Full Text
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