Brian Joseph Soher

Journal article Magn Reson Med · May 2012 Featured Publication Robust spectral analysis of magnetic resonance spectroscopy data frequently uses a spectral model with prior metabolite signal information within a nonlinear least squares optimization algorithm. Starting values for the spectral model greatly influence the ... Full text Link to item Cite

Comprehensive analysis of the Cramer-Rao bounds for magnetic resonance temperature change measurement in fat-water voxels using multi-echo imaging.

Journal article MAGMA · February 2012 Featured Publication OBJECT: The aim of this paper is to characterize the noise propagation for MRI temperature change measurement with emphasis on finding the best echo time combinations that yield the lowest temperature noise. MATERIALS AND METHODS: A Cramer-Rao lower-bound ... Full text Link to item Cite

Correction of breathing-induced errors in magnetic resonance thermometry of hyperthermia using multiecho field fitting techniques.

Journal article Med Phys · December 2010 Featured Publication PURPOSE: Breathing motion can create large errors when performing magnetic resonance (MR) thermometry of the breast. Breath holds can be used to minimize these errors, but not eliminate them. Between breath holds, the referenceless method can be used to fu ... Full text Link to item Cite

Bayesian k -space-time reconstruction of MR spectroscopic imaging for enhanced resolution.

Journal article IEEE Trans Med Imaging · July 2010 Featured Publication A k-space-time Bayesian statistical reconstruction method (K-Bayes) is proposed for the reconstruction of metabolite images of the brain from proton (1H) magnetic resonance (MR) spectroscopic imaging (MRSI) data. K-Bayes performs full spectral fitting of t ... Full text Link to item Cite

Noninvasive temperature mapping with MRI using chemical shift water-fat separation.

Journal article Magn Reson Med · May 2010 Featured Publication Tissues containing both water and lipids, e.g., breast, confound standard MR proton reference frequency-shift methods for mapping temperatures due to the lack of temperature-induced frequency shift in lipid protons. Generalized Dixon chemical shift-based w ... Full text Link to item Cite

(1)H MRS detection of glycine residue of reduced glutathione in vivo.

Journal article J Magn Reson · February 2010 Featured Publication Glutathione (GSH) is a powerful antioxidant found inside different kinds of cells, including those of the central nervous system. Detection of GSH in the human brain using (1)H MR spectroscopy is hindered by low concentration and spectral overlap with othe ... Full text Link to item Cite

Characterization of adrenal lesions: comparison of 2D and 3D dual gradient-echo MR imaging at 3 T--preliminary results.

Journal article Radiology · January 2010 Featured Publication PURPOSE: To retrospectively compare a two-dimensional (2D) and a three-dimensional (3D) technique for in-phase (IP) and opposed-phase (OP) single-breath-hold 3-T magnetic resonance (MR) imaging in the characterization of adrenal lesions, with histopatholog ... Full text Link to item Cite

Hyperthermia MRI temperature measurement: evaluation of measurement stabilisation strategies for extremity and breast tumours.

Journal article Int J Hyperthermia · 2009 Featured Publication PURPOSE: MR thermometry using the proton resonance frequency shift (PRFS) method has been used to measure temperature changes during clinical hyperthermia treatment. However, frequency drift of the MRI system can add large errors to the measured temperatur ... Full text Link to item Cite

Effect of echo time pair selection on quantitative analysis for adrenal tumor characterization with in-phase and opposed-phase MR imaging: initial experience.

Journal article Radiology · July 2008 Featured Publication PURPOSE: To determine the effect of two pairs of echo times (TEs) for in-phase (IP) and opposed-phase (OP) 3.0-T magnetic resonance (MR) imaging on (a) quantitative analysis prospectively in a phantom study and (b) diagnostic accuracy retrospectively in a ... Full text Link to item Cite

GAVA: spectral simulation for in vivo MRS applications.

Journal article J Magn Reson · April 2007 Featured Publication An application that provides a flexible and easy to use interface to the GAMMA spectral simulation package is described that is targeted at investigations using in vivo MR spectroscopic methods. The program makes available a number of widely used spatially ... Full text Link to item Cite

Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging.

Journal article NMR Biomed · June 2006 Featured Publication Image reconstruction for magnetic resonance spectroscopic imaging (MRSI) requires specialized spatial and spectral data processing methods and benefits from the use of several sources of prior information that are not commonly available, including MRI-deri ... Full text Link to item Cite

Robust analysis of short echo time (1)H MRSI of human brain.

Journal article Magn Reson Med · March 2006 Featured Publication Short echo time proton MR Spectroscopic Imaging (MRSI) suffers from low signal-to-noise ratio (SNR), limiting accuracy to estimate metabolite intensities. A method to coherently sum spectra in a region of interest of the human brain by appropriate peak ali ... Full text Link to item Cite

Observation of coupled 1H metabolite resonances at long TE.

Journal article Magn Reson Med · June 2005 Featured Publication A PRESS localization (1)H MRS acquisition sequence with a Carr-Purcell train of refocusing pulses (CP-PRESS) has been implemented using global refocusing "sandwich" pulses. The CP pulse train minimized the effects of J-coupled dephasing in metabolites with ... Full text Link to item Cite

Numerical simulation of PRESS localized MR spectroscopy.

Journal article J Magn Reson · March 2005 Featured Publication Numerical simulations of NMR spectra can provide a rapid and convenient method for optimizing acquisition sequence parameters and generating prior spectral information required for parametric spectral analysis. For spatially resolved spectroscopy, spatiall ... Full text Link to item Cite

Magnetic resonance spectroscopic imaging reconstruction with deformable shape-intensity models.

Journal article Magn Reson Med · September 2003 Featured Publication A new method, based on a deformable shape-intensity model (DSM), was developed to improve the signal-to-noise ratio (SNR) of multidimensional magnetic resonance spectroscopic imaging (MRSI) data sets without affecting spectral lineshapes and linewidths. Im ... Full text Link to item Cite

Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis.

Journal article Magn Reson Imaging · November 2000 Featured Publication Spectral analysis of short TE in vivo proton magnetic resonance spectroscopic imaging (MRSI) data are complicated by the presence of spectral overlap, low signal to noise and uncharacterized signal contributions. In this study, it is shown that an automate ... Full text Link to item Cite

Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging.

Journal article Magn Reson Med · December 1998 Featured Publication An automated method for analysis of in vivo proton magnetic resonance (MR) spectra and reconstruction of metabolite distributions from MR spectroscopic imaging (MRSI) data is described. A parametric spectral model using acquisition specific, a priori infor ... Full text Link to item Cite

Automated spectral analysis II: application of wavelet shrinkage for characterization of non-parameterized signals.

Journal article Magn Reson Med · December 1998 Featured Publication An iterative method for differentiating between known resonances and uncharacterized baseline contributions in MR spectra is described. The method alternates parametric modeling, using a priori knowledge of spectral parameters, with non-parametric characte ... Full text Link to item Cite

Automated spectral analysis I: formation of a priori information by spectral simulation.

Journal article Magn Reson Med · December 1998 Featured Publication A spectral simulation method is described for generating a priori information for use in parametric spectral analysis. The method makes use of GAMMA (S. A. Smith, T. O. Levante, B. H. Meier, R. R. Ernst, J. Magn. Reson., 106A, 75-105, 1994), a programming ... Full text Link to item Cite

Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference.

Journal article Magn Reson Med · September 1996 Featured Publication Data from a previously published, multi-site trial (P.G. Webb, N. Sailasuta, S.J. Kohler, T. Raidy, R.A. Moats, R.E. Hurd. Automated single-voxel proton MRS: technical development and multisite verification. Magn. Reson. Med. 31, 365-373 (1994)) of a fully ... Full text Link to item Cite

Quantitative proton MR spectroscopic imaging of the human brain.

Journal article Magn Reson Med · March 1996 Featured Publication Multislice proton MR spectroscopic images (SI) of the brain were quantitated, using the phantom replacement technique. In 16 normal volunteers, ranging in age from 5 to 74 years, average "whole brain" concentrations of choline (Cho), creatine (Cr), and N-a ... Full text Link to item Cite