Scholars@Duke
Brigid L. M. Hogan

Brigid L. M. Hogan

Research Professor of Cell Biology
Cell Biology
brigid.hogan@duke.edu
Duke Box 3709, Durham, NC 27710
445 Sands Bldg, 303 Research Drive, Durham, NC 27710

Featured Works

Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse.

Journal article Development · October 2002 Featured Publication In the mouse and chick embryo, the node plays a central role in generating left-right (LR) positional information. Using several different strategies, we provide evidence in the mouse that bone morphogenetic protein 4 (Bmp4) is required independently in tw ... Full text Link to item Cite

Organogenesis: molecular mechanisms of tubulogenesis.

Journal article Nat Rev Genet · July 2002 Featured Publication As organisms have evolved in size and complexity, tubular systems have developed to enable the efficient transport of substances into and out of tissues. These tubular systems are generated using strategies that are based on common elements of cell behavio ... Full text Link to item Cite

The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.

Journal article Genes Dev · September 15, 2001 Featured Publication The murine Foxc1/Mf1 and Foxc2/Mfh1 genes encode closely related forkhead/winged helix transcription factors with overlapping expression in the forming somites and head mesoderm and endothelial and mesenchymal cells of the developing heart and blood vessel ... Full text Link to item Cite

Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.

Journal article Development · June 2000 Featured Publication Morphogenesis of the mouse lung involves reciprocal interactions between the epithelial endoderm and the surrounding mesenchyme, leading to an invariant early pattern of branching that forms the basis of the respiratory tree. There is evidence that Fibrobl ... Full text Link to item Cite

Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development.

Journal article Development · September 1999 Featured Publication In the mature mouse lung, the proximal-distal (P-D) axis is delineated by two distinct epithelial subpopulations: the proximal bronchiolar epithelium and the distal respiratory epithelium. Little is known about the signaling molecules that pattern the lung ... Full text Link to item Cite

Bmp4 is required for the generation of primordial germ cells in the mouse embryo.

Journal article Genes Dev · February 15, 1999 Featured Publication In many organisms the allocation of primordial germ cells (PGCs) is determined by the inheritance of maternal factors deposited in the egg. However, in mammals, inductive cell interactions are required around gastrulation to establish the germ line. Here, ... Full text Link to item Cite

Morphogenesis.

Journal article Cell · January 22, 1999 Featured Publication Full text Link to item Cite

BMP4 is essential for lens induction in the mouse embryo.

Journal article Genes Dev · December 1, 1998 Featured Publication Vertebrate lens development is a classical model system for studying embryonic tissue interactions. Little is known, however, about the molecules mediating such inductive events. Here, we show that Bmp4, which is expressed strongly in the optic vesicle and ... Full text Link to item Cite