Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., The University of Chicago 2012
• Research
• 

  Selected Grants

  • Control of virus induced type I interferon signaling during pregnancy awarded by National Institutes of Health 2022 - 2027
  • CIVICS Component A - Option 3 awarded by National Institutes of Health 2019 - 2023
  • Rapidly Emerging Antiviral Drug Development Initiative-RTI awarded by University of North Carolina - Chapel Hill 2022 - 2023
  • DNA damage repair and the pathogenic effects of club cells surviving direct influenza virus infection awarded by National Institutes of Health 2019 - 2023
  • The effects of cells that survive direct influenza A virus infection on lung repair awarded by National Institutes of Health 2017 - 2019
  • Effect of m6A editing of RNA on influenza A virus replication awarded by National Institutes of Health 2017 - 2018
  • Survival of influenza A virus infected cells and effects on pathogenesis awarded by National Institutes of Health 2015 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yaron, Tomer M., Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, et al. “Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.” Sci Signal 15, no. 757 (October 25, 2022): eabm0808. https://doi.org/10.1126/scisignal.abm0808.
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    • Wang, Zhaohui, Matteo Boretto, Rosemary Millen, Naveen Natesh, Elena S. Reckzeh, Carolyn Hsu, Marcos Negrete, et al. “Rapid tissue prototyping with micro-organospheres.” Stem Cell Reports 17, no. 9 (September 13, 2022): 1959–75. https://doi.org/10.1016/j.stemcr.2022.07.016.
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    • Chaparian, Ryan R., Alfred T. Harding, Cait E. Hamele, Kristina Riebe, Amelia Karlsson, Gregory D. Sempowski, Nicholas S. Heaton, and Brook E. Heaton. “A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice.” J Virol 96, no. 15 (August 10, 2022): e0068922. https://doi.org/10.1128/jvi.00689-22.
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    • Trimarco, Joseph D., Brook E. Heaton, Ryan R. Chaparian, Kaitlyn N. Burke, Raquel A. Binder, Gregory C. Gray, Clare M. Smith, Vineet D. Menachery, and Nicholas S. Heaton. “TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.” Plos Pathog 17, no. 5 (May 2021): e1009599. https://doi.org/10.1371/journal.ppat.1009599.
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    • Luo, Zhaochen, Alanson W. Girton, Brook E. Heaton, and Nicholas S. Heaton. “Engineered influenza virions reveal the contributions of non-hemagglutinin structural proteins to vaccine mediated protection.” J Virol 95, no. 10 (April 26, 2021). https://doi.org/10.1128/JVI.02021-20.
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    • Katsura, Hiroaki, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Caitlin E. Edwards, Brook E. Heaton, Arvind Konkimalla, et al. “Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.” Cell Stem Cell 27, no. 6 (December 3, 2020): 890-904.e8. https://doi.org/10.1016/j.stem.2020.10.005.
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    • Froggatt, Heather M., Brook E. Heaton, and Nicholas S. Heaton. “Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CLpro Reporter Assay.” J Virol 94, no. 22 (October 27, 2020). https://doi.org/10.1128/JVI.01265-20.
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    • Chambers, Benjamin S., Brook E. Heaton, Keiko Rausch, Rebekah E. Dumm, Jennifer R. Hamilton, Sara Cherry, and Nicholas S. Heaton. “DNA mismatch repair is required for the host innate response and controls cellular fate after influenza virus infection.” Nat Microbiol 4, no. 11 (November 2019): 1964–77. https://doi.org/10.1038/s41564-019-0509-3.
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    • Wipperman, Matthew F., Brook E. Heaton, Astha Nautiyal, Oyindamola Adefisayo, Henry Evans, Richa Gupta, Dave van Ditmarsch, et al. “Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease.” Mol Cell 72, no. 1 (October 4, 2018): 152-161.e7. https://doi.org/10.1016/j.molcel.2018.07.037.
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    • Heaton, Brook E., Edward M. Kennedy, Rebekah E. Dumm, Alfred T. Harding, Matthew T. Sacco, David Sachs, and Nicholas S. Heaton. “A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor.” Cell Rep 20, no. 7 (August 15, 2017): 1503–12. https://doi.org/10.1016/j.celrep.2017.07.060.
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    • Harding, Alfred T., Brook E. Heaton, Rebekah E. Dumm, and Nicholas S. Heaton. “Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs.” Mbio 8, no. 3 (June 6, 2017). https://doi.org/10.1128/mBio.00669-17.
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    • Heaton, Brook E., Daniel Barkan, Paola Bongiorno, Petros C. Karakousis, and Michael S. Glickman. “Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection.” Infect Immun 82, no. 8 (August 2014): 3177–85. https://doi.org/10.1128/IAI.01540-14.
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    • Heaton, Brook E., Julien Herrou, Anne E. Blackwell, Vicki H. Wysocki, and Sean Crosson. “Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus.” J Biol Chem 287, no. 15 (April 6, 2012): 12098–110. https://doi.org/10.1074/jbc.M111.332163.
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