Bryan R. Cullen
James B. Duke Distinguished Professor of Molecular Genetics and Microbiology
My laboratory has for sometime been interested in understanding the molecular biology of the replication cycle of the pathogenic retrovirus HIV-1. Because HIV-1 gene expression is primarily regulated by specific RNA:protein interactions, my laboratory has also become interested in the more general area of RNA sequence mediated gene regulation, including nuclear mRNA export and the phenomenon of RNA interference.
In the past, my laboratory has worked extensively on Tat, the transcriptional regulator encoded by HIV-1, and on Rev, a virally encoded nuclear mRNA export factor. Our major focus at present is a third HIV-1 regulatory protein termed Vif. In the absence of Vif, HIV-1 virions are produced normally but are largely non-infectious. It has now been demonstrated that Vif functions to block an innate human antiretroviral defense pathway that relies on a factor called APOBEC3G or CEM15. In the absence of Vif, APOBEC3G is packaged into virions and induces degradation of the HIV-1 genome during reverse transcription in target cells. Vif directly interacts with APOBEC3G and thereby allows reverse transcription to proceed unimpeded. Among other issues, we are currently interested in how APOBEC3G is packaged into virions and in how Vif blocks APOBEC3G function. The role of APOBEC3G in cellular defense against other retroviruses and retrotransposons is also an area of interest.
A second major research area in my group relates to how microRNA precursors are processed to yield mature microRNAs and how microRNAs, and the closely related small interfering RNAs, function in human cells. We were the first group to demonstrate overexpression of human microRNAs and therefore have a system in place which should allow us to make rapid progress in this area. We also remain interested in using RNA interference to determine the role of specific cellular factors in different processes, including HIV-1 replication and nuclear mRNA export.
In the past, my laboratory has worked extensively on Tat, the transcriptional regulator encoded by HIV-1, and on Rev, a virally encoded nuclear mRNA export factor. Our major focus at present is a third HIV-1 regulatory protein termed Vif. In the absence of Vif, HIV-1 virions are produced normally but are largely non-infectious. It has now been demonstrated that Vif functions to block an innate human antiretroviral defense pathway that relies on a factor called APOBEC3G or CEM15. In the absence of Vif, APOBEC3G is packaged into virions and induces degradation of the HIV-1 genome during reverse transcription in target cells. Vif directly interacts with APOBEC3G and thereby allows reverse transcription to proceed unimpeded. Among other issues, we are currently interested in how APOBEC3G is packaged into virions and in how Vif blocks APOBEC3G function. The role of APOBEC3G in cellular defense against other retroviruses and retrotransposons is also an area of interest.
A second major research area in my group relates to how microRNA precursors are processed to yield mature microRNAs and how microRNAs, and the closely related small interfering RNAs, function in human cells. We were the first group to demonstrate overexpression of human microRNAs and therefore have a system in place which should allow us to make rapid progress in this area. We also remain interested in using RNA interference to determine the role of specific cellular factors in different processes, including HIV-1 replication and nuclear mRNA export.
Current Appointments & Affiliations
- James B. Duke Distinguished Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2000
- Director, Center for Virology, Molecular Genetics and Microbiology, Basic Science Departments 2002
- Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1994
- Professor in Medicine, Medicine, Rheumatology and Immunology, Medicine 2020
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1987
Contact Information
- 367 CARL, Duke Box 3025, Durham, NC 27710
- 367CLIN & Res Labs, Box 3025, Durham, NC 27710
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bryan.cullen@duke.edu
(919) 684-3369
- Background
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Education, Training, & Certifications
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Previous Appointments & Affiliations
- Professor in Medicine, Medicine, Rheumatology and Immunology, Medicine 2006 - 2020
- Research Professor in Medicine, Medicine, Rheumatology and Immunology, Medicine 2002 - 2006
- Associate Research Professor in Medicine, Medicine, Rheumatology and Immunology, Medicine 1999 - 2002
- Professor of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1995 - 2002
- Associate Research Professor in Medicine, Medicine, Clinical Science Departments 1994 - 1999
- Associate Professor of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1994 - 1995
- Associate Professor of Genetics, School of Medicine, Duke University 1993 - 1994
- Associate Professor of Genetics, School of Medicine, Duke University 1991 - 1992
- Associate Professor of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1990 - 1991
- Assistant Medical Research Professor in Medicine, Medicine, Clinical Science Departments 1987 - 1989
- Recognition
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In the News
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NOV 15, 2022 Duke Health News -
NOV 19, 2019 -
NOV 27, 2018 -
OCT 29, 2015 Mashable -
OCT 29, 2015 Mashable -
AUG 8, 2014 -
AUG 8, 2014 Duke Today
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Awards & Honors
- Expertise
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Global Scholarship
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Teaching
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- Research
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Selected Grants
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2025
- Viral Oncology Training Grant awarded by National Institutes of Health 1980 - 2024
- Epitranscriptomic modification of HIV-1 transcripts: Effects of drugs of abuse awarded by National Institutes of Health 2018 - 2023
- Reversal of epigenetic silencing rescues integrase-deficient HIV-1 replication awarded by National Institutes of Health 2021 - 2023
- The Center for HIV/AIDS-Related Structural Biology awarded by University of Michigan 2018 - 2022
- Targeting an inactive conformation of HIV-1 TAR awarded by National Institutes of Health 2020 - 2022
- Investigating Autophagy in GSD-Ia awarded by National Institutes of Health 2020 - 2021
- Use of 3' UTRs to increase mAb titer production awarded by Life Technologies 2020 - 2021
- Disruption of latent HIV-1 proviruses using CRISPR/Cas endonucleases awarded by National Institutes of Health 2015 - 2021
- Investigating Autophagy in GSD-Ia awarded by National Institutes of Health 2015 - 2020
- Effect of m6A editing of RNA on influenza A virus replication awarded by National Institutes of Health 2017 - 2018
- Effect of m6A methylation of HIV-1 transcripts on viral replication awarded by National Institutes of Health 2017 - 2018
- Using bacterial CRISPR/Cas endonucleases to selectively eliminate HPV-transformed cells in vivo awarded by National Institutes of Health 2015 - 2017
- Role and mechanism of action of gamma herpesvirus microRNAs awarded by National Institutes of Health 2006 - 2017
- The Center for HIV RNA Studies; HIV-1: microRNA interactions awarded by Center for HIV RNA Studies 2015 - 2017
- Vector-delivered CRISPR/Cas as a cure for HSV-1-induced keratitis awarded by Editas Medicine Inc. 2015 - 2016
- Development and Validation of Novel Therapeutic Targets in Anal Cancer awarded by The Farrah Fawcett Foundation 2015 - 2016
- Regulation of lytic and latent infection by HSV-1 encoded miRNAs awarded by University of Florida 2012 - 2016
- Reconstitution of a protective antiviral RNAi response in somatic human cells awarded by National Institutes of Health 2014 - 2016
- Elimination of chronic hepatitis B virus by targeted endonuclease-mediated destruction of intracellular viral cccDNA awarded by F. Hoffmann-La Roche Ltd 2013 - 2015
- Illumina Hi-Seq 2000 Sequencing System awarded by National Institutes of Health 2012 - 2013
- Influenza virus small RNAs awarded by National Institutes of Health 2010 - 2013
- Function of alpha herpesvirus microRNAs awarded by National Institutes of Health 2010 - 2011
- Targets and functions of the Kaposi's Sarcoma associated herpesvirus microRNAs awarded by National Institutes of Health 2009 - 2011
- Effect of APOBEC3G on retroviruses and retrotransposons awarded by National Institutes of Health 2005 - 2011
- Regulation and function of EC-SOD awarded by National Institutes of Health 2000 - 2010
- Cis-acting sequences and trans-acting factors regulating human microRNA biosynthesis and activity awarded by National Institutes of Health 2004 - 2009
- Molecular Mechanism of HIV-1 Vif Function awarded by National Institutes of Health 2004 - 2008
- TM-SU Interaction in the Native HIV/SIV Env awarded by National Institutes of Health 2001 - 2008
- NCRR FACSAria Cell Sorter awarded by National Center for Research Resources 2004 - 2006
- Same awarded by National Institutes of Health 1998 - 2003
- Aids Research awarded by National Institutes of Health 1989 - 2002
- Duke University Center For Aids Research awarded by National Institutes of Health 1994 - 1999
- Biological Role And Mechanism Of Action Of Nef awarded by National Institutes of Health 1994 - 1999
- Biological Roles And Mechanism Of Action Of Nef awarded by National Institutes of Health 1995 - 1998
- Preclinical Development Of Rna Decoys awarded by National Institutes of Health 1994 - 1998
- Display Memory Mutant Repressors Of Hiv Replication awarded by National Institutes of Health 1990 - 1995
- Trans-Dominant Mutant Repressors Of Hiv-1 Replication awarded by National Institutes of Health 1990 - 1995
- Mechanism Of Action Of The Hiv-1 Rev Gene Product awarded by National Institutes of Health 1993 - 1994
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External Relationships
- Bartlit Beck
- Dow Agrosciences
- Jones Day
- Kramer, Levin Naftalis and Frankel LLP
- Monsanto
- OpenBiosystems/Horizon Discovery Group
- Pioneer Hi-Bred
- Robbins, Geller, Rudman and Dowd LLP
- Publications & Artistic Works
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Selected Publications
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Books
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Academic Articles
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Irwan, Ishak D., Hal P. Bogerd, and Bryan R. Cullen. “Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency.” Nat Microbiol 7, no. 12 (December 2022): 2101–13. https://doi.org/10.1038/s41564-022-01264-z.Full Text Link to Item
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Martinez Campos, Cecilia, Kevin Tsai, David G. Courtney, Hal P. Bogerd, Christopher L. Holley, and Bryan R. Cullen. “Mapping of pseudouridine residues on cellular and viral transcripts using a novel antibody-based technique.” Rna 27, no. 11 (November 2021): 1400–1411. https://doi.org/10.1261/rna.078940.121.Full Text Link to Item
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Tsai, Kevin, Hal P. Bogerd, Edward M. Kennedy, Ann Emery, Ronald Swanstrom, and Bryan R. Cullen. “Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing.” Genes & Development 35, no. 13–14 (July 2021): 992–1004. https://doi.org/10.1101/gad.348508.121.Full Text
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Irwan, Ishak D., and Bryan R. Cullen. “Tax Induces the Recruitment of NF-κB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication.” J Virol 95, no. 13 (June 10, 2021): e0028521. https://doi.org/10.1128/JVI.00285-21.Full Text Link to Item
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Campos, Cecilia Martinez, Kevin Tsai, David G. Courtney, Hal P. Bogerd, Christopher L. Holley, and Bryan R. Cullen. “Mapping of pseudouridine residues on cellular and viral transcripts using a novel antibody-based technique,” May 4, 2021. https://doi.org/10.1101/2021.05.01.442255.Full Text Open Access Copy
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Cullen, Bryan R., and Kevin Tsai. “Mapping RNA Modifications Using Photo-Crosslinking-Assisted Modification Sequencing.” Methods Mol Biol 2298 (2021): 123–34. https://doi.org/10.1007/978-1-0716-1374-0_8.Full Text Link to Item
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Kelly, Megan L., Chia-Chieh Chu, Honglue Shi, Laura R. Ganser, Hal P. Bogerd, Kelly Huynh, Yuze Hou, Bryan R. Cullen, and Hashim M. Al-Hashimi. “Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays.” Rna (New York, N.Y.) 27, no. 1 (January 2021): 12–26. https://doi.org/10.1261/rna.076257.120.Full Text
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Tsai, Kevin, and Bryan R. Cullen. “Epigenetic and epitranscriptomic regulation of viral replication.” Nat Rev Microbiol 18, no. 10 (October 2020): 559–70. https://doi.org/10.1038/s41579-020-0382-3.Full Text Link to Item
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Tsai, Kevin, Ananda Ayyappan Jaguva Vasudevan, Cecilia Martinez Campos, Ann Emery, Ronald Swanstrom, and Bryan R. Cullen. “Acetylation of Cytidine Residues Boosts HIV-1 Gene Expression by Increasing Viral RNA Stability.” Cell Host Microbe 28, no. 2 (August 12, 2020): 306-312.e6. https://doi.org/10.1016/j.chom.2020.05.011.Full Text Link to Item
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Irwan, Ishak D., Heather L. Karnowski, Hal P. Bogerd, Kevin Tsai, and Bryan R. Cullen. “Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function.” Mbio 11, no. 3 (June 2, 2020). https://doi.org/10.1128/mBio.01038-20.Full Text Link to Item
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Ganser, Laura R., Chia-Chieh Chu, Hal P. Bogerd, Megan L. Kelly, Bryan R. Cullen, and Hashim M. Al-Hashimi. “Probing RNA Conformational Equilibria within the Functional Cellular Context.” Cell Rep 30, no. 8 (February 25, 2020): 2472-2480.e4. https://doi.org/10.1016/j.celrep.2020.02.004.Full Text Link to Item
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Courtney, David G., Kevin Tsai, Hal P. Bogerd, Edward M. Kennedy, Brittany A. Law, Ann Emery, Ronald Swanstrom, Christopher L. Holley, and Bryan R. Cullen. “Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression.” Cell Host Microbe 26, no. 2 (August 14, 2019): 217-227.e6. https://doi.org/10.1016/j.chom.2019.07.005.Full Text Link to Item
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Courtney, David G., Andrea Chalem, Hal P. Bogerd, Brittany A. Law, Edward M. Kennedy, Christopher L. Holley, and Bryan R. Cullen. “Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression.” Mbio 10, no. 3 (June 11, 2019). https://doi.org/10.1128/mBio.01209-19.Full Text Link to Item
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Courtney, David G., Kevin Tsai, Hal P. Bogerd, Edward M. Kennedy, Brittany A. Law, Ann Emery, Ronald Swanstrom, Christopher L. Holley, and Bryan R. Cullen. “Epitranscriptomic Regulation of HIV-1 Gene Expression by m 5C and the Novel m 5C Reader MBD2,” February 15, 2019.
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Tsai, Kevin, David G. Courtney, Edward M. Kennedy, and Bryan R. Cullen. “Influenza A virus-derived siRNAs increase in the absence of NS1 yet fail to inhibit virus replication.” Rna 24, no. 9 (September 2018): 1172–82. https://doi.org/10.1261/rna.066332.118.Full Text Link to Item
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Hsu, David S., Anand Vr Kornepati, Wayne Glover, Edward M. Kennedy, and Bryan R. Cullen. “Targeting HPV16 DNA using CRISPR/Cas inhibits anal cancer growth in vivo.” Future Virol 13, no. 7 (July 2018): 475–82. https://doi.org/10.2217/fvl-2018-0010.Full Text Link to Item
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Mefferd, Adam L., Hal P. Bogerd, Ishak D. Irwan, and Bryan R. Cullen. “Insights into the mechanisms underlying the inactivation of HIV-1 proviruses by CRISPR/Cas.” Virology 520 (July 2018): 116–26. https://doi.org/10.1016/j.virol.2018.05.016.Full Text Link to Item
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Tsai, Kevin, David G. Courtney, and Bryan R. Cullen. “Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.” Plos Pathog 14, no. 2 (February 2018): e1006919. https://doi.org/10.1371/journal.ppat.1006919.Full Text Link to Item
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Heaton, Nicholas S., and Bryan R. Cullen. “INFECTION Viruses hijack a long non-coding RNA.” Nature 552, no. 7684 (December 14, 2017). https://doi.org/10.1038/d41586-017-07613-x.Full Text Link to Item
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Heaton, Nicholas S., and Bryan R. Cullen. “Viruses hijack a long non-coding RNA.” Nature 552, no. 7684 (December 14, 2017): 184–85. https://doi.org/10.1038/d41586-017-07692-w.Full Text Link to Item
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Kennedy, Edward M., Hal P. Bogerd, Anand V. R. Kornepati, Dong Kang, Delta Ghoshal, Joy B. Marshall, Brigid C. Poling, et al. “Posttranscriptional m6A Editing of HIV-1 mRNAs Enhances Viral Gene Expression.” Cell Host Microbe 22, no. 6 (December 13, 2017): 830. https://doi.org/10.1016/j.chom.2017.11.010.Full Text Link to Item
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Poling, Brigid Chiyoko, Alexander M. Price, Micah A. Luftig, and Bryan R. Cullen. “The Epstein-Barr virus miR-BHRF1 microRNAs regulate viral gene expression in cis.” Virology 512 (December 2017): 113–23. https://doi.org/10.1016/j.virol.2017.09.015.Full Text Link to Item
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Poling, Brigid Chiyoko, Kevin Tsai, Dong Kang, Linda Ren, Edward M. Kennedy, and Bryan R. Cullen. “A lentiviral vector bearing a reverse intron demonstrates superior expression of both proteins and microRNAs.” Rna Biol 14, no. 11 (November 2, 2017): 1570–79. https://doi.org/10.1080/15476286.2017.1334755.Full Text Link to Item
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Courtney, David G., Edward M. Kennedy, Rebekah E. Dumm, Hal P. Bogerd, Kevin Tsai, Nicholas S. Heaton, and Bryan R. Cullen. “Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication.” Cell Host Microbe 22, no. 3 (September 13, 2017): 377-386.e5. https://doi.org/10.1016/j.chom.2017.08.004.Full Text Link to Item
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Cullen, Bryan R. “RNA Interference in Mammals: The Virus Strikes Back.” Immunity 46, no. 6 (June 20, 2017): 970–72. https://doi.org/10.1016/j.immuni.2017.05.004.Full Text Link to Item
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Kennedy, Edward M., David G. Courtney, Kevin Tsai, and Bryan R. Cullen. “Viral Epitranscriptomics.” J Virol 91, no. 9 (May 1, 2017). https://doi.org/10.1128/JVI.02263-16.Full Text Link to Item
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Kennedy, Edward M., Anand V. R. Kornepati, Hal P. Bogerd, and Bryan R. Cullen. “Partial reconstitution of the RNAi response in human cells using Drosophila gene products.” Rna 23, no. 2 (February 2017): 153–60. https://doi.org/10.1261/rna.059345.116.Full Text Link to Item
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Bogerd, Hal P., Edward M. Kennedy, Adam W. Whisnant, and Bryan R. Cullen. “Induced Packaging of Cellular MicroRNAs into HIV-1 Virions Can Inhibit Infectivity.” Mbio 8, no. 1 (January 17, 2017). https://doi.org/10.1128/mBio.02125-16.Full Text Link to Item
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Kennedy, Edward M., and Bryan R. Cullen. “Gene Editing: A New Tool for Viral Disease.” Annu Rev Med 68 (January 14, 2017): 401–11. https://doi.org/10.1146/annurev-med-051215-031129.Full Text Link to Item
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Kennedy, E. M., A. W. Whisnant, A. V. R. Kornepati, J. B. Marshall, H. P. Bogerd, and B. R. Cullen. “Erratum: Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer (Proceedings of the National Academy of Sciences of the United States of America (2015) 112: 50 (E6945-E6954) DOI: 10.1073/pnas.1513421112).” Proceedings of the National Academy of Sciences of the United States of America 113, no. 42 (October 18, 2016): E6547. https://doi.org/10.1073/pnas.1615446113.Full Text
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Kennedy, Edward M., Hal P. Bogerd, Anand V. R. Kornepati, Dong Kang, Delta Ghoshal, Joy B. Marshall, Brigid C. Poling, et al. “Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression.” Cell Host Microbe 19, no. 5 (May 11, 2016): 675–85. https://doi.org/10.1016/j.chom.2016.04.002.Full Text Link to Item
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Bogerd, Hal P., Anand V. R. Kornepati, Joy B. Marshall, Edward M. Kennedy, and Bryan R. Cullen. “Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators.” Proc Natl Acad Sci U S A 112, no. 52 (December 29, 2015): E7249–56. https://doi.org/10.1073/pnas.1516305112.Full Text Link to Item
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Kennedy, Edward M., Adam W. Whisnant, Anand V. R. Kornepati, Joy B. Marshall, Hal P. Bogerd, and Bryan R. Cullen. “Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer.” Proc Natl Acad Sci U S A 112, no. 50 (December 15, 2015): E6945–54. https://doi.org/10.1073/pnas.1513421112.Full Text Link to Item
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Kennedy, Edward M., Anand V. R. Kornepati, Adam L. Mefferd, Joy B. Marshall, Kevin Tsai, Hal P. Bogerd, and Bryan R. Cullen. “Optimization of a multiplex CRISPR/Cas system for use as an antiviral therapeutic.” Methods 91 (December 2015): 82–86. https://doi.org/10.1016/j.ymeth.2015.08.012.Full Text Link to Item
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Friedland, Ari E., Reshica Baral, Pankhuri Singhal, Katherine Loveluck, Shen Shen, Minerva Sanchez, Eugenio Marco, et al. “Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications.” Genome Biol 16 (November 24, 2015): 257. https://doi.org/10.1186/s13059-015-0817-8.Full Text Link to Item
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Gregorovic, Goran, Elizabeth A. Boulden, Rachel Bosshard, Claudio Elgueta Karstegl, Rebecca Skalsky, Bryan R. Cullen, Cornelia Gujer, Patrick Rämer, Christian Münz, and Paul J. Farrell. “Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice.” J Virol 89, no. 22 (November 2015): 11711–14. https://doi.org/10.1128/JVI.01873-15.Full Text Link to Item
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Kennedy, Edward M., Anand V. R. Kornepati, and Bryan R. Cullen. “Targeting hepatitis B virus cccDNA using CRISPR/Cas9.” Antiviral Res 123 (November 2015): 188–92. https://doi.org/10.1016/j.antiviral.2015.10.004.Full Text Link to Item
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Mefferd, Adam L., Anand V. R. Kornepati, Hal P. Bogerd, Edward M. Kennedy, and Bryan R. Cullen. “Expression of CRISPR/Cas single guide RNAs using small tRNA promoters.” Rna 21, no. 9 (September 2015): 1683–89. https://doi.org/10.1261/rna.051631.115.Full Text Link to Item
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Kang, Dong, Rebecca L. Skalsky, and Bryan R. Cullen. “EBV BART MicroRNAs Target Multiple Pro-apoptotic Cellular Genes to Promote Epithelial Cell Survival.” Plos Pathog 11, no. 6 (June 2015): e1004979. https://doi.org/10.1371/journal.ppat.1004979.Full Text Link to Item
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Kennedy, Edward M., and Bryan R. Cullen. “Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment.” Virology 479–480 (May 2015): 213–20. https://doi.org/10.1016/j.virol.2015.02.024.Full Text Link to Item
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Cullen, Bryan R. “The virology-RNA biology connection.” Rna 21, no. 4 (April 2015): 592–94. https://doi.org/10.1261/rna.049882.115.Full Text Link to Item
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Kennedy, Edward M., Leda C. Bassit, Henrik Mueller, Anand V. R. Kornepati, Hal P. Bogerd, Ting Nie, Payel Chatterjee, Hassan Javanbakht, Raymond F. Schinazi, and Bryan R. Cullen. “Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease.” Virology 476 (February 2015): 196–205. https://doi.org/10.1016/j.virol.2014.12.001.Full Text Link to Item
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Renugopalakrishnan, V., S. J. Koester, M. R. McDevitt, P. M. Ajayan, D. Liepmann, U. Demirci, R. Paulmurugan, and S. Viswanathan. “Preface.” Materials Research Society Symposium Proceedings 1725 (January 1, 2015). https://doi.org/10.1557/opl.2015.344.Full Text
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Skalsky, Rebecca L., and Bryan R. Cullen. “EBV Noncoding RNAs.” Curr Top Microbiol Immunol 391 (2015): 181–217. https://doi.org/10.1007/978-3-319-22834-1_6.Full Text Link to Item
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Skalsky, R. L., and B. R. Cullen. “Viruses and MicroRNAs,” December 15, 2014. https://doi.org/10.1016/B978-0-12-801238-3.00089-1.Full Text
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Cullen, Bryan R. “HIV-1 Packing to Leave.” Cell 159, no. 5 (November 20, 2014): 975–76. https://doi.org/10.1016/j.cell.2014.11.008.Full Text Link to Item
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Cullen, Bryan R. “Viruses and RNA interference: issues and controversies.” J Virol 88, no. 22 (November 2014): 12934–36. https://doi.org/10.1128/JVI.01179-14.Full Text Link to Item
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Kennedy, Edward M., Anand V. R. Kornepati, Michael Goldstein, Hal P. Bogerd, Brigid C. Poling, Adam W. Whisnant, Michael B. Kastan, and Bryan R. Cullen. “Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease.” J Virol 88, no. 20 (October 2014): 11965–72. https://doi.org/10.1128/JVI.01879-14.Full Text Link to Item
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Bogerd, Hal P., Rebecca L. Skalsky, Edward M. Kennedy, Yuki Furuse, Adam W. Whisnant, Omar Flores, Kimberly L. W. Schultz, et al. “Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.” J Virol 88, no. 14 (July 2014): 8065–76. https://doi.org/10.1128/JVI.00985-14.Full Text Link to Item
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Skalsky, Rebecca L., Ken E. Olson, Carol D. Blair, Mariano A. Garcia-Blanco, and Bryan R. Cullen. “A "microRNA-like" small RNA expressed by Dengue virus?” Proc Natl Acad Sci U S A 111, no. 23 (June 10, 2014): E2359. https://doi.org/10.1073/pnas.1406854111.Full Text Link to Item
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Bogerd, Hal P., Adam W. Whisnant, Edward M. Kennedy, Omar Flores, and Bryan R. Cullen. “Derivation and characterization of Dicer- and microRNA-deficient human cells.” Rna 20, no. 6 (June 2014): 923–37. https://doi.org/10.1261/rna.044545.114.Full Text Link to Item
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Whisnant, Adam W., Timo Kehl, Qiuying Bao, Magdalena Materniak, Jacek Kuzmak, Martin Löchelt, and Bryan R. Cullen. “Identification of novel, highly expressed retroviral microRNAs in cells infected by bovine foamy virus.” J Virol 88, no. 9 (May 2014): 4679–86. https://doi.org/10.1128/JVI.03587-13.Full Text Link to Item
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Pan, Dongli, Omar Flores, Jennifer L. Umbach, Jean M. Pesola, Peris Bentley, Pamela C. Rosato, David A. Leib, Bryan R. Cullen, and Donald M. Coen. “A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency.” Cell Host Microbe 15, no. 4 (April 9, 2014): 446–56. https://doi.org/10.1016/j.chom.2014.03.004.Full Text Link to Item
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Flores, Omar, Edward M. Kennedy, Rebecca L. Skalsky, and Bryan R. Cullen. “Differential RISC association of endogenous human microRNAs predicts their inhibitory potential.” Nucleic Acids Res 42, no. 7 (April 2014): 4629–39. https://doi.org/10.1093/nar/gkt1393.Full Text Link to Item
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Furuse, Yuki, Akbar Dastjerdi, Katharina Seilern-Moy, Falko Steinbach, and Bryan R. Cullen. “Analysis of viral microRNA expression by elephant endotheliotropic herpesvirus 1.” Virology 454–455 (April 2014): 102–8. https://doi.org/10.1016/j.virol.2014.02.009.Full Text Link to Item
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Skalsky, Rebecca L., Dong Kang, Sarah D. Linnstaedt, and Bryan R. Cullen. “Evolutionary conservation of primate lymphocryptovirus microRNA targets.” J Virol 88, no. 3 (February 2014): 1617–35. https://doi.org/10.1128/JVI.02071-13.Full Text Link to Item
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Parnas, O., D. L. Corcoran, and B. R. Cullen. “Analysis of the mRNA targetome of microRNAs expressed by Marek's disease virus.” Mbio 5, no. 1 (January 21, 2014). https://doi.org/10.1128/mBio.01060-13.Full Text
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Parnas, Oren, David L. Corcoran, and Bryan R. Cullen. “Analysis of the mRNA targetome of microRNAs expressed by Marek's disease virus.” Mbio 5, no. 1 (January 21, 2014): e01060–e01013. https://doi.org/10.1128/mBio.01060-13.Full Text Link to Item
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Cullen, B. R. “Interview with Bryan R Cullen.” Future Virology 9, no. 4 (January 1, 2014): 345–50. https://doi.org/10.2217/fvl.14.17.Full Text
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Furuse, Yuki, Ryan Finethy, Hector A. Saka, Ana M. Xet-Mull, Dana M. Sisk, Kristen L Jurcic Smith, Sunhee Lee, et al. “Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells.” Plos One 9, no. 9 (2014): e106434. https://doi.org/10.1371/journal.pone.0106434.Full Text Open Access Copy Link to Item
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Furuse, Yuki, David A. Ornelles, and Bryan R. Cullen. “Persistently adenovirus-infected lymphoid cells express microRNAs derived from the viral VAI and especially VAII RNA.” Virology 447, no. 1–2 (December 2013): 140–45. https://doi.org/10.1016/j.virol.2013.08.024.Full Text Link to Item
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Cullen, Bryan R., Sara Cherry, and Benjamin R. tenOever. “Is RNA interference a physiologically relevant innate antiviral immune response in mammals?” Cell Host Microbe 14, no. 4 (October 16, 2013): 374–78. https://doi.org/10.1016/j.chom.2013.09.011.Full Text Link to Item
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Jin, Hyun Yong, Hiroyo Oda, Maoyi Lai, Rebecca L. Skalsky, Kelly Bethel, Jovan Shepherd, Seung Goo Kang, et al. “MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.” Embo J 32, no. 17 (August 28, 2013): 2377–91. https://doi.org/10.1038/emboj.2013.178.Full Text Link to Item
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Majoros, William H., Parawee Lekprasert, Neelanjan Mukherjee, Rebecca L. Skalsky, David L. Corcoran, Bryan R. Cullen, and Uwe Ohler. “MicroRNA target site identification by integrating sequence and binding information.” Nat Methods 10, no. 7 (July 2013): 630–33. https://doi.org/10.1038/nmeth.2489.Full Text Link to Item
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Flores, Omar, Sanae Nakayama, Adam W. Whisnant, Hassan Javanbakht, Bryan R. Cullen, and David C. Bloom. “Mutational inactivation of herpes simplex virus 1 microRNAs identifies viral mRNA targets and reveals phenotypic effects in culture.” J Virol 87, no. 12 (June 2013): 6589–6603. https://doi.org/10.1128/JVI.00504-13.Full Text Link to Item
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Majoros, W. H., P. Lekprasert, N. Mukherjee, R. L. Skalsky, D. L. Corcoran, B. R. Cullen, and U. Ohler. “MicroRNA target site identification by integrating sequence and binding information (Accepted).” Nature Methods, May 26, 2013. https://doi.org/10.138/nmeth.2489.Full Text
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Wahl, Angela, Sarah D. Linnstaedt, Caitlin Esoda, John F. Krisko, Francisco Martinez-Torres, Henri-Jacques Delecluse, Bryan R. Cullen, and J Victor Garcia. “A cluster of virus-encoded microRNAs accelerates acute systemic Epstein-Barr virus infection but does not significantly enhance virus-induced oncogenesis in vivo.” J Virol 87, no. 10 (May 2013): 5437–46. https://doi.org/10.1128/JVI.00281-13.Full Text Link to Item
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Whisnant, Adam W., Hal P. Bogerd, Omar Flores, Phong Ho, Jason G. Powers, Natalia Sharova, Mario Stevenson, Chin-Ho Chen, and Bryan R. Cullen. “In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms.” Mbio 4, no. 2 (April 16, 2013): e000193. https://doi.org/10.1128/mBio.00193-13.Full Text Link to Item
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Cullen, Bryan R. “Making a NeST for a persistent virus.” Cell Host Microbe 13, no. 3 (March 13, 2013): 241–42. https://doi.org/10.1016/j.chom.2013.02.016.Full Text Link to Item
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Cullen, Bryan R. “MicroRNAs as mediators of viral evasion of the immune system.” Nat Immunol 14, no. 3 (March 2013): 205–10. https://doi.org/10.1038/ni.2537.Full Text Link to Item
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Cullen, B. R. “MicroRNAs as mediators of viral evasion of the immune system.” Nature Immunology 14, no. 3 (2013): 205–10. https://doi.org/10.1038/ni2537.Full Text
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Cullen, Bryan R. “How do viruses avoid inhibition by endogenous cellular microRNAs?” Plos Pathog 9, no. 11 (2013): e1003694. https://doi.org/10.1371/journal.ppat.1003694.Full Text Link to Item
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Cullen, Bryan R. “Intrinsic Immunity Preface.” Edited by B. R. Cullen. Intrinsic Immunity 371 (January 1, 2013): V–VI.Link to Item
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Majoros, W. H., P. Lekprasert, N. Mukherjee, R. L. Skalsky, D. L. Corcoran, B. R. Cullen, and U. Ohler. “MicroRNA target site identification by integrating sequence and binding information.” Nature Methods 10, no. 7 (2013): 630–33. https://doi.org/10.1038/nmeth.2489.Full Text
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Cullen, Bryan R. “MicroRNA expression by an oncogenic retrovirus.” Proc Natl Acad Sci U S A 109, no. 8 (February 21, 2012): 2695–96. https://doi.org/10.1073/pnas.1200328109.Full Text Link to Item
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Skalsky, Rebecca L., David L. Corcoran, Eva Gottwein, Christopher L. Frank, Dong Kang, Markus Hafner, Jeffrey D. Nusbaum, et al. “The viral and cellular microRNA targetome in lymphoblastoid cell lines.” Plos Pathog 8, no. 1 (January 2012): e1002484. https://doi.org/10.1371/journal.ppat.1002484.Full Text Link to Item
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Zhang, Ao, Hal Bogerd, Francois Villinger, Jaydip Das Gupta, Beihua Dong, Eric A. Klein, John Hackett, Gerald Schochetman, Bryan R. Cullen, and Robert H. Silverman. “In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins.” Virology 421, no. 1 (December 5, 2011): 28–33. https://doi.org/10.1016/j.virol.2011.08.030.Full Text Link to Item
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Cullen, B. R. “RNA interference does not function as an innate antiviral response in mammalian somatic cells.” Future Virology 6, no. 12 (December 1, 2011): 1381–84. https://doi.org/10.2217/fvl.11.112.Full Text
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Gottwein, Eva, David L. Corcoran, Neelanjan Mukherjee, Rebecca L. Skalsky, Markus Hafner, Jeffrey D. Nusbaum, Priscilla Shamulailatpam, et al. “Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.” Cell Host Microbe 10, no. 5 (November 17, 2011): 515–26. https://doi.org/10.1016/j.chom.2011.09.012.Full Text Link to Item
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Feederle, Regina, Janina Haar, Katharina Bernhardt, Sarah D. Linnstaedt, Helmut Bannert, Helge Lips, Bryan R. Cullen, and Henri-Jacques Delecluse. “The members of an Epstein-Barr virus microRNA cluster cooperate to transform B lymphocytes.” J Virol 85, no. 19 (October 2011): 9801–10. https://doi.org/10.1128/JVI.05100-11.Full Text Link to Item
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Cullen, Bryan R. “Viruses and microRNAs: RISCy interactions with serious consequences.” Genes Dev 25, no. 18 (September 15, 2011): 1881–94. https://doi.org/10.1101/gad.17352611.Full Text Link to Item
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Cullen, Bryan R. “Herpesvirus microRNAs: phenotypes and functions.” Curr Opin Virol 1, no. 3 (September 2011): 211–15. https://doi.org/10.1016/j.coviro.2011.04.003.Full Text Link to Item
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Bogerd, Hal P., Fengwen Zhang, Paul D. Bieniasz, and Bryan R. Cullen. “Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity.” Virology 410, no. 1 (February 5, 2011): 234–39. https://doi.org/10.1016/j.virol.2010.11.011.Full Text Link to Item
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Feederle, Regina, Sarah D. Linnstaedt, Helmut Bannert, Helge Lips, Maja Bencun, Bryan R. Cullen, and Henri-Jacques Delecluse. “A viral microRNA cluster strongly potentiates the transforming properties of a human herpesvirus.” Plos Pathog 7, no. 2 (February 2011): e1001294. https://doi.org/10.1371/journal.ppat.1001294.Full Text Link to Item
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Skalsky, Rebecca L., and Bryan R. Cullen. “Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene.” Plos One 6, no. 9 (2011): e24248. https://doi.org/10.1371/journal.pone.0024248.Full Text Link to Item
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Linnstaedt, Sarah D., Eva Gottwein, Rebecca L. Skalsky, Micah A. Luftig, and Bryan R. Cullen. “Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus.” J Virol 84, no. 22 (November 2010): 11670–78. https://doi.org/10.1128/JVI.01248-10.Full Text Link to Item
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Umbach, Jennifer L., Lisa I. Strelow, Scott W. Wong, and Bryan R. Cullen. “Analysis of rhesus rhadinovirus microRNAs expressed in virus-induced tumors from infected rhesus macaques.” Virology 405, no. 2 (September 30, 2010): 592–99. https://doi.org/10.1016/j.virol.2010.06.036.Full Text Link to Item
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Umbach, Jennifer L., Hui-Ling Yen, Leo L. M. Poon, and Bryan R. Cullen. “Influenza A virus expresses high levels of an unusual class of small viral leader RNAs in infected cells.” Mbio 1, no. 4 (September 14, 2010). https://doi.org/10.1128/mBio.00204-10.Full Text Link to Item
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Gottwein, Eva, and Bryan R. Cullen. “A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest.” J Virol 84, no. 10 (May 2010): 5229–37. https://doi.org/10.1128/JVI.00202-10.Full Text Link to Item
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Kelly, Elizabeth J., Elizabeth M. Hadac, Bryan R. Cullen, and Stephen J. Russell. “MicroRNA antagonism of the picornaviral life cycle: alternative mechanisms of interference.” Plos Pathog 6, no. 3 (March 19, 2010): e1000820. https://doi.org/10.1371/journal.ppat.1000820.Full Text Open Access Copy Link to Item
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Cullen, Bryan R. “Five questions about viruses and microRNAs.” Plos Pathog 6, no. 2 (February 26, 2010): e1000787. https://doi.org/10.1371/journal.ppat.1000787.Full Text Open Access Copy Link to Item
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Skalsky, Rebecca L., Dana L. Vanlandingham, Frank Scholle, Stephen Higgs, and Bryan R. Cullen. “Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus.” Bmc Genomics 11 (February 18, 2010): 119. https://doi.org/10.1186/1471-2164-11-119.Full Text Open Access Copy Link to Item
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Bogerd, Hal P., Heather W. Karnowski, Xuezhong Cai, Jinwook Shin, Michael Pohlers, and Bryan R. Cullen. “A mammalian herpesvirus uses noncanonical expression and processing mechanisms to generate viral MicroRNAs.” Mol Cell 37, no. 1 (January 15, 2010): 135–42. https://doi.org/10.1016/j.molcel.2009.12.016.Full Text Link to Item
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Skalsky, Rebecca L., and Bryan R. Cullen. “Viruses, microRNAs, and host interactions.” Annu Rev Microbiol 64 (2010): 123–41. https://doi.org/10.1146/annurev.micro.112408.134243.Full Text Link to Item
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Umbach, Jennifer L., Kening Wang, Shuang Tang, Philip R. Krause, Erik K. Mont, Jeffrey I. Cohen, and Bryan R. Cullen. “Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2.” J Virol 84, no. 2 (January 2010): 1189–92. https://doi.org/10.1128/JVI.01712-09.Full Text Link to Item
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Umbach, Jennifer L., and Bryan R. Cullen. “In-depth analysis of Kaposi's sarcoma-associated herpesvirus microRNA expression provides insights into the mammalian microRNA-processing machinery.” J Virol 84, no. 2 (January 2010): 695–703. https://doi.org/10.1128/JVI.02013-09.Full Text Link to Item
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Umbach, Jennifer L., Maria A. Nagel, Randall J. Cohrs, Donald H. Gilden, and Bryan R. Cullen. “Analysis of human alphaherpesvirus microRNA expression in latently infected human trigeminal ganglia.” J Virol 83, no. 20 (October 2009): 10677–83. https://doi.org/10.1128/JVI.01185-09.Full Text Link to Item
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Umbach, Jennifer L., and Bryan R. Cullen. “The role of RNAi and microRNAs in animal virus replication and antiviral immunity.” Genes Dev 23, no. 10 (May 15, 2009): 1151–64. https://doi.org/10.1101/gad.1793309.Full Text Link to Item
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Cullen, Bryan R. “Viruses, microRNAs and RNA Interference.” Faseb Journal 23 (April 1, 2009).Link to Item
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Cullen, Bryan R. “Viral RNAs: lessons from the enemy.” Cell 136, no. 4 (February 20, 2009): 592–97. https://doi.org/10.1016/j.cell.2009.01.048.Full Text Link to Item
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Cullen, Bryan R. “Viral and cellular messenger RNA targets of viral microRNAs.” Nature 457, no. 7228 (January 22, 2009): 421–25. https://doi.org/10.1038/nature07757.Full Text Link to Item
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Bogerd, Hal P., Rebecca L. Tallmadge, J Lindsay Oaks, Susan Carpenter, and Bryan R. Cullen. “Equine infectious anemia virus resists the antiretroviral activity of equine APOBEC3 proteins through a packaging-independent mechanism.” J Virol 82, no. 23 (December 2008): 11889–901. https://doi.org/10.1128/JVI.01537-08.Full Text Link to Item
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Gooch, Barry D., and Bryan R. Cullen. “Functional domain organization of human APOBEC3G.” Virology 379, no. 1 (September 15, 2008): 118–24. https://doi.org/10.1016/j.virol.2008.06.013.Full Text Link to Item
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Umbach, Jennifer Lin, Martha F. Kramer, Igor Jurak, Heather W. Karnowski, Donald M. Coen, and Bryan R. Cullen. “MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs.” Nature 454, no. 7205 (August 7, 2008): 780–83. https://doi.org/10.1038/nature07103.Full Text Link to Item
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Gottwein, Eva, and Bryan R. Cullen. “Viral and cellular microRNAs as determinants of viral pathogenesis and immunity.” Cell Host Microbe 3, no. 6 (June 12, 2008): 375–87. https://doi.org/10.1016/j.chom.2008.05.002.Full Text Link to Item
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Bogerd, Hal P., and Bryan R. Cullen. “Single-stranded RNA facilitates nucleocapsid: APOBEC3G complex formation.” Rna 14, no. 6 (June 2008): 1228–36. https://doi.org/10.1261/rna.964708.Full Text Link to Item
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Gottwein, Eva, Neelanjan Mukherjee, Christoph Sachse, Corina Frenzel, William H. Majoros, Jen-Tsan A. Chi, Ravi Braich, et al. “A viral microRNA functions as an orthologue of cellular miR-155.” Nature 450, no. 7172 (December 13, 2007): 1096–99. https://doi.org/10.1038/nature05992.Full Text Link to Item
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Wiegand, Heather L., and Bryan R. Cullen. “Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins.” J Virol 81, no. 24 (December 2007): 13694–99. https://doi.org/10.1128/JVI.01646-07.Full Text Link to Item
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Lin, Jennifer, and Bryan R. Cullen. “Analysis of the interaction of primate retroviruses with the human RNA interference machinery.” J Virol 81, no. 22 (November 2007): 12218–26. https://doi.org/10.1128/JVI.01390-07.Full Text Link to Item
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Bogerd, Hal P., Heather L. Wiegand, Brian P. Doehle, and Bryan R. Cullen. “The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domains.” Virology 364, no. 2 (August 1, 2007): 486–93. https://doi.org/10.1016/j.virol.2007.03.019.Full Text Link to Item
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Cullen, Bryan R. “Immunology. Outwitted by viral RNAs.” Science 317, no. 5836 (July 20, 2007): 329–30. https://doi.org/10.1126/science.1146077.Full Text Link to Item
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Schäfer, Alexandra, Xuezhong Cai, John P. Bilello, Ronald C. Desrosiers, and Bryan R. Cullen. “Cloning and analysis of microRNAs encoded by the primate gamma-herpesvirus rhesus monkey rhadinovirus.” Virology 364, no. 1 (July 20, 2007): 21–27. https://doi.org/10.1016/j.virol.2007.03.029.Full Text Link to Item
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Hulme, Amy E., Hal P. Bogerd, Bryan R. Cullen, and John V. Moran. “Selective inhibition of Alu retrotransposition by APOBEC3G.” Gene 390, no. 1–2 (April 1, 2007): 199–205. https://doi.org/10.1016/j.gene.2006.08.032.Full Text Link to Item
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Cai, Xuezhong, and Bryan R. Cullen. “The imprinted H19 noncoding RNA is a primary microRNA precursor.” Rna 13, no. 3 (March 2007): 313–16. https://doi.org/10.1261/rna.351707.Full Text Link to Item
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Gottwein, Eva, and Bryan R. Cullen. “Protocols for expression and functional analysis of viral microRNAs.” Methods Enzymol 427 (2007): 229–43. https://doi.org/10.1016/S0076-6879(07)27013-2.Full Text Link to Item
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Doehle, Brian P., Hal P. Bogerd, Heather L. Wiegand, Nolwenn Jouvenet, Paul D. Bieniasz, Eric Hunter, and Bryan R. Cullen. “The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles.” J Virol 80, no. 24 (December 2006): 12102–8. https://doi.org/10.1128/JVI.01600-06.Full Text Link to Item
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Cai, Xuezhong, Gu Li, Laimonis A. Laimins, and Bryan R. Cullen. “Human papillomavirus genotype 31 does not express detectable microRNA levels during latent or productive virus replication.” J Virol 80, no. 21 (November 2006): 10890–93. https://doi.org/10.1128/JVI.01175-06.Full Text Link to Item
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Cullen, Bryan R. “Enhancing and confirming the specificity of RNAi experiments.” Nat Methods 3, no. 9 (September 2006): 677–81. https://doi.org/10.1038/nmeth913.Full Text Link to Item
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Bogerd, Hal P., Heather L. Wiegand, Amy E. Hulme, José L. Garcia-Perez, K Sue O’Shea, John V. Moran, and Bryan R. Cullen. “Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.” Proc Natl Acad Sci U S A 103, no. 23 (June 6, 2006): 8780–85. https://doi.org/10.1073/pnas.0603313103.Full Text Link to Item
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Cullen, Bryan R. “Viruses and microRNAs.” Nat Genet 38 Suppl (June 2006): S25–30. https://doi.org/10.1038/ng1793.Full Text Link to Item
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Cullen, Bryan R. “Is RNA interference involved in intrinsic antiviral immunity in mammals?” Nat Immunol 7, no. 6 (June 2006): 563–67. https://doi.org/10.1038/ni1352.Full Text Link to Item
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Gottwein, Eva, Xuezhong Cai, and Bryan R. Cullen. “A novel assay for viral microRNA function identifies a single nucleotide polymorphism that affects Drosha processing.” J Virol 80, no. 11 (June 2006): 5321–26. https://doi.org/10.1128/JVI.02734-05.Full Text Link to Item
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Wäldele, Katja, Katrin Silbermann, Grit Schneider, Tobias Ruckes, Bryan R. Cullen, and Ralph Grassmann. “Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes.” Blood 107, no. 11 (June 1, 2006): 4491–99. https://doi.org/10.1182/blood-2005-08-3138.Full Text Link to Item
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Cai, X., A. Schäfer, S. Lu, J. P. Bilello, R. C. Desrosiers, R. Edwards, N. Raab-Traub, and B. R. Cullen. “Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed.” Plos Pathogens 2, no. 3 (March 1, 2006): 0236–47. https://doi.org/10.1371/journal.ppat.0020023.Full Text
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Cai, Xuezhong, Alexandra Schäfer, Shihua Lu, John P. Bilello, Ronald C. Desrosiers, Rachel Edwards, Nancy Raab-Traub, and Bryan R. Cullen. “Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed.” Plos Pathog 2, no. 3 (March 2006): e23. https://doi.org/10.1371/journal.ppat.0020023.Full Text Link to Item
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Cai, Xuezhong, and Bryan R. Cullen. “Transcriptional origin of Kaposi's sarcoma-associated herpesvirus microRNAs.” J Virol 80, no. 5 (March 2006): 2234–42. https://doi.org/10.1128/JVI.80.5.2234-2242.2006.Full Text Link to Item
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Cullen, Bryan R. “Induction of stable RNA interference in mammalian cells.” Gene Ther 13, no. 6 (March 2006): 503–8. https://doi.org/10.1038/sj.gt.3302656.Full Text Link to Item
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Cullen, Bryan R. “Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors.” J Virol 80, no. 3 (February 2006): 1067–76. https://doi.org/10.1128/JVI.80.3.1067-1076.2006.Full Text Link to Item
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Bogerd, Hal P., Heather L. Wiegand, Brian P. Doehle, Kira K. Lueders, and Bryan R. Cullen. “APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells.” Nucleic Acids Res 34, no. 1 (2006): 89–95. https://doi.org/10.1093/nar/gkj416.Full Text Link to Item
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Gottwein, E., X. Cai, and B. R. Cullen. “Expression and function of microRNAs encoded by Kaposi's sarcoma-associated herpesvirus.” Cold Spring Harb Symp Quant Biol 71 (2006): 357–64. https://doi.org/10.1101/sqb.2006.71.004.Full Text Link to Item
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Zeng, Yan, and Bryan R. Cullen. “Recognition and cleavage of primary microRNA transcripts.” Methods Mol Biol 342 (2006): 49–56. https://doi.org/10.1385/1-59745-123-1:49.Full Text Link to Item
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Cullen, Bryan R. “RNAi the natural way.” Nat Genet 37, no. 11 (November 2005): 1163–65. https://doi.org/10.1038/ng1105-1163.Full Text Link to Item
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Doehle, Brian P., Alexandra Schäfer, and Bryan R. Cullen. “Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif.” Virology 339, no. 2 (September 1, 2005): 281–88. https://doi.org/10.1016/j.virol.2005.06.005.Full Text Link to Item
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Zeng, Yan, and Bryan R. Cullen. “Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences.” J Biol Chem 280, no. 30 (July 29, 2005): 27595–603. https://doi.org/10.1074/jbc.M504714200.Full Text Link to Item
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Heitman, Joseph, and Bryan R. Cullen. “Cyclophilin B escorts the hepatitis C virus RNA polymerase: a viral achilles heel?” Mol Cell 19, no. 2 (July 22, 2005): 145–46. https://doi.org/10.1016/j.molcel.2005.07.001.Full Text Link to Item
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Doehle, Brian P., Alexandra Schäfer, Heather L. Wiegand, Hal P. Bogerd, and Bryan R. Cullen. “Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion.” J Virol 79, no. 13 (July 2005): 8201–7. https://doi.org/10.1128/JVI.79.13.8201-8207.2005.Full Text Link to Item
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Moore, Michael D., Michael J. McGarvey, Rebecca A. Russell, Bryan R. Cullen, and Myra O. McClure. “Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors.” J Gene Med 7, no. 7 (July 2005): 918–25. https://doi.org/10.1002/jgm.739.Full Text Link to Item
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Russell, Rebecca A., Heather L. Wiegand, Michael D. Moore, Alexandra Schäfer, Myra O. McClure, and Bryan R. Cullen. “Foamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors.” J Virol 79, no. 14 (July 2005): 8724–31. https://doi.org/10.1128/JVI.79.14.8724-8731.2005.Full Text Link to Item
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Dutko, James A., Alexandra Schäfer, Alison E. Kenny, Bryan R. Cullen, and M Joan Curcio. “Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases.” Curr Biol 15, no. 7 (April 12, 2005): 661–66. https://doi.org/10.1016/j.cub.2005.02.051.Full Text Link to Item
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Cai, Xuezhong, Shihua Lu, Zhihong Zhang, Carlos M. Gonzalez, Blossom Damania, and Bryan R. Cullen. “Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells.” Proc Natl Acad Sci U S A 102, no. 15 (April 12, 2005): 5570–75. https://doi.org/10.1073/pnas.0408192102.Full Text Link to Item
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Yi, Rui, Brian P. Doehle, Yi Qin, Ian G. Macara, and Bryan R. Cullen. “Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs.” Rna 11, no. 2 (February 2005): 220–26. https://doi.org/10.1261/rna.7233305.Full Text Link to Item
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Zeng, Yan, Rui Yi, and Bryan R. Cullen. “Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha.” Embo J 24, no. 1 (January 12, 2005): 138–48. https://doi.org/10.1038/sj.emboj.7600491.Full Text Link to Item
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Cullen, Bryan R. “Human immunodeficiency virus: nuclear RNA export unwound.” Nature 433, no. 7021 (January 6, 2005): 26–27. https://doi.org/10.1038/433026a.Full Text Link to Item
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Cullen, Bryan R. “Does RNA interference have a future as a treatment for HIV-1 induced disease?” Aids Rev 7, no. 1 (2005): 22–25.Link to Item
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Zeng, Yan, Xuezhong Cai, and Bryan R. Cullen. “Use of RNA polymerase II to transcribe artificial microRNAs.” Methods Enzymol 392 (2005): 371–80. https://doi.org/10.1016/S0076-6879(04)92022-8.Full Text Link to Item
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Cullen, Bryan R. “Transcription and processing of human microRNA precursors.” Mol Cell 16, no. 6 (December 22, 2004): 861–65. https://doi.org/10.1016/j.molcel.2004.12.002.Full Text Link to Item
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Cai, Xuezhong, Curt H. Hagedorn, and Bryan R. Cullen. “Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs.” Rna 10, no. 12 (December 2004): 1957–66. https://doi.org/10.1261/rna.7135204.Full Text Link to Item
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Lu, Shihua, and Bryan R. Cullen. “Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis.” J Virol 78, no. 23 (December 2004): 12868–76. https://doi.org/10.1128/JVI.78.23.12868-12876.2004.Full Text Link to Item
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Schäfer, Alexandra, Hal P. Bogerd, and Bryan R. Cullen. “Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor.” Virology 328, no. 2 (October 25, 2004): 163–68. https://doi.org/10.1016/j.virol.2004.08.006.Full Text Link to Item
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Wiegand, Heather L., Brian P. Doehle, Hal P. Bogerd, and Bryan R. Cullen. “A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins.” Embo J 23, no. 12 (June 16, 2004): 2451–58. https://doi.org/10.1038/sj.emboj.7600246.Full Text Link to Item
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Cullen, Bryan R. “Derivation and function of small interfering RNAs and microRNAs.” Virus Res 102, no. 1 (June 1, 2004): 3–9. https://doi.org/10.1016/j.virusres.2004.01.009.Full Text Link to Item
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Lu, Shihua, and Bryan R. Cullen. “Nonsense mediated decay induced by tethered human UPF3B is restricted to the cytoplasm.” Rna Biol 1, no. 1 (May 2004): 42–47.Link to Item
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Bogerd, Hal P., Brian P. Doehle, Heather L. Wiegand, and Bryan R. Cullen. “A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.” Proc Natl Acad Sci U S A 101, no. 11 (March 16, 2004): 3770–74. https://doi.org/10.1073/pnas.0307713101.Full Text Link to Item
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Zeng, Yan, and Bryan R. Cullen. “Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.” Nucleic Acids Res 32, no. 16 (2004): 4776–85. https://doi.org/10.1093/nar/gkh824.Full Text Link to Item
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Cullen, Bryan R. “Assaying nuclear messenger RNA export in human cells.” Methods Mol Biol 257 (2004): 85–92. https://doi.org/10.1385/1-59259-750-5:085.Full Text Link to Item
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Yi, Rui, Yi Qin, Ian G. Macara, and Bryan R. Cullen. “Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.” Genes Dev 17, no. 24 (December 15, 2003): 3011–16. https://doi.org/10.1101/gad.1158803.Full Text Link to Item
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Lee, Ming-Ta M., Glen A. Coburn, Myra O. McClure, and Bryan R. Cullen. “Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector.” J Virol 77, no. 22 (November 2003): 11964–72. https://doi.org/10.1128/jvi.77.22.11964-11972.2003.Full Text Link to Item
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Cullen, Bryan R. “HIV-1 Vif: counteracting innate antiretroviral defenses.” Mol Ther 8, no. 4 (October 2003): 525–27. https://doi.org/10.1016/j.ymthe.2003.08.010.Full Text Link to Item
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Wiegand, Heather L., Shihua Lu, and Bryan R. Cullen. “Exon junction complexes mediate the enhancing effect of splicing on mRNA expression.” Proc Natl Acad Sci U S A 100, no. 20 (September 30, 2003): 11327–32. https://doi.org/10.1073/pnas.1934877100.Full Text Link to Item
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Cullen, Bryan R. “HIV-1 infection: fooling the gatekeeper.” Nat Med 9, no. 9 (September 2003): 1112–13. https://doi.org/10.1038/nm0903-1112.Full Text Link to Item
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Zeng, Yan, Rui Yi, and Bryan R. Cullen. “MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms.” Proc Natl Acad Sci U S A 100, no. 17 (August 19, 2003): 9779–84. https://doi.org/10.1073/pnas.1630797100.Full Text Link to Item
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Cullen, Bryan R. “Nuclear mRNA export: insights from virology.” Trends Biochem Sci 28, no. 8 (August 2003): 419–24. https://doi.org/10.1016/S0968-0004(03)00142-7.Full Text Link to Item
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Shoya, Yuko, Kenzo Tokunaga, Hirofumi Sawa, Masae Maeda, Tomonori Ueno, Tomoki Yoshikawa, Hideki Hasegawa, et al. “Human topoisomerase I promotes HIV-1 proviral DNA synthesis: implications for the species specificity and cellular tropism of HIV-1 infection.” Proc Natl Acad Sci U S A 100, no. 14 (July 8, 2003): 8442–47. https://doi.org/10.1073/pnas.1430827100.Full Text Link to Item
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Lu, Shihua, and Bryan R. Cullen. “Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells.” Rna 9, no. 5 (May 2003): 618–30. https://doi.org/10.1261/rna.5260303.Full Text Link to Item
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Coburn, Glen A., and Bryan R. Cullen. “siRNAs: a new wave of RNA-based therapeutics.” J Antimicrob Chemother 51, no. 4 (April 2003): 753–56. https://doi.org/10.1093/jac/dkg166.Full Text Link to Item
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Cullen, Bryan R. “Nuclear RNA export.” J Cell Sci 116, no. Pt 4 (February 15, 2003): 587–97. https://doi.org/10.1242/jcs.00268.Full Text Link to Item
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Zeng, Yan, and Bryan R. Cullen. “Sequence requirements for micro RNA processing and function in human cells.” Rna 9, no. 1 (January 2003): 112–23. https://doi.org/10.1261/rna.2780503.Full Text Link to Item
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Coburn, Glen A., and Bryan R. Cullen. “Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference.” J Virol 76, no. 18 (September 2002): 9225–31. https://doi.org/10.1128/jvi.76.18.9225-9231.2002.Full Text Link to Item
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Cullen, Bryan R. “RNA interference: antiviral defense and genetic tool.” Nat Immunol 3, no. 7 (July 2002): 597–99. https://doi.org/10.1038/ni0702-597.Full Text Link to Item
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Zeng, Yan, and Bryan R. Cullen. “RNA interference in human cells is restricted to the cytoplasm.” Rna 8, no. 7 (July 2002): 855–60. https://doi.org/10.1017/s1355838202020071.Full Text Link to Item
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Zeng, Yan, Eric J. Wagner, and Bryan R. Cullen. “Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells.” Mol Cell 9, no. 6 (June 2002): 1327–33. https://doi.org/10.1016/s1097-2765(02)00541-5.Full Text Link to Item
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Cullen, B. R., and L. Owens. “Experimental challenge and clinical cases of Bohle iridovirus (BIV) in native Australian anurans.” Dis Aquat Organ 49, no. 2 (May 10, 2002): 83–92. https://doi.org/10.3354/dao049083.Full Text Link to Item
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Yi, Rui, Hal P. Bogerd, and Bryan R. Cullen. “Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs.” J Virol 76, no. 5 (March 2002): 2036–42. https://doi.org/10.1128/jvi.76.5.2036-2042.2002.Full Text Link to Item
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Ho, Dona N., Glen A. Coburn, Yibin Kang, Bryan R. Cullen, and Millie M. Georgiadis. “The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.” Proc Natl Acad Sci U S A 99, no. 4 (February 19, 2002): 1888–93. https://doi.org/10.1073/pnas.042698599.Full Text Link to Item
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Yi, Rui, Hal P. Bogerd, Heather L. Wiegand, and Bryan R. Cullen. “Both ran and importins have the ability to function as nuclear mRNA export factors.” Rna 8, no. 2 (February 2002): 180–87. https://doi.org/10.1017/s1355838202012384.Full Text Link to Item
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Cullen, Bryan R. “Using retroviruses to study the nuclear export of mRNA.” Results Probl Cell Differ 35 (2002): 151–68. https://doi.org/10.1007/978-3-540-44603-3_8.Full Text Link to Item
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Oakey, H. J., B. R. Cullen, and L. Owens. “The complete nucleotide sequence of the Vibrio harveyi bacteriophage VHML.” J Appl Microbiol 93, no. 6 (2002): 1089–98. https://doi.org/10.1046/j.1365-2672.2002.01776.x.Full Text Link to Item
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Wiegand, Heather L., Glen A. Coburn, Yan Zeng, Yibin Kang, Hal P. Bogerd, and Bryan R. Cullen. “Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes.” Mol Cell Biol 22, no. 1 (January 2002): 245–56. https://doi.org/10.1128/MCB.22.1.245-256.2002.Full Text Link to Item
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Russell, R. A., Y. Zeng, O. Erlwein, B. R. Cullen, and M. O. McClure. “The R region found in the human foamy virus long terminal repeat is critical for both Gag and Pol protein expression.” J Virol 75, no. 15 (August 2001): 6817–24. https://doi.org/10.1128/JVI.75.15.6817-6824.2001.Full Text Link to Item
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Yang, J., H. P. Bogerd, P. J. Wang, D. C. Page, and B. R. Cullen. “Two closely related human nuclear export factors utilize entirely distinct export pathways.” Mol Cell 8, no. 2 (August 2001): 397–406. https://doi.org/10.1016/s1097-2765(01)00303-3.Full Text Link to Item
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Tokunaga, K., M. L. Greenberg, M. A. Morse, R. I. Cumming, H. K. Lyerly, and B. R. Cullen. “Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates.” J Virol 75, no. 15 (August 2001): 6776–85. https://doi.org/10.1128/JVI.75.15.6776-6785.2001.Full Text Link to Item
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Cullen, B. R. “Journey to the center of the cell.” Cell 105, no. 6 (June 15, 2001): 697–700. https://doi.org/10.1016/s0092-8674(01)00392-0.Full Text Link to Item
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Coburn, G. A., H. L. Wiegand, Y. Kang, D. N. Ho, M. M. Georgiadis, and B. R. Cullen. “Using viral species specificity to define a critical protein/RNA interaction surface.” Genes Dev 15, no. 10 (May 15, 2001): 1194–1205. https://doi.org/10.1101/gad.888201.Full Text Link to Item
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Cullen, B. R., J. Yang, H. Bogerd, and H. Wiegand. “The human endogenous retrovirus HERV-K encodes a functional homolog of the HTLV-1 Rex protein.” Aids Research and Human Retroviruses 17 (January 1, 2001): S16–S16.Link to Item
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Russell, R. A., O. Erlwein, Y. Zeng, B. R. Cullen, and M. O. McClure. “The R region found in the Human Foamy Virus long terminal repeat is critical for both Gag and Pol expression.” Aids Research and Human Retroviruses 17 (January 1, 2001): S15–S15.Link to Item
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Cullen, B. R. “A new entry route for HIV.” Nat Med 7, no. 1 (January 2001): 20–21. https://doi.org/10.1038/83295.Full Text Link to Item
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Neufeld, K. L., D. A. Nix, H. Bogerd, Y. B. Kang, F. Zhang, M. C. Beckerle, B. R. Cullen, and R. L. White. “APC protein shuttles between nucleus and cytoplasm and interacts with nuclear beta-catenin.” Molecular Biology of the Cell 11 (December 1, 2000): 459A-459A.Link to Item
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Neufeld, K. L., F. Zhang, B. R. Cullen, and R. L. White. “APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export.” Embo Rep 1, no. 6 (December 2000): 519–23. https://doi.org/10.1093/embo-reports/kvd117.Full Text Link to Item
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Bieniasz, P. D., and B. R. Cullen. “Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells.” J Virol 74, no. 21 (November 2000): 9868–77. https://doi.org/10.1128/jvi.74.21.9868-9877.2000.Full Text Link to Item
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Yang, J., H. Bogerd, S. Y. Le, and B. R. Cullen. “The human endogenous retrovirus K Rev response element coincides with a predicted RNA folding region.” Rna 6, no. 11 (November 2000): 1551–64. https://doi.org/10.1017/s135583820000100x.Full Text Link to Item
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Neufeld, K. L., D. A. Nix, H. Bogerd, Y. Kang, M. C. Beckerle, B. R. Cullen, and R. L. White. “Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm.” Proc Natl Acad Sci U S A 97, no. 22 (October 24, 2000): 12085–90. https://doi.org/10.1073/pnas.220401797.Full Text Link to Item
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Bogerd, H. P., H. L. Wiegand, J. Yang, and B. R. Cullen. “Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.” J Virol 74, no. 20 (October 2000): 9353–61. https://doi.org/10.1128/jvi.74.20.9353-9361.2000.Full Text Link to Item
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Kang, Y., H. P. Bogerd, and B. R. Cullen. “Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-Pfizer monkey virus constitutive transport element.” J Virol 74, no. 13 (July 2000): 5863–71. https://doi.org/10.1128/jvi.74.13.5863-5871.2000.Full Text Link to Item
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Cullen, B. R. “Nuclear RNA export pathways.” Mol Cell Biol 20, no. 12 (June 2000): 4181–87. https://doi.org/10.1128/MCB.20.12.4181-4187.2000.Full Text Link to Item
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Bogerd, H. P., H. L. Wiegand, P. D. Bieniasz, and B. R. Cullen. “Functional differences between human and bovine immunodeficiency virus Tat transcription factors.” J Virol 74, no. 10 (May 2000): 4666–71. https://doi.org/10.1128/jvi.74.10.4666-4671.2000.Full Text Link to Item
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Cullen, B. R. “Connections between the processing and nuclear export of mRNA: evidence for an export license?” Proc Natl Acad Sci U S A 97, no. 1 (January 4, 2000): 4–6. https://doi.org/10.1073/pnas.97.1.4.Full Text Link to Item
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Cullen, B. R. “Principles and applications of a Tat-based assay for analyzing specific RNA-protein interactions in mammalian cells.” Methods Enzymol 328 (2000): 322–29. https://doi.org/10.1016/s0076-6879(00)28405-x.Full Text Link to Item
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Cullen, B. R. “Utility of the secreted placental alkaline phosphatase reporter enzyme.” Methods Enzymol 326 (2000): 159–64. https://doi.org/10.1016/s0076-6879(00)26053-9.Full Text Link to Item
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Yang, J., and B. R. Cullen. “Structural and functional analysis of the avian leukemia virus constitutive transport element.” Rna 5, no. 12 (December 1999): 1645–55. https://doi.org/10.1017/s1355838299991616.Full Text Link to Item
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Yang, J., H. P. Bogerd, S. Peng, H. Wiegand, R. Truant, and B. R. Cullen. “An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein.” Proc Natl Acad Sci U S A 96, no. 23 (November 9, 1999): 13404–8. https://doi.org/10.1073/pnas.96.23.13404.Full Text Link to Item
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Truant, R., Y. Kang, and B. R. Cullen. “The human tap nuclear RNA export factor contains a novel transportin-dependent nuclear localization signal that lacks nuclear export signal function.” J Biol Chem 274, no. 45 (November 5, 1999): 32167–71. https://doi.org/10.1074/jbc.274.45.32167.Full Text Link to Item
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Kang, Y., H. P. Bogerd, J. Yang, and B. R. Cullen. “Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor.” Virology 262, no. 1 (September 15, 1999): 200–209. https://doi.org/10.1006/viro.1999.9906.Full Text Link to Item
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Cullen, B. R. “HIV-1 Nef protein: An invitation to a kill.” Nat Med 5, no. 9 (September 1999): 985–86. https://doi.org/10.1038/12417.Full Text Link to Item
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Bieniasz, P. D., T. A. Grdina, H. P. Bogerd, and B. R. Cullen. “Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.” Proc Natl Acad Sci U S A 96, no. 14 (July 6, 1999): 7791–96. https://doi.org/10.1073/pnas.96.14.7791.Full Text Link to Item
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Bieniasz, P. D., T. A. Grdina, H. P. Bogerd, and B. R. Cullen. “Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.” J Virol 73, no. 7 (July 1999): 5777–86. https://doi.org/10.1128/JVI.73.7.5777-5786.1999.Full Text Link to Item
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Bieniasz, P. D., T. A. Grdina, H. P. Bogerd, and B. R. Cullen. “Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism.” Mol Cell Biol 19, no. 7 (July 1999): 4592–99. https://doi.org/10.1128/MCB.19.7.4592.Full Text Link to Item
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Ross, T. M., A. E. Oran, and B. R. Cullen. “Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein.” Curr Biol 9, no. 12 (June 17, 1999): 613–21. https://doi.org/10.1016/s0960-9822(99)80283-8.Full Text Link to Item
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Kang, Y., and B. R. Cullen. “The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences.” Genes Dev 13, no. 9 (May 1, 1999): 1126–39. https://doi.org/10.1101/gad.13.9.1126.Full Text Link to Item
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Bogerd, H. P., R. E. Benson, R. Truant, A. Herold, M. Phingbodhipakkiya, and B. R. Cullen. “Definition of a consensus transportin-specific nucleocytoplasmic transport signal.” J Biol Chem 274, no. 14 (April 2, 1999): 9771–77. https://doi.org/10.1074/jbc.274.14.9771.Full Text Link to Item
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Truant, R., and B. R. Cullen. “The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals.” Mol Cell Biol 19, no. 2 (February 1999): 1210–17. https://doi.org/10.1128/MCB.19.2.1210.Full Text Link to Item
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Ross, T. M., P. D. Bieniasz, and B. R. Cullen. “Role of chemokine receptors in HIV-1 infection and pathogenesis.” Adv Virus Res 52 (1999): 233–67. https://doi.org/10.1016/s0065-3527(08)60300-0.Full Text Link to Item
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Bieniasz, P. D., T. A. Grdina, H. P. Bogerd, and B. R. Cullen. “Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.” Embo J 17, no. 23 (December 1, 1998): 7056–65. https://doi.org/10.1093/emboj/17.23.7056.Full Text Link to Item
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Truant, R., R. A. Fridell, E. R. Benson, A. Herold, and B. R. Cullen. “Nucleocytoplasmic shuttling by protein nuclear import factors.” Eur J Cell Biol 77, no. 4 (December 1998): 269–75. https://doi.org/10.1016/s0171-9335(98)80085-x.Full Text Link to Item
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Bogerd, H. P., A. Echarri, T. M. Ross, and B. R. Cullen. “Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1.” J Virol 72, no. 11 (November 1998): 8627–35. https://doi.org/10.1128/JVI.72.11.8627-8635.1998.Full Text Link to Item
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Herold, A., R. Truant, H. Wiegand, and B. R. Cullen. “Determination of the functional domain organization of the importin alpha nuclear import factor.” J Cell Biol 143, no. 2 (October 19, 1998): 309–18. https://doi.org/10.1083/jcb.143.2.309.Full Text Link to Item
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Cullen, B. R. “Retroviruses as model systems for the study of nuclear RNA export pathways.” Virology 249, no. 2 (September 30, 1998): 203–10. https://doi.org/10.1006/viro.1998.9331.Full Text Link to Item
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Kang, Y., and B. R. Cullen. “Derivation and functional characterization of a consensus DNA binding sequence for the tas transcriptional activator of simian foamy virus type 1.” J Virol 72, no. 7 (July 1998): 5502–9. https://doi.org/10.1128/JVI.72.7.5502-5509.1998.Full Text Link to Item
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Ross, T. M., and B. R. Cullen. “The ability of HIV type 1 to use CCR-3 as a coreceptor is controlled by envelope V1/V2 sequences acting in conjunction with a CCR-5 tropic V3 loop.” Proc Natl Acad Sci U S A 95, no. 13 (June 23, 1998): 7682–86. https://doi.org/10.1073/pnas.95.13.7682.Full Text Link to Item
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Cullen, B. R. “HIV-1 auxiliary proteins: making connections in a dying cell.” Cell 93, no. 5 (May 29, 1998): 685–92. https://doi.org/10.1016/s0092-8674(00)81431-2.Full Text Link to Item
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Ross, T. M., P. D. Bieniasz, and B. R. Cullen. “Multiple residues contribute to the inability of murine CCR-5 to function as a coreceptor for macrophage-tropic human immunodeficiency virus type 1 isolates.” J Virol 72, no. 3 (March 1998): 1918–24. https://doi.org/10.1128/JVI.72.3.1918-1924.1998.Full Text Link to Item
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Truant, R., R. A. Fridell, R. E. Benson, H. Bogerd, and B. R. Cullen. “Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein.” Mol Cell Biol 18, no. 3 (March 1998): 1449–58. https://doi.org/10.1128/MCB.18.3.1449.Full Text Link to Item
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Blair, W. S., T. B. Parsley, H. P. Bogerd, J. S. Towner, B. L. Semler, and B. R. Cullen. “Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases.” Rna 4, no. 2 (February 1998): 215–25.Link to Item
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Bieniasz, P. D., and B. R. Cullen. “Chemokine receptors and human immunodeficiency virus infection.” Front Biosci 3 (January 1, 1998): d44–58. https://doi.org/10.2741/a265.Full Text Link to Item
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Cullen, B. R. “Posttranscriptional regulation by the HIV-1 rev protein.” Seminars in Virology 8, no. 4 (January 1, 1998): 327–34. https://doi.org/10.1006/smvy.1997.0135.Full Text
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Kang, Y., W. S. Blair, and B. R. Cullen. “Identification and functional characterization of a high-affinity Bel-1 DNA binding site located in the human foamy virus internal promoter.” J Virol 72, no. 1 (January 1998): 504–11. https://doi.org/10.1128/JVI.72.1.504-511.1998.Full Text Link to Item
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Bieniasz, P. D., R. A. Fridell, K. Anthony, and B. R. Cullen. “Murine CXCR-4 is a functional coreceptor for T-cell-tropic and dual-tropic strains of human immunodeficiency virus type 1.” J Virol 71, no. 9 (September 1997): 7097–7100. https://doi.org/10.1128/JVI.71.9.7097-7100.1997.Full Text Link to Item
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Hua, J., and B. R. Cullen. “Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4.” J Virol 71, no. 9 (September 1997): 6742–48. https://doi.org/10.1128/JVI.71.9.6742-6748.1997.Full Text Link to Item
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Aramori, I., S. S. Ferguson, P. D. Bieniasz, J. Zhang, B. Cullen, and M. G. Cullen. “Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor.” Embo J 16, no. 15 (August 1, 1997): 4606–16. https://doi.org/10.1093/emboj/16.15.4606.Full Text Link to Item
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Fridell, R. A., R. Truant, L. Thorne, R. E. Benson, and B. R. Cullen. “Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta.” J Cell Sci 110 ( Pt 11) (June 1997): 1325–31. https://doi.org/10.1242/jcs.110.11.1325.Full Text Link to Item
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Bieniasz, P. D., R. A. Fridell, I. Aramori, S. S. Ferguson, M. G. Caron, and B. R. Cullen. “HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor.” Embo J 16, no. 10 (May 15, 1997): 2599–2609. https://doi.org/10.1093/emboj/16.10.2599.Full Text Link to Item
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Hua, J., W. Blair, R. Truant, and B. R. Cullen. “Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4.” Virology 231, no. 2 (May 12, 1997): 231–38. https://doi.org/10.1006/viro.1997.8517.Full Text Link to Item
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Blair, W. S., and B. R. Cullen. “A yeast TATA-binding protein mutant that selectively enhances gene expression from weak RNA polymerase II promoters.” Mol Cell Biol 17, no. 5 (May 1997): 2888–96. https://doi.org/10.1128/MCB.17.5.2888.Full Text Link to Item
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Cullen, B. R. “HIV-1: is Nef a PAK animal?” Curr Biol 6, no. 12 (December 1, 1996): 1557–59. https://doi.org/10.1016/s0960-9822(02)70770-7.Full Text Link to Item
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Fridell, R. A., R. E. Benson, J. Hua, H. P. Bogerd, and B. R. Cullen. “A nuclear role for the Fragile X mental retardation protein.” Embo J 15, no. 19 (October 1, 1996): 5408–14.Link to Item
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Hua, J., J. J. Caffrey, and B. R. Cullen. “Functional consequences of natural sequence variation in the activation domain of HIV-1 Rev.” Virology 222, no. 2 (August 15, 1996): 423–29. https://doi.org/10.1006/viro.1996.0439.Full Text Link to Item
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Bogerd, H. P., R. A. Fridell, R. E. Benson, J. Hua, and B. R. Cullen. “Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay.” Mol Cell Biol 16, no. 8 (August 1996): 4207–14. https://doi.org/10.1128/MCB.16.8.4207.Full Text Link to Item
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He, F., W. S. Blair, J. Fukushima, and B. R. Cullen. “The human foamy virus Bel-1 transcription factor is a sequence-specific DNA binding protein.” J Virol 70, no. 6 (June 1996): 3902–8. https://doi.org/10.1128/JVI.70.6.3902-3908.1996.Full Text Link to Item
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Fridell, R. A., H. P. Bogerd, and B. R. Cullen. “Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.” Proc Natl Acad Sci U S A 93, no. 9 (April 30, 1996): 4421–24. https://doi.org/10.1073/pnas.93.9.4421.Full Text Link to Item
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Fridell, R. A., U. Fischer, R. Lührmann, B. E. Meyer, J. L. Meinkoth, M. H. Malim, and B. R. Cullen. “Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.” Proc Natl Acad Sci U S A 93, no. 7 (April 2, 1996): 2936–40. https://doi.org/10.1073/pnas.93.7.2936.Full Text Link to Item
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Blair, W. S., R. A. Fridell, and B. R. Cullen. “Synergistic enhancement of both initiation and elongation by acidic transcription activation domains.” Embo J 15, no. 7 (April 1, 1996): 1658–65.Link to Item
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Cullen, B. R. “Virology. New trick from an old foe.” Nature 379, no. 6562 (January 18, 1996): 208–9. https://doi.org/10.1038/379208a0.Full Text Link to Item
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Bogerd, H. P., R. A. Fridell, S. Madore, and B. R. Cullen. “Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.” Cell 82, no. 3 (August 11, 1995): 485–94. https://doi.org/10.1016/0092-8674(95)90437-9.Full Text Link to Item
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Okuda, K., H. Bukawa, K. Hamajima, S. Kawamoto, K. Sekigawa, Y. Yamada, S. Tanaka, N. Ishi, I. Aoki, and M. Nakamura. “Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products.” Aids Res Hum Retroviruses 11, no. 8 (August 1995): 933–43. https://doi.org/10.1089/aid.1995.11.933.Full Text Link to Item
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Fridell, R. A., L. S. Harding, H. P. Bogerd, and B. R. Cullen. “Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins.” Virology 209, no. 2 (June 1, 1995): 347–57. https://doi.org/10.1006/viro.1995.1266.Full Text Link to Item
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Madore, S. J., and B. R. Cullen. “Functional similarities between HIV-1 Tat and DNA sequence-specific transcriptional activators.” Virology 206, no. 2 (February 1, 1995): 1150–54. https://doi.org/10.1006/viro.1995.1041.Full Text Link to Item
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BOGERD, H. P., R. A. FRIDELL, S. J. MADORE, and B. R. CULLEN. “IDENTIFICATION OF A HUMAN COFACTOR FOR THE REV/REX CLASS OF RETROVIRAL REGULATORY PROTEINS.” Aids Research and Human Retroviruses 11 (January 1, 1995): S86–S86.Link to Item
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Cullen, B. R. “Regulation of HIV gene expression.” Aids 9 Suppl A (1995): S19–32.Link to Item
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Cullen, B. R., and J. Heitman. “Human immunodeficiency virus. Chaperoning a pathogen.” Nature 372, no. 6504 (November 24, 1994): 319–20. https://doi.org/10.1038/372319a0.Full Text Link to Item
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Cullen, B. R. “The role of Nef in the replication cycle of the human and simian immunodeficiency viruses.” Virology 205, no. 1 (November 15, 1994): 1–6. https://doi.org/10.1006/viro.1994.1613.Full Text Link to Item
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Blair, W. S., H. P. Bogerd, S. J. Madore, and B. R. Cullen. “Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module.” Mol Cell Biol 14, no. 11 (November 1994): 7226–34. https://doi.org/10.1128/mcb.14.11.7226-7234.1994.Full Text Link to Item
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Gröne, M., E. Hoffmann, S. Berchtold, B. R. Cullen, and R. Grassmann. “A single stem-loop structure within the HTLV-1 Rex response element is sufficient to mediate Rex activity in vivo.” Virology 204, no. 1 (October 1994): 144–52. https://doi.org/10.1006/viro.1994.1518.Full Text Link to Item
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Madore, S. J., L. S. Tiley, M. H. Malim, and B. R. Cullen. “Sequence requirements for Rev multimerization in vivo.” Virology 202, no. 1 (July 1994): 186–94. https://doi.org/10.1006/viro.1994.1334.Full Text Link to Item
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Blair, W. S., H. Bogerd, and B. R. Cullen. “Genetic analysis indicates that the human foamy virus Bel-1 protein contains a transcription activation domain of the acidic class.” J Virol 68, no. 6 (June 1994): 3803–8. https://doi.org/10.1128/JVI.68.6.3803-3808.1994.Full Text Link to Item
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Sanfridson, A., B. R. Cullen, and C. Doyle. “The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells.” J Biol Chem 269, no. 6 (February 11, 1994): 3917–20.Link to Item
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Cullen, B. R. “RNA-sequence-mediated gene regulation in HIV-1.” Infect Agents Dis 3, no. 2–3 (1994): 68–76.Link to Item
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Paca-Uccaralertkun, S., L. J. Zhao, N. Adya, J. V. Cross, B. R. Cullen, I. M. Boros, and C. Z. Giam. “In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax.” Mol Cell Biol 14, no. 1 (January 1994): 456–62. https://doi.org/10.1128/mcb.14.1.456-462.1994.Full Text Link to Item
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Fridell, R. A., K. M. Partin, S. Carpenter, and B. R. Cullen. “Identification of the activation domain of equine infectious anemia virus rev.” J Virol 67, no. 12 (December 1993): 7317–23. https://doi.org/10.1128/JVI.67.12.7317-7323.1993.Full Text Link to Item
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Garrett, E. D., F. He, H. P. Bogerd, and B. R. Cullen. “Transcriptional trans activators of human and simian foamy viruses contain a small, highly conserved activation domain.” J Virol 67, no. 11 (November 1993): 6824–27. https://doi.org/10.1128/JVI.67.11.6824-6827.1993.Full Text Link to Item
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Malim, M. H., and B. R. Cullen. “Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes.” Mol Cell Biol 13, no. 10 (October 1993): 6180–89. https://doi.org/10.1128/mcb.13.10.6180-6189.1993.Full Text Link to Item
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Luo, Y., S. J. Madore, T. G. Parslow, B. R. Cullen, and B. M. Peterlin. “Functional analysis of interactions between Tat and the trans-activation response element of human immunodeficiency virus type 1 in cells.” J Virol 67, no. 9 (September 1993): 5617–22. https://doi.org/10.1128/JVI.67.9.5617-5622.1993.Full Text Link to Item
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Bogerd, H. P., R. A. Fridell, W. S. Blair, and B. R. Cullen. “Genetic evidence that the Tat proteins of human immunodeficiency virus types 1 and 2 can multimerize in the eukaryotic cell nucleus.” J Virol 67, no. 8 (August 1993): 5030–34. https://doi.org/10.1128/JVI.67.8.5030-5034.1993.Full Text Link to Item
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Madore, S. J., and B. R. Cullen. “Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function.” J Virol 67, no. 7 (July 1993): 3703–11. https://doi.org/10.1128/JVI.67.7.3703-3711.1993.Full Text Link to Item
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Benson, R. E., A. Sanfridson, J. S. Ottinger, C. Doyle, and B. R. Cullen. “Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection.” J Exp Med 177, no. 6 (June 1, 1993): 1561–66. https://doi.org/10.1084/jem.177.6.1561.Full Text Link to Item
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CULLEN, B. R. “NEW INSIGHTS INTO THE MECHANISM OF ACTION OF TAT AND REV.” Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 6, no. 6 (June 1, 1993): 700–700.Link to Item
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Cullen, B. R. “Does HIV-1 Tat induce a change in viral initiation rights?” Cell 73, no. 3 (May 7, 1993): 417–20. https://doi.org/10.1016/0092-8674(93)90126-b.Full Text Link to Item
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He, F., J. D. Sun, E. D. Garrett, and B. R. Cullen. “Functional organization of the Bel-1 trans activator of human foamy virus.” J Virol 67, no. 4 (April 1993): 1896–1904. https://doi.org/10.1128/JVI.67.4.1896-1904.1993.Full Text Link to Item
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CULLEN, B. R. “REGULATORY PROTEINS OF HIV-1.” Journal of Cellular Biochemistry, March 13, 1993, 5–5.Link to Item
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MADORE, S. J., L. S. TILEY, M. H. MALIM, B. R. CULLEN, and H. HUGHES. “THE VP16 TRANSCRIPTION ACTIVATION DOMAIN IS FUNCTIONAL WHEN TARGETED TO A PROMOTER PROXIMAL RNA SEQUENCE.” Journal of Cellular Biochemistry, January 9, 1993, 117–117.Link to Item
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Bogerd, H. P., L. S. Tiley, and B. R. Cullen. “Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element.” J Virol 66, no. 12 (December 1992): 7572–75. https://doi.org/10.1128/JVI.66.12.7572-7575.1992.Full Text Link to Item
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Tiley, L. S., S. J. Madore, M. H. Malim, and B. R. Cullen. “The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence.” Genes Dev 6, no. 11 (November 1992): 2077–87. https://doi.org/10.1101/gad.6.11.2077.Full Text Link to Item
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Malim, M. H., W. W. Freimuth, J. Liu, T. J. Boyle, H. K. Lyerly, B. R. Cullen, and G. J. Nabel. “Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.” J Exp Med 176, no. 4 (October 1, 1992): 1197–1201. https://doi.org/10.1084/jem.176.4.1197.Full Text Link to Item
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Cullen, B. R. “Mechanism of action of regulatory proteins encoded by complex retroviruses.” Microbiol Rev 56, no. 3 (September 1992): 375–94. https://doi.org/10.1128/mr.56.3.375-394.1992.Full Text Link to Item
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Chen, H., T. J. Boyle, M. H. Malim, B. R. Cullen, and H. K. Lyerly. “Derivation of a biologically contained replication system for human immunodeficiency virus type 1.” Proc Natl Acad Sci U S A 89, no. 16 (August 15, 1992): 7678–82. https://doi.org/10.1073/pnas.89.16.7678.Full Text Link to Item
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Hwang, S. S., T. J. Boyle, H. K. Lyerly, and B. R. Cullen. “Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1.” Science 257, no. 5069 (July 24, 1992): 535–37. https://doi.org/10.1126/science.1636088.Full Text Link to Item
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Garrett, E. D., and B. R. Cullen. “Comparative analysis of Rev function in human immunodeficiency virus types 1 and 2.” J Virol 66, no. 7 (July 1992): 4288–94. https://doi.org/10.1128/JVI.66.7.4288-4294.1992.Full Text Link to Item
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Keller, A., E. D. Garrett, and B. R. Cullen. “The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site.” J Virol 66, no. 6 (June 1992): 3946–49. https://doi.org/10.1128/JVI.66.6.3946-3949.1992.Full Text Link to Item
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Tiley, L. S., and B. R. Cullen. “Structural and functional analysis of the visna virus Rev-response element.” J Virol 66, no. 6 (June 1992): 3609–15. https://doi.org/10.1128/JVI.66.6.3609-3615.1992.Full Text Link to Item
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Timmerman, V., E. Nelis, W. Van Hul, B. W. Nieuwenhuijsen, K. L. Chen, S. Wang, K. Ben Othman, B. Cullen, R. J. Leach, and C. O. Hanemann. “The peripheral myelin protein gene PMP-22 is contained within the Charcot-Marie-Tooth disease type 1A duplication.” Nat Genet 1, no. 3 (June 1992): 171–75. https://doi.org/10.1038/ng0692-171.Full Text Link to Item
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Cullen, B. R., and E. D. Garrett. “A comparison of regulatory features in primate lentiviruses.” Aids Res Hum Retroviruses 8, no. 3 (March 1992): 387–93. https://doi.org/10.1089/aid.1992.8.387.Full Text Link to Item
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Tiley, L. S., M. H. Malim, H. K. Tewary, P. G. Stockley, and B. R. Cullen. “Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type 1 Rev protein.” Proc Natl Acad Sci U S A 89, no. 2 (January 15, 1992): 758–62. https://doi.org/10.1073/pnas.89.2.758.Full Text Link to Item
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Tiley, L. S., M. H. Malim, H. K. Tewary, P. G. Stockley, and B. R. Cullen. “Erratum: Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type 1 Rev protein (Proc. Natl. Acad. Sci. USA (1992) 89 (758-762)).” Proceedings of the National Academy of Sciences of the United States of America 89, no. 5 (January 1, 1992): 1997. https://doi.org/10.1073/pnas.89.5.1997a.Full Text
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Cullen, B. R., and M. H. Malim. “Secreted placental alkaline phosphatase as a eukaryotic reporter gene.” Methods Enzymol 216 (1992): 362–68. https://doi.org/10.1016/0076-6879(92)16033-g.Full Text Link to Item
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Weinberg, J. B., T. J. Matthews, B. R. Cullen, and M. H. Malim. “Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes.” J Exp Med 174, no. 6 (December 1, 1991): 1477–82. https://doi.org/10.1084/jem.174.6.1477.Full Text Link to Item
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Garcia-Blanco, M. A., and B. R. Cullen. “Molecular basis of latency in pathogenic human viruses.” Science 254, no. 5033 (November 8, 1991): 815–20. https://doi.org/10.1126/science.1658933.Full Text Link to Item
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Cullen, B. R., and M. H. Malim. “The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators.” Trends Biochem Sci 16, no. 9 (September 1991): 346–50. https://doi.org/10.1016/0968-0004(91)90141-h.Full Text Link to Item
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Malim, M. H., D. F. McCarn, L. S. Tiley, and B. R. Cullen. “Mutational definition of the human immunodeficiency virus type 1 Rev activation domain.” J Virol 65, no. 8 (August 1991): 4248–54. https://doi.org/10.1128/JVI.65.8.4248-4254.1991.Full Text Link to Item
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Hwang, S. S., T. J. Boyle, H. K. Lyerly, and B. R. Cullen. “Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.” Science 253, no. 5015 (July 5, 1991): 71–74. https://doi.org/10.1126/science.1905842.Full Text Link to Item
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Brown, P. H., L. S. Tiley, and B. R. Cullen. “Effect of RNA secondary structure on polyadenylation site selection.” Genes Dev 5, no. 7 (July 1991): 1277–84. https://doi.org/10.1101/gad.5.7.1277.Full Text Link to Item
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Tiley, L. S., M. H. Malim, and B. R. Cullen. “Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins.” J Virol 65, no. 7 (July 1991): 3877–81. https://doi.org/10.1128/JVI.65.7.3877-3881.1991.Full Text Link to Item
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Cullen, B. R. “Regulation of HIV-1 gene expression.” Faseb J 5, no. 10 (July 1991): 2361–68. https://doi.org/10.1096/fasebj.5.10.1712325.Full Text Link to Item
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Cullen, B. R. “AIDS. The positive effect of the negative factor.” Nature 351, no. 6329 (June 27, 1991): 698–99. https://doi.org/10.1038/351698a0.Full Text Link to Item
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Brown, P. H., L. S. Tiley, and B. R. Cullen. “Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences.” J Virol 65, no. 6 (June 1991): 3340–43. https://doi.org/10.1128/JVI.65.6.3340-3343.1991.Full Text Link to Item
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Riske, F. J., B. R. Cullen, and R. Chizzonite. “Characterization of human interferon-gamma and human interleukin-2 from recombinant mammalian cell lines and peripheral blood lymphocytes.” Lymphokine Cytokine Res 10, no. 3 (June 1991): 213–18.Link to Item
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Keller, A., K. M. Partin, M. Löchelt, H. Bannert, R. M. Flügel, and B. R. Cullen. “Characterization of the transcriptional trans activator of human foamy retrovirus.” J Virol 65, no. 5 (May 1991): 2589–94. https://doi.org/10.1128/JVI.65.5.2589-2594.1991.Full Text Link to Item
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Kubota, S., T. Nosaka, B. R. Cullen, M. Maki, and M. Hatanaka. “Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals.” J Virol 65, no. 5 (May 1991): 2452–56. https://doi.org/10.1128/JVI.65.5.2452-2456.1991.Full Text Link to Item
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Malim, M. H., and B. R. Cullen. “HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency.” Cell 65, no. 2 (April 19, 1991): 241–48. https://doi.org/10.1016/0092-8674(91)90158-u.Full Text Link to Item
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Cullen, B. R. “Human immunodeficiency virus as a prototypic complex retrovirus.” J Virol 65, no. 3 (March 1991): 1053–56. https://doi.org/10.1128/JVI.65.3.1053-1056.1991.Full Text Link to Item
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Garrett, E. D., L. S. Tiley, and B. R. Cullen. “Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products.” J Virol 65, no. 3 (March 1991): 1653–57. https://doi.org/10.1128/JVI.65.3.1653-1657.1991.Full Text Link to Item
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Cullen, B. R. “Regulation of gene expression in the human immunodeficiency virus type 1.” Adv Virus Res 40 (1991): 1–17. https://doi.org/10.1016/s0065-3527(08)60275-4.Full Text Link to Item
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Cullen, B. R. “Regulation of human immunodeficiency virus replication.” Annu Rev Microbiol 45 (1991): 219–50. https://doi.org/10.1146/annurev.mi.45.100191.001251.Full Text Link to Item
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Tiley, L. S., P. H. Brown, P. H. Shu-yu Le, J. V. Maizel, J. E. Clements, and B. R. Cullen. “Erratum: Visna virus encodes a post-transcriptional regulator of viral structural gene expression (Proc. Natl. Acad. Sci. USA (October 1990) 87 (7497-7501)).” Proceedings of the National Academy of Sciences of the United States of America 87, no. 23 (December 1, 1990): 9508.
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Tiley, L. S., P. H. Brown, S. Y. Le, J. V. Maizel, J. E. Clements, and B. R. Cullen. “Visna virus encodes a post-transcriptional regulator of viral structural gene expression.” Proceedings of the National Academy of Sciences of the United States of America 87, no. 19 (December 1, 1990): 7502–6.
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Cullen, B. R. “The HIV-1 Tat protein: an RNA sequence-specific processivity factor?” Cell 63, no. 4 (November 16, 1990): 655–57. https://doi.org/10.1016/0092-8674(90)90129-3.Full Text Link to Item
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Tiley, L. S., P. H. Brown, S. Y. Le, J. V. Maizel, J. E. Clements, and B. R. Cullen. “Visna virus encodes a post-transcriptional regulator of viral structural gene expression.” Proc Natl Acad Sci U S A 87, no. 19 (October 1990): 7497–7501. https://doi.org/10.1073/pnas.87.19.7497.Full Text Link to Item
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Tiley, L. S., P. H. Brown, and B. R. Cullen. “Does the human immunodeficiency virus Tat trans-activator contain a discrete activation domain?” Virology 178, no. 2 (October 1990): 560–67. https://doi.org/10.1016/0042-6822(90)90354-t.Full Text Link to Item
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Cullen, B. R., and W. C. Greene. “Functions of the auxiliary gene products of the human immunodeficiency virus type 1.” Virology 178, no. 1 (September 1990): 1–5. https://doi.org/10.1016/0042-6822(90)90373-y.Full Text Link to Item
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Ahmed, Y. F., S. M. Hanly, M. H. Malim, B. R. Cullen, and W. C. Greene. “Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action.” Genes Dev 4, no. 6 (June 1990): 1014–22. https://doi.org/10.1101/gad.4.6.1014.Full Text Link to Item
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AHMED, Y. F., S. M. HANLY, M. H. MALIM, B. R. CULLEN, and W. C. GREENE. “MOLECULAR ANALYSIS OF THE STRUCTURE AND FUNCTION OF THE HTLV-I REX AND HIV-1 REV RESPONSE ELEMENTS.” Clinical Research 38, no. 2 (April 1, 1990): A278–A278.Link to Item
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Le, S. Y., M. H. Malim, B. R. Cullen, and J. V. Maizel. “A highly conserved RNA folding region coincident with the Rev response element of primate immunodeficiency viruses.” Nucleic Acids Res 18, no. 6 (March 25, 1990): 1613–23. https://doi.org/10.1093/nar/18.6.1613.Full Text Link to Item
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Malim, M. H., L. S. Tiley, D. F. McCarn, J. R. Rusche, J. Hauber, and B. R. Cullen. “HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.” Cell 60, no. 4 (February 23, 1990): 675–83. https://doi.org/10.1016/0092-8674(90)90670-a.Full Text Link to Item
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MALIM, M. H., S. BOHNLEIN, J. HAUBER, and B. R. CULLEN. “FUNCTIONAL DISSECTION OF THE HIV-1 REV TRANS-ACTIVATOR DERIVATION OF A TRANS-DOMINANT REPRESSOR OF REV FUNCTION.” Aids Research and Human Retroviruses 6, no. 1 (January 1, 1990): 50–50.Link to Item
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Fenrick, R., M. H. Malim, J. Hauber, S. Y. Le, J. Maizel, and B. R. Cullen. “Functional analysis of the Tat trans activator of human immunodeficiency virus type 2.” J Virol 63, no. 12 (December 1989): 5006–12. https://doi.org/10.1128/JVI.63.12.5006-5012.1989.Full Text Link to Item
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Hammes, S. R., E. P. Dixon, M. H. Malim, B. R. Cullen, and W. C. Greene. “Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.” Proc Natl Acad Sci U S A 86, no. 23 (December 1989): 9549–53. https://doi.org/10.1073/pnas.86.23.9549.Full Text Link to Item
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Malim, M. H., S. Böhnlein, R. Fenrick, S. Y. Le, J. V. Maizel, and B. R. Cullen. “Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species.” Proc Natl Acad Sci U S A 86, no. 21 (November 1989): 8222–26. https://doi.org/10.1073/pnas.86.21.8222.Full Text Link to Item
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Sadaie, M. R., Z. N. Benaissa, B. R. Cullen, and F. Wong-Staal. “Human immunodeficiency virus type 1 rev protein as a negative trans-regulator.” Dna 8, no. 9 (November 1989): 669–74. https://doi.org/10.1089/dna.1.1989.8.669.Full Text Link to Item
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Hanly, S. M., L. T. Rimsky, M. H. Malim, J. H. Kim, J. Hauber, M. Duc Dodon, S. Y. Le, J. V. Maizel, B. R. Cullen, and W. C. Greene. “Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements.” Genes Dev 3, no. 10 (October 1989): 1534–44. https://doi.org/10.1101/gad.3.10.1534.Full Text Link to Item
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Cullen, B. R., and W. C. Greene. “Regulatory pathways governing HIV-1 replication.” Cell 58, no. 3 (August 11, 1989): 423–26. https://doi.org/10.1016/0092-8674(89)90420-0.Full Text Link to Item
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Malim, M. H., R. Fenrick, D. W. Ballard, J. Hauber, E. Böhnlein, and B. R. Cullen. “Functional characterization of a complex protein-DNA-binding domain located within the human immunodeficiency virus type 1 long terminal repeat leader region.” J Virol 63, no. 8 (August 1989): 3213–19. https://doi.org/10.1128/JVI.63.8.3213-3219.1989.Full Text Link to Item
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Malim, M. H., S. Böhnlein, J. Hauber, and B. R. Cullen. “Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function.” Cell 58, no. 1 (July 14, 1989): 205–14. https://doi.org/10.1016/0092-8674(89)90416-9.Full Text Link to Item
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HANLY, S. M., M. MALIM, L. T. RIMSKY, J. H. KIM, B. R. CULLEN, and W. C. GREENE. “TRANS-REGULATION OF RETROVIRAL STRUCTURAL GENE-EXPRESSION IN ADULT T-CELL LEUKEMIA (ATL) AND THE ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) - CONSERVED ACTION OF THE HTLV-I REX AND HIV-1 REV PROTEINS.” Clinical Research 37, no. 2 (April 1, 1989): A556–A556.Link to Item
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Malim, M. H., J. Hauber, S. Y. Le, J. V. Maizel, and B. R. Cullen. “The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA.” Nature 338, no. 6212 (March 16, 1989): 254–57. https://doi.org/10.1038/338254a0.Full Text Link to Item
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Hauber, J., M. H. Malim, and B. R. Cullen. “Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein.” J Virol 63, no. 3 (March 1989): 1181–87. https://doi.org/10.1128/JVI.63.3.1181-1187.1989.Full Text Link to Item
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Böhnlein, S., J. Hauber, and B. R. Cullen. “Identification of a U5-specific sequence required for efficient polyadenylation within the human immunodeficiency virus long terminal repeat.” J Virol 63, no. 1 (January 1989): 421–24. https://doi.org/10.1128/JVI.63.1.421-424.1989.Full Text Link to Item
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Hauber, J., M. Bouvier, M. H. Malim, and B. R. Cullen. “Phosphorylation of the rev gene product of human immunodeficiency virus type 1.” J Virol 62, no. 12 (December 1988): 4801–4. https://doi.org/10.1128/JVI.62.12.4801-4804.1988.Full Text Link to Item
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Cullen, B. R. “Expression of a cloned human interleukin-2 cDNA is enhanced by the substitution of a heterologous mRNA leader region.” Dna 7, no. 9 (November 1988): 645–50. https://doi.org/10.1089/dna.1988.7.645.Full Text Link to Item
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Rimsky, L., J. Hauber, M. Dukovich, M. H. Malim, A. Langlois, B. R. Cullen, and W. C. Greene. “Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein.” Nature 335, no. 6192 (October 20, 1988): 738–40. https://doi.org/10.1038/335738a0.Full Text Link to Item
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Malim, M. H., J. Hauber, R. Fenrick, and B. R. Cullen. “Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes.” Nature 335, no. 6186 (September 8, 1988): 181–83. https://doi.org/10.1038/335181a0.Full Text Link to Item
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Berger, J., A. D. Howard, L. Brink, L. Gerber, J. Hauber, B. R. Cullen, and S. Udenfriend. “COOH-terminal requirements for the correct processing of a phosphatidylinositol-glycan anchored membrane protein.” J Biol Chem 263, no. 20 (July 15, 1988): 10016–21.Link to Item
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Cullen, B. R., J. Hauber, K. Campbell, J. G. Sodroski, W. A. Haseltine, and C. A. Rosen. “Subcellular localization of the human immunodeficiency virus trans-acting art gene product.” J Virol 62, no. 7 (July 1988): 2498–2501. https://doi.org/10.1128/JVI.62.7.2498-2501.1988.Full Text Link to Item
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Berger, J., J. Hauber, R. Hauber, R. Geiger, and B. R. Cullen. “Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells.” Gene 66, no. 1 (June 15, 1988): 1–10. https://doi.org/10.1016/0378-1119(88)90219-3.Full Text Link to Item
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Cullen, B. R., F. J. Podlaski, N. J. Peffer, J. B. Hosking, and W. C. Greene. “Sequence requirements for ligand binding and cell surface expression of the Tac antigen, a human interleukin-2 receptor.” J Biol Chem 263, no. 10 (April 5, 1988): 4900–4906.Link to Item
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Hauber, J., and B. R. Cullen. “Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat.” J Virol 62, no. 3 (March 1988): 673–79. https://doi.org/10.1128/JVI.62.3.673-679.1988.Full Text Link to Item
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Goldstein, A. M., L. Marcon, B. R. Cullen, and D. L. Nelson. “A competitive enzyme-linked immunoassay (ELISA) for the measurement of soluble human interleukin-2 receptors (IL-2R, Tac protein).” J Immunol Methods 107, no. 1 (February 24, 1988): 103–9. https://doi.org/10.1016/0022-1759(88)90015-4.Full Text Link to Item
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Hakimi, J., C. Seals, L. E. Anderson, F. J. Podlaski, P. Lin, W. Danho, J. C. Jenson, A. Perkins, P. E. Donadio, and P. C. Familletti. “Biochemical and functional analysis of soluble human interleukin-2 receptor produced in rodent cells. Solid-phase reconstitution of a receptor-ligand binding reaction.” J Biol Chem 262, no. 36 (December 25, 1987): 17336–41.Link to Item
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Hauber, J., A. Perkins, E. P. Heimer, and B. R. Cullen. “Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events.” Proc Natl Acad Sci U S A 84, no. 18 (September 1987): 6364–68. https://doi.org/10.1073/pnas.84.18.6364.Full Text Link to Item
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Berger, J., A. D. Howard, L. Gerber, B. R. Cullen, and S. Udenfriend. “Expression of active, membrane-bound human placental alkaline phosphatase by transfected simian cells.” Proc Natl Acad Sci U S A 84, no. 14 (July 1987): 4885–89. https://doi.org/10.1073/pnas.84.14.4885.Full Text Link to Item
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Dukovich, M., Y. Wano, Y. Le thi Bich Thuy, P. Katz, B. R. Cullen, J. H. Kehrl, and W. C. Greene. “A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors.” Nature 327, no. 6122 (June 11, 1987): 518–22. https://doi.org/10.1038/327518a0.Full Text Link to Item
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Wano, Y., B. R. Cullen, P. A. Svetlik, N. J. Peffer, and W. C. Greene. “Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector.” Mol Biol Med 4, no. 2 (April 1987): 95–109.Link to Item
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Cullen, B. R. “Use of eukaryotic expression technology in the functional analysis of cloned genes.” Methods Enzymol 152 (1987): 684–704. https://doi.org/10.1016/0076-6879(87)52074-2.Full Text Link to Item
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Sharon, M., R. D. Klausner, B. R. Cullen, R. Chizzonite, and W. J. Leonard. “Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions.” Science 234, no. 4778 (November 14, 1986): 859–63. https://doi.org/10.1126/science.3095922.Full Text Link to Item
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Cullen, B. R. “Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism.” Cell 46, no. 7 (September 26, 1986): 973–82. https://doi.org/10.1016/0092-8674(86)90696-3.Full Text Link to Item
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Katz, R. A., B. R. Cullen, R. Malavarca, and A. M. Skalka. “Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control.” Mol Cell Biol 6, no. 2 (February 1986): 372–79. https://doi.org/10.1128/mcb.6.2.372-379.1986.Full Text Link to Item
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Cullen, B. R. “A rapid and simple procedure for the preparation of homogeneously labeled DNA probes.” Gene 43, no. 3 (1986): 305–10. https://doi.org/10.1016/0378-1119(86)90221-0.Full Text Link to Item
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Butnick, N. Z., C. Miyamoto, R. Chizzonite, B. R. Cullen, G. Ju, and A. M. Skalka. “Regulation of the human c-myc gene: 5' noncoding sequences do not affect translation.” Mol Cell Biol 5, no. 11 (November 1985): 3009–16. https://doi.org/10.1128/mcb.5.11.3009-3016.1985.Full Text Link to Item
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Cullen, B. R., R. A. Katz, and G. Ju. “Expression of transfected DNA in avian cells can be enhanced in trans by retroviral infection.” Mol Cell Biol 5, no. 7 (July 1985): 1804–7. https://doi.org/10.1128/mcb.5.7.1804-1807.1985.Full Text Link to Item
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Cullen, B. R., K. Raymond, and G. Ju. “Functional analysis of the transcription control region located within the avian retroviral long terminal repeat.” Mol Cell Biol 5, no. 3 (March 1985): 438–47. https://doi.org/10.1128/mcb.5.3.438-447.1985.Full Text Link to Item
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Cullen, B. R., K. Raymond, and G. Ju. “Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity.” J Virol 53, no. 2 (February 1985): 515–21. https://doi.org/10.1128/JVI.53.2.515-521.1985.Full Text Link to Item
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Ju, G., and B. R. Cullen. “The role of avian retroviral LTRs in the regulation of gene expression and viral replication.” Adv Virus Res 30 (1985): 179–223. https://doi.org/10.1016/s0065-3527(08)60451-0.Full Text Link to Item
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Cullen, B. R., P. T. Lomedico, and G. Ju. “Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.” Nature 307, no. 5948 (January 19, 1984): 241–45. https://doi.org/10.1038/307241a0.Full Text Link to Item
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Cullen, B. R., A. M. Skalka, and G. Ju. “Endogenous avian retroviruses contain deficient promoter and leader sequences.” Proc Natl Acad Sci U S A 80, no. 10 (May 1983): 2946–50. https://doi.org/10.1073/pnas.80.10.2946.Full Text Link to Item
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Skalka, A. M., P. N. Tsichlis, R. Malavarca, B. Cullen, and G. Ju. “Viral sequences determining the oncogenicity of avian leukosis viruses.” Prog Clin Biol Res 119 (1983): 105–18.Link to Item
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Cullen, B. R., J. J. Kopchick, and D. W. Stacey. “Effect of intron size on splicing efficiency in retroviral transcripts.” Nucleic Acids Res 10, no. 19 (October 11, 1982): 6177–90. https://doi.org/10.1093/nar/10.19.6177.Full Text Link to Item
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Kopchick, J. J., B. R. Cullen, and D. W. Stacey. “Rapid analysis of small nucleic acid samples by gel electrophoresis.” Anal Biochem 115, no. 2 (August 1981): 419–23. https://doi.org/10.1016/0003-2697(81)90027-0.Full Text Link to Item
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Cullen, B., K. Emigholz, and J. Monahan. “The transient appearance of specific proteins in one-cell mouse embryos.” Dev Biol 76, no. 1 (April 1980): 215–21. https://doi.org/10.1016/0012-1606(80)90373-5.Full Text Link to Item
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Alexander, A., B. Cullen, K. Emigholz, M. V. Norgard, and J. J. Monahan. “A computer program for displaying two-dimensional gel electrophoresis data.” Anal Biochem 103, no. 1 (March 15, 1980): 176–83. https://doi.org/10.1016/0003-2697(80)90253-5.Full Text Link to Item
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Fasy, T. M., B. R. Cullen, D. Luk, and M. D. Bick. “Studies on the enhanced interaction of halodeoxyuridine-substituted DNAs with H1 histones and other polypeptides.” J Biol Chem 255, no. 4 (February 25, 1980): 1380–87.Link to Item
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Cullen, B. R., K. Emigholz, and J. J. Monahan. “Protein patterns of early mouse embryos during development.” Differentiation 17, no. 3 (1980): 151–60. https://doi.org/10.1111/j.1432-0436.1980.tb01092.x.Full Text Link to Item
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Cullen, B. R., and M. D. Bick. “Bromodeoxyuridine induction of deoxycytidine deaminase activity in a hamster cell line.” Biochim Biophys Acta 517, no. 1 (January 26, 1978): 158–68. https://doi.org/10.1016/0005-2787(78)90043-6.Full Text Link to Item
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Bick, M. D., and B. R. Cullen. “Bromodeoxyuridine inhibition of Friend leukemia cell induction by butyric acid: Time course of inhibition, reversal, and effect of other base analogs.” Somatic Cell Genetics 2, no. 6 (November 1, 1976): 545–58. https://doi.org/10.1007/BF01542691.Full Text
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Cullen, B. R., and M. D. Bick. “Thermal denaturation of DNA from bromodeoxyuridine substituted cells.” Nucleic Acids Res 3, no. 1 (January 1976): 49–62. https://doi.org/10.1093/nar/3.1.49.Full Text Link to Item
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Book Sections
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Umbach, Jennifer L., and Bryan R. Cullen. “Human Alphaherpesvirus MicroRNAs: Expression and Functions.” In ALPHAHERPESVIRUSES: MOLECULAR VIROLOGY, 391–99, 2011.Link to Item
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Sullivan, C. S., and B. R. Cullen. “Non-coding regulatory RNAs of the DNA tumor viruses.” In DNA Tumor Viruses, 645–82, 2009. https://doi.org/10.1007/978-0-387-68945-6_25.Full Text
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Conference Papers
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Arnson, Benjamin, Songtao Li, Dorothy Gheorgiu, Elizabeth Brooks, Sang-Oh Han, Ekaterina Ilich, Bryan R. Cullen, and Dwight D. Koeberl. “Efficacy of Genome Editing in Infant Mice with Glycogen Storage Disease Type Ia.” In Molecular Therapy, 30:115–16, 2022.Link to Item
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Arnson, Benjamin, Jason Wang, David Courtney, Sang-oh Han, Songtao Li, Bryan R. Cullen, Nenad Bursac, and Dwight Koeberl. “Single Vector AAV Approach to Genome Editing in Pompe Disease.” In Molecular Therapy, 29:291–291, 2021.Link to Item
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Mefferd, Adam L., Anand V. R. Kornepati, Hal P. Bogerd, Edward M. Kennedy, and Bryan R. Cullen. “Expression of CRISPR-Cas9 Single Guide RNA's Using Small tRNA Promoters.” In Molecular Therapy, 26:229–229. CELL PRESS, 2018.Link to Item
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Gottwein, E., X. Cai, and B. R. Cullen. “Expression and Function of MicroRNAs Encoded by Kaposi's Sarcoma-associated Herpesvirus.” In Regulatory Rnas, 71:357–64, 2006.Link to Item
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Cullen, B. R. “Inhibition of cellular and viral gene expression using RNA interference.” In Abstracts of Papers of the American Chemical Society, 228:U171–U171. AMER CHEMICAL SOC, 2004.Link to Item
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Cullen, B. R. “Inhibition of cellular and viral gene expression using RNAi.” In Biophysical Journal, 86:367A-367A. BIOPHYSICAL SOCIETY, 2004.Link to Item
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MALIM, M. H., W. W. FREIMUTH, J. LIU, T. J. BOYLE, H. K. LYERLY, B. R. CULLEN, and G. J. NABEL. “TRANSDOMINANT REV PROTEIN INHIBITS HIV REPLICATION WITHOUT AFFECTING T-CELL FUNCTION.” In Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 6:669–669. LIPPINCOTT-RAVEN PUBL, 1993.Link to Item
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MALIM, M. H., W. W. FREIMUTH, J. LIU, T. J. BOYLE, H. K. LYERLY, B. R. CULLEN, and G. J. NABEL. “TRANSDOMINANT REV PROTEIN INHIBITS HIV REPLICATION WITHOUT AFFECTING T-CELL FUNCTION.” In Clinical Research, 40:A701–A701. SLACK INC, 1992.Link to Item
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BOYLE, T. J., S. S. HWANG, H. CHEN, M. TAMBURINI, B. R. CULLEN, and H. K. LYERLY. “PH-INDEPENDENT HIV-1 ENTRY INTO MACROPHAGE.” In Aids Research and Human Retroviruses, 8:920–920. MARY ANN LIEBERT INC PUBL, 1992.Link to Item
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HWANG, S. S., T. J. BOYLE, H. K. LYERLY, and B. R. CULLEN. “THE ENVELOPE V3 LOOP IS THE PRIMARY DETERMINANT OF CELL TROPISM IN HIV-1.” In Aids Research and Human Retroviruses, 8:867–867. MARY ANN LIEBERT INC PUBL, 1992.Link to Item
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MALIM, M. H., W. W. FREIMUTH, J. LIU, T. J. BOYLE, H. K. LYERLY, B. R. CULLEN, and G. J. NABEL. “TRANSDOMINANT REV PROTEIN INHIBITS HIV REPLICATION WITHOUT AFFECTING T-CELL FUNCTION.” In Clinical Research, 40:A253–A253. SLACK INC, 1992.Link to Item
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MALIM, M. H., D. F. MCCARN, L. S. TILEY, and B. R. CULLEN. “DOMAIN-STRUCTURE OF THE HIV-1 REV PROTEIN.” In Genetic Structure and Regulation of Hiv, edited by W. A. HASELTINE and F. WONGSTAAL, 1:369–76. RAVEN PRESS, 1991.Link to Item
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GREENE, W. C., D. W. BALLARD, E. BOHNLEIN, L. T. RIMSKY, S. M. HANLY, J. H. KIM, M. H. MALIM, and B. R. CULLEN. “THE TRANSREGULATORY PROTEINS OF HTLV-I - ANALYSIS OF TAX AND REX.” In Human Retrovirology : Htlv, edited by W. A. Blattner, 35–43. RAVEN PRESS, 1990.Link to Item
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GREENE, W. C., J. H. KIM, D. W. BALLARD, J. W. LOWENTHAL, E. BOHNLEIN, L. T. RIMSKY, S. M. HANLY, M. H. MALIM, and B. R. CULLEN. “MOLECULAR ANALYSIS OF THE HTLV-1 TAX AND REX PROTEINS.” In Human Retroviruses /, edited by J. E. GROOPMAN, I. S. Y. CHEN, M. ESSEX, and R. A. WEISS, 119:49–60. WILEY-LISS, INC, 1990.Link to Item
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MALIM, M. H., J. HAUBER, R. FENRICK, S. BOHNLEIN, and B. R. CULLEN. “NUCLEAR EXPORT OF UNSPLICED HIV-1 MESSENGER-RNAS IS REGULATED BY THE VIRAL REV TRANSACTIVATOR.” In Human Retroviruses /, edited by J. E. GROOPMAN, I. S. Y. CHEN, M. ESSEX, and R. A. WEISS, 119:97–108. WILEY-LISS, INC, 1990.Link to Item
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