Overview
Program Year: 2019
Jing Li Laboratory
Recent Publications
Neoadjuvant anti-4-1BB confers protection against spontaneous metastasis through low-affinity intratumor CD8 + T cells in triple-negative breast cancer.
Preprint · February 2, 2025 Full text Link to item CiteAberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response.
Journal Article Nat Commun · October 3, 2024 Immunotherapy successfully complements traditional cancer treatment. However, primary and acquired resistance might limit efficacy. Reduced antigen presentation by MHC-I has been identified as potential resistance factor. Here we show that the epigenetic r ... Full text Link to item CiteBreaking NGF-TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection.
Journal Article Nat Immunol · February 2024 Melanoma cells, deriving from neuroectodermal melanocytes, may exploit the nervous system's immune privilege for growth. Here we show that nerve growth factor (NGF) has both melanoma cell intrinsic and extrinsic immunosuppressive functions. Autocrine NGF e ... Full text Link to item CiteRecent Grants
Synthetic lethality by targeting the core senescent mechanism in lung cancer.
ResearchResearch Assistant · Awarded by National Institutes of Health · 2020 - 2025Targeting UHRF1 in combinational immunotherapy
ResearchResearch Assistant · Awarded by National Institutes of Health · 2019 - 2024View All Grants