Journal articleAm J Ophthalmol · December 2024
PURPOSE: To evaluate the clinical characteristics and management of patients with an anteriorly and nasally inserted superior oblique tendon. DESIGN: Retrospective interventional case series. METHODS: Institutional clinical records between 2020 and 2024 we ...
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Journal articleBMC Med Educ · April 14, 2023
BACKGROUND: The COVID-19 pandemic in parallel with concerns about bias in grading resulted in many medical schools adopting pass/fail clinical grading and relying solely on narrative assessments. However, narratives often contain bias and lack specificity. ...
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Journal articleOphthalmology Science · December 1, 2022
Objective: To compare the rate of refractive growth (RRG3) of the crystalline lens (“lens”) versus the eye excluding the lens (“globe”) for the fellow, noncataractous eyes of participants in the Infant Aphakia Treatment Study. Design: Retrospective cohort ...
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Journal articleOphthalmology · September 2022
We studied the myopic shift and anisometropia at 10.6 (+/−0.3) years of age in the Infant Aphakia Treatment Study. We found myopic shift continues in the operated eye from 5-10.5 years at a lower rate than that prior to age five years while anisometropia i ...
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Journal articleBMC Med Educ · January 27, 2022
BACKGROUND: Clinical education across the professions is challenged by a lack of recognition for faculty and pressure for patient throughput and revenue generation. These pressures may reduce direct observation of patient care provided by students, a requi ...
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Journal articleOphthalmology · August 2019
PURPOSE: To evaluate outcomes of unilateral cataract surgery in children 7 to 24 months of age. DESIGN: Retrospective case series at 10 Infant Aphakia Treatment Study (IATS) sites. PARTICIPANTS: The Toddler Aphakia and Pseudophakia Study is a registry of c ...
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Journal articleMed Educ Online · December 2018
BACKGROUND: Medical education program evaluation allows for curricular improvements to both Undergraduate (UME) and Graduate Medical Education (GME). UME programs are left with little more than match rates and self-report to evaluate success of graduates i ...
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Journal articleAm J Ophthalmol · February 2018
PURPOSE: To evaluate low- vs high-dose plaque brachytherapy for juxtapapillary choroidal melanoma. DESIGN: Retrospective interventional case series. METHODS: Setting: Single institution. STUDY POPULATION: Forty-seven patients with juxtapapillary choroidal ...
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Journal articleOphthalmology · September 2017
PURPOSE: To report differences in visual acuities among patients with Coats' disease who sought treatment at a tertiary care university-based practice. DESIGN: Single-center retrospective cohort study. PARTICIPANTS: Patients with Coats' disease diagnosed c ...
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Journal articleAm J Ophthalmol · August 2017
PURPOSE: To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. DESIGN: Prospective randomized clinical trial. METHODS: Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with ...
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Journal articleJ Neuroophthalmol · June 2017
Fulminant idiopathic intracranial hypertension (FIIH) is a subtype of idiopathic intracranial hypertension (IIH) characterized by rapid, severe, progressive vision loss. Surgical intervention is often performed either as a cerebrospinal fluid (CSF) shunt p ...
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Journal articleOphthalmology · June 2017
PURPOSE: To report the myopic shift at 5 years of age after cataract surgery with intraocular lens (IOL) implantation for infants enrolled in the Infant Aphakia Treatment Study (IATS). METHODS: Refractions were performed at 1 month and every 3 months posto ...
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Journal articleCurr Opin Ophthalmol · January 2017
PURPOSE OF REVIEW: The basic procedure of pediatric cataract surgery has not dramatically changed over the past few years. Recent multicenter study results along with technological innovations, however, have increased our understanding and armamentarium of ...
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Journal articleJ Cataract Refract Surg · December 2016
PURPOSE: To compare the rate of refractive growth (RRG) between aphakic eyes and pseudophakic eyes in the Infant Aphakia Treatment Study (IATS). SETTING: Twelve clinical sites across the United States. DESIGN: Randomized clinical trial. METHODS: Patients r ...
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Journal articleMed Educ Online · 2016
BACKGROUND: There is a paucity of information regarding institutional targets for the number of undergraduate medical education (UME) graduates being matched to graduate medical education (GME) programs at their home institutions. At our institution, the D ...
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Journal articleJ AAPOS · October 2015
PURPOSE: To compare the in vitro characteristics of Tenon's capsule fibroblasts from children and adults that may be relevant to filtration surgery success. METHODS: Fibroblast cell lines derived from 5 young (median patient age, 2.4 years) and 7 old (medi ...
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Journal articleJ AAPOS · April 2015
PURPOSE: To evaluate a clinical observation that prepubertal children with idiopathic intracranial hypertension (IIH) have low cerebrospinal fluid (CSF) protein levels compared to healthy children and pubertal patients with IIH. METHODS: The medical record ...
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Journal articleInvest Ophthalmol Vis Sci · August 5, 2014
PURPOSE: To study eye movements in a large group of children after the removal of unilateral infantile cataract, and to compare fixation instabilities between treatment groups with or without IOL implantation. METHODS: The Infant Aphakia Treatment Study (I ...
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Journal articleJAMA Ophthalmol · June 2014
IMPORTANCE: The efficacy and safety of primary intraocular lens (IOL) implantation during early infancy is unknown. OBJECTIVE: To compare the visual outcomes of patients optically corrected with contact lenses vs IOLs following unilateral cataract surgery ...
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Journal articleJ AAPOS · December 2012
PURPOSE: To report the unusual development of bilateral myelinated retinal nerve fibers (MRNF) adjacent to the optic nerve in a child after treatment of idiopathic intracranial hypertension (IIH) with unilateral optic nerve sheath fenestration (ONSF) and t ...
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Journal articleArch Ophthalmol · September 2012
How will the ophthalmologist of the future practice? What will be the effect of government policy? How will this impact the mix of health care providers responsible for the delivery of eye care to patients? What part will health record technology play in c ...
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Journal articleOphthalmology · March 2012
PURPOSE: To report the clinical and histopathologic findings associated with congenital fibrovascular pupillary membranes. DESIGN: Case series. PARTICIPANTS: Seven infants were included, 6 with a unilateral congenital pupillary membrane and 1 with classic ...
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Journal articleOphthalmology · December 2011
PURPOSE: To compare rates and severity of complications between infants undergoing cataract surgery with and without intraocular lens (IOL) implantation. DESIGN: Prospective, randomized clinical trial. PARTICIPANTS: The Infant Aphakia Treatment Study (IATS ...
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Journal articleJ AAPOS · October 2011
PURPOSE: To describe a video-documented assessment of cataract type in the eyes of patients with monocular infantile cataract who were enrolled in the Infant Aphakia Treatment Study. METHODS: The Infant Aphakia Treatment Study is a randomized clinical tria ...
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Journal articleInvest Ophthalmol Vis Sci · April 25, 2011
PURPOSE: To determine whether progressive-addition lenses (PALs) relative to single-vision lenses (SVLs) slow the progression of low myopia in children with high accommodative lag and near esophoria. METHODS: One hundred eighteen children 8 to <12 years of ...
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Journal articleMedical Science Educator · April 1, 2011
Duke University has long incorporated research into its medical school curriculum. Its sister school, Duke-National University of Singapore, adopted the same model to inculcate a culture of research and develop graduates with a strong scientific foundation ...
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Journal articleArch Ophthalmol · July 2010
OBJECTIVE: To compare the visual outcomes and adverse events of contact lens with primary intraocular lens (IOL) correction of monocular aphakia during infancy. METHODS: In a randomized, multicenter (12 sites) clinical trial, 114 infants with a unilateral ...
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Journal articleCurr Opin Ophthalmol · January 2010
PURPOSE OF REVIEW: Cataract surgery is the most commonly performed intraocular surgery in the pediatric population worldwide. Although the basic surgical techniques have not significantly changed over the last several years, there are many related issues u ...
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Journal articleArch Ophthalmol · January 2010
OBJECTIVE: To compare the use of contact lenses and intraocular lenses (IOLs) for the optical correction of unilateral aphakia during infancy. METHODS: In a randomized, multicenter (12 sites) clinical trial, 114 infants with unilateral congenital cataracts ...
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Journal articlePediatrics · December 2008
Red reflex testing is an essential component of the neonatal, infant, and child physical examination. This statement, which is a revision of the previous policy statement published in 2002, describes the rationale for testing, the technique used to perform ...
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Journal articleJ AAPOS · October 2008
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PURPOSE: To evaluate the long-term efficacy, safety, and advisability of transscleral-sutured posterior chamber intraocular lenses (IOLs) in pediatric patients with no capsular support and to determine whether a 10-0 polypropylene suture should be used for ...
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Journal articleOphthalmology · June 2008
OBJECTIVE: To assess visual function 15 years after acute unilateral optic neuritis. DESIGN: Longitudinal follow-up of a randomized clinical trial. PARTICIPANTS: Two hundred ninety-four patients who were randomized in the Optic Neuritis Treatment Trial bet ...
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Journal articleJ AAPOS · June 2008
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We present the case of a 9-year-old patient with corneal decompensation that was treated with Descemet stripping automated endothelial keratoplasty (DSAEK) and followed for 18 months. Although the procedure has been used successfully in adult populations, ...
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Journal articleArch Neurol · June 2008
OBJECTIVE: To assess the risk of developing multiple sclerosis (MS) after optic neuritis and the factors predictive of high and low risk. DESIGN: Subjects in the Optic Neuritis Treatment Trial, who were enrolled between July 1, 1988, and June 30, 1991, wer ...
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Journal articleAcad Med · February 2008
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Duke University and the National University of Singapore (NUS) have partnered to launch a new medical school that brings the American style of postbaccalaureate medical education to Asia. The new institution, called the Duke-NUS Graduate Medical School (GM ...
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Journal articleJ Pediatr Ophthalmol Strabismus · 2008
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PURPOSE: To evaluate the safety and efficacy of silicone rod frontalis suspension surgery for childhood ptosis. METHODS: The authors retrospectively studied 89 consecutive children (110 eyelids) who had silicone rod frontalis suspension surgery for ptosis ...
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Journal articleAm Orthopt J · 2008
The surgical approach necessary to achieve the largest field of usable single binocular vision in patients with paralytic strabismus is one that has a greater effect in some directions of gaze than in others. Developing the appropriate "incomitant" strabis ...
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Journal articleJ AAPOS · December 2007
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PURPOSE: To evaluate optical coherence tomography (OCT) measurement of peripapillary retinal nerve fiber layer (RNFL) and macular thickness in children with pseudotumor cerebri. METHODS: Prospective observational series of children with pseudotumor cerebri ...
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Journal articleCurr Opin Ophthalmol · September 2007
PURPOSE OF REVIEW: To provide clinically relevant information regarding the diagnosis, etiology, work-up and treatment of third cranial nerve palsies, while incorporating information from current publications and providing our opinions on these studies. RE ...
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Journal articleNeurology · August 7, 2007
OBJECTIVE: To identify cutpoints for visual measures at baseline and 1 month predictive of abnormal 6-month vision that could be used as eligibility criteria in a clinical trial to test potential neuroprotection or myelin repair agents in patients with opt ...
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Journal articleAcad Med · April 2007
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Duke University School of Medicine offers an unusual doctor of medicine educational program. The core basic sciences are taught in year one, core clinical clerkships are completed in the second year, the entire third year is devoted to scholarly investigat ...
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Journal articleTrans Am Ophthalmol Soc · 2007
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PURPOSE: To evaluate the long-term efficacy, safety, and advisability of using transscleral sutured posterior chamber intraocular lenses (IOLs) in pediatric patients with no capsular support and to determine whether 10-0 polypropylene suture should be used ...
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Journal articlePediatrics · May 2006
Unlike the joints, ocular involvement with juvenile rheumatoid arthritis is most often asymptomatic; yet, the inflammation can cause serious morbidity with loss of vision. Scheduled slit-lamp examinations by an ophthalmologist at specific intervals can det ...
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Journal articleMedical teacher · March 2006
The paper reports an evaluation of digital, split-site and traditional poster presentations at the Association for Medical Education in Europe (AMEE) conference in September 2004. The programme included 300 posters in 19 sessions, viewed, potentially, by 1 ...
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Journal articleJ AAPOS · February 2006
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BACKGROUND: It generally is accepted that cataract surgery during the first 6 weeks of life is associated with the best visual outcomes for children with dense unilateral congenital cataracts. The latent period for children with dense bilateral congenital ...
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Journal articlePediatrics · February 2006
This statement revises a previous statement on screening of preterm infants for retinopathy of prematurity (ROP) that was published in 2001. ROP is a pathologic process that occurs only in immature retinal tissue and can progress to a tractional retinal de ...
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Journal articleCompr Ophthalmol Update · 2006
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The diagnosis and etiologies of sixth cranial nerve palsies are reviewed along with nonsurgical and surgical treatment approaches. Surgical options depend on the function of the paretic muscle, the field of greatest symptoms, and the likelihood of inducing ...
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Journal articleOphthalmology · April 2005
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PURPOSE: To review our experience with optic nerve sheath decompression for pediatric pseudotumor cerebri. DESIGN: Retrospective chart review. PARTICIPANTS: Seventeen eyes in 12 children younger than 16 years of age. All patients were either unresponsive o ...
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Journal articleJ AAPOS · February 2005
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INTRODUCTION: Paradoxical patterns of extraocular muscle, eyelid, or pupillary movements can occur following injury between divisions of the oculomotor nerve, trigeminal and abducens nerves, and trigeminal and oculomotor nerves. We report three cases of un ...
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Journal articleBr J Ophthalmol · November 2004
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AIMS: To compare optotype acuities and re-operation rates in children corrected with a contact lens (CL) compared with an intraocular lens (IOL) following unilateral cataract extraction during infancy in a non-randomised, retrospective case series. METHODS ...
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Journal articleArch Neurol · September 2004
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BACKGROUND: Participants enrolled in the Optic Neuritis Treatment Trial have been observed for more than a decade to assess the relationship between optic neuritis and the development of clinically definite multiple sclerosis. OBJECTIVE: To assess neurolog ...
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Journal articleJ AAPOS · June 2004
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INTRODUCTION: Upgaze paralysis due to supranuclear defects can cause significant visual symptoms. There are only a few reports on the treatment of this problem in the literature. Patients with Parinaud's syndrome may also have retraction nystagmus and conv ...
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Journal articleAm J Ophthalmol · January 2004
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PURPOSE: To assess visual function more than 10 years after an episode of optic neuritis in patients enrolled in the Optic Neuritis Treatment Trial. DESIGN: Longitudinal follow-up of a randomized clinical trial. METHODS: Vision testing included measures of ...
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Journal articleJ AAPOS · December 2003
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BACKGROUND: To determine whether a randomized clinical trial, the Infant Aphakia Treatment Study, comparing intraocular lens (IOL) implantation with contact lens (CL) correction for infants with a unilateral congenital cataract (UCC), is feasible by (1) as ...
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Journal articleArch Ophthalmol · July 2003
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OBJECTIVE: To identify factors associated with a high and low risk of developing multiple sclerosis after an initial episode of optic neuritis. METHODS: Three hundred eighty-eight patients who experienced acute optic neuritis between July 1, 1988, and June ...
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Journal articlePediatrics · April 1, 2003
Early detection and prompt treatment of ocular disorders in children is important to avoid lifelong visual impairment. Examination of the eyes should be performed beginning in the newborn period and at all well-child visits. Newborns should be exam ...
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Journal articleOphthalmology · 2003
Early detection and prompt treatment of ocular disorders in children is important to avoid lifelong visual impairment. Examination of the eyes should be performed beginning in the newborn period and at all well-child visits. Newborns should be examined for ...
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Journal articlePediatrics · March 2002
This statement asserts that all children should be screened for risk factors associated with amblyopia. Guidelines are suggested for the use of photoscreening as a technique for the detection of amblyopia and strabismus in children of various age groups. T ...
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Journal articleArch Ophthalmol · August 2001
OBJECTIVE: To evaluate outcomes at 10 years after randomization for eyes undergoing cryotherapy vs eyes serving as controls, for patients enrolled in the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP). METHODS: The randomized co ...
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Journal articleMed Educ · June 2001
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The current emphasis on providing quality undergraduate and postgraduate medical education has focused attention on the educational responsibilities of all doctors. There is a greater awareness of the need to train doctors as educators and courses have bee ...
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Journal articleJ AAPOS · April 2001
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PURPOSE: The method of correcting aphakia after unilateral cataract extraction during infancy is controversial. Some authorities advocate correction with an intraocular lens (IOL) whereas others advocate correction with a contact lens (CL). We compared gra ...
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Journal articleJ AAPOS · April 2000
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PURPOSE: The purpose of this study was to evaluate the effects of oblique muscle surgery on the large-angle incyclotorsion resulting from macular translocation surgery for severe age-related macular degeneration. METHODS: Patients undergoing macular transl ...
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Journal articleJ AAPOS · February 2000
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PURPOSE: Open-angle glaucoma may develop after surgery for congenital or developmental cataract with an incidence ranging from 3% to 41%. The pathogenesis of "aphakic" (open-angle) glaucoma remains unknown. Despite numerous reported clinical series (>1000 ...
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Journal articleOphthalmology · January 2000
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OBJECTIVE: To compare the rate of refractive growth in pseudophakic children's eyes to that of aphakic eyes. DESIGN: Multicenter, retrospective observational case series. PARTICIPANTS: 83 patients with pseudophakic eyes (100 eyes) and 74 patients with apha ...
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Journal articleJ AAPOS · December 1999
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PURPOSE: The purpose of this study was to determine the incidence of postoperative complications and the occurrence of myopic shift in infantile eyes after cataract surgery and implantation of an intraocular lens (IOL). METHODS: Cataract surgery and IOL im ...
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Journal articleJ AAPOS · October 1999
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BACKGROUND: The treatment of incomitant strabismus is challenging. Traditional approaches include the use of asymmetric bilateral surgery and the fadenoperation (posterior fixation suture). We report our experience with a different approach: combined resec ...
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Journal articleJ AAPOS · October 1999
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BACKGROUND: Optical rehabilitation of unilateral aphakia in eyes with no capsular support is problematic in pediatric patients who cannot tolerate contact lenses. Possible options include a unilateral aphakic spectacle, an anterior chamber intraocular lens ...
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Journal articleOphthalmic Surg Lasers · March 1999
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OBJECTIVE: To review our results with optic nerve sheath decompression (ONSD) for progressive central retinal vein occlusions (CRVO). METHODS: Patients selected all had evidence of progressively worsening CRVO, a component of optic nerve swelling, and most ...
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Journal articleJ AAPOS · February 1999
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PURPOSE: Latanoprost is a prostaglandin F2alpha analogue that substantially reduces intraocular pressure (IOP) in adults with open-angle glaucoma or ocular hypertension. The efficacy and safety of latanoprost in children is unknown. We wished to evaluate l ...
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Journal articleJ Pediatr Hematol Oncol · 1999
PURPOSE: Results of a phase II trial of cyclophosphamide (CPM) for children with progressive low-grade astrocytoma are reported. PATIENTS AND METHODS: Fifteen patients with a median age of 39 months (range, 2 to 71) were included in this study. The tumors ...
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Journal articleAm J Ophthalmol · December 1998
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PURPOSE: To report refractive changes after cataract surgery and intraocular lens implantation in infants and children. METHODS: In an ongoing prospective study, the refractive errors of all patients younger than 18 years undergoing intraocular lens implan ...
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Journal articleOphthalmology · October 1998
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OBJECTIVE: To evaluate the success rate and long-term outcome of cyclocryotherapy for refractory pediatric glaucoma. DESIGN: Retrospective interventional case series. PARTICIPANTS: A total of 64 eyes of 49 patients from 2 institutions with pediatric glauco ...
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Journal articleAm J Ophthalmol · October 1998
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PURPOSE: To determine if latanoprost reduces intraocular pressure in eyes with glaucoma associated with Sturge-Weber syndrome. METHODS: We conducted a prospective study in which eyes with uncontrolled intraocular pressure associated with Sturge-Weber syndr ...
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Journal articleJ AAPOS · October 1998
PURPOSE: The purpose of this study was to determine whether the high rates of ocular problems described in previous retrospective reports of individuals with fragile X syndrome were present in a prospective sample of young boys. Fragile X syndrome is curre ...
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Journal articleCancer · August 15, 1998
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BACKGROUND: Second primary malignancies are common after bilateral retinoblastoma; their estimated incidence has been as high as 51% 50 years after diagnosis. Fifteen patients who developed sebaceous gland carcinoma after radiation therapy have been report ...
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Journal articleNeurosurg Focus · April 15, 1998
In this study, the authors sought to investigate the response rate and toxicity of carboplatin in patients with progressive low-grade glioma (LGG). Thirty-two patients with progressive LGG were treated with carboplatin at a dosage of 560 mg/m(2). Treatment ...
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Journal articleArch Ophthalmol · April 1998
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OBJECTIVE: To report the visual outcome and complications after extracapsular cataract extraction with posterior chamber intraocular lens (IOL) implantation in eyes that underwent external beam radiotherapy for the treatment of retinoblastoma. METHODS: Ele ...
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Journal articleJ AAPOS · February 1998
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PURPOSE: Our purpose was to compare, in a crossover design,the hypotensive effect of oral acetazolamide (Diamox) and topical dorzolamide (Trusopt) in patients with pediatric glaucoma. METHODS: All patients less than 18 years old who were switched from acet ...
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Journal articleArch Ophthalmol · December 1997
OBJECTIVE: To assess the 5-year visual course, including the incidence of recurrent optic neuritis, in 454 patients enrolled in the Optic Neuritis Treatment Trial. METHODS: Five-year follow-up vision testing, which included measures of visual acuity, contr ...
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Journal articleJ AAPOS · September 1997
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PURPOSE: The patient with a large esodeviation at near and a minimal if any deviation at distance who is unable to discontinue bifocal wear or demonstrates a decrease in binocular function presents a difficult therapeutic dilemma to the strabismologist. Th ...
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Journal articleJ Pediatr Ophthalmol Strabismus · 1997
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PURPOSE: To evaluate the success of contact transscleral cyclophotocoagulation (TDC) in patients with refractory pediatric glaucomas. METHODS: Twenty-six eyes of 20 patients with therapy-resistant pediatric glaucomas were included in this retrospective stu ...
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Journal articleAm J Ophthalmol · January 1997
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PURPOSE: To report results of secondary posterior chamber intraocular lens (IOL) implantation in previously aphakic pediatric patients. METHODS: In 19 pediatric patients, 19 aphakic eyes (11 after infantile and eight after traumatic cataract surgery) recei ...
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Journal articleOphthalmic Genet · September 1996
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Patients with germinal retinoblastoma (those with bilateral disease or positive family history) have a mutation which puts them at risk for developing new tumors. It is unclear whether the frequency of new tumor development is effected by the type of treat ...
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Journal articleHealth Bull (Edinb) · July 1996
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OBJECTIVE: Since its introduction in 1990, the Staff Grade has expanded to comprise almost 10% of the career grade establishment in Scotland. A study of this new grade was carried out to determine its progress and whether educational needs were being met. ...
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Journal articleOphthalmology · June 1996
BACKGROUND: Retinal astrocytic hamartoma and retinoblastoma may be very similar clinically, and their differentiation in atypical cases can be difficult, even with the use of ancillary methods such as fluorescein angiography, ultrasonography, and computed ...
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Journal articleArch Ophthalmol · April 1996
OBJECTIVE: To evaluate outcome at 5 1/2 years after randomization in eyes that underwent cryotherapy and in control eyes of patients in the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity. DESIGN: During infancy, patients with bilateral thr ...
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Journal articleArch Ophthalmol · February 1996
OBJECTIVE: To determine whether the extent of retinal vessel development present on early screening examinations for retinopathy of prematurity has prognostic value? DESIGN: The prospectively collected data from the Multicenter Trial of Cryotherapy for Ret ...
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Journal articleJ Pediatr Ophthalmol Strabismus · 1996
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PURPOSE: We examined the efficacy of intraocular lens implantation (IOL) in children younger than 4 years of age for unilateral aphakic visual rehabilitation. METHODS: Twenty-one patients underwent unilateral cataract extraction, IOL placement, posterior c ...
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Journal articleSemin Ophthalmol · March 1995
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Between 5% and 25% of patients may experience persistent diplopia after surgery for retinal detachment. The complexity of the presentation poses a distinct challenge to both the retinal and the strabismus surgeon. Careful evaluation to determine factors co ...
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Journal articleOphthalmology · February 1995
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PURPOSE: To assess the effectiveness of vitrectomy for stage V retinopathy of prematurity (ROP) at the authors' institution, 33 patients with ROP who had initially successful total or partial anatomic retinal attachments (51 eyes) were evaluated for visual ...
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Journal articleN Engl J Med · December 9, 1993
BACKGROUND: Optic neuritis is often the first clinical manifestation of multiple sclerosis, but little is known about the effect of corticosteroid treatment for optic neuritis on the subsequent risk of multiple sclerosis. METHODS: We conducted a multicente ...
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Journal articleAm J Ophthalmol · June 15, 1993
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One of the major obstacles in pediatric intraocular lens implantation has been the subsequent dense opacification of the posterior capsule. We used a modification of the standard pediatric cataract surgical procedure, which involved endocapsular cataract e ...
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Journal articleControl Clin Trials · April 1993
The Optic Neuritis Treatment Trial (ONTT) was an investigator-initiated, multi-centered, randomized, controlled clinical trial supported by cooperative agreements and grants. It was designed to evaluate the efficacy and safety of oral prednisone or intrave ...
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Journal articleMed Dosim · 1993
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The application of radiation therapy in the retreatment of unilateral recurrent retinoblastoma presents a very difficult dilemma in which consideration must be given to preservation of vision in the remaining eye while tumoricidal doses of irradiation are ...
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Journal articleJournal of the American Medical Association · 1993
Objective. - To determine the incidence of side effects from short-term glucocorticoid therapy prescribed for treatment of optic neuritis in the Optic Neuritis Treatment Trial. Design. - Randomized, placebo-controlled, multicenter clinical trial. Setting. ...
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Journal articleAm J Ophthalmol · July 15, 1992
Trilateral retinoblastoma, the intracranial malignancy associated with bilateral retinoblastoma, is an uncommon and clinically aggressive malignancy with a uniformly fatal outcome. Three children with newly diagnosed trilateral retinoblastoma were treated ...
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Journal articleN Engl J Med · April 16, 1992
BACKGROUND: Retinopathy of prematurity is a disease affecting the blood vessels of the retina in premature infants that may result in scarring, retinal detachment, and loss of vision. An association between this condition and the exposure of premature infa ...
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Journal articleOphthalmology · March 1992
The authors report on the incidence of myopia in a large group of premature infants with birth weights of less than 1251 g followed as part of the multicenter study of Cryotherapy for Retinopathy of Prematurity. None of the eyes reported here underwent cry ...
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Journal articleJ Pediatr Ophthalmol Strabismus · 1992
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Recent trends in the treatment of retinoblastoma have favored radiation therapy as opposed to enucleation. A major determining factor in selecting radiation therapy is the possibility of useful posttreatment visual function. While the treatment of nonmacul ...
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Journal articleArch Ophthalmol · December 1991
The baseline characteristics of 448 eligible patients entered into the Optic Neuritis Treatment Trial are described in an effort to summarize the clinical profile of acute optic neuritis. A total of 77.2% of the patients were women. Mean age was 31.8 years ...
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Journal articleOphthalmology · November 1991
In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, ...
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Journal articleAm J Ophthalmol · June 15, 1991
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We treated three children with optic pathway gliomas who had progressive disease associated with metastatic spread to the leptomeninges. One patient had radiographic resolution of leptomeningeal disease after treatment with intravenous carmustine and oral ...
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Journal articleOphthalmology · April 1991
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Botulinum toxin was used to treat 20 patients with strabismus after retinal detachment surgery. Preinjection motility deviations ranged from 10 to 60 prism diopters (D). Postinjection deviations ranged from 0 to 20 prism D, with 75% being 10 D or less. Eig ...
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Journal articleAm J Ophthalmol · March 15, 1991
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We combined a recession or resection of recti muscles with a vertical or horizontal transposition to correct a complicated paralytic ocular deviation in eight patients. The transposed muscles were reattached to the globe parallel to the spiral of Tillaux a ...
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Journal articleInternational Pediatrics · December 1, 1990
The patient with nystagmus presents a difficult diagnostic challenge. The concern is to insure that the nystagmus is not a sign of significant neurologic abnormality which necessitates immediate intervention. The great majority of patients with nystagmus h ...
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Journal articleGraefes Arch Clin Exp Ophthalmol · 1990
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Six adult patients with acquired, chronic, complete sixth nerve palsy had vertical rectus muscle transposition to the lateral rectus muscle insertion with intraoperative injection of botulinum toxin into the ipsilateral medial rectus muscle. Five of six pa ...
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Journal articleN Engl J Med · December 21, 1989
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Mutations of the retinoblastoma gene, most of which cannot be detected by conventional Southern blotting, are known to cause both the nonhereditary and hereditary forms of retinoblastoma and have been implicated in the development of other cancers. Nonhere ...
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Journal articleJ Pediatr Ophthalmol Strabismus · 1989
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A child with congenital ocular fibrosis syndrome and oculocutaneous albinism displayed two distinct neural misdirection syndromes: synergistic divergence and Marcus Gunn jaw winking. This and other reported cases of misdirected innervation in patients with ...
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Journal articleSurv Ophthalmol · 1989
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A child with interstitial deletion of chromosome 17, right optic nerve hypoplasia, and impaired speech had bilateral congenital optic disc pigmentation, giving the appearance of gray optic discs. This appearance did not change over a period of two-and-a-ha ...
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Journal articleOphthalmology · November 1988
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The authors review their long-term results and complications with the use of botulinum A toxin in the treatment of facial dystonias. Two hundred thirty-two patients in three diagnostic groups--essential blepharospasm, hemifacial spasm, and Meige's syndrome ...
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Journal articleAm J Ophthalmol · March 15, 1988
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We reviewed retrospectively the records of 17 patients with incomitant vertical diplopia secondary to an underacting inferior rectus muscle who had been treated by surgically weakening the contralateral inferior rectus muscle with a posterior fixation sutu ...
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Journal articleArch Ophthalmol · March 1988
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We tested the reliability of brightness comparison testing in predicting relative afferent pupillary defects (RAPDs) in 206 patients. For unselected patients, brightness comparison testing correctly predicted the RAPD in 62% of patients. For subgroups of p ...
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Journal articleOphthalmology · June 1987
This article presents data gathered in a prospective clinical trial of constant monitoring of oxygen therapy on the diagnosis, severity (as coded by a severity index [SI]) and natural history of retinopathy of prematurity (ROP) in 214 surviving infants wit ...
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Journal articleOphthalmology · June 1987
To determine whether the use of continuous transcutaneous oxygen monitoring (tcPO2) could reduce the incidence of retinopathy of prematurity (ROP) in pre-term infants receiving oxygen therapy, a randomized, prospective trial of constant monitoring using th ...
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Journal articleAm J Ophthalmol · November 15, 1986
Current therapy for patients with trilateral retinoblastoma, consisting primarily of surgical intervention and radiotherapy, has resulted in no long-term survivors. The use of adjuvant chemotherapy has not improved this outcome. After observing a tumor res ...
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Journal articleArch Neurol · April 1986
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Seventy-seven patients with blepharospasm unresponsive to other forms of therapy were treated with botulinum A toxin. The drug was injected into the orbicularis oculi muscle of both upper and lower eyelids and, in some patients, into the brows and upper pa ...
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Journal articleOphthalmology · April 1986
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Numerous complications resulting from retrobulbar injections in the injected eye and orbit have been reported. A rare complication of retrobulbar anesthesia is the occurrence of decreased visual acuity and extraocular muscle palsies in the contralateral ey ...
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Journal articleNeurology · April 1986
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In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles. The time course with which the abnormalities developed and cleared, as well a ...
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Journal articleAm J Ophthalmol · October 15, 1985
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We compared magnetic resonance imaging of the optic nerves and chiasm with computed tomography in four patients (a 17-year-old girl, a 14-year-old boy, a 13-year-old girl, and a 22-year-old woman) with biopsy-proven or suspected optic gliomas. Orbital abno ...
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Journal articleAm J Ophthalmol · February 15, 1985
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In 43 patients (81 eyes) with blepharospasm resistant to other forms of therapy, 149 outpatient injections of botulinum A toxin were given into the orbicularis oculi muscle. Subsequent follow-up periods ranged from ten to 210 days. Orbicularis oculi spasm, ...
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Journal articleSurv Ophthalmol · 1985
The clinical and histopathologic features of Axenfeld's anomaly and Rieger's anomaly and syndrome are reviewed, and recent findings regarding the pathogenesis of this spectrum of developmental disorders are discussed. Based on these observations, it has be ...
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Journal articleAnn Ophthalmol · March 1984
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Six children had recurrent sixth nerve palsy the average duration of which was six weeks. One youngster, after several episodes of sixth nerve palsy, had residual esotropia and underwent strabismus surgery. The average interval between recurrences was 1.3 ...
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Journal articleArch Ophthalmol · February 1984
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A case of posttraumatic unilateral enlargement of the optic nerve sheath associated with a venous obstructive retinopathy and progressive visual loss responded with marked improvement in visual function after nerve sheath decompression. Indirect (closed-he ...
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Journal articleJ Pediatr Ophthalmol Strabismus · 1983
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Past experience with weakening the superior oblique muscle by tenotomy has been complicated by unpredictable results. Superior oblique recession has been advocated as a more controlled and reliable procedure. We retrospectively studied 20 cases of superior ...
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Journal articleOphthalmology · February 1982
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The differences in the clinical and diagnostic characteristics of 33 consecutive traumatic unilateral (21 patients, 62%) and bilateral (12 patients, 38%) superior oblique palsies were studied. The unilateral palsies had a large hypertropia in primary posit ...
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Journal articleAm J Ophthalmol · May 1981
We found dyskinetic strabismus in 66 patients with cerebral palsy. The most striking feature of dyskinetic strabismus is the fluctuation from esotropia to exotropia under the same accommodative conditions with a slow tonic deviation similar to a vergence m ...
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