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Candice Yang Johnson

Assistant Professor in Family Medicine and Community Health
Family Medicine and Community Health
Box 104006 DUMC, Durham, NC 27705
P.O. Box 17969, Durham, NC 27705

Selected Publications


Understanding the roles of state demographics and state policies in epidemiologic studies of maternal-child health disparities.

Journal Article Am J Epidemiol · June 3, 2024 Disparities in maternal-child health outcomes by race and ethnicity highlight structural differences in the opportunity for optimal health in the United States. Examples of these differences include access to state-level social policies that promote matern ... Full text Link to item Cite

Physical job demands in pregnancy and associated musculoskeletal health and employment outcomes: a systematic review.

Journal Article Am J Obstet Gynecol · June 2024 OBJECTIVE: A decline in musculoskeletal health during pregnancy is an underappreciated adverse outcome of pregnancy that can have immediate and long-term health consequences. High physical job demands are known risk factors for nontraumatic musculoskeletal ... Full text Link to item Cite

Prevalence and correlates of workplace violence: descriptive results from the National Transgender Discrimination Survey.

Journal Article Occup Environ Med · April 28, 2024 OBJECTIVE: To describe the lifetime prevalence of workplace harassment, physical violence and sexual assault against transgender and non-binary workers targeted due to their gender identity and to identify correlates of this workplace violence. METHODS: Th ... Full text Link to item Cite

Asking MultiCrit Questions: A Reflexive and Critical Framework to Promote Health Data Equity for the Multiracial Population.

Journal Article Milbank Q · February 29, 2024 Policy Points Health equity work primarily centers monoracial populations; however, the rapid growth of the Multiracial population and increasingly clear health disparities affecting the people in that population complicate our understanding of racial heal ... Full text Link to item Cite

Occupational physical demands and menstrual cycle irregularities in flight attendants and teachers.

Journal Article Occup Environ Med · January 6, 2024 OBJECTIVES: Flight attendants perform physically demanding work such as lifting baggage, pushing service carts and spending the workday on their feet. We examined if more frequent exposure to occupational physical demands could explain why previous studies ... Full text Link to item Cite

Fever and antibiotic use in maternal urinary tract infections during pregnancy and risk of congenital heart defects: Findings from the National Birth Defects Prevention Study.

Journal Article Birth Defects Res · January 2024 BACKGROUND: Previous studies report an association between prenatal maternal urinary tract infections (UTI) and specific congenital heart defects (CHDs); however, the role of fever and antibiotic use on this association is poorly understood. Using data fro ... Full text Link to item Cite

Identifying occupational health inequities in the absence of suitable data: are there inequities in access to adequate bathrooms in US workplaces?

Journal Article Occup Environ Med · October 2023 OBJECTIVES: Our research questions are often chosen based on the existence of suitable data for analysis or prior research in the area. For new interdisciplinary research areas, such as occupational health equity, suitable data might not yet exist. In this ... Full text Link to item Cite

Zika virus knowledge, attitudes and prevention behaviors among pregnant women in the ZEN cohort study, Colombia, 2017-2018.

Journal Article Trans R Soc Trop Med Hyg · July 4, 2023 BACKGROUND: Zika virus (ZIKV) infection during pregnancy can cause severe birth defects in the fetus and is associated with neurodevelopmental abnormalities in childhood. Our objective was to describe ZIKV knowledge and attitudes among pregnant women in Co ... Full text Link to item Cite

Paid sick leave among US private sector employees.

Journal Article Am J Ind Med · September 2022 BACKGROUND: Inequities in US employees' access to paid sick leave are known, but it is not clear whether they are increasing or decreasing over time. More than two dozen state and local paid sick leave laws were recently enacted, many with the stated goal ... Full text Link to item Cite

Maternal occupation as a nail technician or hairdresser during pregnancy and birth defects, National Birth Defects Prevention Study, 1997-2011.

Journal Article Occup Environ Med · January 2022 OBJECTIVE: Nail technicians and hairdressers may be exposed to chemicals with potential reproductive effects. While studies have examined birth defects in children of hairdressers, those in children of nail technicians have not been evaluated. We investiga ... Full text Link to item Cite

Characteristics of Women with Urinary Tract Infection in Pregnancy.

Journal Article J Womens Health (Larchmt) · November 2021 Background: Urinary tract infection (UTI) is the most common bacterial infection in pregnancy. Known risk factors for UTI in pregnancy include diabetes and certain urologic conditions. Other maternal characteristics might also be associated with risk and c ... Full text Link to item Cite

Occupational exposure to high-level disinfectants and risk of miscarriage among nurses.

Journal Article Occup Environ Med · October 2021 OBJECTIVES: To examine the association of occupational exposure to high-level disinfectants (HLDs) with risk of miscarriage among nurses. METHODS: Our study included women who enrolled in the Nurses' Health Study 3 (2010-2020) and had at least one pregnanc ... Full text Link to item Cite

Prepregnancy body mass index and spina bifida: Potential contributions of bias.

Journal Article Birth Defects Res · May 2021 BACKGROUND: Epidemiologists have consistently observed associations between prepregnancy obesity and spina bifida in offspring. Most studies, however, used self-reported body mass index (potential for exposure misclassification) and incompletely ascertaine ... Full text Link to item Cite

Prepregnancy handling of antineoplastic drugs and risk of miscarriage in female nurses.

Journal Article Annals of epidemiology · January 2021 PurposeTo examine the association betweenantineoplastic drug (AD) handling and risk of miscarriage.MethodsNurses' Health Study-3 participants self-reported AD administration and engineering controls (ECs) and personal protective equipment ... Full text Cite

Folate intake, markers of folate status and oral clefts: An updated set of systematic reviews and meta-analyses.

Journal Article Birth Defects Res · November 2020 BACKGROUND: There has been a longstanding debate about the role of folate in the etiology of orofacial clefts (OFCs). Studies of different measures of nutritional intake or folate status have been done to investigate the possible role of folate in the prev ... Full text Link to item Cite

Improving Diversity and Promoting Inclusion in the Society for Epidemiologic Research Through Choice of Conference Location.

Journal Article Am J Epidemiol · October 1, 2020 Scientific conferences provide attendees opportunities to network, share research, learn new skills and ideas, and initiate collaborations. Conference attendance is especially important for students and early-career researchers who are establishing their r ... Full text Link to item Cite

Nonfatal Violent Workplace Crime Characteristics and Rates by Occupation - United States, 2007-2015.

Journal Article MMWR Morb Mortal Wkly Rep · March 27, 2020 Featured Publication Workplace violence can lead to adverse physical and psychological outcomes and affect work function (1). According to the U.S. Bureau of Labor Statistics, intentional injury by another person is a leading cause of nonfatal injury requiring missed workdays ... Full text Link to item Cite

Night shift work and cardiovascular disease biomarkers in female nurses.

Journal Article Am J Ind Med · March 2020 BACKGROUND: Night shift work is associated with cardiovascular disease, but its associations with cardiovascular disease biomarkers are unclear. We investigated these associations in a study of female nurses. METHODS: We used data from the Nurses' Health S ... Full text Link to item Cite

Understanding the roles of state demographics and state policies in epidemiologic studies of maternal-child health disparities.

Journal Article Am J Epidemiol · June 3, 2024 Disparities in maternal-child health outcomes by race and ethnicity highlight structural differences in the opportunity for optimal health in the United States. Examples of these differences include access to state-level social policies that promote matern ... Full text Link to item Cite

Physical job demands in pregnancy and associated musculoskeletal health and employment outcomes: a systematic review.

Journal Article Am J Obstet Gynecol · June 2024 OBJECTIVE: A decline in musculoskeletal health during pregnancy is an underappreciated adverse outcome of pregnancy that can have immediate and long-term health consequences. High physical job demands are known risk factors for nontraumatic musculoskeletal ... Full text Link to item Cite

Prevalence and correlates of workplace violence: descriptive results from the National Transgender Discrimination Survey.

Journal Article Occup Environ Med · April 28, 2024 OBJECTIVE: To describe the lifetime prevalence of workplace harassment, physical violence and sexual assault against transgender and non-binary workers targeted due to their gender identity and to identify correlates of this workplace violence. METHODS: Th ... Full text Link to item Cite

Asking MultiCrit Questions: A Reflexive and Critical Framework to Promote Health Data Equity for the Multiracial Population.

Journal Article Milbank Q · February 29, 2024 Policy Points Health equity work primarily centers monoracial populations; however, the rapid growth of the Multiracial population and increasingly clear health disparities affecting the people in that population complicate our understanding of racial heal ... Full text Link to item Cite

Occupational physical demands and menstrual cycle irregularities in flight attendants and teachers.

Journal Article Occup Environ Med · January 6, 2024 OBJECTIVES: Flight attendants perform physically demanding work such as lifting baggage, pushing service carts and spending the workday on their feet. We examined if more frequent exposure to occupational physical demands could explain why previous studies ... Full text Link to item Cite

Fever and antibiotic use in maternal urinary tract infections during pregnancy and risk of congenital heart defects: Findings from the National Birth Defects Prevention Study.

Journal Article Birth Defects Res · January 2024 BACKGROUND: Previous studies report an association between prenatal maternal urinary tract infections (UTI) and specific congenital heart defects (CHDs); however, the role of fever and antibiotic use on this association is poorly understood. Using data fro ... Full text Link to item Cite

Identifying occupational health inequities in the absence of suitable data: are there inequities in access to adequate bathrooms in US workplaces?

Journal Article Occup Environ Med · October 2023 OBJECTIVES: Our research questions are often chosen based on the existence of suitable data for analysis or prior research in the area. For new interdisciplinary research areas, such as occupational health equity, suitable data might not yet exist. In this ... Full text Link to item Cite

Zika virus knowledge, attitudes and prevention behaviors among pregnant women in the ZEN cohort study, Colombia, 2017-2018.

Journal Article Trans R Soc Trop Med Hyg · July 4, 2023 BACKGROUND: Zika virus (ZIKV) infection during pregnancy can cause severe birth defects in the fetus and is associated with neurodevelopmental abnormalities in childhood. Our objective was to describe ZIKV knowledge and attitudes among pregnant women in Co ... Full text Link to item Cite

Paid sick leave among US private sector employees.

Journal Article Am J Ind Med · September 2022 BACKGROUND: Inequities in US employees' access to paid sick leave are known, but it is not clear whether they are increasing or decreasing over time. More than two dozen state and local paid sick leave laws were recently enacted, many with the stated goal ... Full text Link to item Cite

Maternal occupation as a nail technician or hairdresser during pregnancy and birth defects, National Birth Defects Prevention Study, 1997-2011.

Journal Article Occup Environ Med · January 2022 OBJECTIVE: Nail technicians and hairdressers may be exposed to chemicals with potential reproductive effects. While studies have examined birth defects in children of hairdressers, those in children of nail technicians have not been evaluated. We investiga ... Full text Link to item Cite

Characteristics of Women with Urinary Tract Infection in Pregnancy.

Journal Article J Womens Health (Larchmt) · November 2021 Background: Urinary tract infection (UTI) is the most common bacterial infection in pregnancy. Known risk factors for UTI in pregnancy include diabetes and certain urologic conditions. Other maternal characteristics might also be associated with risk and c ... Full text Link to item Cite

Occupational exposure to high-level disinfectants and risk of miscarriage among nurses.

Journal Article Occup Environ Med · October 2021 OBJECTIVES: To examine the association of occupational exposure to high-level disinfectants (HLDs) with risk of miscarriage among nurses. METHODS: Our study included women who enrolled in the Nurses' Health Study 3 (2010-2020) and had at least one pregnanc ... Full text Link to item Cite

Prepregnancy body mass index and spina bifida: Potential contributions of bias.

Journal Article Birth Defects Res · May 2021 BACKGROUND: Epidemiologists have consistently observed associations between prepregnancy obesity and spina bifida in offspring. Most studies, however, used self-reported body mass index (potential for exposure misclassification) and incompletely ascertaine ... Full text Link to item Cite

Prepregnancy handling of antineoplastic drugs and risk of miscarriage in female nurses.

Journal Article Annals of epidemiology · January 2021 PurposeTo examine the association betweenantineoplastic drug (AD) handling and risk of miscarriage.MethodsNurses' Health Study-3 participants self-reported AD administration and engineering controls (ECs) and personal protective equipment ... Full text Cite

Folate intake, markers of folate status and oral clefts: An updated set of systematic reviews and meta-analyses.

Journal Article Birth Defects Res · November 2020 BACKGROUND: There has been a longstanding debate about the role of folate in the etiology of orofacial clefts (OFCs). Studies of different measures of nutritional intake or folate status have been done to investigate the possible role of folate in the prev ... Full text Link to item Cite

Improving Diversity and Promoting Inclusion in the Society for Epidemiologic Research Through Choice of Conference Location.

Journal Article Am J Epidemiol · October 1, 2020 Scientific conferences provide attendees opportunities to network, share research, learn new skills and ideas, and initiate collaborations. Conference attendance is especially important for students and early-career researchers who are establishing their r ... Full text Link to item Cite

Nonfatal Violent Workplace Crime Characteristics and Rates by Occupation - United States, 2007-2015.

Journal Article MMWR Morb Mortal Wkly Rep · March 27, 2020 Featured Publication Workplace violence can lead to adverse physical and psychological outcomes and affect work function (1). According to the U.S. Bureau of Labor Statistics, intentional injury by another person is a leading cause of nonfatal injury requiring missed workdays ... Full text Link to item Cite

Night shift work and cardiovascular disease biomarkers in female nurses.

Journal Article Am J Ind Med · March 2020 BACKGROUND: Night shift work is associated with cardiovascular disease, but its associations with cardiovascular disease biomarkers are unclear. We investigated these associations in a study of female nurses. METHODS: We used data from the Nurses' Health S ... Full text Link to item Cite

Anti-Müllerian hormone levels in nurses working night shifts.

Journal Article Arch Environ Occup Health · 2020 Featured Publication Our objective was to examine associations between night shift work and serum anti-Müllerian hormone (AMH) levels. We analyzed 1,537 blood samples from premenopausal female nurses in the Nurses' Health Study II, assayed for AMH. Rotating or permanent night ... Full text Link to item Cite

Administration of antineoplastic drugs and fecundity in female nurses.

Journal Article Am J Ind Med · August 2019 BACKGROUND: We examined the association between the administration of antineoplastic drugs (AD) and fecundity among female nurses. METHODS: AD administration and use of exposure controls (EC) such as gloves, gowns, and needleless systems were self-reported ... Full text Link to item Cite

Maternal Occupational Oil Mist Exposure and Birth Defects, National Birth Defects Prevention Study, 1997⁻2011.

Journal Article Int J Environ Res Public Health · May 4, 2019 Workers in various industries can be exposed to oil mists when oil-based fluids are aerosolized during work processes. Oil mists can be inhaled or deposited on the skin. Little research exists on the reproductive effects of oil mist exposure in pregnant wo ... Full text Link to item Cite

Structure and Control of Healthy Worker Effects in Studies of Pregnancy Outcomes.

Journal Article Am J Epidemiol · March 1, 2019 Featured Publication Much of the literature on the healthy worker effect focuses on studies of chronic disease and mortality; however, when studying pregnancy outcomes, these effects might differ because of the short, defined risk periods of most pregnancy outcomes. Three preg ... Full text Link to item Cite

CE: Original Research: Antineoplastic Drug Administration by Pregnant and Nonpregnant Nurses: An Exploration of the Use of Protective Gloves and Gowns.

Journal Article Am J Nurs · January 2019 UNLABELLED: : Background: Many antineoplastic (chemotherapeutic) drugs are known or probable human carcinogens, and many have been shown to be reproductive toxicants in cancer patients. Evidence from occupational exposure studies suggests that health care ... Full text Link to item Cite

Multiple bias analysis using logistic regression: an example from the National Birth Defects Prevention Study.

Journal Article Ann Epidemiol · August 2018 Featured Publication PURPOSE: Exposure misclassification, selection bias, and confounding are important biases in epidemiologic studies, yet only confounding is routinely addressed quantitatively. We describe how to combine two previously described methods and adjust for multi ... Full text Link to item Cite

Risk Assessment Studies: Epidemiology

Chapter · January 1, 2018 Extrapolating results of animal models to humans in real-life settings can be difficult; epidemiologic studies of the factors influencing the frequency and distribution of diseases in human populations are therefore critical to identifying human reproducti ... Full text Cite

Infection prevention and control training and capacity building during the Ebola epidemic in Guinea.

Journal Article PLoS One · 2018 BACKGROUND: During the 2014-2016 Ebola epidemic in West Africa, a key epidemiological feature was disease transmission within healthcare facilities, indicating a need for infection prevention and control (IPC) training and support. METHODS: IPC training wa ... Full text Link to item Cite

Risk Assessment Studies: Epidemiology

Chapter · January 1, 2018 Extrapolating results of animal models to humans in real-life settings can be difficult; epidemiologic studies of the factors influencing the frequency and distribution of diseases in human populations are therefore critical to identifying human reproducti ... Full text Cite

Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study.

Journal Article Cleft Palate Craniofac J · November 2017 BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (nsCL±P) and nonsyndromic cleft palate (nsCP) are caused by a combination of genetic and environmental risk factors. We investigated gene-environment and gene-gene joint effects in a large mul ... Full text Link to item Cite

Factors affecting workforce participation and healthy worker biases in U.S. women and men.

Journal Article Ann Epidemiol · September 2017 Featured Publication PURPOSE: To investigate potential attenuation of healthy worker biases in populations in which healthy women of reproductive age opt out of the workforce to provide childcare. METHODS: We used 2013-2015 data from 120,928 U.S. women and men aged 22-44 years ... Full text Link to item Cite

Agreement between two methods for retrospective assessment of occupational exposure intensity to six chlorinated solvents: Data from The National Birth Defects Prevention Study.

Journal Article J Occup Environ Hyg · May 2017 The wide variety of jobs encountered in population-based studies makes retrospective exposure assessment challenging in occupational epidemiology. In this analysis, two methods for estimating exposure intensity to chlorinated solvents are compared: rated ( ... Full text Link to item Cite

Impact of Missing Data for Body Mass Index in an Epidemiologic Study.

Journal Article Matern Child Health J · July 2016 Objective To assess the potential impact of missing data on body mass index (BMI) on the association between prepregnancy obesity and specific birth defects. Methods Data from the National Birth Defects Prevention Study (NBDPS) were analyzed. We assessed t ... Full text Link to item Cite

"Will my work affect my pregnancy?" Resources for anticipating and answering patients' questions.

Journal Article Am J Obstet Gynecol · May 2016 Featured Publication Authoritative information on occupational reproductive hazards is scarce and complex because exposure levels vary, multiple exposures may be present, and the reproductive toxicity of many agents remains unknown. For these reasons, women's health providers ... Full text Link to item Cite

Occupational risk factors for endometriosis in a cohort of flight attendants.

Journal Article Scand J Work Environ Health · January 2016 OBJECTIVES: This study aimed to (i) compare odds of endometriosis in a cohort of flight attendants against a comparison group of teachers and (ii) investigate occupational risk factors for endometriosis among flight attendants. METHODS: We included 1945 fl ... Full text Link to item Cite

Bias from Differential Exposure Measurement Error in a Study of Flight Attendants.

Journal Article Aerosp Med Hum Perform · November 2015 BACKGROUND: Self-reported occupational exposures are often used in epidemiological studies when actual exposure measurements are unavailable, which could cause measurement error and bias study results. This study provides a numeric example of this potentia ... Full text Link to item Cite

Ebola Virus Disease in Health Care Workers--Guinea, 2014.

Journal Article MMWR Morb Mortal Wkly Rep · October 2, 2015 An outbreak of Ebola virus disease (Ebola) began in Guinea in December 2013 and has continued through September 2015. Health care workers (HCWs) in West Africa are at high risk for Ebola infection owing to lack of appropriate triage procedures, insufficien ... Full text Link to item Cite

Inequities in workplace secondhand smoke exposure among nonsmoking women of reproductive age.

Journal Article Am J Public Health · July 2015 Featured Publication OBJECTIVES: We characterized workplace secondhand smoke exposure among nonsmoking women of reproductive age as a proxy for workplace secondhand smoke exposure during pregnancy. METHODS: We included nonsmoking women aged 18 to 44 years employed during the p ... Full text Link to item Cite

Adjusting for bias due to incomplete case ascertainment in case-control studies of birth defects.

Journal Article Am J Epidemiol · April 15, 2015 Case-control studies of birth defects might be subject to selection bias when there is incomplete ascertainment of cases among pregnancies that are terminated after a prenatal diagnosis of the defect. We propose a simple method to estimate inverse probabil ... Full text Link to item Cite

Work schedule and physically demanding work in relation to menstrual function: the Nurses' Health Study 3.

Journal Article Scand J Work Environ Health · March 2015 OBJECTIVES: This study aimed to evaluate occupational exposures and menstrual cycle characteristics among nurses. METHODS: Using cross-sectional data collected in 2010-2012 from 6309 nurses aged 21-45 years, we investigated nurses' menstrual function in th ... Full text Link to item Cite

Piloting a computer assisted telephone interview: the FUCHSIA Women's Study.

Journal Article BMC Womens Health · November 30, 2014 BACKGROUND: Loss of fertility has been reported as an important concern of reproductive age women diagnosed with cancer. The Furthering Understanding of Cancer, Health, and Survivorship In Adult (FUCHSIA) Women's Study examines how cancer treatment affects ... Full text Link to item Cite

Potential sensitivity of bias analysis results to incorrect assumptions of nondifferential or differential binary exposure misclassification.

Journal Article Epidemiology · November 2014 BACKGROUND: Results of bias analyses for exposure misclassification are dependent on assumptions made during analysis. We describe how adjustment for misclassification is affected by incorrect assumptions about whether sensitivity and specificity are the s ... Full text Link to item Cite

Injuries and illnesses among American Red Cross responders-United States, 2008-2012.

Journal Article Disaster Med Public Health Prep · October 2014 OBJECTIVE: Occupational injury and illness rates for volunteer responders have not been well documented. We analyzed data specific to volunteers from the American Red Cross (ARC). METHODS: Data collected by the ARC between 2008 and 2012 were analyzed to id ... Full text Link to item Cite

Prenatal diagnosis of nonsyndromic congenital heart defects.

Journal Article Prenat Diagn · March 2014 OBJECTIVES: Congenital heart defects (CHDs) occur in nearly 1% of live births. We sought to assess factors associated with prenatal CHD diagnosis in the National Birth Defects Prevention Study (NBDPS). METHODS: We analyzed data from mothers with CHD-affect ... Full text Link to item Cite

Causal pie bingo!

Journal Article Epidemiology · March 2013 Full text Link to item Cite

Pregnancy termination following prenatal diagnosis of anencephaly or spina bifida: a systematic review of the literature.

Journal Article Birth Defects Res A Clin Mol Teratol · November 2012 BACKGROUND: In regions where prenatal screening for anencephaly and spina bifida is widespread, many cases of these defects are diagnosed prenatally. The purpose of this study was to estimate the frequency of termination of pregnancy (TOP) following prenat ... Full text Link to item Cite

The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.

Journal Article Blood · March 8, 2012 The endothelial protein C receptor (EPCR) limits thrombus formation by enhancing activation of the protein C anticoagulant pathway, and therefore may play a role in the etiology of thrombotic disorders. The rs867186 single-nucleotide polymorphism in the PR ... Full text Link to item Cite

Dependence of confounding on the target population: a modification of causal graphs to account for co-action.

Journal Article Ann Epidemiol · September 2011 PURPOSE: Directed acyclic graphs (DAGs) are useful tools for assessing confounding. However, the basic approach to detecting confounding in DAGs does not distinguish among various forms of interaction between the exposure and covariates and between differe ... Full text Link to item Cite

The factor XII -4C>T variant and risk of common thrombotic disorders: A HuGE review and meta-analysis of evidence from observational studies.

Journal Article Am J Epidemiol · January 15, 2011 Coagulation factor XII is involved in thrombus formation and therefore may play a role in the etiology of thrombotic disorders. A common variant in the factor XII (F12) gene (-4C>T, rs1801020) results in decreased plasma levels of this coagulation factor. ... Full text Link to item Cite

Human papillomavirus infection and anxiety: analyses in women with low-grade cervical cytological abnormalities unaware of their infection status.

Journal Article PLoS One · 2011 BACKGROUND: Women testing positive for human papillomavirus (HPV) infection experience increased levels of anxiety that have been attributed to fears of stigmatization and developing cervical cancer. The objective of this study was to investigate the assoc ... Full text Link to item Cite

STrengthening the REporting of Genetic Association studies (STREGA)-an extension of the STROBE statement

Chapter · May 1, 2010 This chapter proposes and justifies a set of guiding principles for reporting results of genetic association studies. The epidemiology community has recently developed the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) Statem ... Full text Cite

Colorectal cancer

Chapter · May 1, 2010 Inherited genetic factors play an important role in the etiology of colorectal cancer. Rare high-penetrance mutations account for a small proportion of diseases but their identification plays an important role in the clinical management of the high-risk fa ... Full text Cite

Non-genetic risk factors for holoprosencephaly.

Journal Article Am J Med Genet C Semin Med Genet · February 15, 2010 Holoprosencephaly (HPE) is a congenital defect of the brain characterized by incomplete cleavage of the embryonic forebrain into left and right hemispheres. Although a substantial proportion of cases of HPE can be attributed to genetic abnormalities, the e ... Full text Link to item Cite

Prenatal diagnosis of orofacial clefts, National Birth Defects Prevention Study, 1998-2004.

Journal Article Prenat Diagn · September 2009 OBJECTIVE: The aims of this study were to determine how frequently orofacial clefts were diagnosed prenatally and to investigate factors associated with prenatal diagnosis. METHODS: We included 2298 mothers from the National Birth Defects Prevention Study, ... Full text Link to item Cite

Segregation analysis of cleft lip with or without cleft palate in the First Nations (Amerindian) people of British Columbia and review of isolated cleft palate etiologies.

Journal Article Birth Defects Res A Clin Mol Teratol · June 2009 BACKGROUND: The First Nations (Amerindian) population of British Columbia, Canada, has the highest reported birth prevalence in the world of cleft lip with or without cleft palate (CL/P) at nearly 3 per 1000 births. In addition, a substantial proportion of ... Full text Link to item Cite

STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement.

Journal Article Ann Intern Med · February 3, 2009 Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information into the practice of medicine and public health. Assessment of the strengths and weak ... Full text Link to item Cite

Folate intake, markers of folate status and oral clefts: is the evidence converging?

Journal Article Int J Epidemiol · October 2008 BACKGROUND: The ability of folic acid in the periconceptional period to prevent the occurrence of neural tube defects has stimulated tremendous interest in its effects on other health outcomes. Its possible effect on oral clefts has generated considerable ... Full text Link to item Cite