Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellowship, Neurology, Duke University School of Medicine 2009 - 2012
  • Ph.D., University of Alabama Birmingham 2008
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Neurology, Neurology, Headache and Pain, Neurology 2018 - 2020
• Expertise
• 

  Subject Headings

  • Pain
• Research
• 

  Selected Grants

  • The role of TRPV4 in migraine pain with focus on non-neural, keratinocytes and mast cells and mechanisms of racial differences in migraine pain suffering awarded by National Institutes of Health 2021 - 2024
  • Going on a migraine TRP: Defining mechanisms of action of botox on the trigeminal sensory system that provide an explanation for the anti-migraine pain effects of botox awarded by Allergan, Inc. 2020 - 2023
  • Role of trpv4 in trigeminally mediated nociception awarded by National Institutes of Health 2007 - 2012
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Moore, Carlene. “The role of TRPV4 channels in cutaneous epithelia.” Curr Top Membr 89 (2022): 139–54. https://doi.org/10.1016/bs.ctm.2022.06.003.
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    • Chen, Yong, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Hui-Ping Ding, Xin Zhang, et al. “Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.” Gastroenterology 161, no. 1 (July 2021): 301-317.e16. https://doi.org/10.1053/j.gastro.2021.03.049.
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    • Moore, Carlene, Rupali Gupta, Sven-Eric Jordt, Yong Chen, and Wolfgang B. Liedtke. “Regulation of Pain and Itch by TRP Channels.” Neurosci Bull 34, no. 1 (February 2018): 120–42. https://doi.org/10.1007/s12264-017-0200-8.
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    • Chen, Yong, Carlene D. Moore, Jennifer Y. Zhang, Russell P. Hall, Amanda S. MacLeod, and Wolfgang Liedtke. “TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.” J Invest Dermatol 137, no. 4 (April 2017): 801–4. https://doi.org/10.1016/j.jid.2016.12.013.
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    • Arnold, Miranda, Rebecca Cross, Kaela S. Singleton, Stephanie Zlatic, Christopher Chapleau, Ariana P. Mullin, Isaiah Rolle, et al. “The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.” Frontiers in Cellular Neuroscience 10 (September 22, 2016). https://doi.org/10.3389/fncel.2016.00218.
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    • Chen, Yong, Patrick Kanju, Quan Fang, Suk Hee Lee, Puja K. Parekh, Whasil Lee, Carlene Moore, et al. “TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.” Pain 155, no. 12 (December 2014): 2662–72. https://doi.org/10.1016/j.pain.2014.09.033.
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    • Moore, C., F. Cevikbas, H. A. Pasolli, Y. Chen, W. Kong, C. Kempkes, P. Parekh, et al. “Erratum: UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling (Proceedings of the National Academy of Sciences of the United States of America).” Proceedings of the National Academy of Sciences of the United States of America 110, no. 38 (October 17, 2013): 15502. https://doi.org/10.1073/pnas.1315603110.
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    • Moore, Carlene, Ferda Cevikbas, H Amalia Pasolli, Yong Chen, Wei Kong, Cordula Kempkes, Puja Parekh, et al. “UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.” Proc Natl Acad Sci U S A 110, no. 34 (August 20, 2013): E3225–34. https://doi.org/10.1073/pnas.1312933110.
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    • Chen, Yong, Susan H. Williams, Amy L. McNulty, Ji Hee Hong, Suk Hee Lee, Nicole E. Rothfusz, Puja K. Parekh, et al. “Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.” Pain 154, no. 8 (August 2013): 1295–1304. https://doi.org/10.1016/j.pain.2013.04.004.
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    • Moore, Carlene D., Erin E. Thacker, Jennifer Larimore, David Gaston, Alison Underwood, Brian Kearns, Sean I. Patterson, et al. “The neuronal Arf GAP centaurin α1 modulates dendritic differentiation.” Journal of Cell Science 120, no. 15 (August 1, 2007): 2683–93. https://doi.org/10.1242/jcs.006346.
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    • Crimmins, Stephen, Youngam Jin, Crystal Wheeler, Alexis K. Huffman, Carlene Chapman, Lynn E. Dobrunz, Alan Levey, Kevin A. Roth, Julie A. Wilson, and Scott M. Wilson. “Transgenic Rescue ofataxiaMice with Neuronal-Specific Expression of Ubiquitin-Specific Protease 14.” The Journal of Neuroscience 26, no. 44 (November 1, 2006): 11423–31. https://doi.org/10.1523/jneurosci.3600-06.2006.
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    • Thacker, Erin, Brian Kearns, Carlene Chapman, Jennifer Hammond, Audrey Howell, and Anne Theibert. “The Arf6 GAP centaurin α-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.” European Journal of Cell Biology 83, no. 10 (2004): 541–54. https://doi.org/10.1078/0171-9335-00416.
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    • Moore, Carlene, and Wolfgang Liedtke. “Osmomechanical-Sensitive TRPV Channels in Mammals.” Edited by Tamara Luti Rosenbaum Emir. Crc Press/Taylor & Francis, n.d. https://doi.org/10.4324/9781315152837-5.
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• Teaching & Mentoring
• 

  Advising & Mentoring

  • Shinbe Choi -2019- 2022
    Gene Moon - 2019- 2022
    Emma Xiong 2021-
    Lily Orta - 2021
• Scholarly, Clinical, & Service Activities
• 

  Presentations & Appearances

  • “Going on a migraine TR(i)P: Exploring the role of TRP channels in migraine pain”. Pain Research In Progress. Center for Translational Pain Medicine. February 16, 2022  2022
  • Meeting of the MINDs advisory board. 2021 Meeting of the MINDS. Allergan. October 29, 2021 - October 30, 2021  2021
  • Epidermal TRPV4 ion channels regulate UVB induced sunburn by triggering inflammmasome activation and ERK signaling. Inside Scientific. June 8, 2021 - June 11, 2021  2021
  • A panel of esteemed professors and researchers from top universities discussing their work in neuroscience & psychology with high schoolers!. The Neuro. March 2021  2021
  • Neuroanatomy. WINS Outreach Program Session. March 2021  2021
• 

  Outreach & Engaged Scholarship

  • Summer Neuroscience Program Mentor. Summer Neuroscience Program. 2021 - 2022  2021 - 2022
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  Service to the Profession

  • Primary Member. Duke IUCUC. August 2020  2020

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