Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellowship, Neurology, Duke University School of Medicine 2009 - 2012
  • Ph.D., University of Alabama Birmingham 2008
• 

  Duke Appointment History

  • Assistant Professor of Neurology, Neurology, Headache and Pain, Neurology 2018 - 2020
• Expertise
• 

  Subject Headings

  • Pain
• Research
• 

  Selected Grants

  • Going on a migraine TRP: Defining mechanisms of action of botox on the trigeminal sensory system that provide an explanation for the anti-migraine pain effects of botox awarded by Allergan, Inc. 2020 - 2023
  • Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
  • Role of trpv4 in trigeminally mediated nociception awarded by National Institutes of Health 2007 - 2012
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Moore, Carlene, Rupali Gupta, Sven-Eric Jordt, Yong Chen, and Wolfgang B. Liedtke. “Regulation of Pain and Itch by TRP Channels.” Neurosci Bull 34, no. 1 (February 2018): 120–42. https://doi.org/10.1007/s12264-017-0200-8.
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    • Chen, Yong, Carlene D. Moore, Jennifer Y. Zhang, Russell P. Hall, Amanda S. MacLeod, and Wolfgang Liedtke. “TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.” J Invest Dermatol 137, no. 4 (April 2017): 801–4. https://doi.org/10.1016/j.jid.2016.12.013.
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    • Chen, Yong, Patrick Kanju, Quan Fang, Suk Hee Lee, Puja K. Parekh, Whasil Lee, Carlene Moore, et al. “TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.” Pain 155, no. 12 (December 2014): 2662–72. https://doi.org/10.1016/j.pain.2014.09.033.
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    • Moore, Carlene, Ferda Cevikbas, H Amalia Pasolli, Yong Chen, Wei Kong, Cordula Kempkes, Puja Parekh, et al. “UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.” Proc Natl Acad Sci U S A 110, no. 34 (August 20, 2013): E3225–34. https://doi.org/10.1073/pnas.1312933110.
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    • Chen, Yong, Susan H. Williams, Amy L. McNulty, Ji Hee Hong, Suk Hee Lee, Nicole E. Rothfusz, Puja K. Parekh, et al. “Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.” Pain 154, no. 8 (August 2013): 1295–1304. https://doi.org/10.1016/j.pain.2013.04.004.
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    • Moore, Carlene D., Erin E. Thacker, Jennifer Larimore, David Gaston, Alison Underwood, Brian Kearns, Sean I. Patterson, et al. “The neuronal Arf GAP centaurin α1 modulates dendritic differentiation.” Journal of Cell Science 120, no. 15 (August 1, 2007): 2683–93. https://doi.org/10.1242/jcs.006346.
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    • Crimmins, S., Y. Jin, C. Wheeler, A. K. Huffman, C. Chapman, L. E. Dobrunz, A. Levey, K. A. Roth, J. A. Wilson, and S. M. Wilson. “Transgenic Rescue of ataxia Mice with Neuronal-Specific Expression of Ubiquitin-Specific Protease 14.” Journal of Neuroscience 26, no. 44 (November 1, 2006): 11423–31. https://doi.org/10.1523/jneurosci.3600-06.2006.
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    • Thacker, Erin, Brian Kearns, Carlene Chapman, Jennifer Hammond, Audrey Howell, and Anne Theibert. “The Arf6 GAP centaurin α-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.” European Journal of Cell Biology 83, no. 10 (2004): 541–54. https://doi.org/10.1078/0171-9335-00416.
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    • Arnold, Miranda, Rebecca Cross, Kaela S. Singleton, Stephanie Zlatic, Christopher Chapleau, Ariana P. Mullin, Isaiah Rolle, et al. “The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.” Frontiers in Cellular Neuroscience 10 (n.d.). https://doi.org/10.3389/fncel.2016.00218.
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• Teaching & Mentoring
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  Advising & Mentoring

  • Shinbe Choi
    Gene Moon
• Scholarly, Clinical, & Service Activities
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  Presentations & Appearances

  • Epidermal TRPV4 ion channels regulate UVB induced sunburn by triggering inflammmasome activation and ERK signaling. Inside Scientific. June 8, 2021 - June 11, 2021  2021
  • A panel of esteemed professors and researchers from top universities discussing their work in neuroscience & psychology with high schoolers!. The Neuro. March 2021  2021
  • Neuroanatomy. WINS Outreach Program Session. March 2021  2021
• 

  Service to the Profession

  • Primary Member. Duke IUCUC. August 2020  2020

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