Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pediatric Critical Care Medicine Fellowship, Pediatrics, Duke University 2006 - 2009
  • Pediatric Residency, Pediatrics, Oregon Health and Science University 2003 - 2006
  • M.D., University of South Alabama 2003
• 

  Medical Licensure

  • 134857. North Carolina. 2018
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2021 - 2022
  • Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2015 - 2020
  • Medical Instructor in the Department of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2011 - 2015
  • Clinical Associate in the Department of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2009 - 2011
• 

  Leadership & Clinical Positions at Duke

  • Director of Pediatric Extracorporeal Membrane Oxygenation
• Expertise
• 

  Subject Headings

  • Anticoagulants (Medicine)
  • Blood platelets--Transfusion
  • Blood platelets--Transfusion--Immunological aspects
  • Blood--Transfusion
  • Blood--Transfusion--Complications
  • Erythrocytes--Transfusion
  • Extracorporeal Membrane Oxygenation
• Research
• 

  Selected Grants

  • A Randomized Double-Blind, Phase 3 Study Comparing the Efficacy and Safety of High-Titer versus Low-Titer Anti-Influenza Immune Plasma for the Treatment of Severe Influenza A; IRC-005 awarded by Social & Scientific Systems, Inc. 2015 - 2019
  • SEPSIS-INDUCED RED CELL DYSFUNCTION (SIRD) awarded by Washington University School of Medicine 2017 - 2019
  • 7 day study of the safety, efficacy and the pharmacokinetic and pharmacodyamic properties of oral rivaroxaban in children from birth to less than 6 months with catheter-related aterial or venous thrombosis awarded by Bayer Healthcare Pharmaceuticals Inc 2015 - 2018
• 

  External Relationships

  • Kaufman & Canoles, P.C.
  • Wiseman Ashworth Law Group
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Modarelli, R., P. G. Balikcioglu, G. Hendrix, M. DeRusso, and C. Ozment. “The Perfect Storm: Rapid Progression of Diabetic Ketoacidosis in Pediatric Diabetes in the Setting of COVID-19.” Aace Clinical Case Reports 7, no. 6 (November 1, 2021): 357–59. https://doi.org/10.1016/j.aace.2021.05.007.
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    • Scott, Briana L., Desiree Bonadonna, Caroline P. Ozment, and Kyle J. Rehder. “Extracorporeal membrane oxygenation in critically ill neonatal and pediatric patients with acute respiratory failure: a guide for the clinician.” Expert Rev Respir Med 15, no. 10 (October 2021): 1281–91. https://doi.org/10.1080/17476348.2021.1932469.
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    • Ozment, Caroline P., Briana L. Scott, Melania M. Bembea, Philip C. Spinella, and Philip C. Pediatric ECMO (PediECMO) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Extracorporeal Life Support Organization (ELSO). “Anticoagulation and Transfusion Management During Neonatal and Pediatric Extracorporeal Membrane Oxygenation: A Survey of Medical Directors in the United States.” Pediatr Crit Care Med 22, no. 6 (June 1, 2021): 530–41. https://doi.org/10.1097/PCC.0000000000002696.
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    • McMichael, Ali B. V., Kanecia O. Zimmerman, Karan R. Kumar, and Caroline P. Ozment. “Evaluation of effect of scheduled fresh frozen plasma on ECMO circuit life: A randomized pilot trial.” Transfusion 61, no. 1 (January 2021): 42–51. https://doi.org/10.1111/trf.16164.
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    • McMichael, Ali B. V., Christoph P. Hornik, Susan R. Hupp, Sharon E. Gordon, and Caroline P. Ozment. “Correlation Among Antifactor Xa, Activated Partial Thromboplastin Time, and Heparin Dose and Association with Pediatric Extracorporeal Membrane Oxygenation Complications.” Asaio J 66, no. 3 (March 2020): 307–13. https://doi.org/10.1097/MAT.0000000000000986.
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    • Gordon, Sharon E., Travis S. Heath, Ali B. V. McMichael, Christoph P. Hornik, and Caroline P. Ozment. “Evaluation of Heparin Anti-Factor Xa Levels Following Antithrombin Supplementation in Pediatric Patients Supported With Extracorporeal Membrane Oxygenation.” J Pediatr Pharmacol Ther 25, no. 8 (2020): 717–22. https://doi.org/10.5863/1551-6776-25.8.717.
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    • Beigel, John H., Evgenia Aga, Marie-Carmelle Elie-Turenne, Josalyn Cho, Pablo Tebas, Carol L. Clark, Jordan P. Metcalf, et al. “Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial.” Lancet Respir Med 7, no. 11 (November 2019): 941–50. https://doi.org/10.1016/S2213-2600(19)30199-7.
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    • Nellis, Marianne E., Ruchika Goel, Oliver Karam, Melissa M. Cushing, Peter J. Davis, Marie E. Steiner, Marisa Tucci, Simon J. Stanworth, Philip C. Spinella, and Philip C. Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the Point Prevalence Study of Platelet Transfusions in Critically Ill Children (P3T) Investigators. “International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis.” Pediatr Crit Care Med 20, no. 7 (July 2019): e342–51. https://doi.org/10.1097/PCC.0000000000001987.
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    • Nellis, Marianne E., Ruchika Goel, Oliver Karam, Melissa M. Cushing, Peter J. Davis, Marie E. Steiner, Marisa Tucci, et al. “Effects of ABO Matching of Platelet Transfusions in Critically Ill Children.” Pediatr Crit Care Med 20, no. 2 (February 2019): e61–69. https://doi.org/10.1097/PCC.0000000000001779.
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    • Nellis, Marianne E., Oliver Karam, Elizabeth Mauer, Melissa M. Cushing, Peter J. Davis, Marie E. Steiner, Marisa Tucci, Simon J. Stanworth, Philip C. Spinella, and Philip C. Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network, Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators. “Platelet Transfusion Practices in Critically Ill Children.” Crit Care Med 46, no. 8 (August 2018): 1309–17. https://doi.org/10.1097/CCM.0000000000003192.
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    • Scott, Briana L., Jennifer I. Sherwin, Kyle J. Rehder, Michael J. Campbell, and Caroline P. Ozment. “Histoplasmosis Myocarditis in an Immunocompetent Host After a Recreational Mud Run.” Pediatrics 141, no. Suppl 5 (April 2018): S462–65. https://doi.org/10.1542/peds.2017-1074.
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    • Karam, O., P. Demaret, A. Duhamel, A. Shefler, P. C. Spinella, M. Tucci, S. Leteurtre, S. J. Stanworth, and S. J. PlasmaTV investigators. “Factors influencing plasma transfusion practices in paediatric intensive care units around the world.” Vox Sang 112, no. 2 (February 2017): 140–49. https://doi.org/10.1111/vox.12490.
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    • Karam, O., P. Demaret, A. Duhamel, A. Shefler, P. C. Spinella, S. J. Stanworth, M. Tucci, et al. “Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions.” Annals of Intensive Care 6, no. 1 (December 1, 2016). https://doi.org/10.1186/s13613-016-0197-6.
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    • Ozment, Caroline P., Lisa B. Mamo, Mary Lee Campbell, Yuliya Lokhnygina, Andrew J. Ghio, and Jennifer L. Turi. “Transfusion-related biologic effects and free hemoglobin, heme, and iron.” Transfusion 53, no. 4 (April 2013): 732–40. https://doi.org/10.1111/j.1537-2995.2012.03837.x.
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    • Turner, David A., Kyle J. Rehder, Stacey L. Peterson-Carmichael, Caroline P. Ozment, Mashael S. Al-Hegelan, Walter L. Williford, Michelle A. Peters, Paul W. Noble, and Ira M. Cheifetz. “Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A.” Respir Care 56, no. 7 (July 2011): 941–46. https://doi.org/10.4187/respcare.01066.
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    • Ozment, Caroline P., and Jennifer L. Turi. “Iron overload following red blood cell transfusion and its impact on disease severity.” Biochim Biophys Acta 1790, no. 7 (July 2009): 694–701. https://doi.org/10.1016/j.bbagen.2008.09.010.
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    • Graham, Alan S., Caroline Ozment, Ken Tegtmeyer, Susanna Lai, and Dana A. V. Braner. “Videos in clinical medicine. Central venous catheterization.” N Engl J Med 356, no. 21 (May 24, 2007): e21. https://doi.org/10.1056/NEJMvcm055053.
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    • Ozment, C., J. Barchue, L. J. Delucas, and D. Chattopadhyay. “Structural study of Escherichia coli NAD synthetase: Overexpression, purification, crystallization, and preliminary crystallographic analysis.” Journal of Structural Biology 127, no. 3 (1999): 279–82. https://doi.org/10.1006/jsbi.1999.4152.
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    • Mcclellan, J. S., W. B. Coblentz, M. Sapp, G. Rulewicz, D. I. Gaines, A. Hawkins, C. Ozment, et al. “cDNA cloning, in vitro expression, and biochemical characterization of cholinesterase 1 and cholinesterase 2 from amphioxus - Comparison with cholinesterase 1 and cholinesterase 2 produced in vivo.” European Journal of Biochemistry 258, no. 2 (1998): 419–29.

  • Book Sections

    • McMillan, K. N., J. Kramer, C. M. Takemoto, and C. P. Ozment. “Coagulation disorders in congenital heart disease.” In Critical Heart Disease in Infants and Children, 282-302.e7, 2018. https://doi.org/10.1016/B978-1-4557-0760-7.00024-3.
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