Catherine Praxede Lavau
Assistant Professor in Neurosurgery

Most of my research career has been devoted to investigating the molecular determinants of leukemias induced by fusion oncoproteins such as PML-RARA, MLL fusions, and CALM-AF10. I recently joined the laboratory of Rory Goodwin in the department of Neurosurgery, to study the molecular mechanisms that govern the metastasis of solid tumors to the spine. We are currently investigating two candidate proteins: (1) the non-receptor tyrosine kinase PYK2/PTK2B, and how SUMOylation of PYK2 affects signaling and the metastatic properties of breast cancer cells; (2) the role of UGDH, an enzyme that participates in the synthesis of glycosaminoglycans, on cell mobility and metastasis of cancer cells. 

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