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Pratap Challa

Professor of Ophthalmology
Ophthalmology, Glaucoma
Box 3802 Med Ctr, Durham, NC 27710
Wadsworth Bldg, Durham, NC 27710

Scholarly Works - Book sections


Adrenergic Agents: Blockers and Agonists

Book section · January 1, 2024 Topical beta-blockers decrease aqueous humor formation (AHF) 1, 2 and are used long term in the therapy of the chronic open-angle glaucomas and short term for various acute glaucomas. The introduction of the topical beta-blocker timolol in 1978 ... Cite

Topical Carbonic Anhydrase Inhibitors

Book section · January 1, 2024 Carbonic anhydrase inhibitors (CAIs) have been used for glaucoma therapy since 1954, following the description of their efficacy by Becker 1 and Grant et al. 2 Despite the fact that these agents reduce intraocular pressure (IOP), thei ... Cite

Carbonic Anhydrase Inhibitors: Systemic Use

Book section · January 1, 2024 Carbonic anhydrase inhibitors (CAIs) can be useful in the treatment of all the glaucomas by virtue of their ability to reduce aqueous secretion and thus lower intraocular pressure (IOP) 1 regardless of the nature or extent of obstruction to outflow. Their ... Cite

The Miotics

Book section · January 1, 2024 Miotics, or more appropriately termed muscarinic (cho-linergic-acting) agonists, have been used in the treatment of the glaucomas for more than 100 years. This is the first class of medications used to treat glaucoma, and they remain an important glaucoma ... Cite

Rho-Associated Protein Kinase Inhibitors and Primary Open-Angle Glaucoma

Book section · January 1, 2024 Rho-associated protein kinase (ROCK) inhibitors have been broadly investigated over the past 15 years as potential agents for the treatment of elevated intraocular pressure (IOP) secondary to primary open-angle glaucoma (POAG). 1, 2 Preclinical ... Cite

Tonography In Pseudoexfoliation

Book section · January 1, 2024 Cite

Pseudoexfoliation Syndrome and Open-Angle Glaucoma

Book section · January 1, 2024 Once thought to be an unusual form of open-angle glaucoma primarily associated with Scandinavian ancestry, we now know that exfoliation (or pseudoexfoliation) glaucoma constitutes a significant portion of most glaucoma practices in the world. This is an ag ... Cite

Timolol and Albino Rabbits

Book section · January 1, 2024 Cite

Statistical and Clinical Significance

Book section · January 1, 2024 Cite

Management of Highly Elevated Intraocular Pressure

Book section · January 1, 2024 The patient with acutely elevated intraocular pressure (IOP) is usually symptomatic, whereas IOP that has gradually increased, even to relatively high levels, usually does not produce symptoms. Common symptoms from acutely elevated IOP include headache, us ... Cite

Laboratory Glaucoma Models

Book section · January 1, 2024 Cite

Evaluating Clinical Trials

Book section · January 1, 2024 Cite

Early Postoperative Increase in Intraocular Pressure

Book section · January 1, 2015 Early postoperative pressure increases following trabeculectomy surgery can occur from many causes. Careful examination, including slit lamp, gonioscopy, and funduscopy, can help discern the etiology of the pressure elevation. Many of the conditions can be ... Full text Cite

Osteogenesis Imperfecta and the Eye

Book section · January 1, 2013 While the many skeletal, auditory, dental and other anomalies in osteogenesis imperfecta (OI) have been well documented in the medical literature, the eye and the visual system are also commonly affected in patients with OI. As type I collagen fibers are a ... Full text Cite