Pratap Challa

Journal article Invest Ophthalmol Vis Sci · June 21, 2011 Featured Publication PURPOSE: To evaluate the potential role that FoxO transcription factors play in modulating resveratrol's protective effects against oxidative stress in lens epithelial cells. METHODS: Primary human or porcine lens epithelial cells (LECs) were treated with ... Full text Link to item Cite

LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma.

Journal article Mol Vis · November 2, 2010 Featured Publication PURPOSE: To study lysyl oxidase-like 1 (LOXL1) expression in freshly collected lens capsules from pseudoexfoliation syndrome (XFS), pseudoexfoliation glaucoma (XFG), and normal cataract control individuals. We also investigated the effects of four glaucoma ... Link to item Cite

Descemet's stripping automated endothelial keratoplasty in a patient with four glaucoma tubes.

Journal article Ann Ophthalmol (Skokie) · 2010 Featured Publication Descemet's stripping automated endothelial keratoplasty (DSAEK) is an increasingly popular techniquefor transplanting corneal endothelial cells. The presence of glaucoma, and especially glaucoma tubes, however, renders the DSAEK procedure more challenging. ... Link to item Cite

Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells.

Journal article Invest Ophthalmol Vis Sci · December 2009 Featured Publication PURPOSE: To investigate the mechanisms that mediate the release of ATP induced by cyclic mechanical stress (CMS) and the role of extracellular ATP in the mobilization of arachidonic acid (AA) and prostaglandin secretion. METHODS: Porcine trabecular meshwor ... Full text Link to item Cite

Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.

Journal article J Ocul Pharmacol Ther · June 2009 Featured Publication AIM: Poor topical bioavailability and ocular irritation have impeded the development of the diuretic, ethacrynic acid (ECA) as a clinically useful ocular hypotensive for the treatment of glaucoma. Thus, the development of analogs and prodrugs of analogs wi ... Full text Link to item Cite

Genetics of pseudoexfoliation syndrome.

Journal article Curr Opin Ophthalmol · March 2009 Featured Publication PURPOSE OF REVIEW: Pseudoexfoliation syndrome (XFS) is a late-onset and complex disorder that is strongly associated with the development of glaucoma. The purpose of this review is to discuss the inheritance patterns and recent genetic advances in the stud ... Full text Link to item Cite

Surgical management of hypotony owing to overfiltration in eyes receiving glaucoma drainage devices.

Journal article J Glaucoma · 2009 Featured Publication PURPOSE: To assess rates of surgical revision of glaucoma drainage devices (GDDs) from hypotony owing to overfiltration and its management. DESIGN: Retrospective case series. METHODS: Demographic characteristics, type of GDD implanted, type of surgical rev ... Full text Link to item Cite

Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells.

Journal article Food Chem Toxicol · January 2009 Featured Publication Elevated intraocular pressure (IOP) constitutes the best characterized risk for primary open-angle glaucoma (POAG). Elevated IOP is believed to result from an increase in aqueous humor outflow resistance at the level of the trabecular meshwork (TM)/Schlemm ... Full text Link to item Cite

Glaucoma patients' trust in the physician.

Journal article J Ophthalmol · 2009 Featured Publication Objectives. To describe glaucoma patients' trust in the physician and to test the hypothesis that increased interpersonal trust is associated with increased medication adherence. Methods. One hundred ninety-five subjects with open-angle glaucoma seen by mu ... Full text Link to item Cite

Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.

Journal article Invest Ophthalmol Vis Sci · August 2008 Featured Publication PURPOSE: Significant association has recently been reported between pseudoexfoliation glaucoma (XFG) and two single-nucleotide polymorphisms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1). The purpose of this study was to invest ... Full text Link to item Cite

Health literacy and vision-related quality of life.

Journal article Br J Ophthalmol · June 2008 Featured Publication BACKGROUND: Non-visual factors influence a person's vision-related quality of life (VRQoL). The purpose of this study was to assess the relationship between health literacy and VRQoL in glaucoma patients. METHODS: One hundred and ninety-five subjects with ... Full text Link to item Cite

Use of a standardized patient satisfaction questionnaire to assess the quality of care provided by ophthalmology residents.

Journal article Ophthalmology · April 2008 Featured Publication PURPOSE: To develop and use a standardized patient satisfaction questionnaire (PSQ) to address two study questions: (1) What is the overall level of satisfaction with resident care? (2) Can the study questionnaire be used to detect differences in the level ... Full text Link to item Cite

Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma.

Journal article Mol Vis · January 29, 2008 Featured Publication PURPOSE: To identify if recently described LOXL1 (lysyl oxidase-like 1) polymorphisms are associated with pseudoexfoliation glaucoma (XFG) in a United States (U.S.) Caucasian patient population. METHODS: Individuals with XFG were identified using standard ... Link to item Cite

Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma.

Journal article Mol Vis · 2008 Featured Publication PURPOSE: Coding variants in the optineurin gene (OPTN, GLC1E) have been reported to play a role in primary open-angle glaucoma (POAG) in various populations. This study investigated the role of OPTN sequence variants in patients with POAG in Ghana (West Af ... Link to item Cite

Glaucoma genetics.

Journal article Int Ophthalmol Clin · 2008 Featured Publication Full text Link to item Cite

Proteomic analysis of regenerated rabbit lenses reveal crystallin expression characteristic of adult rabbits.

Journal article Mol Vis · 2008 Featured Publication PURPOSE: To explore lens crystallin characteristics and morphology of rabbit regenerated lenses in comparison with wild type natural lenses by means of proteomic analysis and histological assay. METHODS: The lens regeneration model of the New Zealand rabbi ... Link to item Cite