Chang Yong Chung
Professor of Biology at Duke Kunshan University
Current Research Interests
Inflammation is a crucial component of the pathophysiology of both acute injuries and chronic neurological diseases, including Parkinson’s and Alzheimer’s. Inflammation in neuronal injuries and neurodegeneration involves important roles for resident inflammatory cells known as microglia. Microglia activation/chemotaxis is a prerequisite for microglia function, whether it is neuroprotective or inflammatory. Therefore, understanding microglial activation/chemotaxis is essential for designing rational approaches for therapeutic modulation of this response, and a better understanding of the regulation of microglia proliferation and chemotaxis has important therapeutic implications. However, it is not fully understood how the activation and chemotaxis of resident microglia in the brain is controlled at early stage of neuroinflammation. We have undertaken the responsibility of unraveling complex networks of signaling pathways controlling microglia activation/chemotaxis. We are also expanding our efforts to find an effective way to inhibit the directed cell migration during tumor metastasis.
Current Appointments & Affiliations
- Professor of Biology at Duke Kunshan University, DKU Faculty, Duke Kunshan University 2019
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., Duke University 1995
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Academic Positions Outside Duke
- Professor, Tianjin University. 2015 - 2019
- Adjunct Professor, Vanderbilt University. 2015 - 2020
- Assistant and Associate Professor, Vanderbilt University School of Medicine. 2001 - 2015
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Bassett, Ben, Selvaraj Subramaniyam, Yang Fan, Seth Varney, Hope Pan, Ana M. D. Carneiro, and Chang Y. Chung. “Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis.” Brain, Behavior, and Immunity 91 (January 2021): 519–30. https://doi.org/10.1016/j.bbi.2020.11.009.Full Text
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Feng, Xiaoye, Yang Fan, and Chang Y. Chung. “Mefenamic acid can attenuate depressive symptoms by suppressing microglia activation induced upon chronic stress.” Brain Research 1740 (August 2020): 146846. https://doi.org/10.1016/j.brainres.2020.146846.Full Text Open Access Copy
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Fan, Yang, Zhilu Chen, Janak L. Pathak, Ana M. D. Carneiro, and Chang Y. Chung. “Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine.” Frontiers in Cellular Neuroscience 12 (January 2018): 309. https://doi.org/10.3389/fncel.2018.00309.Full Text Open Access Copy
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Jalal, N., A. R. Surendranath, J. L. Pathak, S. Yu, and C. Y. Chung. “Bisphenol A (BPA) the mighty and the mutagenic.” Toxicology Reports 5 (January 1, 2018): 76–84. https://doi.org/10.1016/j.toxrep.2017.12.013.Full Text
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Fan, Yang, Lirui Xie, and Chang Y. Chung. “Signaling Pathways Controlling Microglia Chemotaxis.” Molecules and Cells 40, no. 3 (March 17, 2017): 163–68. https://doi.org/10.14348/molcells.2017.0011.Full Text Open Access Copy
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Chung, C. Y., Y. Shi, A. R. Surendranath, N. Jalal, J. L. Pathak, and S. Subramaniyam. “Role of Calcium-Independent Phospholipase A2 VIA in Mediating Neurological Disorder and Cancer.” Transactions of Tianjin University 23, no. 1 (January 1, 2017). https://doi.org/10.1007/s12209-016-0025-y.Full Text
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Lee, Sang-Hyun, Neetu Sud, Narae Lee, Selvaraj Subramaniyam, and Chang Y. Chung. “Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin.” The Journal of Biological Chemistry 291, no. 45 (November 2016): 23645–53. https://doi.org/10.1074/jbc.m116.732610.Full Text Open Access Copy
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Wang, C., D. Jung, Z. Cao, and C. Y. Chung. “Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC.” Biochemical and Biophysical Research Communications 465, no. 3 (September 2015): 613–19. https://doi.org/10.1016/j.bbrc.2015.08.072.Full Text
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Oliver, Kendra H., Tammy Jessen, Emily L. Crawford, Chang Y. Chung, James S. Sutcliffe, and Ana M. Carneiro. “Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606.” Molecular Pharmacology 85, no. 6 (June 2014): 921–31. https://doi.org/10.1124/mol.114.091736.Full Text
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Chung, Chang Y., Alexander Feoktistov, Ryan J. Hollingsworth, Francisco Rivero, and Nicole S. Mandel. “An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis.” Biochemical and Biophysical Research Communications 436, no. 4 (July 2013): 719–24. https://doi.org/10.1016/j.bbrc.2013.06.022.Full Text
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Wang, Dong, Surendra Dasari, Matthew C. Chambers, Jerry D. Holman, Kan Chen, Daniel C. Liebler, Daniel J. Orton, et al. “Basophile: accurate fragment charge state prediction improves peptide identification rates.” Genomics, Proteomics & Bioinformatics 11, no. 2 (April 2013): 86–95. https://doi.org/10.1016/j.gpb.2012.11.004.Full Text
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Lee, Sang-Hyun, Ryan Hollingsworth, Hyeok-Yil Kwon, Narae Lee, and Chang Y. Chung. “β-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis.” Glia 60, no. 9 (September 2012): 1366–77. https://doi.org/10.1002/glia.22355.Full Text Open Access Copy
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Lee, Sang-Hyun, Claus Schneider, Ashlee N. Higdon, Victor M. Darley-Usmar, and Chang Y. Chung. “Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis.” Traffic (Copenhagen, Denmark) 12, no. 7 (July 2011): 878–89. https://doi.org/10.1111/j.1600-0854.2011.01195.x.Full Text Open Access Copy
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Gruver, J Scott, Alka A. Potdar, Junhwan Jeon, Jiqing Sai, Bridget Anderson, Donna Webb, Ann Richmond, Vito Quaranta, Peter T. Cummings, and Chang Y. Chung. “Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility.” Biophysical Journal 99, no. 2 (July 2010): 367–76. https://doi.org/10.1016/j.bpj.2010.03.073.Full Text Open Access Copy
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Lin, Wan-Hsin, Sharon E. Nelson, Ryan J. Hollingsworth, and Chang Y. Chung. “Functional roles of VASP phosphorylation in the regulation of chemotaxis and osmotic stress response.” Cytoskeleton (Hoboken, N.J.) 67, no. 4 (April 2010): 259–71. https://doi.org/10.1002/cm.20443.Full Text
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Lee, S., and C. Y. Chung. “Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation.” Molecular and Cellular Neurosciences 42, no. 4 (December 2009): 382–90. https://doi.org/10.1016/j.mcn.2009.08.010.Full Text
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Lee, S., J. W. Han, L. Leeper, J. S. Gruver, and C. Y. Chung. “Regulation of the formation and trafficking of vesicles from Golgi by PCH family proteins during chemotaxis.” Biochimica Et Biophysica Acta 1793, no. 7 (July 2009): 1199–1209. https://doi.org/10.1016/j.bbamcr.2009.04.012.Full Text
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Gruver, J. S., J. P. Wikswo, and C. Y. Chung. “3'-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis.” Biophysical Journal 95, no. 8 (October 2008): 4057–67. https://doi.org/10.1529/biophysj.108.130179.Full Text
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Han, Ji W., Laura Leeper, Francisco Rivero, and Chang Y. Chung. “Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium.” The Journal of Biological Chemistry 281, no. 46 (November 2006): 35224–34. https://doi.org/10.1074/jbc.m605997200.Full Text
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Myers, Scott A., Laura R. Leeper, and Chang Y. Chung. “WASP-interacting protein is important for actin filament elongation and prompt pseudopod formation in response to a dynamic chemoattractant gradient.” Molecular Biology of the Cell 17, no. 10 (October 2006): 4564–75. https://doi.org/10.1091/mbc.e05-10-0994.Full Text
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Walker, Glenn M., Jiqing Sai, Ann Richmond, Mark Stremler, Chang Y. Chung, and John P. Wikswo. “Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator.” Lab on a Chip 5, no. 6 (June 2005): 611–18. https://doi.org/10.1039/b417245k.Full Text
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Myers, Scott A., Ji W. Han, Yoonsung Lee, Richard A. Firtel, and Chang Y. Chung. “A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis.” Molecular Biology of the Cell 16, no. 5 (May 2005): 2191–2206. https://doi.org/10.1091/mbc.e04-09-0844.Full Text
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Han, Young-Hoon, Chang Y. Chung, Deborah Wessels, Stephen Stephens, Margaret A. Titus, David R. Soll, and Richard A. Firtel. “Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium.” The Journal of Biological Chemistry 277, no. 51 (December 2002): 49877–87. https://doi.org/10.1074/jbc.m209107200.Full Text
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Chung, Chang Y., and Richard A. Firtel. “Signaling pathways at the leading edge of chemotaxing cells.” Journal of Muscle Research and Cell Motility 23, no. 7–8 (January 2002): 773–79. https://doi.org/10.1023/a:1024479728970.Full Text
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Chung, C. Y., S. Funamoto, and R. A. Firtel. “Signaling pathways controlling cell polarity and chemotaxis.” Trends in Biochemical Sciences 26, no. 9 (September 2001): 557–66. https://doi.org/10.1016/s0968-0004(01)01934-x.Full Text
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Chung, C. Y., G. Potikyan, and R. A. Firtel. “Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa.” Molecular Cell 7, no. 5 (May 2001): 937–47. https://doi.org/10.1016/s1097-2765(01)00247-7.Full Text
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Firtel, R. A., and C. Y. Chung. “The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients.” Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 22, no. 7 (July 2000): 603–15. https://doi.org/10.1002/1521-1878(200007)22:7<603::aid-bies3>3.0.co;2-#.Full Text
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Chung, C. Y., S. Lee, C. Briscoe, C. Ellsworth, and R. A. Firtel. “Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells.” Proceedings of the National Academy of Sciences of the United States of America 97, no. 10 (May 2000): 5225–30. https://doi.org/10.1073/pnas.97.10.5225.Full Text
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Chien, S., C. Y. Chung, S. Sukumaran, N. Osborne, S. Lee, C. Ellsworth, J. G. McNally, and R. A. Firtel. “The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis.” Molecular Biology of the Cell 11, no. 4 (April 2000): 1275–91. https://doi.org/10.1091/mbc.11.4.1275.Full Text
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Chung, C. Y., and R. A. Firtel. “PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis.” The Journal of Cell Biology 147, no. 3 (November 1999): 559–76. https://doi.org/10.1083/jcb.147.3.559.Full Text
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Park, M. J., H. S. Kim, J. H. Kang, D. H. Kim, and C. Y. Chung. “Serum levels of insulin-like growth factor (IGF)-I, free IGF-I, IGF binding protein (IGFBP)-1, IGFBP-3 and insulin in obese children.” Journal of Pediatric Endocrinology & Metabolism : Jpem 12, no. 2 (March 1999): 139–44. https://doi.org/10.1515/jpem.1999.12.2.139.Full Text
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Chung, C. Y., T. B. Reddy, K. Zhou, and R. A. Firtel. “A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation.” Genes & Development 12, no. 22 (November 1998): 3564–78. https://doi.org/10.1101/gad.12.22.3564.Full Text
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Lee, J. H., C. Y. Chung, B. H. Lee, and M. H. Choi. “Turn penalty problem model for minimum time AGV routing.” Iecon Proceedings (Industrial Electronics Conference) 3 (December 1, 1997): 1323–26.
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Chung, C. Y., and H. P. Erickson. “Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin-C.” J Cell Sci 110 ( Pt 12) (June 1997): 1413–19.Link to Item
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Chung, C. Y., J. E. Murphy-Ullrich, and H. P. Erickson. “Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II.” Mol Biol Cell 7, no. 6 (June 1996): 883–92. https://doi.org/10.1091/mbc.7.6.883.Full Text Link to Item
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Chung, C. Y., L. Zardi, and H. P. Erickson. “Binding of tenascin-C to soluble fibronectin and matrix fibrils.” J Biol Chem 270, no. 48 (December 1, 1995): 29012–17. https://doi.org/10.1074/jbc.270.48.29012.Full Text Link to Item
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Chung, C. Y., and H. P. Erickson. “Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C.” J Cell Biol 126, no. 2 (July 1994): 539–48. https://doi.org/10.1083/jcb.126.2.539.Full Text Link to Item
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Lee, D. Y., I. H. Choi, C. Y. Chung, P. H. Chung, J. G. Chi, and Y. L. Suh. “Effect of tibial lengthening on the gastrocnemius muscle. A histopathologic and morphometric study in rabbits.” Acta Orthopaedica Scandinavica 64, no. 6 (December 1993): 688–92. https://doi.org/10.3109/17453679308994599.Full Text
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Lee, D. Y., C. Y. Chung, and I. H. Choi. “Longitudinal growth of the rabbit tibia after callotasis.” The Journal of Bone and Joint Surgery. British Volume 75, no. 6 (November 1993): 898–903. https://doi.org/10.1302/0301-620x.75b6.8245079.Full Text
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Joshi, P., C. Y. Chung, I. Aukhil, and H. P. Erickson. “Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin.” J Cell Sci 106 ( Pt 1) (September 1993): 389–400.Link to Item
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Chung, C. Y., and M. S. Kang. “Correlation between fibronectin and its receptor in chick myoblast differentiation.” Journal of Cellular Physiology 142, no. 2 (February 1990): 392–400. https://doi.org/10.1002/jcp.1041420224.Full Text
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CHUNG, C. Y., T. H. HUANG, H. C. LI, M. C. HUANG, and P. T. FANG. “A NEW TECHNIQUE FOR DETECTING MYCOBACTERIUM LEPRAE AND THE PROBLEM OF INFECTIOUSNESS OF TUBERCULOID LEPROSY.” Chinese Medical Journal (Peking, China : 1932) 84 (June 1965): 390–94.
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Conference Papers
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Xie, L., F. Yang, and C. Y. Chung. “ADP-ribosylation of vimentin induces changes in morphology and motility of microglia through enhancing phosphorylation of vimentin at Ser(56) and disassembly of vimentin filaments.” In Molecular Biology of the Cell, Vol. 28, 2017.Link to Item
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Shi, Y., D. Chung, and C. Y. Chung. “Regulation of iPLA2 Activity and Localization by Rab5.” In Molecular Biology of the Cell, Vol. 27, 2016.Link to Item
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Chung, C. Y., and E. Ma. “Welcome from conference co-chairs.” In Asia Pacific Power and Energy Engineering Conference, Appeec, 6, 2013. https://doi.org/10.1109/APPEEC.2013.6837325.Full Text
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Wang, C., Z. Cao, D. Jung, and C. Y. Chung. “RacC is required for the vesicular trafficking of ACA and streaming of Dictyostelium cells.” In Molecular Biology of the Cell, Vol. 24, 2013.Link to Item
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Lee, S. -. H., N. Sud, N. Lee, and C. Y. Chung. “Role of iPLA2 in the regulation of the endosomal recycling of integrin and chemotactic motility of microglia.” In Molecular Biology of the Cell, Vol. 23, 2012.Link to Item
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Lee, S. -. H., and C. Y. Chung. “Alteration of alpha 6 integrin expression and chemotactic motility of microglia upon ADP stimulation.” In Molecular Biology of the Cell, Vol. 22, 2011.Link to Item
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Han, J. W., L. Leeper, F. Rivero, and C. Y. Chung. “Role of RacC for the regulation of WASP activity during chemotaxis of Dictyostelium.” In Molecular Biology of the Cell, 15:42A-42A, 2004.Link to Item
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Chung, C. Y., S. A. Myers, and R. A. Firtel. “Role of WASP in controlling f-actin assembly and motility during Dictyostelium chemotaxis.” In Molecular Biology of the Cell, 13:200A-201A, 2002.Link to Item
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Chung, C. Y., G. Potikyan, and R. A. Firtel. “Regulation of the activity and localization of Dictyostelium PAKa via direct phosphorylation by Akt/PKB.” In Molecular Biology of the Cell, 11:349A-349A, 2000.Link to Item
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Chung, C. Y., and R. A. Firtel. “PAKa is required for cytoskeletal regulation in Dictyostelium cells during chemotaxis and regulated via Akt/PKB pathway.” In Molecular Biology of the Cell, 10:263A-263A, 1999.Link to Item
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