Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 1995
• 

  Academic Positions Outside Duke

  • Professor, Tianjin University. 2015 - 2019
  • Adjunct Professor, Vanderbilt University. 2015 - 2020
  • Assistant and Associate Professor, Vanderbilt University School of Medicine. 2001 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Bassett, Ben, Selvaraj Subramaniyam, Yang Fan, Seth Varney, Hope Pan, Ana M. D. Carneiro, and Chang Y. Chung. “Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis.” Brain, Behavior, and Immunity 91 (January 2021): 519–30. https://doi.org/10.1016/j.bbi.2020.11.009.
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    • Feng, Xiaoye, Yang Fan, and Chang Y. Chung. “Mefenamic acid can attenuate depressive symptoms by suppressing microglia activation induced upon chronic stress.” Brain Research 1740 (August 2020): 146846. https://doi.org/10.1016/j.brainres.2020.146846.
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    • Fan, Yang, Zhilu Chen, Janak L. Pathak, Ana M. D. Carneiro, and Chang Y. Chung. “Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine.” Frontiers in Cellular Neuroscience 12 (January 2018): 309. https://doi.org/10.3389/fncel.2018.00309.
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    • Jalal, N., A. R. Surendranath, J. L. Pathak, S. Yu, and C. Y. Chung. “Bisphenol A (BPA) the mighty and the mutagenic.” Toxicology Reports 5 (January 1, 2018): 76–84. https://doi.org/10.1016/j.toxrep.2017.12.013.
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    • Fan, Yang, Lirui Xie, and Chang Y. Chung. “Signaling Pathways Controlling Microglia Chemotaxis.” Molecules and Cells 40, no. 3 (March 17, 2017): 163–68. https://doi.org/10.14348/molcells.2017.0011.
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    • Chung, C. Y., Y. Shi, A. R. Surendranath, N. Jalal, J. L. Pathak, and S. Subramaniyam. “Role of Calcium-Independent Phospholipase A2 VIA in Mediating Neurological Disorder and Cancer.” Transactions of Tianjin University 23, no. 1 (January 1, 2017). https://doi.org/10.1007/s12209-016-0025-y.
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    • Lee, Sang-Hyun, Neetu Sud, Narae Lee, Selvaraj Subramaniyam, and Chang Y. Chung. “Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin.” The Journal of Biological Chemistry 291, no. 45 (November 2016): 23645–53. https://doi.org/10.1074/jbc.m116.732610.
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    • Wang, C., D. Jung, Z. Cao, and C. Y. Chung. “Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC.” Biochemical and Biophysical Research Communications 465, no. 3 (September 2015): 613–19. https://doi.org/10.1016/j.bbrc.2015.08.072.
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    • Oliver, Kendra H., Tammy Jessen, Emily L. Crawford, Chang Y. Chung, James S. Sutcliffe, and Ana M. Carneiro. “Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606.” Molecular Pharmacology 85, no. 6 (June 2014): 921–31. https://doi.org/10.1124/mol.114.091736.
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    • Chung, Chang Y., Alexander Feoktistov, Ryan J. Hollingsworth, Francisco Rivero, and Nicole S. Mandel. “An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis.” Biochemical and Biophysical Research Communications 436, no. 4 (July 2013): 719–24. https://doi.org/10.1016/j.bbrc.2013.06.022.
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    • Wang, Dong, Surendra Dasari, Matthew C. Chambers, Jerry D. Holman, Kan Chen, Daniel C. Liebler, Daniel J. Orton, et al. “Basophile: accurate fragment charge state prediction improves peptide identification rates.” Genomics, Proteomics & Bioinformatics 11, no. 2 (April 2013): 86–95. https://doi.org/10.1016/j.gpb.2012.11.004.
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    • Lee, Sang-Hyun, Ryan Hollingsworth, Hyeok-Yil Kwon, Narae Lee, and Chang Y. Chung. “β-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis.” Glia 60, no. 9 (September 2012): 1366–77. https://doi.org/10.1002/glia.22355.
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    • Lee, Sang-Hyun, Claus Schneider, Ashlee N. Higdon, Victor M. Darley-Usmar, and Chang Y. Chung. “Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis.” Traffic (Copenhagen, Denmark) 12, no. 7 (July 2011): 878–89. https://doi.org/10.1111/j.1600-0854.2011.01195.x.
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    • Gruver, J Scott, Alka A. Potdar, Junhwan Jeon, Jiqing Sai, Bridget Anderson, Donna Webb, Ann Richmond, Vito Quaranta, Peter T. Cummings, and Chang Y. Chung. “Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility.” Biophysical Journal 99, no. 2 (July 2010): 367–76. https://doi.org/10.1016/j.bpj.2010.03.073.
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    • Lin, Wan-Hsin, Sharon E. Nelson, Ryan J. Hollingsworth, and Chang Y. Chung. “Functional roles of VASP phosphorylation in the regulation of chemotaxis and osmotic stress response.” Cytoskeleton (Hoboken, N.J.) 67, no. 4 (April 2010): 259–71. https://doi.org/10.1002/cm.20443.
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    • Lee, S., and C. Y. Chung. “Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation.” Molecular and Cellular Neurosciences 42, no. 4 (December 2009): 382–90. https://doi.org/10.1016/j.mcn.2009.08.010.
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    • Lee, S., J. W. Han, L. Leeper, J. S. Gruver, and C. Y. Chung. “Regulation of the formation and trafficking of vesicles from Golgi by PCH family proteins during chemotaxis.” Biochimica Et Biophysica Acta 1793, no. 7 (July 2009): 1199–1209. https://doi.org/10.1016/j.bbamcr.2009.04.012.
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    • Gruver, J. S., J. P. Wikswo, and C. Y. Chung. “3'-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis.” Biophysical Journal 95, no. 8 (October 2008): 4057–67. https://doi.org/10.1529/biophysj.108.130179.
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    • Han, Ji W., Laura Leeper, Francisco Rivero, and Chang Y. Chung. “Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium.” The Journal of Biological Chemistry 281, no. 46 (November 2006): 35224–34. https://doi.org/10.1074/jbc.m605997200.
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    • Myers, Scott A., Laura R. Leeper, and Chang Y. Chung. “WASP-interacting protein is important for actin filament elongation and prompt pseudopod formation in response to a dynamic chemoattractant gradient.” Molecular Biology of the Cell 17, no. 10 (October 2006): 4564–75. https://doi.org/10.1091/mbc.e05-10-0994.
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    • Walker, Glenn M., Jiqing Sai, Ann Richmond, Mark Stremler, Chang Y. Chung, and John P. Wikswo. “Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator.” Lab on a Chip 5, no. 6 (June 2005): 611–18. https://doi.org/10.1039/b417245k.
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    • Myers, Scott A., Ji W. Han, Yoonsung Lee, Richard A. Firtel, and Chang Y. Chung. “A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis.” Molecular Biology of the Cell 16, no. 5 (May 2005): 2191–2206. https://doi.org/10.1091/mbc.e04-09-0844.
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    • Han, Young-Hoon, Chang Y. Chung, Deborah Wessels, Stephen Stephens, Margaret A. Titus, David R. Soll, and Richard A. Firtel. “Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium.” The Journal of Biological Chemistry 277, no. 51 (December 2002): 49877–87. https://doi.org/10.1074/jbc.m209107200.
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    • Chung, Chang Y., and Richard A. Firtel. “Signaling pathways at the leading edge of chemotaxing cells.” Journal of Muscle Research and Cell Motility 23, no. 7–8 (January 2002): 773–79. https://doi.org/10.1023/a:1024479728970.
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    • Chung, C. Y., S. Funamoto, and R. A. Firtel. “Signaling pathways controlling cell polarity and chemotaxis.” Trends in Biochemical Sciences 26, no. 9 (September 2001): 557–66. https://doi.org/10.1016/s0968-0004(01)01934-x.
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    • Chung, C. Y., G. Potikyan, and R. A. Firtel. “Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa.” Molecular Cell 7, no. 5 (May 2001): 937–47. https://doi.org/10.1016/s1097-2765(01)00247-7.
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    • Firtel, R. A., and C. Y. Chung. “The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients.” Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 22, no. 7 (July 2000): 603–15. https://doi.org/10.1002/1521-1878(200007)22:7<603::aid-bies3>3.0.co;2-#.
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    • Chung, C. Y., S. Lee, C. Briscoe, C. Ellsworth, and R. A. Firtel. “Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells.” Proceedings of the National Academy of Sciences of the United States of America 97, no. 10 (May 2000): 5225–30. https://doi.org/10.1073/pnas.97.10.5225.
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    • Chien, S., C. Y. Chung, S. Sukumaran, N. Osborne, S. Lee, C. Ellsworth, J. G. McNally, and R. A. Firtel. “The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis.” Molecular Biology of the Cell 11, no. 4 (April 2000): 1275–91. https://doi.org/10.1091/mbc.11.4.1275.
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    • Chung, C. Y., and R. A. Firtel. “PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis.” The Journal of Cell Biology 147, no. 3 (November 1999): 559–76. https://doi.org/10.1083/jcb.147.3.559.
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    • Park, M. J., H. S. Kim, J. H. Kang, D. H. Kim, and C. Y. Chung. “Serum levels of insulin-like growth factor (IGF)-I, free IGF-I, IGF binding protein (IGFBP)-1, IGFBP-3 and insulin in obese children.” Journal of Pediatric Endocrinology & Metabolism : Jpem 12, no. 2 (March 1999): 139–44. https://doi.org/10.1515/jpem.1999.12.2.139.
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    • Chung, C. Y., T. B. Reddy, K. Zhou, and R. A. Firtel. “A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation.” Genes & Development 12, no. 22 (November 1998): 3564–78. https://doi.org/10.1101/gad.12.22.3564.
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    • Lee, J. H., C. Y. Chung, B. H. Lee, and M. H. Choi. “Turn penalty problem model for minimum time AGV routing.” Iecon Proceedings (Industrial Electronics Conference) 3 (December 1, 1997): 1323–26.
    • Chung, C. Y., and H. P. Erickson. “Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin-C.” J Cell Sci 110 ( Pt 12) (June 1997): 1413–19.
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    • Chung, C. Y., J. E. Murphy-Ullrich, and H. P. Erickson. “Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II.” Mol Biol Cell 7, no. 6 (June 1996): 883–92. https://doi.org/10.1091/mbc.7.6.883.
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    • Chung, C. Y., L. Zardi, and H. P. Erickson. “Binding of tenascin-C to soluble fibronectin and matrix fibrils.” J Biol Chem 270, no. 48 (December 1, 1995): 29012–17. https://doi.org/10.1074/jbc.270.48.29012.
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    • Chung, C. Y., and H. P. Erickson. “Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C.” J Cell Biol 126, no. 2 (July 1994): 539–48. https://doi.org/10.1083/jcb.126.2.539.
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    • Lee, D. Y., I. H. Choi, C. Y. Chung, P. H. Chung, J. G. Chi, and Y. L. Suh. “Effect of tibial lengthening on the gastrocnemius muscle. A histopathologic and morphometric study in rabbits.” Acta Orthopaedica Scandinavica 64, no. 6 (December 1993): 688–92. https://doi.org/10.3109/17453679308994599.
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    • Lee, D. Y., C. Y. Chung, and I. H. Choi. “Longitudinal growth of the rabbit tibia after callotasis.” The Journal of Bone and Joint Surgery. British Volume 75, no. 6 (November 1993): 898–903. https://doi.org/10.1302/0301-620x.75b6.8245079.
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    • Joshi, P., C. Y. Chung, I. Aukhil, and H. P. Erickson. “Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin.” J Cell Sci 106 ( Pt 1) (September 1993): 389–400.
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    • Chung, C. Y., and M. S. Kang. “Correlation between fibronectin and its receptor in chick myoblast differentiation.” Journal of Cellular Physiology 142, no. 2 (February 1990): 392–400. https://doi.org/10.1002/jcp.1041420224.
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    • CHUNG, C. Y., T. H. HUANG, H. C. LI, M. C. HUANG, and P. T. FANG. “A NEW TECHNIQUE FOR DETECTING MYCOBACTERIUM LEPRAE AND THE PROBLEM OF INFECTIOUSNESS OF TUBERCULOID LEPROSY.” Chinese Medical Journal (Peking, China : 1932) 84 (June 1965): 390–94.

  • Conference Papers

    • Xie, L., F. Yang, and C. Y. Chung. “ADP-ribosylation of vimentin induces changes in morphology and motility of microglia through enhancing phosphorylation of vimentin at Ser(56) and disassembly of vimentin filaments.” In Molecular Biology of the Cell, Vol. 28, 2017.
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    • Shi, Y., D. Chung, and C. Y. Chung. “Regulation of iPLA2 Activity and Localization by Rab5.” In Molecular Biology of the Cell, Vol. 27, 2016.
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    • Chung, C. Y., and E. Ma. “Welcome from conference co-chairs.” In Asia Pacific Power and Energy Engineering Conference, Appeec, 6, 2013. https://doi.org/10.1109/APPEEC.2013.6837325.
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    • Wang, C., Z. Cao, D. Jung, and C. Y. Chung. “RacC is required for the vesicular trafficking of ACA and streaming of Dictyostelium cells.” In Molecular Biology of the Cell, Vol. 24, 2013.
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    • Lee, S. -. H., N. Sud, N. Lee, and C. Y. Chung. “Role of iPLA2 in the regulation of the endosomal recycling of integrin and chemotactic motility of microglia.” In Molecular Biology of the Cell, Vol. 23, 2012.
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    • Lee, S. -. H., and C. Y. Chung. “Alteration of alpha 6 integrin expression and chemotactic motility of microglia upon ADP stimulation.” In Molecular Biology of the Cell, Vol. 22, 2011.
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    • Han, J. W., L. Leeper, F. Rivero, and C. Y. Chung. “Role of RacC for the regulation of WASP activity during chemotaxis of Dictyostelium.” In Molecular Biology of the Cell, 15:42A-42A, 2004.
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    • Chung, C. Y., S. A. Myers, and R. A. Firtel. “Role of WASP in controlling f-actin assembly and motility during Dictyostelium chemotaxis.” In Molecular Biology of the Cell, 13:200A-201A, 2002.
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    • Chung, C. Y., G. Potikyan, and R. A. Firtel. “Regulation of the activity and localization of Dictyostelium PAKa via direct phosphorylation by Akt/PKB.” In Molecular Biology of the Cell, 11:349A-349A, 2000.
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    • Chung, C. Y., and R. A. Firtel. “PAKa is required for cytoskeletal regulation in Dictyostelium cells during chemotaxis and regulated via Akt/PKB pathway.” In Molecular Biology of the Cell, 10:263A-263A, 1999.
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