Chantell Skye Evans | Scholars@Duke

Chantell Skye Evans
Assistant Professor of Cell Biology

The focus of the Evans lab is to mechanistically define diverse mitochondrial quality control pathways, including mitochondrial fusion and fission events, mitochondrial-derived vesicles, and mitophagy. Our goal is to understand how these pathways collaborate to regulate the mitochondrial network in healthy neurons and what goes wrong in neurodegenerative disease. We integrate advanced live-cell microscopy to visualize mitochondrial dynamics with biochemical techniques and proteomics to define the specificity of these mechanisms in primary neurons, iPSCs, and mouse models of disease.

Current Appointments & Affiliations

Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2021

Contact Information

Background
Education, Training, & Certifications
- Ph.D., University of Wisconsin - Madison 2016
Recognition
In the News
- OCT 21, 2022 Popular Science
  
  Chantell Evans: Bold Thinking on the Roots of Neurodegenerative Disease
- OCT 19, 2022
  
  Three of 25 Science Diversity Leadership Awards Come to Duke
- MAY 17, 2022 School of Medicine Magnify
  
  Cell Biologist Chantell Evans Aims to Set an Example
- FEB 15, 2022
  
  Two Duke Researchers Named Sloan Fellows
- JAN 13, 2022 School of Medicine
  
  Chantell Evans Is Tracking the Link Between Damaged Mitochondria and Brain Disease
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- How does selective autophagy dysfunction contribute to neurodegeneration? awarded by Chan Zuckerberg Initiative 2022 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Investigating mitochondrial turnover in homeostasis and disease awarded by Alfred P. Sloan Foundation 2022 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- HHMI Hanna H. Gray Fellows Program: Mitochondrial surveillance in neuronal homeostasis and disease awarded by Howard Hughes Medical Institute 2021 - 2023
External Relationships
- American Society of Cell Biology
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Dou, Dan, Erin M. Smith, Chantell S. Evans, C Alexander Boecker, and Erika L. F. Holzbaur. “Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.” Cell Rep 42, no. 5 (May 30, 2023): 112448. https://doi.org/10.1016/j.celrep.2023.112448.
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  - Fazli, Mohammad, and Chantell S. Evans. “Fluorescence-Based Quantification of Mitochondrial Membrane Potential and Superoxide Levels using Live Imaging in HeLa Cells.” J Vis Exp, no. 195 (May 12, 2023). https://doi.org/10.3791/65304.
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  - Seibert, Michael J., Chantell S. Evans, Kevin S. Stanley, Zhenyong Wu, and Edwin R. Chapman. “Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 43, no. 9 (March 2023): 1475–91. https://doi.org/10.1523/jneurosci.1857-22.2023.
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  - Schneider, Jordan R., and Chantell S. Evans. “Fluorescent pulse-chase labeling to monitor long-term mitochondrial degradation in primary hippocampal neurons.” Star Protoc 3, no. 4 (December 16, 2022): 101822. https://doi.org/10.1016/j.xpro.2022.101822.
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  - Termini, Christina M., Florentine U. N. Rutaganira, Caroline B. Palavicino-Maggio, Chelsey C. Spriggs, Chantell S. Evans, and Melanie R. McReynolds. “Using virtual interviewing to create a more accessible hybrid academic job market.” Cell 184, no. 26 (December 22, 2021): 6217–21. https://doi.org/10.1016/j.cell.2021.11.027.
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  - Harding, Olivia, Chantell S. Evans, Junqiang Ye, Jonah Cheung, Tom Maniatis, and Erika L. F. Holzbaur. “ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy.” Proc Natl Acad Sci U S A 118, no. 24 (June 15, 2021). https://doi.org/10.1073/pnas.2025053118.
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  - Harding, Olivia, Chantell Evans, Junqiang Ye, Jonah Cheung, Tom Maniatis, and Erika L. F. Holzbaur. “ALS and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy,” 2021. https://doi.org/10.1101/2021.04.12.439050.
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  - Evans, Chantell S., and Erika L. F. Holzbaur. “Lysosomal degradation of depolarized mitochondria is rate-limiting in OPTN-dependent neuronal mitophagy.” Autophagy 16, no. 5 (May 2020): 962–64. https://doi.org/10.1080/15548627.2020.1734330.
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  - Evans, Chantell S., and Erika Lf Holzbaur. “Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons.” Elife 9 (January 14, 2020). https://doi.org/10.7554/eLife.50260.
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  - Evans, Chantell S., and Erika L. F. Holzbaur. “Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms.” J Mol Biol 432, no. 1 (January 3, 2020): 240–60. https://doi.org/10.1016/j.jmb.2019.06.031.
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  - Hoshino, Atsushi, Wei-Jia Wang, Shogo Wada, Chris McDermott-Roe, Chantell S. Evans, Bridget Gosis, Michael P. Morley, et al. “The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.” Nature 575, no. 7782 (November 2019): 375–79. https://doi.org/10.1038/s41586-019-1667-4.
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  - Ruhl, David A., Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, et al. “Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways.” Nat Commun 10, no. 1 (August 6, 2019): 3532. https://doi.org/10.1038/s41467-019-11459-4.
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  - Evans, Chantell S., and Erika L. F. Holzbaur. “Autophagy and mitophagy in ALS.” Neurobiol Dis 122 (February 2019): 35–40. https://doi.org/10.1016/j.nbd.2018.07.005.
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  - Evans, Chantell S., Zixuan He, Hua Bai, Xiaochu Lou, Pia Jeggle, R Bryan Sutton, J Michael Edwardson, and Edwin R. Chapman. “Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.” Mol Biol Cell 27, no. 6 (March 15, 2016): 979–89. https://doi.org/10.1091/mbc.E15-07-0503.
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  - Roper, Lindsey K., Joseph S. Briguglio, Chantell S. Evans, Meyer B. Jackson, and Edwin R. Chapman. “Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9.” Nat Commun 6 (October 20, 2015): 8645. https://doi.org/10.1038/ncomms9645.
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  - Evans, Chantell S., David A. Ruhl, and Edwin R. Chapman. “An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.” J Neurosci 35, no. 34 (August 26, 2015): 11769–79. https://doi.org/10.1523/JNEUROSCI.1694-15.2015.
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  - Liu, Huisheng, Hua Bai, Enfu Hui, Lu Yang, Chantell S. Evans, Zhao Wang, Sung E. Kwon, and Edwin R. Chapman. “Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment.” Elife 3 (February 25, 2014): e01524. https://doi.org/10.7554/eLife.01524.
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  - Striegel, Amelia R., Laurie M. Biela, Chantell S. Evans, Zhao Wang, Jillian B. Delehoy, R Bryan Sutton, Edwin R. Chapman, and Noreen E. Reist. “Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission.” J Neurosci 32, no. 4 (January 25, 2012): 1253–60. https://doi.org/10.1523/JNEUROSCI.4652-11.2012.
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  - Hui, Enfu, Jon D. Gaffaney, Zhao Wang, Colin P. Johnson, Chantell S. Evans, and Edwin R. Chapman. “Mechanism and function of synaptotagmin-mediated membrane apposition.” Nat Struct Mol Biol 18, no. 7 (June 5, 2011): 813–21. https://doi.org/10.1038/nsmb.2075.
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- Preprints
  - Huynh, Duc T., Jimin Hu, Jordan R. Schneider, Kalina N. Tsolova, Erik J. Soderblom, Abigail J. Watson, Jen-Tsan Chi, Chantell S. Evans, and Michael Boyce. “O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations.,” February 22, 2023. https://doi.org/10.1101/2023.02.22.529563.
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  - Dou, Dan, Erin M. Smith, Chantell S. Evans, C Alexander Boecker, and Erika L. F. Holzbaur. “Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.” Cold Spring Harbor Laboratory, November 14, 2022. https://doi.org/10.1101/2022.11.14.516471.
    Full Text
  - Seibert, Michael, Chantell Evans, Kevin Stanley, Zhenyong Wu, and Edwin Chapman. “Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion.” BioRxiv, 2022. https://doi.org/10.1101/2022.04.18.488681.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

In the News

Awards & Honors

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Preprints

Recent Courses