Overview
The focus of the Evans lab is to mechanistically define diverse mitochondrial quality control pathways, including mitochondrial fusion and fission events, mitochondrial-derived vesicles, and mitophagy. Our goal is to understand how these pathways collaborate to regulate the mitochondrial network in healthy neurons and what goes wrong in neurodegenerative disease. We integrate advanced live-cell microscopy to visualize mitochondrial dynamics with biochemical techniques and proteomics to define the specificity of these mechanisms in primary neurons, iPSCs, and mouse models of disease.
Current Appointments & Affiliations
Assistant Professor of Cell Biology
·
2021 - Present
Cell Biology,
Basic Science Departments
Recent Publications
Mitochondrial motility modulators coordinate quality control dynamics to promote neuronal health.
Journal Article Curr Opin Cell Biol · August 2024 Dysfunction in mitochondrial maintenance and trafficking is commonly correlated with the development of neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Thus, biomedical research has been dedicated to understanding how archi ... Full text Link to item CiteASCB statement of commitment to diversity, equity, and inclusion.
Journal Article Mol Biol Cell · August 1, 2024 Full text Link to item CiteNext questions in autophagy.
Journal Article Nat Cell Biol · May 2024 Full text Link to item CiteRecent Grants
Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Tau Mediates Microtubule and Mitochondrial Dynamics to Control Cellular Organization and Alveolar Epithelial Repair
ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2029How does selective autophagy dysfunction contribute to neurodegeneration?
ResearchPrincipal Investigator · Awarded by Chan Zuckerberg Initiative · 2022 - 2027View All Grants
Education, Training & Certifications
University of Wisconsin, Madison ·
2016
Ph.D.