Chantell Skye Evans

Preprint · 2026 ABSTRACT Mitophagy is an essential quality control mechanism that maintains neuronal health by selectively removing damaged mitochondria via autophagosomes. In neurons, mitophagy is mainly driven by Optineurin (OPTN), a selective autophagy recept ... Full text Cite

O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations.

Preprint · February 22, 2023 The neurofilament (NF) cytoskeleton is critical for neuronal morphology and function. In particular, the neurofilament-light (NF-L) subunit is required for NF assembly in vivo and is mutated in subtypes of Charcot-Marie-Tooth (CMT) disease. NFs are highly ... Full text Link to item Cite

Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion

Preprint · 2022 ABSTRACT Synaptotagmin 9 (SYT9) is a tandem C2-domain Ca 2+ sensor for exocytosis in neuroendocrine cells; its function in neurons remains unclear. Here, we show that endogenous SYT9 does not trigger rapid synaptic vesicle exocytosis in cultured ... Full text Cite

Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes

Preprint · 2022 SUMMARY Gain-of-function mutations in the LRRK2 gene cause Parkinson’s disease (PD), increasing phosphorylation of RAB GTPases through hyperactive kinase activity. We found that LRRK2-hyperphosphorylated RABs disrupt the axonal transport of auto ... Full text Cite