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Chao-Chieh Lin

Research Associate, Senior
Molecular Genetics and Microbiology

Current Appointments & Affiliations


Recent Publications


Coenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductase.

Journal Article J Clin Invest · October 1, 2025 The cystine-xCT transporter/glutathione/GPX4 axis is the canonical pathway protecting cells from ferroptosis. Whereas GPX4-targeting ferroptosis-inducing compounds (FINs) act independently of mitochondria, xCT-targeting FINs require mitochondrial lipid per ... Full text Link to item Cite

NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation.

Journal Article Cell Death Dis · October 18, 2024 Ninjurin-1 (NINJ1), initially identified as a stress-induced protein in neurons, recently emerged as a key mediator of plasma membrane rupture (PMR) during apoptosis, necrosis, and pyroptosis. However, its involvement in ferroptosis is less well elucidated ... Full text Link to item Cite
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Recent Grants


The role of ferroptosis in the metastatic ovarian cancer

ResearchPost Doctoral Trainee · Awarded by Ovarian Cancer Research Alliance · 2022 - 2025

Metabolic regulation of KLHL proteins through glycosylation

ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2019 - 2024

Gene expression programs of lactic acidosis in human cancers

ResearchGraduate Student · Awarded by National Institutes of Health · 2007 - 2018

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