Scholars@Duke
Chao-Chieh Lin

Chao-Chieh Lin

Research Associate, Senior
Molecular Genetics and Microbiology

Scholarly Works

MESH1-mediated coenzyme A degradation drives ferroptosis sensitivity and muscle pathology.

Journal article J Clin Invest · June 1, 2026 CoA facilitates fatty acid synthesis, energy production, gene regulation, and antioxidant function. While CoA biosynthesis is well characterized, the mechanisms governing CoA degradation remain poorly understood. Here, we identify the Metazoan Homolog of S ... Full text Open Access Link to item Cite

Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer.

Journal article Nat Commun · May 11, 2026 The peritoneum is a frequent site of metastasis in ovarian cancer (OVCA), often accompanied by the accumulation of ascites in the peritoneal cavity. Despite its prevalence, ascites and its role in the peritoneal growth of OVCA remain poorly understood. OVC ... Full text Link to item Cite

MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation.

Journal article Nat Chem Biol · April 10, 2026 Biological sulfation reactions require 3'-phosphoadenosine-5'-phosphosulfate (PAPS) as the universal sulfate donor. While the biosynthetic pathway of PAPS has been well characterized, the phosphatase degrading PAPS remains unidentified. Here, we discover M ... Full text Open Access Link to item Cite

Coenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductase.

Journal article J Clin Invest · October 1, 2025 The cystine-xCT transporter/glutathione/GPX4 axis is the canonical pathway protecting cells from ferroptosis. Whereas GPX4-targeting ferroptosis-inducing compounds (FINs) act independently of mitochondria, xCT-targeting FINs require mitochondrial lipid per ... Full text Link to item Cite

NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation.

Journal article Cell Death Dis · October 18, 2024 Ninjurin-1 (NINJ1), initially identified as a stress-induced protein in neurons, recently emerged as a key mediator of plasma membrane rupture (PMR) during apoptosis, necrosis, and pyroptosis. However, its involvement in ferroptosis is less well elucidated ... Full text Link to item Cite

Parkin coordinates mitochondrial lipid remodeling to execute mitophagy.

Journal article EMBO Rep · December 6, 2022 Autophagy has emerged as the prime machinery for implementing organelle quality control. In the context of mitophagy, the ubiquitin E3 ligase Parkin tags impaired mitochondria with ubiquitin to activate autophagic degradation. Although ubiquitination is es ... Full text Open Access Link to item Cite

MESH1 knockdown triggers proliferation arrest through TAZ repression.

Journal article Cell Death Dis · March 10, 2022 All organisms are constantly exposed to various stresses, necessitating adaptive strategies for survival. In bacteria, the main stress-coping mechanism is the stringent response triggered by the accumulation of "alarmone" (p)ppGpp to arrest proliferation a ... Full text Link to item Cite

The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2.

Journal article Mol Cancer Res · June 2021 Ferroptosis is a new form of regulated cell death resulting from the accumulation of lipid-reactive oxygen species. A growing number of studies indicate ferroptosis as an important tumor suppressor mechanism having therapeutic potential in cancers. Previou ... Full text Open Access Link to item Cite

DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway.

Journal article Oncogene · March 2021 Recurrent breast cancer presents significant challenges with aggressive phenotypes and treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report that murine recurrent breast tumor cells, when compared with primary tumor cells ... Full text Open Access Link to item Cite

Zinc transporter ZIP7 is a novel determinant of ferroptosis.

Journal article Cell Death Dis · February 19, 2021 Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses and characterized by extensive lipid peroxidation and membrane damages. The name of ferroptosis indicates that the ferroptotic death process depends on iron, but ... Full text Open Access Link to item Cite

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence.

Journal article Cell Death Differ · July 2020 The molecular and genetic basis of tumor recurrence is complex and poorly understood. RIPK3 is a key effector in programmed necrotic cell death and, therefore, its expression is frequently suppressed in primary tumors. In a transcriptome profiling between ... Full text Link to item Cite

MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.

Journal article Nat Metab · March 2020 Critical to the bacterial stringent response is the rapid relocation of resources from proliferation toward stress survival through the respective accumulation and degradation of (p)ppGpp by RelA and SpoT homologues. While mammalian genomes encode MESH1, a ... Full text Open Access Link to item Cite

Parkin coordinates mitochondrial lipid remodeling to execute mitophagy

Journal article · 2020 Mitochondrial failure caused by Parkin mutations contributes to Parkinson’s disease. Parkin binds, ubiquitinates, and targets impaired mitochondria for autophagic destruction. Robust mitophagy involves peri-nuclear concentration of Parkin-tagged mitochondr ... Full text Cite

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence

Journal article · 2019 The molecular and genetic basis of tumor recurrence is complex and poorly understood. RIPK3 is a key effector in programmed necrotic cell death and, therefore, its expression is frequently suppressed in primary tumors. In a transcriptome profiling between ... Full text Cite

CoA synthase regulates mitotic fidelity via CBP-mediated acetylation.

Conference Nat Commun · March 12, 2018 The temporal activation of kinases and timely ubiquitin-mediated degradation is central to faithful mitosis. Here we present evidence that acetylation controlled by Coenzyme A synthase (COASY) and acetyltransferase CBP constitutes a novel mechanism that en ... Full text Open Access Link to item Cite

Abnormal cardiac autonomic regulation in mice lacking ASIC3.

Journal article BioMed research international · January 2014 Integration of sympathetic and parasympathetic outflow is essential in maintaining normal cardiac autonomic function. Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3) is a sensitive acid sensor for cardiac ischemia and prolonged mild acid ... Full text Cite