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Charalambos Costas Charalambous

Medical Instructor in the Department of Neurology
Neurology, Stroke and Vascular Neurology
DUMC Box 3824, Durham, NC 27710
40 Duke Medicine Circle, Box 3824, Durham, NC 27710
Office hours Per appointment.  

Scholarly Works - Preprints


Low-intensity focused ultrasound stimulation in stroke: An intensity escalation phase I safety and feasibility study

Preprint · September 12, 2024 AbstractBACKGROUNDLow-intensity focused ultrasound stimulation (LIFUS) has recently emerged as a promising neuromodulation tool for c ... Full text Cite

Corticospinal and corticoreticulospinal projections benefit motor behaviors in chronic stroke

Preprint · 2024 After corticospinal tract (CST) stroke, several motor deficits in the upper extremity (UE) emerge, including diminished muscle strength, motor control, and muscle individuation. Both the ipsilesional CST and contralesional corticoreticulospinal tract (CReS ... Full text Cite

Leg choice for volitional goal-directed stepping is primarily influenced by effort rather than success: A preliminary investigation in neurotypical adults

Preprint · 2024 During reaching, arm choice depends on success and motor effort. Whether these factors influence leg choice for stepping behavior is unknown. Here, we conducted two experiments (1: proof-of-principle; 2: kinematic analysis) to explore whether limb selectio ... Full text Cite

Intermuscular coherences of plantarflexors during walking suggest distinct neural origin and function for alpha and beta/low-gamma bands after stroke

Preprint · 2023 ABSTRACT Plantarflexors provide propulsion during walking (late stance) and receive input from both corticospinal tract (CST) and corticoreticulospinal tract (CReST). Both descending motor tracts exhibit some frequency-specificity, which allows p ... Full text Cite

Chronic stroke sensorimotor impairment is related to smaller hippocampal volumes: An ENIGMA analysis

Preprint · 2021 Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is involved in sensorimotor behavior but has not been widely studied within the context of post-stroke upper limb sensorimotor impairment. The hippocamp ... Full text Cite