Charles Gersbach

Preprint · July 7, 2026 We present FRACTEL, a statistical framework for region-level analysis of CRISPR perturbation screens. FRACTEL aggregates gRNA p-values using a bounded minimum across order statistics, preserving scale and enabling adaptive sensitivity to sparse or diffuse ... Full text Link to item Cite

DeltaNMF: A Two-Stage Neural NMF for Differential Gene Program Discovery

Preprint · 2026 Non-negative matrix factorization (NMF) is a foundational dimensionality-reduction method in single-cell transcriptomics, valued for its interpretable gene programs. However, in case-control settings common in perturbation and disease research, standard NM ... Full text Cite