Scholars@Duke
Jun Chen

Jun Chen

Professor of Medicine
Medicine, Hematologic Malignancies and Cellular Therapy
chen0032@mc.duke.edu
Box 103866 Med Ctr, Durham, NC 27710
GSRB1 Rm 4004B, 905 S LaSalle Street, Durham, NC 27710

Scholarly Works - Conferences

Imatinib-Sensitive Chronic Myeloid Leukaemia Is Associated with mtDNA Mutations and Reduced Oxphos Capacity

Conference Blood · November 5, 2024 Introduction: Therapy resistance driven by Leukemic Stem/Progenitor Cells (LSPCs) remains a challenge in Chronic Myeloid Leukemia (CML).Recent studies indicate that Tyrosine Kinase Inhibi ... Full text Cite

NT-I7, a Long-Acting Interleukin-7 Molecule, Promotes T Cell Reconstitution Following Radiation Injury through Thymic-Dependent and Independent Pathways

Conference Blood · November 5, 2024 Total body irradiation (TBI) causes suppression of hematopoiesis and T cell depletion. T cell lymphopenia following radiation exposure increases the risk of opportunistic infections. Curr ... Full text Cite

Human Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury

Conference Blood · November 5, 2024 Endothelial cells (ECs) are the major participants in bone marrow microenvironment and key regulators of hematopoiesis. ECs regulate hematopoiesis at least in part by shedding the extrace ... Full text Cite

Bob.1 Blocks a SYK Protein Degradation Pathway in Mice That Develop Chronic Graft Versus Host Disease Manifestations

Conference Blood · November 5, 2021 AbstractAfter elucidating a role for aberrant B Cell Receptor (BCR) signaling in chronic graft versus host disease (cGVHD) (Allen et al, Blood. 2014;123:2108), we showed that the proximal BCR molecule SYK is ... Full text Cite

Microrna-191 Regulates T-Cell Clonal Expansion during Graft-Versus-Host Disease

Conference Blood · November 13, 2019 Allogeneic hematopoietic cell transplantation is a potentially curative treatment choice for a wide variety of hematological malignancies. However, graft-versus-host disease (GVHD), which is mediated by donor alloreactive T cells, limits the succes ... Full text Cite

Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury

Conference Blood · November 29, 2018 AbstractHematopoietic stem cells (HSCs) reside in specialized microenvironments and adjacent to endothelial cells (ECs), from which they receive regulatory cues. Following injury from radiation or chemothera ... Full text Cite

Thymus Transplantation for Chronic Graft Versus Host Disease

Conference Journal of Allergy and Clinical Immunology · February 2017 Full text Cite

Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd

Conference Blood · December 2, 2016 AbstractIncreased B cell-activating factor (BAFF) and aberrant B cell survival and activation are associated with chronic graft versus host disease (cGVHD) in patients. Whether excessive BAFF production has ... Full text Cite

EGF Accelerates Hematopoietic Stem Cell Regeneration Following 5-FU Chemotherapy Via G-CSF Receptor Signaling

Conference Blood · December 2, 2016 AbstractHematopoietic stem cells (HSCs) reside in specialized bone marrow microenvironments adjacent to endothelial cells (BM ECs). BM ECs regulate both HSC self-renewal and regeneration by expressing solubl ... Full text Cite

All-Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients

Conference Blood · December 2, 2016 AbstractAllogeneic hematopoietic stem cell transplantation (HCT)-related immune pathology severely limits patient (Pt) survival, largely due to infections. Chronic graft versus host disease (cGVHD) Pts are p ... Full text Cite

Fibrinogen-Coated Nanospheres Prevent Thrombocytopenia-Related Bleeding

Conference Biology of Blood and Marrow Transplantation · February 2015 Full text Cite

Central Memory T Cells That Express High Level Of CD44 Mediate Strong Anti-Tumor Response Without Gvhd

Conference Blood · November 15, 2013 AbstractSeveral groups have demonstrated directly and indirectly that central memory T cells (TCM) have decreased ability to induce graft-versus-host disease (GVHD) compared with naïve T cells (TN). We have ... Full text Cite

Insulin-Like Growth Factor 1 Mitigates Hematopoietic Toxicity After Lethal Total Body Irradiation

Conference Biology of Blood and Marrow Transplantation · February 2013 Full text Cite

Human Memory T CELL S Elicit Decreased Cytotoxicity Against Allogeneic Targets

Conference Biology of Blood and Marrow Transplantation · February 2009 Full text Cite

Complete Long-Term Hematopoietic Engraftment by Lineage-Depleted ALDH CD34+ UCB Cells

Conference Biology of Blood and Marrow Transplantation · February 2009 Full text Cite

366: Allospecific Effector Memory T cells have Decreased Ability to Induce Acute GVHD

Conference Biology of Blood and Marrow Transplantation · February 2008 Full text Cite

Prevention of Graft-Versus-Host Disease in Mouse Model Using Anti-Mouse C5 Antibody.

Conference Blood · November 16, 2007 AbstractGraft versus-host disease (GVHD) is a major cause of morbidity and mortality after bone marrow transplantation (BMT). An allogeneic GVH reaction is a response of donor lymphoid cells to host minor or ... Full text Cite

Treatment of Established Graft-Versus-Host Disease by PG490-88.

Conference Blood · November 16, 2007 AbstractGraft-versus-host disease (GVHD) is a major complication following hematopoietic cell transplantation. While prophylaxis of GVHD has improved, treatment for GVHD remains unsatisfactory. PG490–88, a s ... Full text Cite

Allogeneic Committed Hematopoietic Progenitors Are Protective Against Radiation.

Conference Blood · November 16, 2007 AbstractWhole-body irradiation may lead to bone marrow failure and death. It was previously reported that congenic myeloerythroid-restricted progenitors are able to radioprotect lethally irradiated animals. ... Full text Cite

345: Radioprotection by growth hormone

Conference Biology of Blood and Marrow Transplantation · February 2007 Full text Cite

In Vivo Radiaprotective Effects of Growth Hormone.

Conference Blood · November 16, 2006 AbstractIonizing irradiation can cause bone marrow failure and death. Very few effective therapeutic agents are currently available for this condition. It was previously published that human recombinant grow ... Full text Cite

Failure of memory T cells to induce GVHD is a result of an abortive alloresponse

Conference Biology of Blood and Marrow Transplantation · February 2006 Full text Cite

Mature T cells alone separate GVL from GVHD: The need for better controls

Conference Biology of Blood and Marrow Transplantation · February 2005 Full text Cite