Chi Hornik
Assistant Professor of Pediatrics
Chi Hornik is the Director of Clinical Research in the Division of Pediatric Critical Care Medicine. She is an Assistant Professor of Pediatrics in the Duke School of Medicine and the Duke Clinical Research Institute (DCRI). She serves as Principal Investigator (PI) of Duke as a site for numerous studies and as clinical coordinating center PI of multi-center trials through the DCRI. As a clinical specialist in neonatal and pediatric critical care, she is committed to ensuring that the research conducted has representation of children from all races/ethnic backgrounds and socio-economic status, in order to continue to move the needle forward to improve health for all children.
Current Appointments & Affiliations
- Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2022
- Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2020
Contact Information
- 2301 Erwin Road, 5th Floor Duke North, Suite 5260Y, Durham, NC 27710
- Dumc, 2301 Erwin Road, 5th Floor Duke North, Suite 5260Y, Durham, NC 27710
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(919) 970-6680
- Background
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Previous Appointments & Affiliations
- Adjunct Assistant Professor in the Department of Pediatrics, Pediatrics, Neonatology, Pediatrics 2016 - 2021
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Leadership & Clinical Positions at Duke
- Director, Pediatric Critical Care Medicine Clinical Research
- Research
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Selected Grants
- North Carolina Clinical Center for the Eunice Kennedy Shiver NICHD Cooperative Multicenter Neonatal Research Network awarded by National Institutes of Health 2001 - 2030
- PTN 2.0 TO 6 Down Syndrome Extension awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2019 - 2025
- PTN TO: BPCA INNOVATIVE TRIAL DESIGNS FOR DOSING, SAFETY, and EFFICACY in PEDIATRIC THERAPEUTICS awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2019 - 2025
- MERCK: Palivizumab (MK 1654) awarded by Merck Sharp & Dohme LLC. 2022 - 2024
- PTN Task Order 8 COVID-19 Studies awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2020 - 2024
- Clinical Outcome Assessments for Acute Pain Therapeutics in Infants and your Children (COA APTIC) awarded by Food and Drug Administration 2019 - 2024
- PTN 2.0: Task order #2 COVID-19 POP02 awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development 2020 - 2023
- Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care awarded by National Institutes of Health 2020 - 2023
- PTN2- TO# BPCA Pharmacology Studies awarded by National Institute for Child Health & Human Develo 2018 - 2023
- A Phase 1b, Multicenter, double blind randomized controlled dose escalating trial of fentanyl vs. fentanyl + dexmedetomidine as the initial regimen for maintenance of sedation in mechanically-ventilated, critically ill children awarded by National Institutes of Health 2019 - 2023
- PTN 2.0- TO 3 - Option 3 - BPCA Concept Development and Clinical Trial Readiness Support awarded by National Institute for Child Health & Human Develo 2021 - 2022
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children per Standard of Care (POPS) awarded by DCRI-Duke-Site 2020 - 2022
- Pharmacokinetics and Safety Profile of Digoxin in Infants with Single Ventricle Congenital Heart Disease awarded by DCRI-Duke-Site 2019 - 2022
- 7586 POPS I (Task Order 2) - DUK99 awarded by DCRI-Duke-Site 2018 - 2022
- Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care awarded by DCRI-Duke-Site 2018 - 2022
- Clinical Pharmacokinetics and Safety Trials in Down Syndrome awarded by National Institutes of Health 2019 - 2022
- Pharmacokinetics and Safety of Anesthetics and Analgesics in Children awarded by National Institutes of Health 2018 - 2022
- An open-label study to evaluate the single-dose pharmacokinetics and safety of ceftobiprole in neonate and infant subjects aged up to 3 months undergoing treatment with systemic antibiotics awarded by Basilea Pharmaceutica 2018 - 2021
- POST ACUTE SEQUELAE OF SARS-COV-2 INFECTION INITIATIVE (Phase 1) awarded by New York University School of Medicine 2021
- PTN2- TO# 3 Concept Development and Clinical Trial Readiness Support Option Period 1 awarded by National Institute for Child Health & Human Develo 2019 - 2020
- Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care awarded by National Institutes of Health 2019 - 2020
- Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care awarded by National Institutes of Health 2019 - 2020
- Pharmacokinetics of ant-epileptic Drugs in Obese Children (HHSN-275201000003I) awarded by Duke Clinical Research Institute 2016 - 2020
- DUKE POP V (DUKE 10)- TO 49 awarded by National Institutes of Health 2017 - 2020
- POP V (Duke 08) TO 49 awarded by National Institutes of Health 2017 - 2020
- NICHD-2017-ABS02 Long-Term Outcomes Protocol of Premature Infants Enrolled in the NICHD-2013-ABS01 (SCAMP) Study awarded by National Institutes of Health 2017 - 2018
- A Phase 2/3 Randomized, Openn-Label, Multi-center Study to Determine the Safety and Efficacy of Solithromycin in Adolescents (12 to17 years of age, inclusive) and Children (>- 2 months to < 12 years of age) with Suspected or Confirmed Community awarded by Duke Clinical Research Institute 2017 - 2018
- POPS III -Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care (HHSN-275201000003I) awarded by Duke Clinical Research Institute 2016 - 2018
- POPS IV - (HHSN-275201000003I) PTN Opportunity 14- Task Order 43 awarded by Duke Clinical Research Institute 2016 - 2018
- Molecular Basis of Postoperative Delirium in the Elderly awarded by National Institutes of Health 2003 - 2010
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External Relationships
- Fresenius-Kabi
- Tellus Therapeutics, Inc.
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Boutzoukas, A. E., Olson, R., Sellers, M. A., Fischer, G., Hornik, C. D., Alibrahim, O., … Becker, M. L. (2023). Mechanisms to expedite pediatric clinical trial site activation: The DOSE trial experience. Contemp Clin Trials, 125, 107067. https://doi.org/10.1016/j.cct.2022.107067Full Text Link to Item
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Titchiner, D., Hornik, C., Benjamin, R., Tolia, V., Smith, P. B., & Greenberg, R. G. (2022). Insulin for Treatment of Neonatal Hyperglycemia in Premature Infants: Prevalence over Time and Association with Outcomes. Am J Perinatol. https://doi.org/10.1055/a-1976-2142Full Text Link to Item
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Lang, J. E., Hornik, C. D., Martz, K., Jacangelo, J., Anand, R., Greenberg, R., … Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee, . (2022). Safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia: Rationale and methods of a phase II randomized trial. Contemp Clin Trials Commun, 30, 101025. https://doi.org/10.1016/j.conctc.2022.101025Full Text Link to Item
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Moorthy, G. S., Greenberg, R. G., Hornik, C. D., Cassino, C., Ghahramani, P., Kumar, K. R., … Cohen-Wolkowiez, M. (2022). Safety and Pharmacokinetics of Exebacase in an Infant With Disseminated Staphylococcus aureus Infection. Clin Infect Dis, 75(2), 338–341. https://doi.org/10.1093/cid/ciab1015Full Text Open Access Copy Link to Item
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Gerhart, J. G., Carreño, F. O., Loop, M. S., Lee, C. R., Edginton, A. N., Sinha, J., … Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee, . (2022). Use of Real-World Data and Physiologically-Based Pharmacokinetic Modeling to Characterize Enoxaparin Disposition in Children With Obesity. Clin Pharmacol Ther, 112(2), 391–403. https://doi.org/10.1002/cpt.2618Full Text Link to Item
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Lang, J. E., Hornik, C. P., Elliott, C., Silverstein, A., Hornik, C., Al-Uzri, A., … SOLI-PEDS Program, . (2022). Solithromycin in Children and Adolescents With Community-acquired Bacterial Pneumonia. Pediatr Infect Dis J, 41(7), 556–562. https://doi.org/10.1097/INF.0000000000003559Full Text Link to Item
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Gerhart, J. G., Carreño, F. O., Ford, J. L., Edginton, A. N., Perrin, E. M., Watt, K. M., … Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee, . (2022). Use of physiologically-based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity. Cpt Pharmacometrics Syst Pharmacol, 11(6), 778–791. https://doi.org/10.1002/psp4.12793Full Text Link to Item
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Aleem, S., Walker, L. S., Hornik, C. D., Smith, M. J., Grotegut, C. A., & Weimer, K. E. D. (2022). Severe Congenital Syphilis in the Neonatal Intensive Care Unit: A Retrospective Case Series. Pediatr Infect Dis J, 41(4), 335–339. https://doi.org/10.1097/INF.0000000000003370Full Text Link to Item
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Gerhart, J. G., Carreño, F. O., Edginton, A. N., Sinha, J., Perrin, E. M., Kumar, K. R., … Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee, . (2022). Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling. Clin Pharmacokinet, 61(2), 307–320. https://doi.org/10.1007/s40262-021-01072-4Full Text Link to Item
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Jackson, W., Gonzalez, D., Smith, P. B., Ambalavanan, N., Atz, A. M., Sokol, G. M., … Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee, . (2022). Safety of sildenafil in extremely premature infants: a phase I trial. J Perinatol, 42(1), 31–36. https://doi.org/10.1038/s41372-021-01261-wFull Text Link to Item
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Karatza, E., Ganguly, S., Hornik, C. D., Muller, W. J., Al-Uzri, A., James, L., … Gonzalez, D. (2022). External Evaluation of Risperidone Population Pharmacokinetic Models Using Opportunistic Pediatric Data. Front Pharmacol, 13, 817276. https://doi.org/10.3389/fphar.2022.817276Full Text Link to Item
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Kilpatrick, R., Scarrow, E., Hornik, C., & Greenberg, R. G. (2022). Neonatal invasive candidiasis: updates on clinical management and prevention. Lancet Child Adolesc Health, 6(1), 60–70. https://doi.org/10.1016/S2352-4642(21)00272-8Full Text Link to Item
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Stark, A., Smith, P. B., Hornik, C. P., Zimmerman, K. O., Hornik, C. D., Pradeep, S., … Greenberg, R. G. (2022). Medication Use in the Neonatal Intensive Care Unit and Changes from 2010 to 2018. J Pediatr, 240, 66-71.e4. https://doi.org/10.1016/j.jpeds.2021.08.075Full Text Link to Item
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Rubino, C. M., Polak, M., Schröpf, S., Münch, H. G., Smits, A., Cossey, V., … Hamed, K. (2021). Pharmacokinetics and Safety of Ceftobiprole in Pediatric Patients. Pediatr Infect Dis J, 40(11), 997–1003. https://doi.org/10.1097/INF.0000000000003296Full Text Link to Item
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Rent, S., Bidegain, M., Bost, M. H., Hornik, C., & Lemmon, M. E. (2021). Neuropalliative Care for Neonates. J Child Neurol, 36(12), 1120–1127. https://doi.org/10.1177/08830738211045238Full Text Link to Item
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Maharaj, A. R., Wu, H., Zimmerman, K. O., Muller, W. J., Sullivan, J. E., Sherwin, C. M. T., … Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee, . (2021). Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity. Paediatr Drugs, 23(5), 499–513. https://doi.org/10.1007/s40272-021-00460-4Full Text Link to Item
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Miller, L. E., DeRienzo, C., Smith, P. B., Bose, C., Clark, R. H., Cotten, C. M., … Greenberg, R. G. (2021). Association between neonatal intensive care unit medication safety practices, adverse events, and death. J Perinatol, 41(7), 1739–1744. https://doi.org/10.1038/s41372-020-00857-yFull Text Link to Item
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Le, J., Greenberg, R. G., Benjamin, D. K., Yoo, Y., Zimmerman, K. O., Cohen-Wolkowiez, M., … Administrative Core Committee of the Best Pharmaceuticals for Children Act–Pediatric Trials Network, . (2021). Prolonged Post-Discontinuation Antibiotic Exposure in Very Low Birth Weight Neonates at Risk for Early-Onset Sepsis. J Pediatric Infect Dis Soc, 10(5), 615–621. https://doi.org/10.1093/jpids/piaa172Full Text Link to Item
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Abdel-Rahman, S. M., Paul, I. M., Hornik, C., Sullivan, J. E., Wade, K., Delmore, P., … Zimmerman, K. O. (2021). Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act. Pediatrics, 147(5). https://doi.org/10.1542/peds.2020-042903Full Text Link to Item
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Commander, S. J., Wu, H., Boakye-Agyeman, F., Melloni, C., Hornik, C. D., Zimmerman, K., … Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee, . (2021). Pharmacokinetics of Hydrochlorothiazide in Children: A Potential Surrogate for Renal Secretion Maturation. J Clin Pharmacol, 61(3), 368–377. https://doi.org/10.1002/jcph.1739Full Text Link to Item
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Hornik, C. D., Bondi, D. S., Greene, N. M., Cober, M. P., & John, B. (2021). Review of Fluconazole Treatment and Prophylaxis for Invasive Candidiasis in Neonates. J Pediatr Pharmacol Ther, 26(2), 115–122. https://doi.org/10.5863/1551-6776-26.2.115Full Text Link to Item
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Salerno, S. N., Edginton, A., Gerhart, J. G., Laughon, M. M., Ambalavanan, N., Sokol, G. M., … Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee, . (2021). Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants. Clin Pharmacol Ther, 109(1), 253–262. https://doi.org/10.1002/cpt.1990Full Text Link to Item
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Stark, A., Peterson, J., Weimer, K., & Hornik, C. (2021). Postnatally acquired CMV meningitis diagnosed via BioFire FilmArray: A case report. J Neonatal Perinatal Med, 14(3), 445–450. https://doi.org/10.3233/NPM-200524Full Text Link to Item
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Maharaj, A. R., Wu, H., Hornik, C. P., Balevic, S. J., Hornik, C. D., Smith, P. B., … Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee, . (2020). Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019. Jama Pediatr, 174(10), e202422. https://doi.org/10.1001/jamapediatrics.2020.2422Full Text Link to Item
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Scott, B. L., Hornik, C. D., & Zimmerman, K. (2020). Pharmacokinetic, efficacy, and safety considerations for the use of antifungal drugs in the neonatal population. Expert Opin Drug Metab Toxicol, 16(7), 605–616. https://doi.org/10.1080/17425255.2020.1773793Full Text Link to Item
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Donoghue, A. J., Kou, M., Good, G. L., Eiger, C., Nash, M., Henretig, F. M., … Best Pharmaceuticals for Children Act – Pediatric Trials Network, . (2020). Impact of Personal Protective Equipment on Pediatric Cardiopulmonary Resuscitation Performance: A Controlled Trial. Pediatr Emerg Care, 36(6), 267–273. https://doi.org/10.1097/PEC.0000000000002109Full Text Link to Item
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Gonzalez, D., Laughon, M. M., Smith, P. B., Ge, S., Ambalavanan, N., Atz, A., … Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee, . (2019). Population pharmacokinetics of sildenafil in extremely premature infants. Br J Clin Pharmacol, 85(12), 2824–2837. https://doi.org/10.1111/bcp.14111Full Text Link to Item
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Ku, L. C., Simmons, C., Smith, P. B., Greenberg, R. G., Fisher, K., Hornik, C. D., … Bidegain, M. (2019). Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit. J Neonatal Perinatal Med, 12(2), 143–148. https://doi.org/10.3233/NPM-17149Full Text Link to Item
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Parker, W., Hornik, C. D., Bilbo, S., Holzknecht, Z. E., Gentry, L., Rao, R., … Nevison, C. D. (2017). The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. J Int Med Res, 45(2), 407–438. https://doi.org/10.1177/0300060517693423Full Text Link to Item
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Edwards, L. E., Hutchison, L. B., Hornik, C. D., Smith, P. B., Cotten, C. M., & Bidegain, M. (2017). A case of infant delirium in the neonatal intensive care unit. J Neonatal Perinatal Med, 10(1), 119–123. https://doi.org/10.3233/NPM-1637Full Text Link to Item
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Edwards, L., DeMeo, S., Hornik, C. D., Cotten, C. M., Smith, P. B., Pizoli, C., … Bidegain, M. (2016). Gabapentin Use in the Neonatal Intensive Care Unit. J Pediatr, 169, 310–312. https://doi.org/10.1016/j.jpeds.2015.10.013Full Text Link to Item
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DeMeo, S. D., Sherwood, A., Hornik, C. D., Goldberg, R. N., Cotten, C. M., & Bidegain, M. (2014). Pulmonary artery thrombus in a premature neonate treated with recombinant tissue plasminogen activator. J Perinatol, 34(7), 569–571. https://doi.org/10.1038/jp.2014.34Full Text Link to Item
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Crouchley, J. L., Smith, P. B., Cotten, C. M., Hornik, C. D., Goldberg, R. N., Foreman, J. W., & Wynn, J. L. (2013). Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates. J Perinatol, 33(8), 619–621. https://doi.org/10.1038/jp.2013.20Full Text Link to Item
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Dang, C. N., Katakam, L. I., Smith, P. B., Cotten, C. M., Goldberg, R. N., Chandler, N., … Bidegain, M. (2011). Recombinant activated factor VIIa treatment for refractory hemorrhage in infants. J Perinatol, 31(3), 188–192. https://doi.org/10.1038/jp.2010.85Full Text Link to Item
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Bidegain, M., Greenberg, R., Simmons, C., Dang, C., Cotten, C. M., & Smith, P. B. (2010). Vasopressin for refractory hypotension in extremely low birth weight infants. J Pediatr, 157(3), 502–504. https://doi.org/10.1016/j.jpeds.2010.04.038Full Text Link to Item
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Katakam, L. I., Cotten, C. M., Goldberg, R. N., Dang, C. N., & Smith, P. B. (2010). Safety and effectiveness of indomethacin versus ibuprofen for treatment of patent ductus arteriosus. Am J Perinatol, 27(5), 425–429. https://doi.org/10.1055/s-0029-1243371Full Text Link to Item
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Book Sections
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Dallefeld, S., Hornik, C. D., Zimmerman, K., & Cohen-Wolkowiez, M. (2018). Antibiotic Dosing Considerations for Term and Preterm Infants. In Infectious Disease and Pharmacology: Neonatology Questions and Controversies (pp. 167–184). https://doi.org/10.1016/B978-0-323-54391-0.00014-XFull Text
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Hornik, C. D., O’Donnell, C., & Barfield, R. (2014). Ethical Considerations in Pharmacogenomic Testing and Research in Pediatrics. In Handbook of Pharmacogenomics and Stratified Medicine (pp. 931–950). https://doi.org/10.1016/B978-0-12-386882-4.00041-4Full Text
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Conference Papers
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Sinha, J., Zimmerman, K., Balevic, S., Muller, W., Hornik, C., Rathore, M., … Gonzalez, D. (2022). USE OF POPULATION MODELING TO CHARACTERIZE THE PHARMACOKINETICS OF OXCARBAZEPINE AND ITS METABOLITE IN CHILDREN AND ADOLESCENTS WITH OBESITY. In Clinical Pharmacology & Therapeutics (Vol. 111, pp. S48–S48).Link to Item
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Ganguly, S., Edginton, A. N., Gerhart, J. G., Cohen-Wolkowiez, M., Greenberg, R. G., Gonzalez, D., & Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee, . (2021). Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants. In Clin Pharmacokinet (Vol. 60, pp. 1591–1604). Switzerland. https://doi.org/10.1007/s40262-021-01046-6Full Text Link to Item
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Titchiner, D. M., athavale, K., Hornik, C., Shaikh, S. K., & Tanaka, D. (2021). Oral Glucose Gel for Asymptomatic Neonatal Hypoglycemia: Is It A Sweet Deal? In Pediatrics (Vol. 147, pp. 139–140). American Academy of Pediatrics (AAP). https://doi.org/10.1542/peds.147.3ma2.139Full Text
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Abdel-Rahman, S., Delmore, P., Hornik, C., Paul, I., Sharma, G., Sullivan, J., … Zimmerman, K. (2021). MINORITY REPRESENTATION IN PEDIATRIC STUDIES FUNDED UNDER THE BEST PHARMACEUTICALS FOR CHILDREN'S ACT (BPCA). In Clinical Pharmacology & Therapeutics (Vol. 109, pp. S58–S58).Link to Item
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Ku, L. C., Simmons, C., Smith, B., Greenberg, R., Fisher, K., Hornik, C., … Bidegain, M. (2018). Intranasal Midazolam and Fentanyl for Analgesia and Sedation in Infants in the Neonatal Intensive Care Unit. In Section on Neonatal Perinatal Medicine Program. American Academy of Pediatrics. https://doi.org/10.1542/peds.141.1_meetingabstract.532Full Text
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Sherwin, J., Thomas, M., Thompson, E., Hornik, C., Sullivan, L., & Lodge, A. (2018). 233: VANCOMYCIN LEVELS IN CHILDREN SUPPORTED BY A VENTRICULAR ASSIST DEVICE. In Critical Care Medicine (Vol. 46, pp. 99–99). Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1097/01.ccm.0000528252.57219.30Full Text
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