Overview
Chi Hornik is the Director of Heart Center Research and the Director of Critical Care Medicine Research in the Department of Pediatrics. She is an Associate Professor in the Duke School of Medicine and a member of the Duke Clinical Research Institute (DCRI). She serves as Principal Investigator (PI) of Duke as a site for numerous studies and as clinical coordinating center PI of multi-center trials through the DCRI. As a clinical specialist in neonatal and pediatric critical care, she is dedicated to advancing drug and device development. She ensures that the research encompasses patients who are representative of the disease or condition being studied. Her commitment is to advance health outcomes for all children, striving for equity in clinical research.
Current Appointments & Affiliations
Recent Publications
Epidemiology and treatment of herpes simplex virus in the neonatal intensive care unit.
Journal Article J Perinatol · January 2025 OBJECTIVE: Describe the epidemiology and clinical characteristics of infants in the neonatal intensive care unit (NICU) with acyclovir exposure and herpes simplex virus (HSV) infection. STUDY DESIGN: Our primary analysis was to evaluate the prevalence of H ... Full text Link to item CitePharmacokinetics of Dexamethasone in Children and Adolescents with Obesity.
Journal Article Journal of clinical pharmacology · December 2024 Dexamethasone is a synthetic glucocorticoid approved for treating disorders of various organ systems in both adult and pediatric populations. Currently, approved pediatric dosing recommendations are weight-based, but it is unknown whether differences in de ... Full text CitePostdiscontinuation Antibiotic Exposure in Hospitalized Infants at Risk for Late-onset Sepsis in the Neonatal Intensive Care Unit.
Journal Article Pediatr Infect Dis J · October 1, 2024 BACKGROUND: In the neonatal intensive care unit, infants are at risk for late-onset sepsis. When blood cultures are negative, antibiotic stewardship efforts encourage stopping antibiotics, yet the duration of therapeutic exposure after the last dose is unk ... Full text Link to item CiteRecent Grants
North Carolina Clinical Center for the Eunice Kennedy Shiver NICHD Cooperative Multicenter Neonatal Research Network
ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2001 - 2030BPCA Innovative Trial Designs and Assay Developments in Pediatric Therapeutics
ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2026Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children per Standard of Care / (POPS)
ResearchPrincipal Investigator · Awarded by DCRI-Duke-Site · 2024 - 2026View All Grants