Overview
Chi Hornik is the Director of Heart Center Research and the Director of Critical Care Medicine Research in the Department of Pediatrics. She is an Associate Professor in the Duke School of Medicine and a member of the Duke Clinical Research Institute (DCRI). She serves as Principal Investigator (PI) of Duke as a site for numerous studies and as clinical coordinating center PI of multi-center trials through the DCRI. As a clinical specialist in neonatal and pediatric critical care, she is dedicated to advancing drug and device development. She ensures that the research encompasses patients who are representative of the disease or condition being studied. Her commitment is to advance health outcomes for all children, striving for equity in clinical research.
Current Appointments & Affiliations
Recent Publications
Population Pharmacokinetics and Dosing Simulations of Pentobarbital in the Pediatric Population.
Journal Article J Clin Pharmacol · May 2026 Pentobarbital is a barbiturate with sedative and anticonvulsant properties, occasionally used in pediatric patients for preoperative sedation, deep sedation during mechanical ventilation, and seizure control. Despite its long-standing clinical use, age-app ... Full text Link to item CitePopulation Pharmacokinetics and Exposure-Safety Analysis of Furosemide in Preterm Infants.
Journal Article J Clin Pharmacol · April 2026 Furosemide is the most commonly used diuretic in preterm infants despite an incompletely understood relationship between dosing, exposure, and safety within this population. The goals of this study were to characterize furosemide population pharmacokinetic ... Full text Link to item CitePhysiologically Based Pharmacokinetic Modeling of Oxcarbazepine to Characterize Its Disposition in Children with Obesity.
Journal Article J Clin Pharmacol · February 2026 Oxcarbazepine (OXC) is a second-generation antiseizure medication, effective through its active metabolite, 10-mono-hydroxy derivative (MHD). OXC is used as adjunctive therapy for focal-onset and primary generalized tonic-clonic seizures, with recommended ... Full text Link to item CiteRecent Grants
BPCA PTN 3.0 TO#1 Core Function Activities_ Option Period 1
ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2032North Carolina Clinical Center for the Eunice Kennedy Shiver NICHD Cooperative Multicenter Neonatal Research Network
ResearchCollaborating Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2001 - 2030Pharmacokinetics and Safety of Anesthetics and Analgesics in Children and Adolescents (ANA01)
ResearchPrincipal Investigator · Awarded by DCRI-Duke-Site · 2025 - 2028View All Grants