Overview
Chi Hornik is the Director of Heart Center Research and the Director of Critical Care Medicine Research in the Department of Pediatrics. She is an Associate Professor in the Duke School of Medicine and a member of the Duke Clinical Research Institute (DCRI). She serves as Principal Investigator (PI) of Duke as a site for numerous studies and as clinical coordinating center PI of multi-center trials through the DCRI. As a clinical specialist in neonatal and pediatric critical care, she is dedicated to advancing drug and device development. She ensures that the research encompasses patients who are representative of the disease or condition being studied. Her commitment is to advance health outcomes for all children, striving for equity in clinical research.
Current Appointments & Affiliations
Recent Publications
Population Pharmacokinetic Modeling of Oxcarbazepine and Its Active Metabolite 10-Monohydroxy Derivative to Inform Dosing in Children with Obesity.
Journal Article Clin Pharmacokinet · November 17, 2025 BACKGROUND: Oxcarbazepine (OXZ) is an antiepileptic drug whose pharmacological effect is primarily mediated by its active metabolite, 10-monohydroxy derivative (MHD). OXZ is approved for use in adults and children older than 2 years with an age- and body w ... Full text Link to item CiteMetronidazole exposure-response and safety in infants.
Journal Article Antimicrob Agents Chemother · November 5, 2025 The nitroimidazole antibiotic, metronidazole, is frequently prescribed to infants with serious intra-abdominal infections, and multiple dosing recommendations exist. We sought to evaluate the extent to which metronidazole doses and associated exposures ach ... Full text Link to item CitePopulation Pharmacokinetics of Alfentanil in Children.
Journal Article J Clin Pharmacol · October 2025 Alfentanil is an opioid analgesic and anesthetic agent used in surgical procedures. Despite its widespread use in children, the U.S. Food and Drug Administration label lacks specific dosing recommendations for those under 12 years. A population pharmacokin ... Full text Link to item CiteRecent Grants
North Carolina Clinical Center for the Eunice Kennedy Shiver NICHD Cooperative Multicenter Neonatal Research Network
ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2001 - 2030Pharmacokinetics and Safety of Anesthetics and Analgesics in Children and Adolescents (ANA01)
ResearchPrincipal Investigator · Awarded by DCRI-Duke-Site · 2025 - 2028BPCA Innovative Trial Designs and Assay Developments in Pediatric Therapeutics
ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2027View All Grants