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Ching-yi Chang

Associate Research Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology

Advising & Mentoring Summary


Past graduate students:

 

Andrea Sherk (2001-2007)

 

Thesis project: Elucidation of the molecular mechanisms underlying androgen-mediated regulation of prostate cancer growth and progression

 

Tianyu Li (2001-2007)

 

Thesis Project: Molecular mechanisms underlying the estrogen regulated lipid homeostasis in the liver

 

Niharika Bansal Mettu (1001-2007)

 

Thesis Project: Targeting the coactivator interaction surface as a mechanism of regulating nuclear receptor transcriptional activity

 

Rebecca Stein (2004-2008)

 

Thesis Project: Defining the functional significance of estrogen-related receptor alpha in breast cancer

 

Hilary Wade (2005-2009)

 

Thesis Project: Multimodal regulation of gene transcription by progestins

 

Junfei Liu (2009-2013)

 

Thesis Project: Molecular dissection and functional definition of estrogen-related receptor alpha

 

Abby Brunner (2009-2015)

 

Thesis Project: Targeting Histone Deacetylase in Advanced Prostate Cancer

 

Kim Cocce (2014-2017)

 

Thesis Project: Molecular mechanisms governing the untoward tumor growth promoting effects of Selective Estrogen Receptor Modulators

 

Kaitlyn Andreano (2015-2020):

 

Thesis Project: Definition of the mechanisms involved in the anti-inflammatory actions of steroid hormones

 

Taylor Krebs (2016-2021)

 

Thesis project: Identification of endocrine therapy induced targetable vulnerabilities in cancer

 

Felicia Lim (2017-2023)

 

Thesis project: The roles of estrogens in immune functions and breast cancer pathogenesis 

 

Patrick Juras (2016-2023)

 

Thesis project: The role of CaMKK2 in natural killer cell anti-tumor immunity

 

Jovita Byemerwa (2018-2023)

 

Thesis project: Elucidation of the Role(s) of Estrogens in Regulating Natural Killer Cell Biology in Breast Cancer Metastasis

 

 

 

Past postdoctoral fellows:

 

Dmitri Kazmin (2002-2007): (1) Linking ligand-induced alterations in androgen receptor structure to gene expression and (2) Define the clinical significance of estrogen-related receptor alpha using gene expression signature.

 

Sakiko Kobayashi (2006-2010): Define the mechanisms involved in the anti-inflammatory actions of progestins in breast cancer

 

Mary Dwyer (2005-2011): Define WNT11 as a direct target of ERRα and beta-catenin pathway and its involvement in breast cancer migration

 

Scott Lawrence (2011-2015): Identification of the structural determinants of ERRα degrader

 

James Stice (2009-2016): RIP140 as a mediator of the anti-inflammatory actions of progestins in breast cancer

 

Mahmoud Alfaqih (2010-2013): Regulation of cholesterol homeostasis by CYP27A1 and its metabolite, 27-hydroxycholesterol, in Prostate Cancer

 

Sunghee Park (2011-2017): ERRα-regulated mitochondria metabolism in breast cancer pathogenesis

 

Wen Liu (2014-2020): CYP27A1 and 27-hydroxycholesterol in immune modulation and breast cancer progression

 

Debarati Mukherjee (2016-2022): The cancer cell intrinsic and extrinsic actions of CaMKK2

 

Binita Chakraborty (2015-2021): The effects of estrogen and estrogen-receptor modulators in immune function and breast cancer progression

 

Corine Haines (2019-2022): Regulation of cancer associated fibroblasts by estrogens

 

Sandeep Artham (2018-2024): The impact of estrogen signaling in tumor-associated tissue eosinophilia and breast cancer pathogenesis

 

 

 

Current graduate students:

 

Min-Yu Ko (2021-present): Elucidating the mechanisms by which androgens induce mTOR activation

 

Caleb McIver (2023-present): The impact of estrogens on dendritic cells function and hematopoiesis

 

Christopher Shields (2023-present): The CaMKK2/PDE1 signaling axis in breast cancer metastasis

 

Jill Caiazzi (2024-present): Estrogen signaling in the brain and its impact on peripheral tumor growth 

Sarah Giorgi (2025-present): Estrogen signaling in NK cells and its impact on breast cancer metastasis

Chloe Gulbronson (2025-present): Mechanisms of endocrine therapy resistance

Elizabeth Florida (2025-present): Nutrient transporter as therapeutic targets in prostate cancer