Current Appointments & Affiliations
Professor Emeritus in Surgery
·
2024 - Present
Surgery, Surgical Sciences,
Surgery
Recent Publications
Hexakisphosphate (IP6) potentiates HIV-1 maturation inhibitor binding at the CA-SP1 junction: insights from molecular modeling and biophysical assays.
Journal Article Int J Biol Macromol · November 2025 Bevirimat (BVM) and related compounds act as HIV maturation inhibitors (MIs), impeding protease-mediated cleavage of the Gag polyprotein by binding to and stabilizing the capsid (CA) and spacer peptide 1 (SP1) domains (CA-SP1). The CA-SP1 six-helix bundle ... Full text Link to item CiteDevelopment of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles.
Journal Article Sci Adv · May 30, 2025 HIV-1 infection is a manageable chronic condition, with non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) remaining a cornerstone of antiretroviral therapy. Nevertheless, drug resistance to existing therapeutics is a serious and immediate conc ... Full text Link to item CiteAnti-HIV diterpenoids from Daphne pseudomezereum.
Journal Article Phytochemistry · April 2025 The plants of the genus Daphne (Thymelaeaceae) are known to be sources of anti-HIV diterpenoids. Therefore, the present study focused on investigating the anti-HIV diterpenoids in Daphne pseudomezereum, for which the isolation of diterpenoids has not been ... Full text Link to item CiteRecent Grants
New Non-Nuceleotide Reverse Transcriptase Inhibitors for Drug Resistant HIV Strains
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2024Small Molecule HIV-1 Entry Inhibitor with Novel Mechanisms of Action
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2021Aloperine derivatives as novel anti-influenza agents
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2020 - 2021View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
1991
Ph.D.