Current Appointments & Affiliations
Professor Emeritus in Surgery
·
2024 - Present
Surgery, Surgical Sciences,
Surgery
Member of the Duke Cancer Institute
·
2003 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Anti-HIV diterpenoids from Daphne pseudomezereum.
Journal Article Phytochemistry · April 2025 The plants of the genus Daphne (Thymelaeaceae) are known to be sources of anti-HIV diterpenoids. Therefore, the present study focused on investigating the anti-HIV diterpenoids in Daphne pseudomezereum, for which the isolation of diterpenoids has not been ... Full text Link to item CiteIdentification of anti-HIV cycloartane triterpenoids from Actaea vaginata using UPLC‐QTOF‐MS/MS, DFT calculations, docking, and molecular dynamics studies
Journal Article Journal of Molecular Structure · February 15, 2025 Structurally diverse triterpenoids have shown potential as pharmaceutical precursors for HIV treatment. Our previous research led to the discovery of a potent antiviral cycloartane triterpenoid derivative, (20S,24S)-15β,16β-diacetoxy-18,24;20,24-diepoxy-9, ... Full text CiteRecent progress on triterpenoid derivatives and their anticancer potential.
Journal Article Phytochemistry · January 2025 Cancer poses a significant global public health challenge, with commonly used adjuvant or neoadjuvant chemotherapy often leading to adverse side effects and drug resistance. Therefore, advancing cancer treatment necessitates the ongoing development of nove ... Full text Link to item CiteRecent Grants
New Non-Nuceleotide Reverse Transcriptase Inhibitors for Drug Resistant HIV Strains
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2024Small Molecule HIV-1 Entry Inhibitor with Novel Mechanisms of Action
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2021Aloperine derivatives as novel anti-influenza agents
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2020 - 2021View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
1991
Ph.D.