Christopher Freel | Scholars@Duke

Christopher Freel
Assoc Vice Provost, Research

Current Appointments & Affiliations

Assoc Vice Provost, Research, Institutes and Provost's Academic Units, Duke University

Contact Information

121 Allen Building, Box 90037, 421 Chapel Drive, Durham, NC 27708
christopher.freel@duke.edu +1 919 668 4378

Research
Selected Grants
- Inhibition of Cytochrome c-induced Caspase Activation awarded by National Institutes of Health 2003 - 2016
- Engineering tyrosine kinase-activated caspases for selective cancer cell killing awarded by National Institutes of Health 2010 - 2014
- Apoptotic Signaling Pathways awarded by National Institutes of Health 2000 - 2009
- Reaper Mediated Apoptosis awarded by National Institutes of Health 2004 - 2007
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Costello, MJ, Gilliland, KP, Freel, CD, Fowler, WC, and Johnsen, S. "Mie light scattering analysis of human age-related nuclear cataracts." April 2004. Link to Item
  - Gilliland, KO, Freel, CD, Lane, CW, Fowler, WC, and Costello, MJ. "Random distribution of multilannellar bodies in human age-related nuclear cataracts." May 2002. Link to Item
- Journal Articles
  - Yang, C-S, Sinenko, SA, Thomenius, MJ, Robeson, AC, Freel, CD, Horn, SR, and Kornbluth, S. "The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis." Cell Death Differ 21, no. 4 (April 2014): 604-611. Full Text Link to Item
  - Parrish, AB, Freel, CD, and Kornbluth, S. "Cellular mechanisms controlling caspase activation and function. (Published online)" Cold Spring Harb Perspect Biol 5, no. 6 (June 1, 2013). (Review) Full Text Link to Item
  - Kim, J, Parrish, AB, Kurokawa, M, Matsuura, K, Freel, CD, Andersen, JL, Johnson, CE, and Kornbluth, S. "Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis." EMBO J 31, no. 5 (March 7, 2012): 1279-1292. Full Text Link to Item
  - Thomenius, M, Freel, CD, Horn, S, Krieser, R, Abdelwahid, E, Cannon, R, Balasundaram, S, White, K, and Kornbluth, S. "Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death." Cell Death Differ 18, no. 10 (October 2011): 1640-1650. Full Text Open Access Copy Link to Item
  - Andersen, JL, Thompson, JW, Lindblom, KR, Johnson, ES, Yang, C-S, Lilley, LR, Freel, CD, Moseley, MA, and Kornbluth, S. "A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2." Molecular cell 43, no. 5 (September 2011): 834-842. Full Text
  - Horn, SR, Thomenius, MJ, Johnson, ES, Freel, CD, Wu, JQ, Coloff, JL, Yang, C-S, Tang, W, An, J, Ilkayeva, OR, Rathmell, JC, Newgard, CB, and Kornbluth, S. "Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability." Mol Biol Cell 22, no. 8 (April 15, 2011): 1207-1216. Full Text Link to Item
  - Yang, C-S, Thomenius, MJ, Gan, EC, Tang, W, Freel, CD, Merritt, TJS, Nutt, LK, and Kornbluth, S. "Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc." EMBO J 29, no. 18 (September 15, 2010): 3196-3207. Full Text Link to Item
  - Tang, W, Wu, JQ, Chen, C, Yang, C-S, Guo, JY, Freel, CD, and Kornbluth, S. "Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism." Mol Biol Cell 21, no. 15 (August 1, 2010): 2589-2597. Full Text Open Access Copy Link to Item
  - Johnson, CE, Freel, CD, and Kornbluth, S. "Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring." Cell Death Differ 17, no. 1 (January 2010): 170-179. Full Text Open Access Copy Link to Item
  - Nutt, LK, Buchakjian, MR, Gan, E, Darbandi, R, Yoon, S-Y, Wu, JQ, Miyamoto, YJ, Gibbons, JA, Andersen, JL, Freel, CD, Tang, W, He, C, Kurokawa, M, Wang, Y, Margolis, SS, Fissore, RA, and Kornbluth, S. "Metabolic Control of Oocyte Apoptosis Mediated by 14-3-3ζ-Regulated Dephosphorylation of Caspase-2 (DOI:10.1016/j.devcel.2009.04.005)." Developmental Cell 18, no. 1 (2010): 165--. Full Text
  - Andersen, JL, Johnson, CE, Freel, CD, Parrish, AB, Day, JL, Buchakjian, MR, Nutt, LK, Thompson, JW, Moseley, MA, and Kornbluth, S. "Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2." The EMBO journal 28, no. 20 (October 2009): 3216-3227. Full Text
  - Nutt, LK, Buchakjian, MR, Gan, E, Darbandi, R, Yoon, S-Y, Wu, JQ, Miyamoto, YJ, Gibbons, JA, Andersen, JL, Freel, CD, Tang, W, He, C, Kurokawa, M, Wang, Y, Margolis, SS, Fissore, RA, and Kornbluth, S. "Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2." Dev Cell 16, no. 6 (June 2009): 856-866. Full Text Link to Item
  - Wu, JQ, Guo, JY, Tang, W, Yang, C-S, Freel, CD, Chen, C, Nairn, AC, and Kornbluth, S. "PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation." Nat Cell Biol 11, no. 5 (May 2009): 644-651. Full Text Link to Item
  - Tang, W, Wu, JQ, Guo, Y, Hansen, DV, Perry, JA, Freel, CD, Nutt, L, Jackson, PK, and Kornbluth, S. "Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition." Mol Biol Cell 19, no. 8 (August 2008): 3536-3543. Full Text Link to Item
  - Guo, JY, Yamada, A, Kajino, T, Wu, JQ, Tang, W, Freel, CD, Feng, J, Chau, BN, Wang, MZ, Margolis, SS, Yoo, HY, Wang, X-F, Dunphy, WG, Irusta, PM, Hardwick, JM, and Kornbluth, S. "Aven-dependent activation of ATM following DNA damage." Curr Biol 18, no. 13 (July 8, 2008): 933-942. Full Text Link to Item
  - Freel, CD, Richardson, DA, Thomenius, MJ, Gan, EC, Horn, SR, Olson, MR, and Kornbluth, S. "Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions." J Biol Chem 283, no. 1 (January 4, 2008): 367-379. Full Text Link to Item
  - Wu, JQ, Hansen, DV, Guo, Y, Wang, MZ, Tang, W, Freel, CD, Tung, JJ, Jackson, PK, and Kornbluth, S. "Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A." Proc Natl Acad Sci U S A 104, no. 42 (October 16, 2007): 16564-16569. Full Text Open Access Copy Link to Item
  - Keaton, MA, Bardes, ESG, Marquitz, AR, Freel, CD, Zyla, TR, Rudolph, J, and Lew, DJ. "Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation." Curr Biol 17, no. 14 (July 17, 2007): 1181-1189. Full Text Link to Item
  - Wu, Q, Guo, Y, Yamada, A, Perry, JA, Wang, MZ, Araki, M, Freel, CD, Tung, JJ, Tang, W, Margolis, SS, Jackson, PK, Yamano, H, Asano, M, and Kornbluth, S. "A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest." Curr Biol 17, no. 3 (February 6, 2007): 213-224. Full Text Link to Item
  - Costello, MJ, Johnsen, S, Gilliland, KO, Freel, CD, and Fowler, WC. "Predicted light scattering from particles observed in human age-related nuclear cataracts using mie scattering theory." Investigative Ophthalmology and Visual Science 48, no. 1 (2007): 303-312. Full Text
  - Margolis, SS, Perry, JA, Forester, CM, Nutt, LK, Guo, Y, Jardim, MJ, Thomenius, MJ, Freel, CD, Darbandi, R, Ahn, J-H, Arroyo, JD, Wang, X-F, Shenolikar, S, Nairn, AC, Dunphy, WG, Hahn, WC, Virshup, DM, and Kornbluth, S. "Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis." Cell 127, no. 4 (November 17, 2006): 759-773. Full Text Link to Item
  - Margolis, SS, Perry, JA, Weitzel, DH, Freel, CD, Yoshida, M, Haystead, TA, and Kornbluth, S. "A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25." Mol Biol Cell 17, no. 4 (April 2006): 1779-1789. Full Text Link to Item
  - Peterson, LJ, Rajfur, Z, Maddox, AS, Freel, CD, Chen, Y, Edlund, M, Otey, C, and Burridge, K. "Simultaneous stretching and contraction of stress fibers in vivo." MOLECULAR BIOLOGY OF THE CELL 15, no. 7 (July 2004): 3497-3508. Full Text Link to Item
  - Peterson, LJ, Rajfur, Z, Maddox, AS, Freel, CD, Chen, Y, Edlund, M, Otey, C, and Burridge, K. "Simultaneous stretching and contraction of stress fibers in vivo." Mol Biol Cell 15, no. 7 (July 2004): 3497-3508. Full Text Link to Item
  - Gilliland, KO, Freel, CD, Johnsen, S, Fowler, WC, and Costello, MJ. "Distribution, spherical structure and predicted Mie scattering of multilamellar bodies in human age-related nuclear cataracts." Experimental Eye Research 79, no. 4 (2004): 563-576. Full Text
  - Marsili, S, Salganik, RI, Albright, CD, Freel, CD, Johnsen, S, Peiffer, RL, and Costello, MJ. "Cataract formation in a strain of rats selected for high oxidative stress." Experimental Eye Research 79, no. 5 (2004): 595-612. Full Text
  - Freel, CD, Gilliland, KO, Mekeel, HE, Giblin, FJ, and Costello, MJ. "Ultrastructural characterization and Fourier analysis of fiber cell cytoplasm in the hyperbaric oxygen treated guinea pig lens opacification model." EXPERIMENTAL EYE RESEARCH 76, no. 4 (April 2003): 405-415. Full Text Link to Item
  - Freel, CD, Gilliland, KO, Lane, CW, Giblin, FJ, and Costello, MJ. "Fourier analysis of cytoplasmic texture in nuclear fiber cells from transparent and cataractous human and animal lenses." EXPERIMENTAL EYE RESEARCH 74, no. 6 (June 2002): 689-702. Full Text Link to Item
  - Freel, CD, Gilliland, KO, and Costello, MJ. "Online two-dimensional Fourier and autocorrelation analysis of TEM micrographs: An examination of cytoplasmic texture, subunit composition, and junctional complex spacings in the nuclear fiber cells of the ocular lens." MOLECULAR BIOLOGY OF THE CELL 12 (November 2001): 261A-261A. Link to Item
  - Gilliland, KO, Freel, CD, Lane, CW, Fowler, WC, and Costello, MJ. "Multilamellar bodies as potential scattering particles in human age-related nuclear cataracts." MOLECULAR VISION 7, no. 18 (June 22, 2001): 120-130. Link to Item

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Selected Grants

Selected Publications

Conference Papers

Journal Articles