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Chris Freel

Assoc VP, Research
Duke University
Office for Research & Innovation, Box 90037, Durham, NC 27708
121 Allen Building, Box 90037, 421 Chapel Drive, Durham, NC 27708

Current Appointments & Affiliations


Assoc VP, Research Duke University

Recent Publications


The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis.

Journal Article Cell Death Differ · April 2014 Deubiquitinating enzymes (DUBs) counteract ubiquitin ligases to modulate the ubiquitination and stability of target signaling molecules. In Drosophila, the ubiquitin-proteasome system has a key role in the regulation of apoptosis, most notably, by controll ... Full text Link to item Cite

Cellular mechanisms controlling caspase activation and function.

Journal Article Cold Spring Harbor perspectives in biology · June 2013 Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors, caspases are activated in response to a variety of cell death stim ... Full text Cite

Cellular mechanisms controlling caspase activation and function

Journal Article Cold Spring Harbor Perspectives in Medicine · June 1, 2013 Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors, caspases are activated in response to a variety of cell death stim ... Cite
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Recent Grants


Inhibition of Cytochrome c-induced Caspase Activation

ResearchResearch Scientist · Awarded by National Institutes of Health · 2003 - 2016

Engineering tyrosine kinase-activated caspases for selective cancer cell killing

ResearchScientist · Awarded by National Institutes of Health · 2010 - 2014

Apoptotic Signaling Pathways

ResearchResearch Associate · Awarded by National Institutes of Health · 2000 - 2009

View All Grants

External Links


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