Christopher Freel | Scholars@Duke

Christopher Freel
Assoc Vice Provost, Research

Current Appointments & Affiliations

Assoc Vice Provost, Research, Institutes and Provost's Academic Units, Duke University

Contact Information

121 Allen Building, Box 90037, 421 Chapel Drive, Durham, NC 27708
christopher.freel@duke.edu +1 919 668 4378

Research
Selected Grants
- Inhibition of Cytochrome c-induced Caspase Activation awarded by National Institutes of Health 2003 - 2016
- Engineering tyrosine kinase-activated caspases for selective cancer cell killing awarded by National Institutes of Health 2010 - 2014
- Apoptotic Signaling Pathways awarded by National Institutes of Health 2000 - 2009
- Reaper Mediated Apoptosis awarded by National Institutes of Health 2004 - 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Yang, C-S, Sinenko, SA, Thomenius, MJ, Robeson, AC, Freel, CD, Horn, SR, and Kornbluth, S. "The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis." Cell Death and Differentiation 21, no. 4 (April 2014): 604-611. Full Text
  - Parrish, AB, Freel, CD, and Kornbluth, S. "Cellular mechanisms controlling caspase activation and function." Cold Spring Harbor Perspectives in Biology 5, no. 6 (June 2013). (Review) Full Text
  - Kim, J, Parrish, AB, Kurokawa, M, Matsuura, K, Freel, CD, Andersen, JL, Johnson, CE, and Kornbluth, S. "Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis." The Embo Journal 31, no. 5 (March 2012): 1279-1292. Full Text
  - Thomenius, M, Freel, CD, Horn, S, Krieser, R, Abdelwahid, E, Cannon, R, Balasundaram, S, White, K, and Kornbluth, S. "Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death." Cell Death and Differentiation 18, no. 10 (October 2011): 1640-1650. Full Text Open Access Copy
  - Andersen, JL, Thompson, JW, Lindblom, KR, Johnson, ES, Yang, C-S, Lilley, LR, Freel, CD, Moseley, MA, and Kornbluth, S. "A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2." Molecular cell 43, no. 5 (September 2011): 834-842. Full Text
  - Horn, SR, Thomenius, MJ, Johnson, ES, Freel, CD, Wu, JQ, Coloff, JL, Yang, C-S, Tang, W, An, J, Ilkayeva, OR, Rathmell, JC, Newgard, CB, and Kornbluth, S. "Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability." Molecular Biology of the Cell 22, no. 8 (April 2011): 1207-1216. Full Text
  - Yang, C-S, Thomenius, MJ, Gan, EC, Tang, W, Freel, CD, Merritt, TJS, Nutt, LK, and Kornbluth, S. "Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc." The Embo Journal 29, no. 18 (September 2010): 3196-3207. Full Text
  - Tang, W, Wu, JQ, Chen, C, Yang, C-S, Guo, JY, Freel, CD, and Kornbluth, S. "Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism." Molecular Biology of the Cell 21, no. 15 (August 2010): 2589-2597. Full Text Open Access Copy
  - Johnson, CE, Freel, CD, and Kornbluth, S. "Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring." Cell Death and Differentiation 17, no. 1 (January 2010): 170-179. Full Text Open Access Copy
  - Nutt, LK, Buchakjian, MR, Gan, E, Darbandi, R, Yoon, S-Y, Wu, JQ, Miyamoto, YJ, Gibbons, JA, Andersen, JL, Freel, CD, Tang, W, He, C, Kurokawa, M, Wang, Y, Margolis, SS, Fissore, RA, and Kornbluth, S. "Metabolic Control of Oocyte Apoptosis Mediated by 14-3-3ζ-Regulated Dephosphorylation of Caspase-2." Developmental Cell 18, no. 1 (January 2010): 165-165. Full Text
  - Andersen, JL, Johnson, CE, Freel, CD, Parrish, AB, Day, JL, Buchakjian, MR, Nutt, LK, Thompson, JW, Moseley, MA, and Kornbluth, S. "Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2." The Embo Journal 28, no. 20 (October 2009): 3216-3227. Full Text
  - Nutt, LK, Buchakjian, MR, Gan, E, Darbandi, R, Yoon, S-Y, Wu, JQ, Miyamoto, YJ, Gibbons, JA, Andersen, JL, Freel, CD, Tang, W, He, C, Kurokawa, M, Wang, Y, Margolis, SS, Fissore, RA, and Kornbluth, S. "Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2." Developmental Cell 16, no. 6 (June 2009): 856-866. Full Text
  - Wu, JQ, Guo, JY, Tang, W, Yang, C-S, Freel, CD, Chen, C, Nairn, AC, and Kornbluth, S. "PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation." Nature Cell Biology 11, no. 5 (May 2009): 644-651. Full Text
  - Tang, W, Wu, JQ, Guo, Y, Hansen, DV, Perry, JA, Freel, CD, Nutt, L, Jackson, PK, and Kornbluth, S. "Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition." Molecular Biology of the Cell 19, no. 8 (August 2008): 3536-3543. Full Text
  - Guo, JY, Yamada, A, Kajino, T, Wu, JQ, Tang, W, Freel, CD, Feng, J, Chau, BN, Wang, MZ, Margolis, SS, Yoo, HY, Wang, X-F, Dunphy, WG, Irusta, PM, Hardwick, JM, and Kornbluth, S. "Aven-dependent activation of ATM following DNA damage." Current Biology : Cb 18, no. 13 (July 2008): 933-942. Full Text
  - Freel, CD, Richardson, DA, Thomenius, MJ, Gan, EC, Horn, SR, Olson, MR, and Kornbluth, S. "Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions." The Journal of Biological Chemistry 283, no. 1 (January 2008): 367-379. Full Text
  - Wu, JQ, Hansen, DV, Guo, Y, Wang, MZ, Tang, W, Freel, CD, Tung, JJ, Jackson, PK, and Kornbluth, S. "Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A." Proceedings of the National Academy of Sciences of the United States of America 104, no. 42 (October 2007): 16564-16569. Full Text Open Access Copy
  - Keaton, MA, Bardes, ESG, Marquitz, AR, Freel, CD, Zyla, TR, Rudolph, J, and Lew, DJ. "Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation." Current Biology : Cb 17, no. 14 (July 5, 2007): 1181-1189. Full Text
  - Wu, Q, Guo, Y, Yamada, A, Perry, JA, Wang, MZ, Araki, M, Freel, CD, Tung, JJ, Tang, W, Margolis, SS, Jackson, PK, Yamano, H, Asano, M, and Kornbluth, S. "A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest." Current Biology : Cb 17, no. 3 (February 2007): 213-224. Full Text
  - Costello, MJ, Johnsen, S, Gilliland, KO, Freel, CD, and Fowler, WC. "Predicted light scattering from particles observed in human age-related nuclear cataracts using mie scattering theory." Investigative Ophthalmology & Visual Science 48, no. 1 (January 2007): 303-312. Full Text
  - Margolis, SS, Perry, JA, Forester, CM, Nutt, LK, Guo, Y, Jardim, MJ, Thomenius, MJ, Freel, CD, Darbandi, R, Ahn, J-H, Arroyo, JD, Wang, X-F, Shenolikar, S, Nairn, AC, Dunphy, WG, Hahn, WC, Virshup, DM, and Kornbluth, S. "Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis." Cell 127, no. 4 (November 2006): 759-773. Full Text
  - Margolis, SS, Perry, JA, Weitzel, DH, Freel, CD, Yoshida, M, Haystead, TA, and Kornbluth, S. "A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25." Molecular Biology of the Cell 17, no. 4 (April 2006): 1779-1789. Full Text
  - Peterson, LJ, Rajfur, Z, Maddox, AS, Freel, CD, Chen, Y, Edlund, M, Otey, C, and Burridge, K. "Simultaneous stretching and contraction of stress fibers in vivo." Molecular Biology of the Cell 15, no. 7 (July 2004): 3497-3508. Full Text
  - Peterson, LJ, Rajfur, Z, Maddox, AS, Freel, CD, Chen, Y, Edlund, M, Otey, C, and Burridge, K. "Simultaneous stretching and contraction of stress fibers in vivo." Mol Biol Cell 15, no. 7 (July 2004): 3497-3508. Full Text Link to Item
  - Gilliland, KO, Freel, CD, Johnsen, S, Fowler, WC, and Costello, MJ. "Distribution, spherical structure and predicted Mie scattering of multilamellar bodies in human age-related nuclear cataracts." Experimental Eye Research 79, no. 4 (2004): 563-576. Full Text
  - Marsili, S, Salganik, RI, Albright, CD, Freel, CD, Johnsen, S, Peiffer, RL, and Costello, MJ. "Cataract formation in a strain of rats selected for high oxidative stress." Experimental Eye Research 79, no. 5 (2004): 595-612. Full Text
  - Freel, CD, Gilliland, KO, Mekeel, HE, Giblin, FJ, and Costello, MJ. "Ultrastructural characterization and Fourier analysis of fiber cell cytoplasm in the hyperbaric oxygen treated guinea pig lens opacification model." Experimental Eye Research 76, no. 4 (April 2003): 405-415. Full Text
  - Freel, CD, Gilliland, KO, Lane, CW, Giblin, FJ, and Costello, MJ. "Fourier analysis of cytoplasmic texture in nuclear fiber cells from transparent and cataractous human and animal lenses." EXPERIMENTAL EYE RESEARCH 74, no. 6 (June 2002): 689-702. Full Text Link to Item
  - Freel, CD, Gilliland, KO, and Costello, MJ. "Online two-dimensional Fourier and autocorrelation analysis of TEM micrographs: An examination of cytoplasmic texture, subunit composition, and junctional complex spacings in the nuclear fiber cells of the ocular lens." MOLECULAR BIOLOGY OF THE CELL 12 (November 2001): 261A-261A. Link to Item
  - Gilliland, KO, Freel, CD, Lane, CW, Fowler, WC, and Costello, MJ. "Multilamellar bodies as potential scattering particles in human age-related nuclear cataracts." MOLECULAR VISION 7, no. 18 (June 22, 2001): 120-130. Link to Item
- Conference Papers
  - Costello, MJ, Gilliland, KP, Freel, CD, Fowler, WC, and Johnsen, S. "Mie light scattering analysis of human age-related nuclear cataracts." April 2004. Link to Item
  - Gilliland, KO, Freel, CD, Lane, CW, Fowler, WC, and Costello, MJ. "Random distribution of multilannellar bodies in human age-related nuclear cataracts." May 2002. Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Selected Grants

Selected Publications

Academic Articles

Conference Papers