Recent Publications
The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis.
Journal Article Cell Death Differ · April 2014 Deubiquitinating enzymes (DUBs) counteract ubiquitin ligases to modulate the ubiquitination and stability of target signaling molecules. In Drosophila, the ubiquitin-proteasome system has a key role in the regulation of apoptosis, most notably, by controll ... Full text Link to item CiteCellular mechanisms controlling caspase activation and function.
Journal Article Cold Spring Harbor perspectives in biology · June 2013 Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors, caspases are activated in response to a variety of cell death stim ... Full text CiteCellular mechanisms controlling caspase activation and function
Journal Article Cold Spring Harbor Perspectives in Medicine · June 1, 2013 Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors, caspases are activated in response to a variety of cell death stim ... CiteRecent Grants
Inhibition of Cytochrome c-induced Caspase Activation
ResearchResearch Scientist · Awarded by National Institutes of Health · 2003 - 2016Engineering tyrosine kinase-activated caspases for selective cancer cell killing
ResearchScientist · Awarded by National Institutes of Health · 2010 - 2014Apoptotic Signaling Pathways
ResearchResearch Associate · Awarded by National Institutes of Health · 2000 - 2009View All Grants