Christopher Freel
Assoc VP, Research
Current Appointments & Affiliations
- Assoc VP, Research, Institutes and Provost's Academic Units, Duke University
Contact Information
- 121 Allen Building, Box 90037, 421 Chapel Drive, Durham, NC 27708
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christopher.freel@duke.edu
+1 919 668 4378
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LinkedIn Profile
- Research
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Selected Grants
- Inhibition of Cytochrome c-induced Caspase Activation awarded by National Institutes of Health 2003 - 2016
- Engineering tyrosine kinase-activated caspases for selective cancer cell killing awarded by National Institutes of Health 2010 - 2014
- Apoptotic Signaling Pathways awarded by National Institutes of Health 2000 - 2009
- Reaper Mediated Apoptosis awarded by National Institutes of Health 2004 - 2007
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Yang, C. -. S., S. A. Sinenko, M. J. Thomenius, A. C. Robeson, C. D. Freel, S. R. Horn, and S. Kornbluth. “The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis.” Cell Death Differ 21, no. 4 (April 2014): 604–11. https://doi.org/10.1038/cdd.2013.184.Full Text Link to Item
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Parrish, A. B., C. D. Freel, and S. Kornbluth. “Cellular mechanisms controlling caspase activation and function.” Cold Spring Harbor Perspectives in Medicine 3, no. 6 (June 1, 2013).
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Parrish, Amanda B., Christopher D. Freel, and Sally Kornbluth. “Cellular mechanisms controlling caspase activation and function.” Cold Spring Harbor Perspectives in Biology 5, no. 6 (June 2013). https://doi.org/10.1101/cshperspect.a008672.Full Text
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Kim, Jiyeon, Amanda B. Parrish, Manabu Kurokawa, Kenkyo Matsuura, Christopher D. Freel, Joshua L. Andersen, Carrie E. Johnson, and Sally Kornbluth. “Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis.” The Embo Journal 31, no. 5 (March 2012): 1279–92. https://doi.org/10.1038/emboj.2011.491.Full Text
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Thomenius, M., C. D. Freel, S. Horn, R. Krieser, E. Abdelwahid, R. Cannon, S. Balasundaram, K. White, and S. Kornbluth. “Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death.” Cell Death Differ 18, no. 10 (October 2011): 1640–50. https://doi.org/10.1038/cdd.2011.26.Full Text Open Access Copy Link to Item
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Andersen, Joshua L., J Will Thompson, Kelly R. Lindblom, Erika S. Johnson, Chih-Sheng Yang, Lauren R. Lilley, Christopher D. Freel, M Arthur Moseley, and Sally Kornbluth. “A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2.” Mol Cell 43, no. 5 (September 2, 2011): 834–42. https://doi.org/10.1016/j.molcel.2011.07.028.Full Text Link to Item
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Horn, Sarah R., Michael J. Thomenius, Erika Segear Johnson, Christopher D. Freel, Judy Q. Wu, Jonathan L. Coloff, Chih-Sheng Yang, et al. “Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.” Mol Biol Cell 22, no. 8 (April 15, 2011): 1207–16. https://doi.org/10.1091/mbc.E10-07-0567.Full Text Link to Item
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Yang, Chih-Sheng, Michael J. Thomenius, Eugene C. Gan, Wanli Tang, Christopher D. Freel, Thomas J. S. Merritt, Leta K. Nutt, and Sally Kornbluth. “Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc.” The Embo Journal 29, no. 18 (September 2010): 3196–3207. https://doi.org/10.1038/emboj.2010.191.Full Text
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Tang, Wanli, Judy Qiju Wu, Chen Chen, Chih-Sheng Yang, Jessie Yanxiang Guo, Christopher D. Freel, and Sally Kornbluth. “Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism.” Molecular Biology of the Cell 21, no. 15 (August 2010): 2589–97. https://doi.org/10.1091/mbc.e09-08-0708.Full Text Open Access Copy
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Nutt, L. K., M. R. Buchakjian, E. Gan, R. Darbandi, S. Y. Yoon, J. Q. Wu, Y. J. Miyamoto, et al. “Metabolic Control of Oocyte Apoptosis Mediated by 14-3-3ζ-Regulated Dephosphorylation of Caspase-2 (DOI:10.1016/j.devcel.2009.04.005).” Developmental Cell 18, no. 1 (January 19, 2010): 165. https://doi.org/10.1016/j.devcel.2010.01.005.Full Text
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Johnson, C. E., C. D. Freel, and S. Kornbluth. “Features of programmed cell death in intact Xenopus oocytes and early embryos revealed by near-infrared fluorescence and real-time monitoring.” Cell Death and Differentiation 17, no. 1 (January 2010): 170–79. https://doi.org/10.1038/cdd.2009.120.Full Text Open Access Copy
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Andersen, Joshua L., Carrie E. Johnson, Christopher D. Freel, Amanda B. Parrish, Jennifer L. Day, Marisa R. Buchakjian, Leta K. Nutt, J Will Thompson, M Arthur Moseley, and Sally Kornbluth. “Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.” Embo J 28, no. 20 (October 21, 2009): 3216–27. https://doi.org/10.1038/emboj.2009.253.Full Text Link to Item
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Nutt, Leta K., Marisa R. Buchakjian, Eugene Gan, Rashid Darbandi, Sook-Young Yoon, Judy Q. Wu, Yuko J. Miyamoto, et al. “Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.” Developmental Cell 16, no. 6 (June 2009): 856–66. https://doi.org/10.1016/j.devcel.2009.04.005.Full Text
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Wu, Judy Qiju, Jessie Yanxiang Guo, Wanli Tang, Chih-Sheng Yang, Christopher D. Freel, Chen Chen, Angus C. Nairn, and Sally Kornbluth. “PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.” Nature Cell Biology 11, no. 5 (May 2009): 644–51. https://doi.org/10.1038/ncb1871.Full Text
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Tang, Wanli, Judy Qiju Wu, Yanxiang Guo, David V. Hansen, Jennifer A. Perry, Christopher D. Freel, Leta Nutt, Peter K. Jackson, and Sally Kornbluth. “Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.” Molecular Biology of the Cell 19, no. 8 (August 2008): 3536–43. https://doi.org/10.1091/mbc.e08-04-0417.Full Text
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Guo, Jessie Yanxiang, Ayumi Yamada, Taisuke Kajino, Judy Qiju Wu, Wanli Tang, Christopher D. Freel, Junjie Feng, et al. “Aven-dependent activation of ATM following DNA damage.” Curr Biol 18, no. 13 (July 8, 2008): 933–42. https://doi.org/10.1016/j.cub.2008.05.045.Full Text Link to Item
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Freel, Christopher D., D Ashley Richardson, Michael J. Thomenius, Eugene C. Gan, Sarah R. Horn, Michael R. Olson, and Sally Kornbluth. “Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions.” J Biol Chem 283, no. 1 (January 4, 2008): 367–79. https://doi.org/10.1074/jbc.M708931200.Full Text Link to Item
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Wu, Judy Qiju, David V. Hansen, Yanxiang Guo, Michael Zhuo Wang, Wanli Tang, Christopher D. Freel, Jeffrey J. Tung, Peter K. Jackson, and Sally Kornbluth. “Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A.” Proceedings of the National Academy of Sciences of the United States of America 104, no. 42 (October 2007): 16564–69. https://doi.org/10.1073/pnas.0707537104.Full Text Open Access Copy
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Keaton, Mignon A., Elaine S. G. Bardes, Aron R. Marquitz, Christopher D. Freel, Trevin R. Zyla, Johannes Rudolph, and Daniel J. Lew. “Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation.” Curr Biol 17, no. 14 (July 17, 2007): 1181–89. https://doi.org/10.1016/j.cub.2007.05.075.Full Text Link to Item
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Wu, Qiju, Yanxiang Guo, Ayumi Yamada, Jennifer A. Perry, Michael Z. Wang, Marito Araki, Christopher D. Freel, et al. “A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest.” Current Biology : Cb 17, no. 3 (February 2007): 213–24. https://doi.org/10.1016/j.cub.2006.12.045.Full Text
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Costello, M Joseph, Sönke Johnsen, Kurt O. Gilliland, Christopher D. Freel, and W Craig Fowler. “Predicted light scattering from particles observed in human age-related nuclear cataracts using mie scattering theory.” Invest Ophthalmol Vis Sci 48, no. 1 (January 2007): 303–12. https://doi.org/10.1167/iovs.06-0480.Full Text Link to Item
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Margolis, Seth S., Jennifer A. Perry, Craig M. Forester, Leta K. Nutt, Yanxiang Guo, Melanie J. Jardim, Michael J. Thomenius, et al. “Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.” Cell 127, no. 4 (November 17, 2006): 759–73. https://doi.org/10.1016/j.cell.2006.10.035.Full Text Link to Item
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Margolis, Seth S., Jennifer A. Perry, Douglas H. Weitzel, Christopher D. Freel, Minoru Yoshida, Timothy A. Haystead, and Sally Kornbluth. “A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.” Mol Biol Cell 17, no. 4 (April 2006): 1779–89. https://doi.org/10.1091/mbc.e05-08-0751.Full Text Link to Item
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Marsili, Stefania, Rudolf I. Salganik, Craig D. Albright, Christopher D. Freel, Sonke Johnsen, Robert L. Peiffer, and M Joseph Costello. “Cataract formation in a strain of rats selected for high oxidative stress.” Exp Eye Res 79, no. 5 (November 2004): 595–612. https://doi.org/10.1016/j.exer.2004.06.008.Full Text Link to Item
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Gilliland, Kurt O., Christopher D. Freel, Sonke Johnsen, W. Craig Fowler, and M Joseph Costello. “Distribution, spherical structure and predicted Mie scattering of multilamellar bodies in human age-related nuclear cataracts.” Exp Eye Res 79, no. 4 (October 2004): 563–76. https://doi.org/10.1016/j.exer.2004.05.017.Full Text Link to Item
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Peterson, Lynda J., Zenon Rajfur, Amy S. Maddox, Christopher D. Freel, Yun Chen, Magnus Edlund, Carol Otey, and Keith Burridge. “Simultaneous stretching and contraction of stress fibers in vivo.” Molecular Biology of the Cell 15, no. 7 (July 2004): 3497–3508. https://doi.org/10.1091/mbc.e03-09-0696.Full Text
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Freel, Christopher D., Kurt O. Gilliland, Harold E. Mekeel, Frank J. Giblin, and M Joseph Costello. “Ultrastructural characterization and Fourier analysis of fiber cell cytoplasm in the hyperbaric oxygen treated guinea pig lens opacification model.” Exp Eye Res 76, no. 4 (April 2003): 405–15. https://doi.org/10.1016/s0014-4835(03)00004-6.Full Text Link to Item
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Freel, C. D., K. J. Al-Ghoul, J. R. Kuszak, and M. J. Costello. “Analysis of nuclear fiber cell compaction in transparent and cataractous diabetic human lenses by scanning electron microscopy.” Bmc Ophthalmology 3 (January 6, 2003): 1–9. https://doi.org/10.1186/1471-2415-3-1.Full Text
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Freel, Christopher D., Kurt O. Gilliland, C. Wesley Lane, Frank J. Giblin, and M Joseph Costello. “Fourier analysis of cytoplasmic texture in nuclear fiber cells from transparent and cataractous human and animal lenses.” Exp Eye Res 74, no. 6 (June 2002): 689–702. https://doi.org/10.1006/exer.2001.1166.Full Text Link to Item
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Freel, C. D., K. O. Gilliland, and M. J. Costello. “Online two-dimensional Fourier and autocorrelation analysis of TEM micrographs: An examination of cytoplasmic texture, subunit composition, and junctional complex spacings in the nuclear fiber cells of the ocular lens.” Molecular Biology of the Cell 12 (November 1, 2001): 261A-261A.Link to Item
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Gilliland, K. O., C. D. Freel, C. W. Lane, W. C. Fowler, and M. J. Costello. “Multilamellar bodies as potential scattering particles in human age-related nuclear cataracts.” Mol Vis 7 (June 22, 2001): 120–30.Link to Item
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Al-Ghoul, K. J., R. K. Nordgren, A. J. Kuszak, C. D. Freel, M. J. Costello, and J. R. Kuszak. “Structural evidence of human nuclear fiber compaction as a function of ageing and cataractogenesis.” Exp Eye Res 72, no. 3 (March 2001): 199–214. https://doi.org/10.1006/exer.2000.0937.Full Text Link to Item
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Conference Papers
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Costello, M. J., K. P. Gilliland, C. D. Freel, W. C. Fowler, and S. Johnsen. “Mie light scattering analysis of human age-related nuclear cataracts.” In Investigative Ophthalmology & Visual Science, 45:U170–U170. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
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Gilliland, K. O., C. D. Freel, C. W. Lane, W. C. Fowler, and M. J. Costello. “Random distribution of multilannellar bodies in human age-related nuclear cataracts.” In Investigative Ophthalmology & Visual Science, 43:U94–U94. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.Link to Item
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Costello, M. J., K. O. Gilliland, and C. D. Freel. “Morphological evidence for adhesive role of thin-symmetric junctions in undulating membranes of lens nuclear fiber cells.” In Microscopy and Microanalysis, 8:1004–5, 2002. https://doi.org/10.1017/s1431927602106842.Full Text
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