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Christopher Mosher

Assistant Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
DCRI - Durham Centre Building, 300 West Morgan St., Office 833, Durham, NC 27701

Overview


As a physician-investigator my research focus is to identify new therapies and strategies to improve outcomes in persons living with Chronic Obstructive Pulmonary Disease (COPD). In pursuit of this goal, I've focused my research in the following areas: 1) clinical trial investigation of novel COPD therapeutics, 2) investigating mechanisms responsible for the treatment response to pulmonary rehabilitation through an aging lens, and 3) risk of cardiovascular disease in COPD. 

Current Duke Appointments & Affiliations


Assistant Professor of Medicine · 2023 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine
Member in the Duke Clinical Research Institute · 2021 - Present Duke Clinical Research Institute, Institutes and Centers

Recent News Items


Published June 5, 2025
MEDPAGE TODAY
Pulmonary Rehabilitation for COPD Pushes Forward
Published May 15, 2025
MedCentral
Point-of-Care Testing Safely Reduces Antibiotic Use in COPD Exacerbations
Published June 27, 2024
The News & Observer
FDA approves new COPD drug developed by firm in Raleigh. First new treatment in a decade.

View All News Items

Recent Scholarly Works


Respiratory mortality per STAR, GOLD, and ERS/ATS COPD severity classification.

Journal article Annals of the American Thoracic Society · July 2026 Full text Cite

Pulmonary rehabilitation prolongs life…and may be dying.

Journal article Am J Respir Crit Care Med · June 1, 2026 Full text Link to item Cite

Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE.

Journal article J Am Heart Assoc · December 2, 2025 BACKGROUND: Guidelines recommend aspirin (75-100 mg daily) for the secondary prevention of atherosclerotic cardiovascular disease (ASCVD). However, it is unknown if people with a history of ASCVD and chronic obstructive pulmonary disease (COPD) or asthma, ... Full text Link to item Cite
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Recent Grants


Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations (INSPIRE-COPD-E).

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030

Blueprint-COPD: Coping skills support for patients with comorbid COPD and anxiety or depression

ResearchInvestigator · Awarded by American Lung Association · 2025 - 2028

RofLumilast or Azithromycin to preveNt COPD Exacerbations (RELIANCE) - REIMBURSEABLE

ResearchPrincipal Investigator · Awarded by University of Illinois at Chicago · 2017 - 2027

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Education


Duke University · 2021 M.H.S.
Indiana University, School of Medicine · 2014 M.D.