Book section · January 1, 2026
Intraoperative radiotherapy (IORT) is the delivery of radiation at the time of operation in patients at high risk for harboring residual disease following resection. The role of IORT has been explored across many tumor types, and its use in clinical practi ...
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Book section · January 1, 2026
Colon cancer is a common source of cancer-related morbidity and mortality with prognosis strongly determined by stage of disease. In patients with localized disease, resection is the primary therapy, although recurrences are common. Adjuvant chemotherapy h ...
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Book section · January 1, 2024
The liver is the most common site for blood-borne metastasis from colorectal cancers, and is the dominant metastatic disease site just prior to death (Stewart et al. 2018). Until the early 1980s, it was generally accepted that hepatic metastases from color ...
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Book section · May 25, 2021
The leadership position of a departmental chair can be a positive and rewarding opportunity. These rewards principally stem from the success of the faculty, trainees, staff, and everyone supporting the department. With healthcare reform and the constraints ...
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Book section · January 1, 2020
Early and late GI organ injury may occur following irradiation of thoracic, abdominal, and pelvic malignancies of GI and non-GI origin. As with all toxicities associated with radiation therapy, GI side effects are categorized broadly into 2 types: early or ...
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Book section · January 1, 2020
Intraoperative radiotherapy (IORT) is the delivery of radiation at the time of operation in patients at high risk for harboring residual disease following resection. The role of IORT been explored across many tumor types and its use in clinical practice is ...
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Book section · January 1, 2020
Colon cancer is a common source of cancer-related morbidity and mortality with prognosis strongly determined by stage of disease. In patients with localized disease, resection is the primary therapy, although recurrences are common. Adjuvant chemotherapy h ...
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Book section · April 11, 2018
Pancreatic cancer carries a poor prognosis regardless of stage, and incidence and death rates are increasing. Pancreatic cancer is divided into four general categories, resectable, borderline resectable, locally advanced/unresectable, and metastatic. Only ...
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Book section · January 1, 2017
The treatment of esophageal cancer with radiation therapy presents many challenges. The propensity of esophageal cancer to invade and spread within the submucosa with resultant lymph node involvement requires particular attention to areas of elective cover ...
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Book section · January 1, 2017
Although esophageal cancer represents only 6 % of all gastrointestinal malignancies diagnosed in the United States, it remains a highly lethal disease and the seventh most common cause of cancer death in males. Rates of squamous cell carcinoma have been de ...
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Book section · January 1, 2015
Radiation therapy with concurrent chemotherapy is the standard treatment for patients with nonmetastatic squamous cell carcinoma of the anal canal. In the studies that established this approach, high rates of locoregional control have been reported, but th ...
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Book section · June 20, 2014
This chapter talks about four case studies of radiotherapy for gastrointestinal malignancies. One of the case study, a 65-year-old female presents with painless jaundice and diarrhea for 1 month. Labs show an elevation in liver function tests and total bil ...
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Book section · January 1, 2014
There is significant debate regarding the optimal neoadjuvant radiotherapy regimen for resectable rectal cancer patients. In much of Northern Europe the use of short-course preoperative radiotherapy (RT) alone (25 Gy in 5 fractions), followed by total meso ...
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Book section · January 1, 2011
Retroperitoneal sarcomas are rare, accounting for approximately 10–15% of all soft-tissue sarcomas with an estimated 1,500 cases occurring annually in USA [1, 2]. The most common histologic subtypes include liposarcoma, leiomyosarcoma, and malignant fibroh ...
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Book section · January 1, 2011
Despite its infrequency, pancreatic cancer is the fourth leading cause of cancer death in USA with an estimated 42,140 new cases and 36,800 deaths projected in the USA for 2010 [1]. Although mortality rates have slightly improved in recent years, overall, ...
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Book section · January 1, 2011
Aggressive, curative intent treatment approaches in patients with local or regional relapse after resection of primary rectal or colon cancers are often not considered. A growing body of evidence supports an aggressive approach combining external beam irra ...
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Book section · January 1, 2011
Carcinoma of the rectum is a heterogeneous disease. At one end of the clinical spectrum, a small number of patients present with superficially invasive cancers who are well served by limited Âprocedures, such as local excision or endocavitary irradiation. ...
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Book section · January 1, 2011
Early clinical investigations of intraoperative electron irradiation (IOERT) as an alternative to conventional external-beam irradiation (EBRT) were based on a limited number of preclinical studies to provide important information regarding the radiobiolog ...
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Book section · January 1, 2011
Most of the major advances in clinical applications of radiation therapy in the treatment of cancer have been due to differences in dose distribution between tumor and dose-limiting normal tissue. For most tumor types, the likelihood of obtaining local tum ...
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Book section · January 1, 2011
Long-term experience has shown that the use of IORT as a component of treatment in conjunction with other modalities (EBRT, concurrent and maintenance chemotherapy, maximal surgical resection) is feasible and practical if close multidisciplinary cooperatio ...
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Book section · January 1, 2011
Intraoperative irradiation (IORT) refers to delivery of a single dose of irradiation to a surgically exposed tumor or tumor bed while the normal tissues are protected from the irradiation either by retracting the mobilized tissue or by shielding the anatom ...
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Book section · January 1, 2011
Since IORT using electron beams first became popular in the late 1970s and early 1980s, enthusiasm for the technique using conventional accelerators waned. The reasons for this are manyfold. The main factor was that IORT required considerable effort on the ...
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Book section · January 1, 2010
Intensity-modulated photon radiation therapy (IMRT) and proton therapy are advanced radiation technologies that permit improved conformation of radiation dose to target structures while limiting radiation dose to surrounding normal tissues. Application of ...
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Book section · January 1, 2008
The goal of this book is to provide practical guidance for anyone who is interested in initiating a teledermatology program or expanding their current system. This book was written for a wide audience to include anyone in a private practice, academic cente ...
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Book section · January 1, 2007
The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combinati ...
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