Scholars@Duke
Christopher G. Willett

Christopher G. Willett

Mark W. Dewhirst Distinguished Professor of Radiation Oncology
Radiation Oncology
christopher.willett@duke.edu
Box 3085 Med Ctr, Durham, NC
Morris Bldg, Durham, NC

Scholarly Works - Conferences

Pembrolizumab, radiotherapy, and chemotherapy in neoadjuvant treatment of malignant esophago-gastric diseases (PROCEED): Assessment of survival and patterns of recurrence in a prospective, phase II single-arm trial.

Conference Journal of Clinical Oncology · January 1, 2024 Background: Locally advanced esophagogastric adenocarcinoma (EGA) is commonly treated with neoadjuvant chemoradiation (CRT) prior to surgical resection. Adjuvant immunotherapy has been shown to improve outcomes for these patients. The primary objective of ... Full text Cite

Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy.

Conference Phys Med Biol · December 6, 2021 Objective:To design a deep transfer learning framework for modeling fluence map predictions for stereotactic body radiation therapy (SBRT) of adrenal cancer and similar sites that usually have a small number of cases.Approach:We developed a transfer learni ... Full text Link to item Cite

The Role of Hypofractionated Radiation Therapy in the Management of Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Management of HCC without surgical resection or transplantation is poorly defined with no standard. Stereotactic body radiation therapy (SBRT) or hypofractionated image-guided radiotherapy (HIGRT), is an evolving, non-invasive, ... Full text Cite

Toxicity and Dosimetric Parameters of Ablative Radiation Therapy in the Management of Patients with Child-Pugh B/C Liver Function and Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)To date there is no clear standard non-surgical therapeutic option for HCC patients. Ablative radiation therapy (SBRT/HIGRT) is an emerging non-invasive treatment for patients with HCC. However, there is concern about the risk ... Full text Cite

Treatment of locally advanced/metastatic colorectal cancer

Conference Jnccn Journal of the National Comprehensive Cancer Network · May 1, 2021 Few treatment advances have been observed in recent years for the treatment of advanced colorectal cancer (CRC). The goal remains to find approaches beyond FOLFOX and bevacizumab that will prolong remission. Immunotherapy for patients with microsatellite i ... Full text Cite

Trimodal therapy approaches for localized rectal cancer

Conference Jnccn Journal of the National Comprehensive Cancer Network · July 1, 2020 Excellent long-term outcomes and manageable toxicity are being achieved with contemporary treatment strategies for rectal cancer. Short-course radiotherapy is now an acceptable standard. Total neoadjuvant therapy (TNT), which incorporates induction or cons ... Full text Cite

SU‐E‐T‐419: Clinical Protocol for the Use of Scrotal Shields in IMRT Treatment of Anal Cancer

Conference Medical Physics · January 1, 2011 Purpose: To implement a clinical protocol for the use of scrotal shields for anal cancer IMRT treatment. Methods and Results: (1) Simulation The patient is immobilized in a full‐body alpha‐cradle mold in the frog‐leg position. Further, the mold is built up ... Full text Cite

SU‐FF‐T‐545: Feasibility Study for Treatment of Intracranial Multi‐Focal Stereotactic Radiosurgery with Multiple Intensity Modulated Arc Technique

Conference Medical Physics · January 1, 2009 Objectives: To investigate the feasibility of using an intensity modulated arc technique for multi‐focal intracranial stereotactic radiosurgery with a single isocenter setup to significantly decrease the treatment time. Methods: A Novalis Tx linear acceler ... Full text Cite

SU‐FF‐T‐548: Comparison of Cone‐Beam CT and Frame‐Based Localizations for Stereotactic Radiosurgery with Fixed Head Rings and Removable Frames

Conference Medical Physics · January 1, 2009 Objectives: To compare localization accuracy using both conventional frame‐based localizers and cone‐beam CT (CBCT) images for stereotactic radiosurgery (SRS). Methods: A SRS geometric phantom was used to verify the localization accuracy based on a SRS loc ... Full text Cite

SU‐FF‐T‐252: Improvement of Localization Accuracy by Using 3D Cone Beam CT for Stereotactic Body Radiation Therapy of Liver, Lung and Spine Lesions

Conference Medical Physics · January 1, 2007 Purpose: To compare treatment isocenter placement based on OBI 2D kV imaging and OBI 3D‐CBCT imaging for patients undergoing SBRT, and compare the CBCT based isocenter shifts among liver, lung and spine lesions. Material and Methods: 119 SBRT fractions wer ... Full text Cite

TH‐D‐M100F‐01: An Evaluation of Noise in Radiotracer Emission Imaging Using Flat‐Panel Detectors

Conference Medical Physics · January 1, 2007 Purpose: Single Photon Emission Computed Tomography (SPECT) onboard radiation therapy machines could enable the use of functional and molecular imaging in guiding the therapy beam and in monitoring disease. Costs and spatial constraints of onboard SPECT mi ... Full text Cite

TH‐E‐M100F‐07: Amplitude Gated Breath‐Hold Treatment for Upper Abdominal Lesions with On Board Imaging Guidance

Conference Medical Physics · January 1, 2007 Purpose: To apply on‐boardmdash;image (OBI) guided amplitude gating for breath‐hold treatment and to assess treatment margin adequacy by analyzing the isocenter placement based on orthogonal 2D kV radiographs and 3D cone‐beam CT (CBCT) acquired under ampli ... Full text Cite

SU‐FF‐T‐66: A Technique for Cone‐Beam CT‐Guided Stereotactic Body Radiation Therapy

Conference Medical Physics · January 1, 2006 Purpose: To develop and assess a technique using cone‐beam CT (CBCT) to localize treatment targets for stereotactic body radiation therapy (SBRT). Material and Methods: Patients selected for SBRT had 3‐D or 4‐D CT simulation with immobilization. GTV, CTV, ... Full text Cite

TU‐FF‐A3‐02: Preliminary Investigations Into Combined CT/SPECT Imaging Onboard Therapy Machines

Conference Medical Physics · January 1, 2006 Purpose: Functional and molecular (F&M) imaging onboard radiation therapy machines would allow for targeting of functional tumor volume, and avoiding of healthy tissue, by guiding and modifying radiation beams, in the treatment room, based on real‐time F&M ... Full text Cite

SU‐EE‐A1‐04: Verifying Internal Target Volume Using Cone‐Beam CT for Stereotactic Body Radiotherapy Treatment

Conference Medical Physics · January 1, 2006 Purpose: The internal target volume (ITV) could be determined using 4D CT simulation images and be verified in the treatment room using on‐board cone‐beam CT (CBCT) since the CBCT projection images are acquired over approximately 10 breathing cycles. This ... Full text Cite

SU‐FF‐J‐86: Intra‐ and Inter‐Breath‐Hold Position Variations for OBI Guided Amplitude Gating Treatment with Breath Hold

Conference Medical Physics · January 1, 2006 Purpose: We have applied OBI guidance together with a respiratory gating system to effectively control patient positioning for amplitude gating treatment with breath hold. The deep inspiration breath‐hold treatment has been proven effective in reducing the ... Full text Cite

SU‐FF‐J‐16: A Tool for Off‐Line Review of 3D Target Verification and Localization with Cone‐Beam Computed Tomography

Conference Medical Physics · January 1, 2006 Purpose: To implement a clinical tool for off‐line review of Cone‐Beam Computed Tomography (CBCT) based 3D target verification and localization. Methods and Materials: An in‐house 3D target localization and verification tool is being developed to allow phy ... Full text Cite

SU‐FF‐J‐96: Modeling Correlation Between External Surface Motion and Internal Organ Motion Based On 4DCT

Conference Medical Physics · January 1, 2006 Purpose: To develop a method for modeling the dynamic relationship between patient surface motion and internal target motion using 4DCT data. Then, to verify its capability to interpolate internal target motion with real‐time patient surface motion informa ... Full text Cite

SU‐FF‐J‐30: Quantification of Normal Organ Motion Due to the Respiratory and Cardiac Cycles

Conference Medical Physics · January 1, 2005 Purpose: To quantify the degree of normal organ motion due to the respiratory and cardiac cycles. Better definition of such motion may be useful in defining field margins and in assessing the utility of gating technologies. Method and Materials: Four healt ... Full text Cite

SU‐EE‐A4‐04: Compartment Modeling Analysis of Cu‐ATSM Dynamic PET Images

Conference Medical Physics · January 1, 2005 Purpose: Copper labeled diacetyl‐bis(N4‐methylthiosemicarbazone) (Cu‐ATSM) has been reported to selectively bind to hypoxic tumor cells. This makes Cu‐ATSM PET a promising modality to image tumor hypoxia. However, intravascular Cu‐ATSM that is not related ... Full text Cite