Chuan-Yuan Li
Professor of Dermatology
Dr. Li is the Vice Chair for Research in the Dept. of Dermatology. Some of the areas that his laboratory conducts research on include:
•Tumor response to therapy, with special emphasis on skin cancer such as melanoma and squamous cell carcinoma where current treatment outcomes are dismal;
•Stem cell and regenerative medicine, we will conduct research to investigate novel mechanisms of stem cell biology so that knowledge gained can be translated into regenerative medicine;
•Mechanisms of carcinogenesis, with emphasis on skin cancers, so that better strategies could be devised to prevent and treat these cancers.
Within these broad areas we have different ongoing research projects. Examples of some of the research projects include:
Unconventional roles of caspases in tumor response to chemotherapy or radiotherapy. A recent area of our laboratory has been the relationship of cell death and repopulation in tumors undergoing radiation and chemotherapy. In our studies, we discovered that cell death is a key trigger for tumor cell repopulation in radiation and chemotherapy. Unexpectedly, caspase 3, which is an executioner in cell death, positively regulate paracrine signaling from dying cells to stimulate proliferation of surviving tumor cells. Furthermore, we found that higher levels of pretreat caspase 3 activation is correlated with worse outcome in head and neck and breast cancers. This is again quite unexpected and contrary to established paradigm. We are currently actively studying the relevance of this mechanism in other malignancies including melanoma. We believe such studies will not only yield promising novel treatments for cancer but also new biomarkers of diagnostic or prognostic values.
Positive roles of apoptosis in wound healing and tissue regeneration. Another area of our research is the relationship between apoptosis and wound healing/tissue regeneration. In our recent research we discovered that cellular apoptosis, in particular, apoptotic caspases 3&7, play key roles in promoting skin wound healing and tissue regeneration. We named this pathway the “Phoenix Rising” pathway for wound healing and tissue regeneration. We are actively studying this mechanism with the hope that knowledge gained could be used for regenerative medicine.
Molecular factors involved in stem cell biology regulation and trans-differentiation. Recently our lab started to investigate molecular mechanisms involved in the maintenance and self-renewal of stem cells. Our efforts led to the discovery that caspases 8&3 play critical roles in the induction of pluripotent stem cells from human fibroblasts. We are in the process of dissecting additional roles of caspases in embryonic stem cells.
Direct reprogramming of one differentiated cell type into another differentiated cell type. Recently, we have been able to directly reprogram human fibroblast cells into dopaminergic neurons, which have great potential in Parksinson’s Disease. We are actively pursuing similar studies to reprogram skin fibroblasts into various cells of interest, including other skin cells, through direct reprogramming.
•Tumor response to therapy, with special emphasis on skin cancer such as melanoma and squamous cell carcinoma where current treatment outcomes are dismal;
•Stem cell and regenerative medicine, we will conduct research to investigate novel mechanisms of stem cell biology so that knowledge gained can be translated into regenerative medicine;
•Mechanisms of carcinogenesis, with emphasis on skin cancers, so that better strategies could be devised to prevent and treat these cancers.
Within these broad areas we have different ongoing research projects. Examples of some of the research projects include:
Unconventional roles of caspases in tumor response to chemotherapy or radiotherapy. A recent area of our laboratory has been the relationship of cell death and repopulation in tumors undergoing radiation and chemotherapy. In our studies, we discovered that cell death is a key trigger for tumor cell repopulation in radiation and chemotherapy. Unexpectedly, caspase 3, which is an executioner in cell death, positively regulate paracrine signaling from dying cells to stimulate proliferation of surviving tumor cells. Furthermore, we found that higher levels of pretreat caspase 3 activation is correlated with worse outcome in head and neck and breast cancers. This is again quite unexpected and contrary to established paradigm. We are currently actively studying the relevance of this mechanism in other malignancies including melanoma. We believe such studies will not only yield promising novel treatments for cancer but also new biomarkers of diagnostic or prognostic values.
Positive roles of apoptosis in wound healing and tissue regeneration. Another area of our research is the relationship between apoptosis and wound healing/tissue regeneration. In our recent research we discovered that cellular apoptosis, in particular, apoptotic caspases 3&7, play key roles in promoting skin wound healing and tissue regeneration. We named this pathway the “Phoenix Rising” pathway for wound healing and tissue regeneration. We are actively studying this mechanism with the hope that knowledge gained could be used for regenerative medicine.
Molecular factors involved in stem cell biology regulation and trans-differentiation. Recently our lab started to investigate molecular mechanisms involved in the maintenance and self-renewal of stem cells. Our efforts led to the discovery that caspases 8&3 play critical roles in the induction of pluripotent stem cells from human fibroblasts. We are in the process of dissecting additional roles of caspases in embryonic stem cells.
Direct reprogramming of one differentiated cell type into another differentiated cell type. Recently, we have been able to directly reprogram human fibroblast cells into dopaminergic neurons, which have great potential in Parksinson’s Disease. We are actively pursuing similar studies to reprogram skin fibroblasts into various cells of interest, including other skin cells, through direct reprogramming.
Current Appointments & Affiliations
- Professor of Dermatology, Dermatology, Clinical Science Departments 2011
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1997
- Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- Box 3135 Med Ctr, Durham, NC 27710
- Box 3135, DUMC, C303a/Lsrc, Durham, NC 27710
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chuan.li@duke.edu
(919) 613-8754
- Background
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Education, Training, & Certifications
- D.Sc., Harvard University 1992
- B.S., Chinese Academy of Sciences (China) 1987
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Previous Appointments & Affiliations
- Adjunct Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2006 - 2011
- Research Professor in Radiation Oncology, Radiation Oncology, Clinical Science Departments 2006
- Assistant Research Professor of Pathology, Pathology, Clinical Science Departments 2005 - 2006
- Associate Research Professor in Radiation Oncology, Radiation Oncology, Clinical Science Departments 2002 - 2005
- Assistant Research Professor in Radiation Oncology, Radiation Oncology, Clinical Science Departments 1997 - 2002
- Instructor, Temporary in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1997
- Expertise
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Subject Headings
- Research
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Selected Grants
- Novel roles of PCSK9 in regulating the tumor immune microenvironment during radiotherapy awarded by National Institutes of Health 2022 - 2027
- Targeting ATM to boost systemic effects of radiotherapy and immunotherapy awarded by National Institutes of Health 2021 - 2026
- Anti-PD1 in combination with an inhibitor of PCSK9 to increase MHC class I molecule expression on tumor cells as immunotherapy for NSCLC awarded by Department of Defense 2021 - 2024
- K63-Ubiquitin-mediated cell signal regulation in epidermis awarded by National Institutes of Health 2019 - 2024
- Cabinet Radiation Therapy System for Small Animals 2022 - 2023
- Necroptotic genes in cancer cellular response to radiation awarded by National Institutes of Health 2017 - 2023
- Targeting PCSK9 to enhance immunotherapy of LKB1/STK11-mutant lung cancer 2022
- Targeting apoptotic caspases to enhance cancer radiotherapy awarded by National Institutes of Health 2017 - 2022
- Image-Guided Radiation Therapy System for Small Animals awarded by National Institutes of Health 2021 - 2022
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pro-oncogenic roles of apoptotic caspases awarded by National Institutes of Health 2014 - 2020
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
- Exploring BCL-XL addiction in pancreatic ductal adenocarcinoma awarded by National Institutes of Health 2016 - 2019
- Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus awarded by National Institutes of Health 2016 - 2018
- The "Phoenix Rising" pathway of tumor repopulation during radiotherapy awarded by National Institutes of Health 2011 - 2017
- Mechanisms involved in HP802-mediated wound healing 2014 - 2016
- Molecular Mechanisms of Tumor Response to Cytotoxic Chemotherapy awarded by National Institutes of Health 2011 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- HIF Genes in Head and Neck Cancer Radiotherapy awarded by National Institutes of Health 2012 - 2015
- A mechanistic investigation of space radiation-induced carcinogensis 2012 - 2013
- Mechanisms of HZE Particle-Induced Genetic Instability/Carcinogenic Transformation 2003 - 2007
- Imaging Tumor Hypoxia in a Transgenic Mouse Model awarded by National Institutes of Health 2003 - 2007
- Molecular Characterization of the Role of SOD Genes in Mammalian Cellular Response: Low Dose Ionizing Radiation awarded by Department of Energy 2003 - 2007
- Hyperthermia-mediated gene therapy approach for cancer awarded by National Institutes of Health 1999 - 2006
- Cell Viability in Implantable Diffusion Chambers awarded by National Institutes of Health 2000 - 2005
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Pan, Dong, Xuhui Bao, Mengjie Hu, Meng Jiao, Fang Li, and Chuan-Yuan Li. “SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy.” Cancer Res 82, no. 15 (August 3, 2022): 2748–60. https://doi.org/10.1158/0008-5472.CAN-21-3523.Full Text Link to Item
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Liu, Pei, Cha Lin, Zheyu Liu, Chenchen Zhu, Zhongda Lin, Dan Xu, Jian Chen, et al. “Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.” Cell Mol Life Sci 79, no. 7 (June 8, 2022): 352. https://doi.org/10.1007/s00018-022-04365-4.Full Text Link to Item
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Pan, Dong, Ya Rong Du, Rong Li, Ai Hua Shen, Xiao Dong Liu, Chuan Yuan Li, and Bu Rong Hu. “SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas.” Biomed Environ Sci 35, no. 3 (March 20, 2022): 194–205. https://doi.org/10.3967/bes2022.028.Full Text Link to Item
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Qian, Danwen, Hongliang Liu, Lingling Zhao, Sheng Luo, Kyle M. Walsh, Jiaoti Huang, Chuan-Yuan Li, and Qingyi Wei. “A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.” Carcinogenesis 43, no. 1 (February 11, 2022): 60–66. https://doi.org/10.1093/carcin/bgab092.Full Text Open Access Copy Link to Item
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Huang, Ying, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, et al. “Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect.” Front Immunol 13 (2022): 751296. https://doi.org/10.3389/fimmu.2022.751296.Full Text Link to Item
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Li, Chuan-Yuan. “Non-canonical roles of apoptotic and DNA double-strand break repair factors in mediating cellular response to ionizing radiation.” Int J Radiat Biol, July 14, 2021, 1–10. https://doi.org/10.1080/09553002.2021.1948139.Full Text Link to Item
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Pan, Dong, Angela Y. Hu, Scott J. Antonia, and Chuan-Yuan Li. “A Gene Mutation Signature Predicting Immunotherapy Benefits in Patients With NSCLC.” J Thorac Oncol 16, no. 3 (March 2021): 419–27. https://doi.org/10.1016/j.jtho.2020.11.021.Full Text Link to Item
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Hu, Mengjie, Min Zhou, Xuhui Bao, Dong Pan, Meng Jiao, Xinjian Liu, Fang Li, and Chuan-Yuan Li. “ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation.” J Clin Invest 131, no. 3 (February 1, 2021). https://doi.org/10.1172/JCI139333.Full Text Link to Item
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Pan, Dong, Yarong Du, Rong Li, Aihua Shen, Xiaodong Liu, Chuanyuan Li, and Burong Hu. “miR-29b-3p Increases Radiosensitivity in Stemness Cancer Cells via Modulating Oncogenes Axis.” Front Cell Dev Biol 9 (2021): 741074. https://doi.org/10.3389/fcell.2021.741074.Full Text Link to Item
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Liu, Xinjian, Xuhui Bao, Mengjie Hu, Hanman Chang, Meng Jiao, Jin Cheng, Liyi Xie, Qian Huang, Fang Li, and Chuan-Yuan Li. “Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.” Nature 588, no. 7839 (December 2020): 693–98. https://doi.org/10.1038/s41586-020-2911-7.Full Text Link to Item
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Li, Chuan-Yuan. “Can Glycine Mitigate COVID-19 Associated Tissue Damage and Cytokine Storm?” Radiat Res 194, no. 3 (September 16, 2020): 199–201. https://doi.org/10.1667/RADE-20-00146.1.Full Text Link to Item
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Liu, Haolin, Srinivas Ramachandran, Nova Fong, Tzu Phang, Schuyler Lee, Pirooz Parsa, Xinjian Liu, et al. “JMJD5 couples with CDK9 to release the paused RNA polymerase II.” Proc Natl Acad Sci U S A 117, no. 33 (August 18, 2020): 19888–95. https://doi.org/10.1073/pnas.2005745117.Full Text Link to Item
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Liu, Xinjian, Mengjie Hu, Pei Liu, Meng Jiao, Min Zhou, Andrew K. Lee, Fang Li, and Chuan-Yuan Li. “ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming.” Cancer Res 80, no. 8 (April 15, 2020): 1669–80. https://doi.org/10.1158/0008-5472.CAN-19-2255.Full Text Link to Item
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Lee, Andrew K., Dong Pan, Xuhui Bao, Mengjie Hu, Fang Li, and Chuan-Yuan Li. “Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy.” Radiat Res 193, no. 4 (April 2020): 305–17. https://doi.org/10.1667/RADE-20-00013.Full Text Link to Item
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Lee, Schuyler, Haolin Liu, Ryan Hill, Chunjing Chen, Xia Hong, Fran Crawford, Molly Kingsley, et al. “JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes.” Elife 9 (February 12, 2020). https://doi.org/10.7554/eLife.53930.Full Text Link to Item
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Bao, Xuhui, Xinjian Liu, Fang Li, and Chuan-Yuan Li. “Limited MOMP, ATM, and their roles in carcinogenesis and cancer treatment.” Cell Biosci 10 (2020): 81. https://doi.org/10.1186/s13578-020-00442-y.Full Text Link to Item
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Wang, Yiwei, Minghui Zhao, Sijia He, Yuntao Luo, Yucui Zhao, Jin Cheng, Yanping Gong, et al. “Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway.” J Exp Clin Cancer Res 38, no. 1 (November 9, 2019): 461. https://doi.org/10.1186/s13046-019-1423-5.Full Text Link to Item
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Cheng, Jin, Sijia He, Min Wang, Ling Zhou, Zhengxiang Zhang, Xiao Feng, Yang Yu, et al. “The Caspase-3/PKCδ/Akt/VEGF-A Signaling Pathway Mediates Tumor Repopulation during Radiotherapy.” Clin Cancer Res 25, no. 12 (June 15, 2019): 3732–43. https://doi.org/10.1158/1078-0432.CCR-18-3001.Full Text Link to Item
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Kaakati, R., R. Zhao, X. Bao, A. K. Lee, X. Liu, F. Li, and C. Y. Li. “Non-apoptotic Roles of Caspases in Stem Cell Biology, Carcinogenesis, and Radiotherapy.” Current Stem Cell Reports 5, no. 1 (March 15, 2019): 31–37. https://doi.org/10.1007/s40778-019-0151-2.Full Text
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Zhao, Ruya, Rayan Kaakati, Xinjian Liu, Lingfan Xu, Andrew K. Lee, Robin Bachelder, Chuan-Yuan Li, and Scott T. Hollenbeck. “CRISPR/Cas9-Mediated BRCA1 Knockdown Adipose Stem Cells Promote Breast Cancer Progression.” Plast Reconstr Surg 143, no. 3 (March 2019): 747–56. https://doi.org/10.1097/PRS.0000000000005316.Full Text Link to Item
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Dikshit, Anushka, Yingai J. Jin, Simone Degan, Jihwan Hwang, Matthew W. Foster, Chuan-Yuan Li, and Jennifer Y. Zhang. “UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling.” Cancer Res 78, no. 22 (November 15, 2018): 6462–72. https://doi.org/10.1158/0008-5472.CAN-18-1040.Full Text Link to Item
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Zhao, Ruya, Rayan Kaakati, Andrew K. Lee, Xinjian Liu, Fang Li, and Chuan-Yuan Li. “Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond.” Cancer Metastasis Rev 37, no. 2–3 (September 2018): 227–36. https://doi.org/10.1007/s10555-018-9736-y.Full Text Link to Item
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Zhou, Min, Xinjian Liu, Zonghai Li, Qian Huang, Fang Li, and Chuan-Yuan Li. “Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells.” Int J Cancer 143, no. 4 (August 15, 2018): 921–30. https://doi.org/10.1002/ijc.31374.Full Text Link to Item
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He, Sijia, Jin Cheng, Lianhui Sun, Yiwei Wang, Chuangui Wang, Xinjian Liu, Zhengxiang Zhang, et al. “HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect.” Cell Death Dis 9, no. 6 (May 29, 2018): 648. https://doi.org/10.1038/s41419-018-0626-6.Full Text Link to Item
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Liu, Haolin, Chao Wang, Schuyler Lee, Yu Deng, Matthew Wither, Sangphil Oh, Fangkun Ning, et al. “Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.” Proc Natl Acad Sci U S A 114, no. 37 (September 12, 2017): E7717–26. https://doi.org/10.1073/pnas.1706831114.Full Text Link to Item
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Cartwright, Ian M., Xinjian Liu, Min Zhou, Fang Li, and Chuan-Yuan Li. “Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis.” Elife 6 (July 10, 2017). https://doi.org/10.7554/eLife.26371.Full Text Link to Item
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Liu, Xinjian, Fang Li, Qian Huang, Zhengxiang Zhang, Ling Zhou, Yu Deng, Min Zhou, et al. “Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells.” Cell Res 27, no. 6 (June 2017): 764–83. https://doi.org/10.1038/cr.2017.41.Full Text Link to Item
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Feng, Xiao, Yang Yu, Sijia He, Jin Cheng, Yanping Gong, Zhengxiang Zhang, Xuguang Yang, et al. “Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism.” Cancer Lett 385 (January 28, 2017): 12–20. https://doi.org/10.1016/j.canlet.2016.10.042.Full Text Link to Item
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Li, Fang, Xinjian Liu, John H. Sampson, Darell D. Bigner, and Chuan-Yuan Li. “Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors.” Cancer Res 76, no. 17 (September 1, 2016): 5143–50. https://doi.org/10.1158/0008-5472.CAN-16-0171.Full Text Link to Item
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Yu, Yang, Ling Tian, Xiao Feng, Jin Cheng, Yanping Gong, Xinjian Liu, Zhengxiang Zhang, et al. “eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation.” Cancer Lett 375, no. 1 (May 28, 2016): 31–38. https://doi.org/10.1016/j.canlet.2016.02.052.Full Text Link to Item
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Liu, Xinjian, Yujun He, Fang Li, Qian Huang, Takamitsu A. Kato, Russell P. Hall, and Chuan-Yuan Li. “Redefining the roles of apoptotic factors in carcinogenesis.” Mol Cell Oncol 3, no. 3 (May 2016): e1054550. https://doi.org/10.1080/23723556.2015.1054550.Full Text Link to Item
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Liu, Xinjian, Min Zhou, Ling Mei, Jiaying Ruan, Qian Hu, Jing Peng, Hang Su, et al. “Key roles of necroptotic factors in promoting tumor growth.” Oncotarget 7, no. 16 (April 19, 2016): 22219–33. https://doi.org/10.18632/oncotarget.7924.Full Text Link to Item
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Feng, Xiao, Ling Tian, Zhengxiang Zhang, Yang Yu, Jin Cheng, Yanping Gong, Chuan-Yuan Li, and Qian Huang. “Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis.” Oncotarget 6, no. 32 (October 20, 2015): 32353–67. https://doi.org/10.18632/oncotarget.5898.Full Text Link to Item
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Zhang, Zhengxiang, Min Wang, Ling Zhou, Xiao Feng, Jin Cheng, Yang Yu, Yanping Gong, et al. “Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer.” J Exp Clin Cancer Res 34, no. 1 (May 20, 2015): 51. https://doi.org/10.1186/s13046-015-0166-1.Full Text Link to Item
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Liu, Xinjian, Yujun He, Fang Li, Qian Huang, Takamitsu A. Kato, Russell P. Hall, and Chuan-Yuan Li. “Caspase-3 promotes genetic instability and carcinogenesis.” Mol Cell 58, no. 2 (April 16, 2015): 284–96. https://doi.org/10.1016/j.molcel.2015.03.003.Full Text Link to Item
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Cheng, Jin, Ling Tian, Jingjing Ma, Yanping Gong, Zhengxiang Zhang, Zhiwei Chen, Bing Xu, Hui Xiong, Chuanyuan Li, and Qian Huang. “Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma.” Mol Oncol 9, no. 1 (January 2015): 105–14. https://doi.org/10.1016/j.molonc.2014.07.024.Full Text Link to Item
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Wei, Fang, Huiping Wang, Xiafang Chen, Chuanyuan Li, and Qian Huang. “Dissecting the roles of E1A and E1B in adenoviral replication and RCAd-enhanced RDAd transduction efficacy on tumor cells.” Cancer Biol Ther 15, no. 10 (October 2014): 1358–66. https://doi.org/10.4161/cbt.29842.Full Text Link to Item
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Liu, XinJian, Qian Huang, Fang Li, and Chuan-Yuan Li. “Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression.” Sci China Life Sci 57, no. 9 (September 2014): 867–75. https://doi.org/10.1007/s11427-014-4730-2.Full Text Link to Item
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Donato, Anne L., Qian Huang, Xinjian Liu, Fang Li, Mary A. Zimmerman, and Chuan-Yuan Li. “Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy.” J Invest Dermatol 134, no. 6 (June 2014): 1686–92. https://doi.org/10.1038/jid.2014.18.Full Text Link to Item
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Liu, Chad, Chuan-Yuan Li, and Fan Yuan. “Mathematical modeling of the Phoenix Rising pathway.” Plos Comput Biol 10, no. 2 (February 2014): e1003461. https://doi.org/10.1371/journal.pcbi.1003461.Full Text Link to Item
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Donato, A. L., Q. Huang, X. Liu, F. Li, M. A. Zimmerman, and C. Y. Li. “Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy.” Journal of Investigative Dermatology 134, no. 6 (January 1, 2014): 1686–92. https://doi.org/10.1038/jid.2014.18.Full Text
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Zhou, Min, Hai Wang, Keke Zhou, Xiaoying Luo, Xiaorong Pan, Bizhi Shi, Hua Jiang, et al. “A novel EGFR isoform confers increased invasiveness to cancer cells.” Cancer Res 73, no. 23 (December 1, 2013): 7056–67. https://doi.org/10.1158/0008-5472.CAN-13-0194.Full Text Link to Item
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Zhou, D., and C. Y. Li. “Preface.” Translational Cancer Research 2, no. 5 (October 1, 2013): 370–71. https://doi.org/10.3978/j.issn.2218-676X.2013.10.06.Full Text
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Zhou, Ling, Ke Li, Yanli Luo, Ling Tian, Min Wang, Chuanyuan Li, and Qian Huang. “Novel prognostic markers for patients with triple-negative breast cancer.” Hum Pathol 44, no. 10 (October 2013): 2180–87. https://doi.org/10.1016/j.humpath.2013.03.021.Full Text Link to Item
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Zimmerman, Mary A., Qian Huang, Fang Li, Xinjiang Liu, and Chuan-Yuan Li. “Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy.” Semin Radiat Oncol 23, no. 4 (October 2013): 288–95. https://doi.org/10.1016/j.semradonc.2013.05.003.Full Text Link to Item
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Zhou, Ling, Yanli Luo, Ke Li, Ling Tian, Min Wang, Chuanyuan Li, and Qian Huang. “Molecular markers of therapeutic resistance in breast cancer.” Hum Pathol 44, no. 7 (July 2013): 1421–28. https://doi.org/10.1016/j.humpath.2012.10.027.Full Text Link to Item
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Su, L. J., X. Yang, C. Altunbas, T. W. Flaig, C. Y. Li, and B. D. Kavanagh. “Relationship of oral glycine with radiation-induced HIF1-alpha and tumor growth delay in a prostate cancer xenograft.” J Clin Oncol 31, no. 6_suppl (February 20, 2013): 81. https://doi.org/10.1200/jco.2013.31.6_suppl.81.Full Text Link to Item
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Wei, Fang, Huiping Wang, Jufeng Zhang, Xiafang Chen, Chuanyuan Li, and Qian Huang. “Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12.” J Exp Clin Cancer Res 32, no. 1 (January 26, 2013): 5. https://doi.org/10.1186/1756-9966-32-5.Full Text Link to Item
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Luo, Yanli, Zhengjun Qiu, Ling Tian, Guanghui Zhu, Ye Feng, Miaoying Yi, Xiafang Chen, Liwei Wang, Chuanyuan Li, and Qian Huang. “Identification of novel predictive markers for the prognosis of pancreatic ductal adenocarcinoma.” Hum Pathol 44, no. 1 (January 2013): 69–76. https://doi.org/10.1016/j.humpath.2012.04.014.Full Text Link to Item
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Ma, Jingjing, Ling Tian, Jin Cheng, Zhiwei Chen, Bing Xu, Liwei Wang, Chuanyuan Li, and Qian Huang. “Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy.” Plos One 8, no. 6 (2013): e65032. https://doi.org/10.1371/journal.pone.0065032.Full Text Link to Item
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Yang, Xiaoping, Elizabeth Kessler, Lih-Jen Su, Andrew Thorburn, Arthur E. Frankel, Yuan Li, Francisco G. La Rosa, et al. “Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer.” Clin Cancer Res 19, no. 1 (January 1, 2013): 148–57. https://doi.org/10.1158/1078-0432.CCR-12-1258.Full Text Link to Item
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Yan, Bin, Ruoyun Ouyang, Chenghui Huang, Franklin Liu, Daniel Neill, Chuanyuan Li, and Mark Dewhirst. “Heat induces gene amplification in cancer cells.” Biochem Biophys Res Commun 427, no. 3 (October 26, 2012): 473–77. https://doi.org/10.1016/j.bbrc.2012.09.011.Full Text Link to Item
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Wang, Huiping, Fang Wei, Jufeng Zhang, Feng Wang, Huiming Li, Xiafang Chen, Kuangcheng Xie, Yufei Wang, Chuanyuan Li, and Qian Huang. “A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy.” Tumour Biol 33, no. 4 (August 2012): 1245–53. https://doi.org/10.1007/s13277-012-0374-7.Full Text Link to Item
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Kon, Takashi, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, and Chuan-Yuan Li. “Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA.” Transl Cancer Res 1, no. 2 (June 2012): 4–14. https://doi.org/10.3978/j.issn.2218-676X.2012.05.02.Full Text Link to Item
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Li, C. Y. “Inhibitors of DNA repair for cancer therapy, ready for prime time?” Translational Cancer Research 1, no. 1 (June 1, 2012): 4–5. https://doi.org/10.3978/j.issn.2218-676X.2012.05.08.Full Text
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Zhang, Shenghai, Jihong Wu, Xiaobing Wu, Ping Xu, Yuhua Tian, Miaoying Yi, Xinjian Liu, et al. “Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs.” Invest Ophthalmol Vis Sci 53, no. 6 (May 4, 2012): 2675–84. https://doi.org/10.1167/iovs.11-8856.Full Text Link to Item
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Brogan, John, Fang Li, Wenrong Li, Zhimin He, Qian Huang, and Chuan-Yuan Li. “Imaging molecular pathways: reporter genes.” Radiat Res 177, no. 4 (April 2012): 508–13. https://doi.org/10.1667/rr2918.1.Full Text Link to Item
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Liu, Xinjian, Fang Li, Elizabeth A. Stubblefield, Barbara Blanchard, Toni L. Richards, Gaynor A. Larson, Yujun He, et al. “Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells.” Cell Res 22, no. 2 (February 2012): 321–32. https://doi.org/10.1038/cr.2011.181.Full Text Link to Item
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Huang, Qian, Fang Li, Xinjian Liu, Wenrong Li, Wei Shi, Fei-Fei Liu, Brian O’Sullivan, et al. “Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.” Nat Med 17, no. 7 (July 3, 2011): 860–66. https://doi.org/10.1038/nm.2385.Full Text Link to Item
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Li, Wenrong, Fang Li, Qian Huang, Jingping Shen, Frank Wolf, Yujun He, Xinjian Liu, Y Angela Hu, Joel S. Bedford, and Chuan-Yuan Li. “Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo.” Cancer Res 71, no. 12 (June 15, 2011): 4130–37. https://doi.org/10.1158/0008-5472.CAN-10-2540.Full Text Link to Item
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Liu, Xinjian, Qijun Qian, Ping Xu, Frank Wolf, Jufeng Zhang, Dabing Zhang, Chuanyuan Li, and Qian Huang. “A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling.” Hum Gene Ther 22, no. 4 (April 2011): 427–37. https://doi.org/10.1089/hum.2010.128.Full Text Link to Item
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Wolf, Frank, Wenrong Li, Fang Li, and Chuan-Yuan Li. “Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours.” Int J Hyperthermia 27, no. 5 (2011): 427–34. https://doi.org/10.3109/02656736.2011.566593.Full Text Link to Item
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Wolf, Frank, Wenrong Li, Fang Li, and Chuan-Yuan Li. “Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy.” Int J Radiat Oncol Biol Phys 79, no. 1 (January 1, 2011): 233–38. https://doi.org/10.1016/j.ijrobp.2010.08.001.Full Text Link to Item
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Li, Fang, Zhimin He, Jingping Shen, Qian Huang, Wenrong Li, Xinjian Liu, Yujun He, Frank Wolf, and Chuan-Yuan Li. “Apoptotic caspases regulate induction of iPSCs from human fibroblasts.” Cell Stem Cell 7, no. 4 (October 8, 2010): 508–20. https://doi.org/10.1016/j.stem.2010.09.003.Full Text Link to Item
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Li, Chuan-Yuan. “Need radioprotection? A MEPE/OF45 mimetic may do the job.” Cell Cycle 9, no. 12 (June 15, 2010): 2271. https://doi.org/10.4161/cc.9.12.12022.Full Text Link to Item
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Li, C. Y., and A. M. Van Hook. “Science signaling podcast: 23 February 2010.” Science Signaling 3, no. 110 (February 23, 2010). https://doi.org/10.1126/scisignal.3110pc5.Full Text
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Li, Fang, Qian Huang, Jiang Chen, Yuanlin Peng, Dennis R. Roop, Joel S. Bedford, and Chuan-Yuan Li. “Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.” Sci Signal 3, no. 110 (February 23, 2010): ra13. https://doi.org/10.1126/scisignal.2000634.Full Text Link to Item
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Liu, Xinjian, Jinjun Li, Yuhua Tian, Ping Xu, Xiafang Chen, Kuangchen Xie, Zhengjun Qiu, et al. “Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide.” Hum Gene Ther 21, no. 2 (February 2010): 157–70. https://doi.org/10.1089/hum.2009.083.Full Text Link to Item
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Ji, Xunda, Lin Cheng, Fang Wei, Huiming Li, Mengyun Wang, Yuhua Tian, Xiafang Chen, et al. “Noninvasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging.” Invest Ophthalmol Vis Sci 50, no. 12 (December 2009): 5544–51. https://doi.org/10.1167/iovs.08-3258.Full Text Link to Item
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Wei, F., H. P. Wang, X. F. Chen, C. Y. Li, and Q. Huang. “Construction and characterization of oncolytic adenovirus controlled under heat shock protein70 gene promoter.” Progress in Biochemistry and Biophysics 36, no. 12 (December 1, 2009): 1536–43. https://doi.org/10.3724/SP.J.1206.2009.00308.Full Text
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Liu, X., J. Wu, S. Zhang, C. Li, and Q. Huang. “Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy.” Cancer Gene Ther 16, no. 11 (November 2009): 861–72. https://doi.org/10.1038/cgt.2009.30.Full Text Link to Item
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Yan, Bin, Huili Wang, Donghua Xie, Nobuko Wakamatsu, Mitchell S. Anscher, Mark W. Dewhirst, Ron E. J. Mitchel, Benny J. Chen, and Chuan-Yuan Li. “Increased skin carcinogenesis in caspase-activated DNase knockout mice.” Carcinogenesis 30, no. 10 (October 2009): 1776–80. https://doi.org/10.1093/carcin/bgp146.Full Text Link to Item
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Ji, Xunda, Jufeng Zhang, Lin Cheng, Fang Wei, Huiming Li, Xinjian Liu, Xiafang Chen, Chuanyuan Li, Yufei Wang, and Qian Huang. “Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.” Exp Eye Res 89, no. 2 (August 2009): 193–99. https://doi.org/10.1016/j.exer.2009.03.007.Full Text Link to Item
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Liu, X. J., X. D. Ji, Y. H. Tian, X. F. Chen, K. C. Xie, J. H. Wu, S. H. Zhang, P. Xu, C. Y. Li, and Q. Huang. “The effect of cobalt chloride on adenovirus gene expression.” Tumor 29, no. 7 (July 1, 2009): 603–10. https://doi.org/10.3781/j.issn.1000-7431.2009.07.001.Full Text
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Moon, Eui Jung, Chuan-Yuan Li, Ines Batinic-Haberle, and Mark Dewhirst. “Hyperthermia-induced HIF-1 activation and tumor reoxygenation.” Cancer Research 69 (May 1, 2009).Link to Item
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Yan, Bin, Yuanlin Peng, and Chuan-Yuan Li. “Molecular analysis of genetic instability caused by chronic inflammation.” Methods Mol Biol 512 (2009): 15–28. https://doi.org/10.1007/978-1-60327-530-9_2.Full Text Link to Item
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Viola, Ronald J., James M. Provenzale, Fang Li, Chuan-Yuan Li, Hong Yuan, Jessica Tashjian, and Mark W. Dewhirst. “In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.” Ajr Am J Roentgenol 191, no. 6 (December 2008): 1779–84. https://doi.org/10.2214/AJR.07.4060.Full Text Link to Item
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Li, Wenrong, Fang Li, Qian Huang, Barbara Frederick, Shideng Bao, and Chuan-Yuan Li. “Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.” Cancer Res 68, no. 13 (July 1, 2008): 4990–97. https://doi.org/10.1158/0008-5472.CAN-07-5984.Full Text Link to Item
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Wu, Jihong, Shenghai Zhang, Xiaobing Wu, Xiaoyan Dong, Ping Xu, Xinjian Liu, Chuanyuan Li, and Qian Huang. “Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus.” Vision Res 48, no. 15 (July 2008): 1648–54. https://doi.org/10.1016/j.visres.2008.04.019.Full Text Link to Item
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Siddiqui, Farzan, Paul R. Avery, Chuan-Yuan Li, Xiuwu Zhang, Susan M. LaRue, Mark W. Dewhirst, and Robert L. Ullrich. “Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy.” Cancer Invest 26, no. 6 (July 2008): 553–61. https://doi.org/10.1080/07357900701788015.Full Text Link to Item
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Wang, F., X. F. Chen, F. Wei, J. H. Wu, K. C. Xie, Y. H. Han, M. Y. Yi, C. Y. Li, and Q. Huang. “Response of hypoxia-response element in human liver cancer cells to different microenvironments.” Tumor 28, no. 5 (May 25, 2008): 367–71. https://doi.org/10.3781/j.issn.1000-7431.2008.05.001.Full Text
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Zhang, Sheng-Hai, Ji-Hong Wu, Xiao-Bing Wu, Xiao-Yan Dong, Xin-Jian Liu, Chuan-Yuan Li, and Chuan-Yuan Qian-Huang. “Distinctive gene transduction efficiencies of commonly used viral vectors in the retina.” Curr Eye Res 33, no. 1 (January 2008): 81–90. https://doi.org/10.1080/02713680701799408.Full Text Link to Item
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Dewhirst, Mark W., Yiting Cao, Chuan Yuan Li, and Benjamin Moeller. “Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.” Radiother Oncol 83, no. 3 (June 2007): 249–55. https://doi.org/10.1016/j.radonc.2007.05.016.Full Text Link to Item
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Cao, Yiting, Pierre Sonveaux, Shanling Liu, Yulin Zhao, Jing Mi, Bryan M. Clary, Chuan-Yuan Li, Christopher D. Kontos, and Mark W. Dewhirst. “Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth.” Cancer Res 67, no. 8 (April 15, 2007): 3835–44. https://doi.org/10.1158/0008-5472.CAN-06-4056.Full Text Link to Item
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Li, Fang, Pierre Sonveaux, Zahid N. Rabbani, Shanling Liu, Bin Yan, Qian Huang, Zeljko Vujaskovic, Mark W. Dewhirst, and Chuan-Yuan Li. “Regulation of HIF-1alpha stability through S-nitrosylation.” Mol Cell 26, no. 1 (April 13, 2007): 63–74. https://doi.org/10.1016/j.molcel.2007.02.024.Full Text Link to Item
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Siddiqui, Farzan, Chuan-Yuan Li, Susan M. Larue, Jean M. Poulson, Paul R. Avery, Amy F. Pruitt, Xiuwu Zhang, et al. “A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas.” Mol Cancer Ther 6, no. 1 (January 2007): 380–89. https://doi.org/10.1158/1535-7163.MCT-06-0342.Full Text Link to Item
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Yan, B., H. Wang, F. Li, and C. -. Y. Li. “Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.” Br J Cancer 95, no. 12 (December 18, 2006): 1696–1700. https://doi.org/10.1038/sj.bjc.6603484.Full Text Link to Item
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Yan, Bin, Huili Wang, Zahid N. Rabbani, Yulin Zhao, Wenrong Li, Yuqing Yuan, Fang Li, Mark W. Dewhirst, and Chuan-Yuan Li. “Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation.” Cancer Res 66, no. 24 (December 15, 2006): 11565–70. https://doi.org/10.1158/0008-5472.CAN-06-2540.Full Text Link to Item
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Siddiqui, Farzan, E. J. Ehrhart, Brad Charles, Laura Chubb, Chuan-Yuan Li, Xiuwu Zhang, Susan M. Larue, Paul R. Avery, Mark W. Dewhirst, and Robert L. Ullrich. “Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct.” Int J Hyperthermia 22, no. 7 (November 2006): 587–606. https://doi.org/10.1080/02656730600983063.Full Text Link to Item
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Yan, B., H. Wang, D. Zhuo, F. Li, T. Kon, M. Dewhirst, and C. -. Y. Li. “Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner.” Oncogene 25, no. 39 (August 31, 2006): 5370–76. https://doi.org/10.1038/sj.onc.1209535.Full Text Link to Item
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Liu, Yunbo, Takashi Kon, Chuanyuan Li, and Pei Zhong. “High intensity focused ultrasound-induced gene activation in solid tumors.” J Acoust Soc Am 120, no. 1 (July 2006): 492–501. https://doi.org/10.1121/1.2205129.Full Text Link to Item
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Yan, B., H. Wang, J. S. Bedford, M. W. Dewhirst, and C. Li. “A novel role of DNA fragmentation factor as a tumor suppressor through maintaining genomic stability.” J Clin Oncol 24, no. 18_suppl (June 20, 2006): 10023.Link to Item
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Liu, Y., T. Kon, C. Li, and P. Zhong. “High intensity focused ultrasound induced gene activation in solid tumors.” Aip Conference Proceedings 829 (May 8, 2006): 588–92. https://doi.org/10.1063/1.2205542.Full Text
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Chuang, Eric Y., Xi Chen, Mong-Hsun Tsai, Hailing Yan, Chuan-Yuan Li, James B. Mitchell, Hatsumi Nagasawa, et al. “Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma.” Cancer Res 66, no. 7 (April 1, 2006): 3428–33. https://doi.org/10.1158/0008-5472.CAN-05-2847.Full Text Link to Item
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Mi, Jing, Shiva Sarraf-Yazdi, Xiuwu Zhang, Yiting Cao, Mark W. Dewhirst, Christopher D. Kontos, Chuan-Yuan Li, and Bryan M. Clary. “A comparison of antiangiogenic therapies for the prevention of liver metastases.” J Surg Res 131, no. 1 (March 2006): 97–104. https://doi.org/10.1016/j.jss.2005.09.008.Full Text Link to Item
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Siddiqui, Farzan, Chuan-Yuan Li, Xiuwu Zhang, Susan M. Larue, Mark W. Dewhirst, Robert L. Ullrich, and Paul R. Avery. “Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy.” Int J Hyperthermia 22, no. 2 (March 2006): 117–34. https://doi.org/10.1080/02656730500462309.Full Text Link to Item
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Wang, Yong, He Wang, Chuan-Yuan Li, and Fan Yuan. “Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery.” Mol Cancer Ther 5, no. 2 (February 2006): 362–66. https://doi.org/10.1158/1535-7163.MCT-05-0266.Full Text Link to Item
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Yan, B., H. Wang, T. Kon, and C. -. Y. Li. “Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection.” Braz J Med Biol Res 39, no. 2 (February 2006): 169–76. https://doi.org/10.1590/s0100-879x2006000200002.Full Text Link to Item
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Yan, Bin, Huili Wang, Yuanlin Peng, Ye Hu, He Wang, Xiuwu Zhang, Qi Chen, Joel S. Bedford, Mark W. Dewhirst, and Chuan-Yuan Li. “A unique role of the DNA fragmentation factor in maintaining genomic stability.” Proc Natl Acad Sci U S A 103, no. 5 (January 31, 2006): 1504–9. https://doi.org/10.1073/pnas.0507779103.Full Text Link to Item
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Liu, Shanling, Jiangao Zhu, He Wang, Takashi Kon, and Chuan- Yuan Li. “427. Adenovirus Mediated GRP94/gp96 Expression in Treatment of Neuroblastoma.” Molecular Therapy 13 (2006): S164–S164. https://doi.org/10.1016/j.ymthe.2006.08.492.Full Text
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Liu, Yunbo, Zhenlin Hu, Xiaochun Lu, Takashi Kon, Chuanyuan Li, and Pei Zhong. “954. High Intensity Focused Ultrasound (HIFU) Induced Trans-Gene Activation in Solid Tumors.” Molecular Therapy 13 (2006): S368–S368. https://doi.org/10.1016/j.ymthe.2006.08.1046.Full Text
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Liu, Yunbo, Takashi Kon, Chuanyuan Li, and Pei Zhong. “High intensity focused ultrasound-induced gene activation in sublethally injured tumor cells in vitro.” J Acoust Soc Am 118, no. 5 (November 2005): 3328–36. https://doi.org/10.1121/1.2041247.Full Text Link to Item
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Plathow, Christian, Frank Lohr, Gabriela Divkovic, Guido Rademaker, Nabeel Farhan, Peter Peschke, Ivan Zuna, et al. “Focal gene induction in the liver of rats by a heat-inducible promoter using focused ultrasound hyperthermia: preliminary results.” Invest Radiol 40, no. 11 (November 2005): 729–35. https://doi.org/10.1097/01.rli.0000184763.62578.06.Full Text Link to Item
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Liu, Shanling, He Wang, Zhonghui Yang, Takashi Kon, Jiangao Zhu, Yiting Cao, Fang Li, John Kirkpatrick, Christopher V. Nicchitta, and Chuan-Yuan Li. “Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression.” Cancer Res 65, no. 20 (October 15, 2005): 9126–31. https://doi.org/10.1158/0008-5472.CAN-05-0945.Full Text Link to Item
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Wang, Yong, Shanling Liu, Chuan-Yuan Li, and Fan Yuan. “A novel method for viral gene delivery in solid tumors.” Cancer Res 65, no. 17 (September 1, 2005): 7541–45. https://doi.org/10.1158/0008-5472.CAN-05-1112.Full Text Link to Item
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Moeller, Benjamin J., Matthew R. Dreher, Zahid N. Rabbani, Thies Schroeder, Yiting Cao, Chuan Y. Li, and Mark W. Dewhirst. “Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.” Cancer Cell 8, no. 2 (August 2005): 99–110. https://doi.org/10.1016/j.ccr.2005.06.016.Full Text Link to Item
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Cao, Yiting, Chuan-Yuan Li, Benjamin J. Moeller, Daohai Yu, Yulin Zhao, Matthew R. Dreher, Siqing Shan, and Mark W. Dewhirst. “Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.” Cancer Res 65, no. 13 (July 1, 2005): 5498–5505. https://doi.org/10.1158/0008-5472.CAN-04-4553.Full Text Link to Item
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Rao, Ponugoti Vasantha, PeiFeng Deng, Rupalatha Maddala, David L. Epstein, Chuan-Yuan Li, and Hiroaki Shimokawa. “Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow.” Mol Vis 11 (April 27, 2005): 288–97.Link to Item
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Wang, Y., Z. Yang, S. Liu, T. Kon, A. Krol, C. -. Y. Li, and F. Yuan. “Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery.” Br J Cancer 92, no. 8 (April 25, 2005): 1414–20. https://doi.org/10.1038/sj.bjc.6602494.Full Text Link to Item
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Li, Chuan-Yuan, Qian Huang, and Hsiang-Fu Kung. “Cytokine and immuno-gene therapy for solid tumors.” Cell Mol Immunol 2, no. 2 (April 2005): 81–91.Link to Item
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Zhang, Xiuwu, Takashi Kon, He Wang, Fang Li, Qian Huang, Zahid N. Rabbani, John P. Kirkpatrick, Zeljko Vujaskovic, Mark W. Dewhirst, and Chuan-Yuan Li. “Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha.” Cancer Res 64, no. 22 (November 15, 2004): 8139–42. https://doi.org/10.1158/0008-5472.CAN-03-2301.Full Text Link to Item
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Moeller, Benjamin J., Yiting Cao, Zeljko Vujaskovic, Chuan Y. Li, Zishan A. Haroon, and Mark W. Dewhirst. “The relationship between hypoxia and angiogenesis.” Semin Radiat Oncol 14, no. 3 (July 2004): 215–21. https://doi.org/10.1016/j.semradonc.2004.04.005.Full Text Link to Item
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Herskind, Carsten, Katharina Fleckenstein, Jens Lohr, Chuan-Yuan Li, Frederik Wenz, and Frank Lohr. “[Antitumoral action of interferons and interleukins in combination with radiotherapy. Part II: radiobiological and immunologic strategies].” Strahlenther Onkol 180, no. 6 (June 2004): 331–39. https://doi.org/10.1007/s00066-004-8119-1.Full Text Link to Item
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Moeller, Benjamin J., Yiting Cao, Chuan Y. Li, and Mark W. Dewhirst. “Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules.” Cancer Cell 5, no. 5 (May 2004): 429–41. https://doi.org/10.1016/s1535-6108(04)00115-1.Full Text Link to Item
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Herskind, Carsten, Katharina Fleckenstein, Jens Lohr, Chuan-Yuan Li, Frederik Wenz, and Frank Lohr. “[Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis].” Strahlenther Onkol 180, no. 4 (April 2004): 187–93. https://doi.org/10.1007/s00066-004-9119-x.Full Text Link to Item
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Zhang, Xiuwu, Qian Huang, Zhonghui Yang, Yongping Li, and Chuan-Yuan Li. “GW112, a novel antiapoptotic protein that promotes tumor growth.” Cancer Res 64, no. 7 (April 1, 2004): 2474–81. https://doi.org/10.1158/0008-5472.can-03-3443.Full Text Link to Item
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Huang, Qian, Xiuwu Zhang, He Wang, Bin Yan, John Kirkpatrick, Mark W. Dewhrist, and Chuan-Yuan Li. “A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells.” Clin Cancer Res 10, no. 4 (February 15, 2004): 1439–45. https://doi.org/10.1158/1078-0432.ccr-03-0122.Full Text Link to Item
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Shan, Siqing, Nicole D. Robson, Yiting Cao, Tong Qiao, Chuan Y. Li, Christopher D. Kontos, Mariano Garcia-Blanco, and Mark W. Dewhirst. “Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.” Faseb J 18, no. 2 (February 2004): 326–28. https://doi.org/10.1096/fj.03-0765fje.Full Text Link to Item
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Wang, Yong, Chuan-Yuan Li, and Fan Yuan. “Systemic virus dissemination during local gene delivery in solid tumors and its control with an alginate solution.” Conf Proc Ieee Eng Med Biol Soc 2004 (2004): 3524–26. https://doi.org/10.1109/IEMBS.2004.1403991.Full Text Link to Item
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Wang, F., J. Wu, Y. Tian, X. Chen, H. Hu, W. Wu, C. Li, and Q. Huang. “Role of VEGF in the growth and metastasis of a murine bladder carcinoma.” Chinese Science Bulletin 48, no. 22 (December 1, 2003): 2404–10. https://doi.org/10.1360/03wc0210.Full Text
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Wang, Yong, Jim Kang Hu, Ava Krol, Yong-Ping Li, Chuan-Yuan Li, and Fan Yuan. “Systemic dissemination of viral vectors during intratumoral injection.” Mol Cancer Ther 2, no. 11 (November 2003): 1233–42.Link to Item
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Rabbani, Zahid N., Mitchell S. Anscher, Xiuwu Zhang, Liguang Chen, Thaddeus V. Samulski, Chuan-Yuan Li, and Zeljko Vujaskovic. “Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats.” Int J Radiat Oncol Biol Phys 57, no. 2 (October 1, 2003): 563–72. https://doi.org/10.1016/s0360-3016(03)00639-4.Full Text Link to Item
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Zhang, Xiuwu, Yongping Li, Qian Huang, He Wang, Bin Yan, Mark W. Dewhirst, and Chuan-Yuan Li. “Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.” Clin Cancer Res 9, no. 3 (March 2003): 1155–60.Link to Item
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Baker-LePain, Julie C., Marcella Sarzotti, Timothy A. Fields, Chuan-Yuan Li, and Christopher V. Nicchitta. “GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression.” J Exp Med 196, no. 11 (December 2, 2002): 1447–59. https://doi.org/10.1084/jem.20020436.Full Text Link to Item
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Azzam, Edouard I., Hatsumi Nagasawa, Yongjia Yu, Chuan-Yuan Li, and John B. Little. “Cell cycle deregulation and xeroderma pigmentosum group C cell transformation.” J Invest Dermatol 119, no. 6 (December 2002): 1350–54. https://doi.org/10.1046/j.1523-1747.2002.19628.x.Full Text Link to Item
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Wang, Y., J. K. Hu, A. Krol, Y. P. Li, C. Y. Li, and F. Yuan. “Reducing systemic toxicity in local tumor gene therapy using an alginate solution.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 1 (December 1, 2002): 565.
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Wang, F., X. F. Chen, Y. H. Tian, J. H. Wu, L. Li, C. Y. Li, and Q. Huang. “Target gene transfer mediated by electroporation for cancer therapy in vivo.” Progress in Biochemistry and Biophysics 29, no. 5 (October 1, 2002): 734–40.
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Zaharoff, D. A., R. C. Barr, C. -. Y. Li, and F. Yuan. “Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery.” Gene Ther 9, no. 19 (October 2002): 1286–90. https://doi.org/10.1038/sj.gt.3301799.Full Text Link to Item
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Wang, Feng, Yu-Hua Tian, Li Li, Xia-Fang Chen, Hong-Hui Hu, Chuan-Yuan Li, and Qian Huang. “[Inhibitation of tumor angiogenesis, growth and metastasis by blocking VEGF paracrine pathway].” Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34, no. 2 (March 2002): 165–70.Link to Item
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Dewhirst, Mark W., S. Shan, Yiting Cao, Benjamin Moeller, Fan Yuan, and Chuan-Yuan Li. “Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals.” Dis Markers 18, no. 5–6 (2002): 293–311. https://doi.org/10.1155/2002/820102.Full Text Link to Item
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Li, Ling, Ping Xu, Hong-Hui Hu, Wen-Wen Liu, Miao-Yin Yi, Chuan-Yuan Li, and Qian Huang. “[A novel model for visualization of tumor cell-induced angiogenesis in vivo].” Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34, no. 1 (January 2002): 21–27.Link to Item
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Li, C. Y., and M. W. Dewhirst. “Hyperthermia-regulated immunogene therapy.” Int J Hyperthermia 18, no. 6 (2002): 586–96. https://doi.org/10.1080/0265673021000017082.Full Text Link to Item
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Zhang, X., K. Hu, and C. Y. Li. “Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase.” Circulation 104, no. 23 (December 4, 2001): 2762–66. https://doi.org/10.1161/hc4801.100792.Full Text Link to Item
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Lohr, F., Q. Huang, K. Hu, M. W. Dewhirst, and C. Y. Li. “Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors.” Clin Cancer Res 7, no. 11 (November 2001): 3625–28.Link to Item
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Shan, S., K. Hu, W. Saito, C. Li, and M. W. Dewhirst. “Effects of soluble Tie-2 receptor and bFGF on GFP-4T1 tumor growth and initiation of angiogenesis in BALB/C mouse dorsal skinfold window chamber.” Clinical Cancer Research 7, no. 11 (November 1, 2001): 3658S-3658S.Link to Item
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Huang, Q., P. Xu, W. Liu, F. Wang, Q. Gu, S. Tian, Y. Fan, K. Xig, X. Chen, and C. Li. “[Preparation of green fluorescent protein retrovirus and its application in mediating gene transfer into retinal pigment epithelial cells].” Zhonghua Yan Ke Za Zhi 37, no. 4 (July 2001): 248–51.Link to Item
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Huang, Q., and C. Li. “[Using Hsp70 promoter to regulate target gene expression in tumor].” Zhonghua Bing Li Xue Za Zhi 30, no. 3 (June 2001): 198–201.Link to Item
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Zhang, X., and C. Y. Li. “Generation of recombinant adeno-associated virus vectors by a complete adenovirus-mediated approach.” Mol Ther 3, no. 5 Pt 1 (May 2001): 787–92. https://doi.org/10.1006/mthe.2001.0306.Full Text Link to Item
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Lohr, F., D. Y. Lo, D. A. Zaharoff, K. Hu, X. Zhang, Y. Li, Y. Zhao, M. W. Dewhirst, F. Yuan, and C. Y. Li. “Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation.” Cancer Res 61, no. 8 (April 15, 2001): 3281–84.Link to Item
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Li, C. Y., J. B. Little, K. Hu, W. Zhang, L. Zhang, M. W. Dewhirst, and Q. Huang. “Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures.” Cancer Res 61, no. 2 (January 15, 2001): 428–32.Link to Item
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Lohr, F., K. Hu, Q. Huang, L. Zhang, T. V. Samulski, M. W. Dewhirst, and C. Y. Li. “Enhancement of radiotherapy by hyperthermia-regulated gene therapy.” Int J Radiat Oncol Biol Phys 48, no. 5 (December 1, 2000): 1513–18. https://doi.org/10.1016/s0360-3016(00)00788-4.Full Text Link to Item
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Yuan, F., D. Zaharoff, X. Y. Zhang, F. Lohr, M. W. Dewhirst, and C. Y. Li. “Delivery of plasmid DNA through intratumoral infusion and electroporation.” American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed 48 (December 1, 2000): 173–76.
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Zaharoff, D., R. Barr, C. Y. Li, and F. Yuan. “Mobility of plasmid DNA subject to pulsed electric fields.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
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Hoffman, R. M. “Re: initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.” J Natl Cancer Inst 92, no. 17 (September 6, 2000): 1445–46. https://doi.org/10.1093/jnci/92.17.1445.Full Text Link to Item
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Li, C. Y., S. Shan, Q. Huang, and M. W. Dewhirst. “RESPONSE: re: initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.” J Natl Cancer Inst 92, no. 17 (September 6, 2000): 1445–46. https://doi.org/10.1093/jnci/92.17.1445-a.Full Text Link to Item
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Lohr, F., K. Hu, Z. Haroon, T. V. Samulski, Q. Huang, J. Beaty, M. W. Dewhirst, and C. Y. Li. “Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy.” Mol Ther 2, no. 3 (September 2000): 195–203. https://doi.org/10.1006/mthe.2000.0114.Full Text Link to Item
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Huang, Q., J. K. Hu, F. Lohr, L. Zhang, R. Braun, J. Lanzen, J. B. Little, M. W. Dewhirst, and C. Y. Li. “Heat-induced gene expression as a novel targeted cancer gene therapy strategy.” Cancer Res 60, no. 13 (July 1, 2000): 3435–39.Link to Item
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Li, C. Y., S. Shan, Q. Huang, R. D. Braun, J. Lanzen, K. Hu, P. Lin, and M. W. Dewhirst. “Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.” J Natl Cancer Inst 92, no. 2 (January 19, 2000): 143–47. https://doi.org/10.1093/jnci/92.2.143.Full Text Link to Item
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Li, C. Y., S. Shan, Y. Cao, and M. W. Dewhirst. “Role of incipient angiogenesis in cancer metastasis.” Cancer Metastasis Rev 19, no. 1–2 (2000): 7–11. https://doi.org/10.1023/a:1026538601947.Full Text Link to Item
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Yonghao, T., H. Qian, L. Chuanyuan, and D. W. Yandell. “Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines.” Chin Med Sci J 14, no. 4 (December 1999): 200–205.Link to Item
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Huang, Q., S. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li. “Noninvasive visualization of tumors in rodent dorsal skin window chambers.” Nat Biotechnol 17, no. 10 (October 1999): 1033–35. https://doi.org/10.1038/13736.Full Text Link to Item
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Little, J. B., C. Y. Li, H. Nagasawa, and H. Huang. “Influence of p53 expression on radiosensitivity of human normal and tumor cells.” Journal De Chimie Physique Et De Physico Chimie Biologique 95, no. 4 (January 1, 1998): 820–29. https://doi.org/10.1051/jcp:1998205.Full Text
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Yu, Y., C. Y. Li, and J. B. Little. “Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells.” Oncogene 14, no. 14 (April 10, 1997): 1661–67. https://doi.org/10.1038/sj.onc.1201026.Full Text Link to Item
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Suardet, L., C. Li, and J. B. Little. “Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line.” Int J Cancer 68, no. 1 (September 27, 1996): 126–31. https://doi.org/10.1002/(SICI)1097-0215(19960927)68:1<126::AID-IJC22>3.0.CO;2-8.Full Text Link to Item
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Huang, H., C. Y. Li, and J. B. Little. “Abrogation of P53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation.” Int J Radiat Biol 70, no. 2 (August 1996): 151–60. https://doi.org/10.1080/095530096145148.Full Text Link to Item
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Little, J. B., C. Li, H. Nagasawa, T. Pfenning, and H. Vetrovs. “Genomic instability and radiation mutagenesis.” Journal De Chimie Physique Et De Physico Chimie Biologique 93, no. 1 (January 1, 1996): 157–64. https://doi.org/10.1051/jcp/1996930157.Full Text
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Li, C. Y., H. Nagasawa, W. K. Dahlberg, and J. B. Little. “Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.” Oncogene 11, no. 9 (November 2, 1995): 1885–92.Link to Item
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Tsang, N. M., H. Nagasawa, C. Li, and J. B. Little. “Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation.” Oncogene 10, no. 12 (June 15, 1995): 2403–8.Link to Item
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Little, J. B., H. Nagasawa, P. C. Keng, Y. Yu, and C. Y. Li. “Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status.” J Biol Chem 270, no. 19 (May 12, 1995): 11033–36. https://doi.org/10.1074/jbc.270.19.11033.Full Text Link to Item
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Nagasawa, H., C. Y. Li, C. G. Maki, A. C. Imrich, and J. B. Little. “Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells.” Cancer Res 55, no. 9 (May 1, 1995): 1842–46.Link to Item
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Li, C. Y., L. Suardet, and J. B. Little. “Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect.” J Biol Chem 270, no. 10 (March 10, 1995): 4971–74. https://doi.org/10.1074/jbc.270.10.4971.Full Text Link to Item
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Li, C. ‐., H. Nagasawa, and J. B. Little. “Role of tumor suppressor genes in determining radiation‐induced G1 arrest and transformation in human cells.” Radiation Oncology Investigations 3, no. 6 (January 1, 1995): 268–71. https://doi.org/10.1002/roi.2970030604.Full Text
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Li, C., H. Nagasawa, N. M. Tsang, and J. B. Little. “Radiation-induced irreversible G(0)/G(1) block is abolished in human diploid fibroblasts transfected with the human papilloma virus E6 gene: Implication of the p53-Cip1/WAF1 pathway.” International Journal of Oncology 6, no. 1 (January 1, 1995): 233–36. https://doi.org/10.3892/ijo.6.1.233.Full Text
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Li, C. Y., D. W. Yandell, and J. B. Little. “Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus.” Mol Cell Biol 14, no. 7 (July 1994): 4373–79. https://doi.org/10.1128/mcb.14.7.4373-4379.1994.Full Text Link to Item
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Spiro, I. J., D. W. Yandell, C. Li, S. Saini, J. Ferry, J. Powelson, W. N. Katkov, and A. B. Cosimi. “Brief report: lymphoma of donor origin occurring in the porta hepatis of a transplanted liver.” N Engl J Med 329, no. 1 (July 1, 1993): 27–29. https://doi.org/10.1056/NEJM199307013290105.Full Text Link to Item
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Poremba, C., B. Dockhorn-Dworniczak, V. Merritt, C. Y. Li, G. Heidl, P. F. Tauber, W. Bocker, and D. W. Yandell. “Immature teratomas of different origin carried by a pregnant mother and her fetus.” Diagnostic Molecular Pathology 2, no. 2 (1993): 131–36.
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Li, C. Y., D. W. Yandell, and J. B. Little. “Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene.” Mol Carcinog 5, no. 4 (1992): 270–77. https://doi.org/10.1002/mc.2940050407.Full Text Link to Item
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Li, C. Y., D. W. Yandell, and J. B. Little. “Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro.” Somat Cell Mol Genet 18, no. 1 (January 1992): 77–87. https://doi.org/10.1007/BF01233450.Full Text Link to Item
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Book Sections
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Cartwright, I., and C. Y. Li. “Post-translational modifications of the hypoxia inducible factors.” In Tumor Hypoxia, 49–68, 2016. https://doi.org/10.1142/9789813147324_0002.Full Text
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Conference Papers
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Dikshit, A., J. Jin, S. Degan, J. Huang, M. Foster, A. Moseley, C. Li, and J. Zhang. “UBE2N promotes melanoma growth by maintaining MEK and FRA1 signaling.” In Journal of Investigative Dermatology, 138:S209–S209. ELSEVIER SCIENCE INC, 2018.Link to Item
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Dai, W., H. Liu, X. Xu, C. Li, Z. Liu, and Q. Wei. “189 Genetic variants in the autophagy pathway genes predict melanoma survival.” In Journal of Investigative Dermatology, 138:S32–S32. Elsevier BV, 2018. https://doi.org/10.1016/j.jid.2018.03.194.Full Text
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Kaakati, R., C. Chang, F. Li, X. Liu, F. Yuan, and C. Li. “1213 Exosome-mediated RNAi delivery for melanoma therapy.” In Journal of Investigative Dermatology, 138:S206–S206. Elsevier BV, 2018. https://doi.org/10.1016/j.jid.2018.03.1228.Full Text
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Xu, X., H. Liu, W. Dai, K. Chen, C. Li, Z. Liu, and Q. Wei. “187 Genetic variants of the ketone metabolism gene PDSS1 predict melanoma survival.” In Journal of Investigative Dermatology, 138:S32–S32. Elsevier BV, 2018. https://doi.org/10.1016/j.jid.2018.03.192.Full Text
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Dikshit, A., J. Y. Jin, J. Hwang, S. Degan, Y. Deng, C. Li, and J. Y. Zhang. “795 K63-Ubiquitin enzyme UBE2N and its variant UBE2V2 play crucial roles in melanoma cell growth and survival.” In Journal of Investigative Dermatology, 137:S137–S137. Elsevier BV, 2017. https://doi.org/10.1016/j.jid.2017.02.820.Full Text
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Li, F., X. Liu, and C. Li. “116 Oncogenic reprogramming of human primary melanocytes into potent tumor initiating cells.” In Journal of Investigative Dermatology, 137:S20–S20. Elsevier BV, 2017. https://doi.org/10.1016/j.jid.2017.02.130.Full Text
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Li, F., and C. Li. “116 Roles of caspases in melanoma response to cytotoxic treatment.” In Journal of Investigative Dermatology, 136:S21–S21. Elsevier BV, 2016. https://doi.org/10.1016/j.jid.2016.02.142.Full Text
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LIU, X. I. N. J. I. A. N., Fang Li, and Chuan-yuan Li. “Abstract LB-087: A facilitative role for caspase 3 in promoting genetic instability and carcinogenesis.” In Cancer Research, Vol. 75. American Association for Cancer Research (AACR), 2015. https://doi.org/10.1158/1538-7445.am2015-lb-087.Full Text
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Donato, A. L., Q. Huang, F. Li, X. Liu, and C. Li. “Apoptosis and caspase 3 stimulate melanoma tumor repopulation during vemurafenib and PD0325901 therapy.” In Journal of Investigative Dermatology, 133:S222–S222. NATURE PUBLISHING GROUP, 2013.Link to Item
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Kessler, Elizabeth Riley, Lih-Jen Su, Xiaoping Yang, Cem Altunbas, Thomas W. Flaig, Chuan-Yuan Li, and Brian D. Kavanagh. “Relationship of oral glycine with radiation-induced HIF1-alpha and tumor growth delay in a prostate cancer xenograft.” In Journal of Clinical Oncology, Vol. 31. AMER SOC CLINICAL ONCOLOGY, 2013. https://doi.org/10.1200/jco.2013.31.6_suppl.81.Full Text Link to Item
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Huang, Q., F. Li, X. Liu, W. Li, F. Liu, B. O’Sullivan, X. Wang, and C. Li. “A counter-intuitive role for apoptotic caspase 3 in treatment of melanoma and other cancers.” In Journal of Investigative Dermatology, 132:S124–S124. NATURE PUBLISHING GROUP, 2012.Link to Item
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Li, F., Q. Huang, J. Chen, D. R. Roop, and C. Li. “A facilitative role for caspase 3 & caspase 7 in wound healing and tissue regeneration.” In Journal of Investigative Dermatology, 132:S137–S137. NATURE PUBLISHING GROUP, 2012.Link to Item
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Liu, X., F. Li, E. A. Stublefield, B. Blanchard, T. Richards, G. A. Larson, Q. Huang, T. A. Benke, J. R. Sladek, and C. Li. “Direct reprogramming of human fibroblasts int dopaminergic neurons.” In Journal of Investigative Dermatology, 132:S138–S138. NATURE PUBLISHING GROUP, 2012.Link to Item
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Yan, B., H. Wang, J. S. Bedford, M. W. Dewhirst, and C. Li. “A novel role of DNA fragmentation factor as a tumor suppressor through maintaining genomic stability.” In Journal of Clinical Oncology, 24:546S-546S. AMER SOC CLINICAL ONCOLOGY, 2006.Link to Item
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Yan, Bin, Huili Wang, Mark W. Dewhirst, Joel S. Bedford, and Chuan-Yuan Li. “A novel role of DNA fragmentation factor as a tumor suppressor through maintaining genetic stability.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.Link to Item
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Siddiqui, F., P. R. Avery, S. M. LaRue, M. L. Hauck, M. W. Dewhirst, C. Li, and R. L. Ullrich. “A phase I hyperthermia-induced interleukin-12 gene-therapy trial in a spontaneously arising feline soft tissue sarcoma model.” In International Journal of Radiation Oncology Biology Physics, 60:S577–S577. ELSEVIER SCIENCE INC, 2004.Link to Item
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Wang, Y., and C. Y. Li. “Adenovirus dissemination in convention-enhanced delivery and its control with a polymeric vehicle.” In Abstracts of Papers of the American Chemical Society, 226:U468–U468. AMER CHEMICAL SOC, 2003.Link to Item
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Li, C. Y., and M. W. Dewhirst. “Control of gene therapy by the heat shock promoter.” In Progress in Radio Oncology Vii, Proceedings, edited by H. D. Kogelnik, P. Lukas, and F. Sedlmayer, 577–86. MEDIMOND S R L, 2001.Link to Item
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Yuan, F., D. Zaharoff, X. Y. Zhang, F. Lohr, M. W. Dewhirst, and C. Y. Li. “Delivery of plasmid DNA through intratumoral infusion and electroporation.” In Asme International Mechanical Engineering Congress and Exposition, Proceedings (Imece), 2000-F:125–28, 2000. https://doi.org/10.1115/IMECE2000-2231.Full Text
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