Chuan-Yuan Li | Scholars@Duke

Chuan-Yuan Li
Professor of Dermatology

Dr. Li is the Vice Chair for Research in the Dept. of Dermatology. Some of the areas that his laboratory conducts research on include:
•Tumor response to therapy, with special emphasis on skin cancer such as melanoma and squamous cell carcinoma where current treatment outcomes are dismal;
•Stem cell and regenerative medicine, we will conduct research to investigate novel mechanisms of stem cell biology so that knowledge gained can be translated into regenerative medicine;
•Mechanisms of carcinogenesis, with emphasis on skin cancers, so that better strategies could be devised to prevent and treat these cancers.

Within these broad areas we have different ongoing research projects. Examples of some of the research projects include:

Unconventional roles of caspases in tumor response to chemotherapy or radiotherapy. A recent area of our laboratory has been the relationship of cell death and repopulation in tumors undergoing radiation and chemotherapy. In our studies, we discovered that cell death is a key trigger for tumor cell repopulation in radiation and chemotherapy. Unexpectedly, caspase 3, which is an executioner in cell death, positively regulate paracrine signaling from dying cells to stimulate proliferation of surviving tumor cells. Furthermore, we found that higher levels of pretreat caspase 3 activation is correlated with worse outcome in head and neck and breast cancers. This is again quite unexpected and contrary to established paradigm. We are currently actively studying the relevance of this mechanism in other malignancies including melanoma. We believe such studies will not only yield promising novel treatments for cancer but also new biomarkers of diagnostic or prognostic values.

Positive roles of apoptosis in wound healing and tissue regeneration. Another area of our research is the relationship between apoptosis and wound healing/tissue regeneration. In our recent research we discovered that cellular apoptosis, in particular, apoptotic caspases 3&7, play key roles in promoting skin wound healing and tissue regeneration. We named this pathway the “Phoenix Rising” pathway for wound healing and tissue regeneration. We are actively studying this mechanism with the hope that knowledge gained could be used for regenerative medicine.

Molecular factors involved in stem cell biology regulation and trans-differentiation. Recently our lab started to investigate molecular mechanisms involved in the maintenance and self-renewal of stem cells. Our efforts led to the discovery that caspases 8&3 play critical roles in the induction of pluripotent stem cells from human fibroblasts. We are in the process of dissecting additional roles of caspases in embryonic stem cells.

Direct reprogramming of one differentiated cell type into another differentiated cell type. Recently, we have been able to directly reprogram human fibroblast cells into dopaminergic neurons, which have great potential in Parksinson’s Disease. We are actively pursuing similar studies to reprogram skin fibroblasts into various cells of interest, including other skin cells, through direct reprogramming.

Current Appointments & Affiliations

Professor of Dermatology, Dermatology, Clinical Science Departments 2011
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1997
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016

Contact Information

Box 3135 Med Ctr, Durham, NC 27710
Box 3135, DUMC, C303a/Lsrc, Durham, NC 27710
chuan.li@duke.edu (919) 613-8754

Background
Education, Training, & Certifications
- D.Sc., Harvard University 1992
- B.S., Chinese Academy of Sciences (China) 1987
Duke Appointment History
- Adjunct Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2006 - 2011
- Research Professor in Radiation Oncology, Radiation Oncology, Clinical Science Departments 2006
- Assistant Research Professor of Pathology, Pathology, Clinical Science Departments 2005 - 2006
- Associate Research Professor in Radiation Oncology, Radiation Oncology, Clinical Science Departments 2002 - 2005
- Assistant Research Professor in Radiation Oncology, Radiation Oncology, Clinical Science Departments 1997 - 2002
- Instructor, Temporary in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1997
Expertise
Subject Headings
- Caspase 3
- Wound Healing
Research
Selected Grants
- Pro-oncogenic roles of apoptotic caspases awarded by National Institutes of Health 2014 - 2029
- Targeting apoptotic caspases to enhance cancer radiotherapy awarded by National Institutes of Health 2017 - 2022
- Necroptotic genes in cancer cellular response to radiation awarded by National Institutes of Health 2017 - 2022
- Exploring BCL-XL addiction in pancreatic ductal adenocarcinoma awarded by National Institutes of Health 2016 - 2019
- Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus awarded by National Institutes of Health 2016 - 2018
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2018
- The "Phoenix Rising" pathway of tumor repopulation during radiotherapy awarded by National Institutes of Health 2011 - 2017
- Mechanisms involved in HP802-mediated wound healing awarded by Smith & Nephew, Inc 2014 - 2016
- Molecular Mechanisms of Tumor Response to Cytotoxic Chemotherapy awarded by National Institutes of Health 2011 - 2016
- HIF Genes in Head and Neck Cancer Radiotherapy awarded by National Institutes of Health 2012 - 2015
- A mechanistic investigation of space radiation-induced carcinogensis awarded by National Aeronautics and Space Administration 2012 - 2013
- Mechanisms of HZE Particle-Induced Genetic Instability/Carcinogenic Transformation awarded by National Aeronautics and Space Administration 2003 - 2007
- Imaging Tumor Hypoxia in a Transgenic Mouse Model awarded by National Institutes of Health 2003 - 2007
- Molecular Characterization of the Role of SOD Genes in Mammalian Cellular Response: Low Dose Ionizing Radiation awarded by Department of Energy 2003 - 2007
- Hyperthemia-Mediated Gene Therapy Approach for Cancer awarded by National Institutes of Health 1999 - 2006
- Cell Viability in Implantable Diffusion Chambers awarded by National Institutes of Health 2000 - 2005
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Dikshit, A, Jin, J, Hwang, J, Degan, S, Deng, Y, Li, C, and Zhang, J. "795 K63-Ubiquitin enzyme UBE2N and its variant UBE2V2 play crucial roles in melanoma cell growth and survival." May 2017. Full Text
  - Li, F, Liu, X, and Li, C. "116 Oncogenic reprogramming of human primary melanocytes into potent tumor initiating cells." May 2017. Full Text
  - Li, F, and Li, C. "116 Roles of caspases in melanoma response to cytotoxic treatment." May 2016. Full Text
  - LIU, X, Li, F, and Li, C-Y. "Abstract LB-087: A facilitative role for caspase 3 in promoting genetic instability and carcinogenesis." August 1, 2015. Full Text
  - Donato, AL, Huang, Q, Li, F, Liu, X, and Li, C. "Apoptosis and caspase 3 stimulate melanoma tumor repopulation during vemurafenib and PD0325901 therapy." May 2013. Link to Item
  - Kessler, ER, Su, L-J, Yang, X, Altunbas, C, Flaig, TW, Li, C-Y, and Kavanagh, BD. "Relationship of oral glycine with radiation-induced HIF1-alpha and tumor growth delay in a prostate cancer xenograft." February 20, 2013. Full Text Link to Item
  - Huang, Q, Li, F, Liu, X, Li, W, Liu, F, O'Sullivan, B, Wang, X, and Li, C. "A counter-intuitive role for apoptotic caspase 3 in treatment of melanoma and other cancers." May 2012. Link to Item
  - Li, F, Huang, Q, Chen, J, Roop, DR, and Li, C. "A facilitative role for caspase 3 & caspase 7 in wound healing and tissue regeneration." May 2012. Link to Item
  - Liu, X, Li, F, Stublefield, EA, Blanchard, B, Richards, T, Larson, GA, Huang, Q, Benke, TA, Sladek, JR, and Li, C. "Direct reprogramming of human fibroblasts int dopaminergic neurons." May 2012. Link to Item
  - Yan, B, Wang, H, Bedford, JS, Dewhirst, MW, and Li, C. "A novel role of DNA fragmentation factor as a tumor suppressor through maintaining genomic stability." June 20, 2006. Link to Item
  - Siddiqui, F, Avery, PR, LaRue, SM, Hauck, ML, Dewhirst, MW, Li, C, and Ullrich, RL. "A phase I hyperthermia-induced interleukin-12 gene-therapy trial in a spontaneously arising feline soft tissue sarcoma model." 2004. Link to Item
  - Wang, Y, and Li, CY. "Adenovirus dissemination in convention-enhanced delivery and its control with a polymeric vehicle." September 2003. Link to Item
  - Li, CY, and Dewhirst, MW. "Control of gene therapy by the heat shock promoter." 2001. Link to Item
- Journal Articles
  - Zhou, M, Liu, X, Li, Z, Huang, Q, Li, F, and Li, C-Y. "Caspase-3 regulates the migration, invasion, and metastasis of colon cancer cells." International journal of cancer (March 10, 2018). Full Text
  - Liu, H, Wang, C, Lee, S, Deng, Y, Wither, M, Oh, S, Ning, F, Dege, C, Zhang, Q, Liu, X, Johnson, AM, Zang, J, Chen, Z, Janknecht, R, Hansen, K, Marrack, P, Li, C-Y, Kappler, JW, Hagman, J, and Zhang, G. "Clipping of arginine-methylated histone tails by JMJD5 and JMJD7." Proceedings of the National Academy of Sciences of the United States of America 114, no. 37 (September 2017): E7717-E7726. Full Text
  - Cartwright, IM, Liu, X, Zhou, M, Li, F, and Li, C-Y. "Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis." eLife 6 (July 10, 2017). Full Text
  - Liu, X, Li, F, Huang, Q, Zhang, Z, Zhou, L, Deng, Y, Zhou, M, Fleenor, DE, Wang, H, Kastan, MB, and Li, C-Y. "Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells." Cell research 27, no. 6 (June 2017): 764-783. Full Text
  - Feng, X, Yu, Y, He, S, Cheng, J, Gong, Y, Zhang, Z, Yang, X, Xu, B, Liu, X, Li, C-Y, Tian, L, and Huang, Q. "Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism." Cancer letters 385 (January 2017): 12-20. Full Text
  - Li, F, Liu, X, Sampson, JH, Bigner, DD, and Li, C-Y. "Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors." Cancer research 76, no. 17 (September 2016): 5143-5150. Full Text
  - Liu, X, He, Y, Li, F, Huang, Q, Kato, TA, Hall, RP, and Li, C-Y. "Redefining the roles of apoptotic factors in carcinogenesis." Molecular & cellular oncology 3, no. 3 (May 2016): e1054550-. Full Text
  - Yu, Y, Tian, L, Feng, X, Cheng, J, Gong, Y, Liu, X, Zhang, Z, Yang, X, He, S, Li, C-Y, and Huang, Q. "eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation." Cancer letters 375, no. 1 (May 2016): 31-38. Full Text
  - Liu, X, Zhou, M, Mei, L, Ruan, J, Hu, Q, Peng, J, Su, H, Liao, H, Liu, S, Liu, W, Wang, H, Huang, Q, Li, F, and Li, C-Y. "Key roles of necroptotic factors in promoting tumor growth." Oncotarget 7, no. 16 (April 2016): 22219-22233. Full Text
  - Feng, X, Tian, L, Zhang, Z, Yu, Y, Cheng, J, Gong, Y, Li, C-Y, and Huang, Q. "Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis." Oncotarget 6, no. 32 (October 2015): 32353-32367. Full Text
  - Zhang, Z, Wang, M, Zhou, L, Feng, X, Cheng, J, Yu, Y, Gong, Y, Zhu, Y, Li, C, Tian, L, and Huang, Q. "Increased HMGB1 and cleaved caspase-3 stimulate the proliferation of tumor cells and are correlated with the poor prognosis in colorectal cancer." Journal of experimental & clinical cancer research : CR 34 (May 20, 2015): 51-. Full Text
  - Liu, X, He, Y, Li, F, Huang, Q, Kato, TA, Hall, RP, and Li, C-Y. "Caspase-3 promotes genetic instability and carcinogenesis." Molecular cell 58, no. 2 (April 9, 2015): 284-296. Full Text
  - Cheng, J, Tian, L, Ma, J, Gong, Y, Zhang, Z, Chen, Z, Xu, B, Xiong, H, Li, C, and Huang, Q. "Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma." Molecular oncology 9, no. 1 (January 2015): 105-114. Full Text
  - Cheng, J, Tian, L, Ma, J, Gong, Y, Zhang, Z, Chen, Z, Xu, B, Xiong, H, Li, C, and Huang, Q. "Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma." Molecular Oncology 9, no. 1 (January 1, 2015): 105-114. Full Text
  - Liu, X, He, Y, Li, F, Huang, Q, Kato, TA, Hall, RP, and Li, CY. "Caspase-3 Promotes Genetic Instability and Carcinogenesis." Molecular Cell 58, no. 2 (January 1, 2015): 284-296. Full Text
  - Wei, F, Wang, H, Chen, X, Li, C, and Huang, Q. "Dissecting the roles of E1A and E1B in adenoviral replication and RCAd-enhanced RDAd transduction efficacy on tumor cells." Cancer biology & therapy 15, no. 10 (October 2014): 1358-1366. Full Text
  - Liu, X, Huang, Q, Li, F, and Li, C-Y. "Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression." Science China. Life sciences 57, no. 9 (September 2014): 867-875. Full Text
  - Donato, AL, Huang, Q, Liu, X, Li, F, Zimmerman, MA, and Li, C-Y. "Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy." The Journal of investigative dermatology 134, no. 6 (June 2014): 1686-1692. Full Text
  - Donato, AL, Huang, Q, Liu, X, Li, F, Zimmerman, MA, and Li, C-Y. "Caspase 3 Promotes Surviving Melanoma Tumor Cell Growth after Cytotoxic Therapy." Journal of Investigative Dermatology 134, no. 6 (June 2014): 1686-1692. Full Text
  - Liu, C, Li, C-Y, and Yuan, F. "Mathematical modeling of the Phoenix Rising pathway." PLoS computational biology 10, no. 2 (February 6, 2014): e1003461-. Full Text
  - Zhou, M, Wang, H, Zhou, K, Luo, X, Pan, X, Shi, B, Jiang, H, Zhang, J, Li, K, Wang, H-M, Gao, H, Lu, S, Yao, M, Mao, Y, Wang, H-Y, Yang, S, Gu, J, Li, C, and Li, Z. "A novel EGFR isoform confers increased invasiveness to cancer cells." Cancer Res 73, no. 23 (December 1, 2013): 7056-7067. Full Text Link to Item
  - Zhou, D, and Li, CY. "Preface." Translational Cancer Research 2, no. 5 (October 1, 2013): 370-371. Full Text
  - Zimmerman, MA, Huang, Q, Li, F, Liu, X, and Li, C-Y. "Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy." Semin Radiat Oncol 23, no. 4 (October 2013): 288-295. (Review) Full Text Link to Item
  - Su, LJ, Yang, X, Altunbas, C, Flaig, TW, Li, CY, and Kavanagh, BD. "Relationship of oral glycine with radiation-induced HIF1-alpha and tumor growth delay in a prostate cancer xenograft." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31, no. 6_suppl (February 2013): 81-.
  - Wei, F, Wang, H, Zhang, J, Chen, X, Li, C, and Huang, Q. "Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12. (Published online)" J Exp Clin Cancer Res 32 (January 26, 2013): 5-. Full Text Link to Item
  - Luo, Y, Qiu, Z, Tian, L, Zhu, G, Feng, Y, Yi, M, Chen, X, Wang, L, Li, C, and Huang, Q. "Identification of novel predictive markers for the prognosis of pancreatic ductal adenocarcinoma." Human Pathology 44, no. 1 (2013): 69-76. Full Text
  - Ma, J, Tian, L, Cheng, J, Chen, Z, Xu, B, Wang, L, Li, C, and Huang, Q. "Sonic Hedgehog Signaling Pathway Supports Cancer Cell Growth during Cancer Radiotherapy." PLoS ONE 8, no. 6 (2013). Full Text
  - Yang, X, Kessler, E, Su, L-J, Thorburn, A, Frankel, AE, Li, Y, Rosa, FGL, Shen, J, Li, C-Y, Varella-Garcia, M, Glodé, LM, and Flaig, TW. "Diphtheria toxin-epidermal growth factor fusion protein DAB ₃₈₉EGF for the treatment of bladder cancer." Clinical Cancer Research 19, no. 1 (2013): 148-157. Full Text
  - Zhou, L, Li, K, Luo, Y, Tian, L, Wang, M, Li, C, and Huang, Q. "Novel prognostic markers for patients with triple-negative breast cancer." Human Pathology (2013). Full Text
  - Zhou, L, Li, K, Luo, Y, Tian, L, Wang, M, Li, C, and Huang, Q. "Novel prognostic markers for patients with triple-negative breast cancer." Human Pathology 44, no. 10 (2013): 2180-2187. Full Text
  - Zhou, L, Luo, Y, Li, K, Tian, L, Wang, M, Li, C, and Huang, Q. "Molecular markers of therapeutic resistance in breast cancer." Human Pathology (2013). Full Text
  - Zhou, L, Luo, Y, Li, K, Tian, L, Wang, M, Li, C, and Huang, Q. "Molecular markers of therapeutic resistance in breast cancer." Human Pathology 44, no. 7 (2013): 1421-1428. Full Text
  - Kon, T, Zhang, X, Huang, Q, Yang, Z, Liu, S, Yan, B, Li, F, Wang, H, and Li, C-Y. "Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA." Transl Cancer Res 1, no. 2 (June 2012): 4-14. Full Text Link to Item
  - Li, CY. "Inhibitors of DNA repair for cancer therapy, ready for prime time?." Translational Cancer Research 1, no. 1 (June 1, 2012): 4-5. Full Text
  - Brogan, J, Li, F, Li, W, He, Z, Huang, Q, and Li, C-Y. "Imaging molecular pathways: reporter genes." Radiat Res 177, no. 4 (April 2012): 508-513. (Review) Link to Item
  - Liu, X, Li, F, Stubblefield, EA, Blanchard, B, Richards, TL, Larson, GA, He, Y, Huang, Q, Tan, A-C, Zhang, D, Benke, TA, Sladek, JR, Zahniser, NR, and Li, C-Y. "Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells." Cell Research 22, no. 2 (2012): 321-332. Full Text
  - Wang, H, Wei, F, Zhang, J, Wang, F, Li, H, Chen, X, Xie, K, Wang, Y, Li, C, and Huang, Q. "A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy." Tumor Biology (2012): 1-9. Full Text
  - Wang, H, Wei, F, Zhang, J, Wang, F, Li, H, Chen, X, Xie, K, Wang, Y, Li, C, and Huang, Q. "A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy." Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 33, no. 4 (2012): 1245-1253. Full Text
  - Yan, B, Ouyang, R, Huang, C, Liu, F, Neill, D, Li, C, and Dewhirst, M. "Heat induces gene amplification in cancer cells." Biochemical and Biophysical Research Communications 427, no. 3 (2012): 473-477. Full Text
  - Zhang, S, Wu, J, Wu, X, Xu, P, Tian, Y, Yi, M, Liu, X, Dong, X, Wolf, F, Li, C, and Huang, Q. "Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-Dose chemotherapeutic drugs." Investigative Ophthalmology and Visual Science 53, no. 6 (2012): 2675-2684. Full Text
  - Huang, Q, Li, F, Liu, X, Li, W, Shi, W, Liu, F-F, O'Sullivan, B, He, Z, Peng, Y, Tan, A-C, Zhou, L, Shen, J, Han, G, Wang, X-J, Thorburn, J, Thorburn, A, Jimeno, A, Raben, D, Bedford, JS, and Li, C-Y. "Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy." Nature Medicine 17, no. 7 (2011): 860-866. Full Text
  - Li, W, Li, F, Huang, Q, Shen, J, Wolf, F, He, Y, Liu, X, Hu, YA, Bedford, JS, and Li, C-Y. "Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo." Cancer Research 71, no. 12 (2011): 4130-4137. Full Text
  - Liu, X, Qian, Q, Xu, P, Wolf, F, Zhang, J, Zhang, D, Li, C, and Huang, Q. "A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling." Human Gene Therapy 22, no. 4 (2011): 427-437. Full Text
  - Wolf, F, Li, W, Li, F, and Li, C-Y. "Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours." International Journal of Hyperthermia 27, no. 5 (2011): 427-434. Full Text
  - Wolf, F, Li, W, Li, F, and Li, C-Y. "Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy." International Journal of Radiation Oncology Biology Physics 79, no. 1 (2011): 233-238. Full Text
  - Li, C-Y, and Hook, AMV. "Science signaling podcast: 23 February 2010." Science Signaling 3, no. 110 (2010): pc5-. Full Text
  - Li, C-Y. "Need radioprotection? A MEPE/OF45 mimetic may do the job." Cell Cycle 9, no. 12 (2010): 2271--.
  - Li, F, He, Z, Shen, J, Huang, Q, Li, W, Liu, X, He, Y, Wolf, F, and Li, C-Y. "Apoptotic caspases regulate induction of iPSCs from human fibroblasts." Cell Stem Cell 7, no. 4 (2010): 508-520. Full Text
  - Li, F, Huang, Q, Chen, J, Peng, Y, Roop, DR, Bedford, JS, and Li, C-Y. "Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration." Science Signaling 3, no. 110 (2010): ra13-. Full Text
  - Liu, X, Li, J, Tian, Y, Xu, P, Chen, X, Xie, K, Qiu, Z, Wang, Y, Zhang, D, Wolf, F, Li, C, and Huang, Q. "Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2=neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide." Human Gene Therapy 21, no. 2 (2010): 157-170. Full Text
  - Yan, B, Wang, H, Xie, D, Wakamatsu, N, Anscher, MS, Dewhirst, MW, Mitchel, REJ, Chen, BJ, and Li, C-Y. "Increased skin carcinogenesis in caspase-activated DNase knockout mice." Carcinogenesis 30, no. 10 (October 2009): 1776-1780. Full Text Link to Item
  - Moon, EJ, Li, C-Y, Batinic-Haberle, I, and Dewhirst, M. "Hyperthermia-induced HIF-1 activation and tumor reoxygenation." CANCER RESEARCH 69 (May 1, 2009). Link to Item
  - Ji, X, Cheng, L, Wei, F, Li, H, Wang, M, Tian, Y, Chen, X, Wang, Y, Wolf, F, Li, C, and Huang, Q. "Noninvasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging." Investigative Ophthalmology and Visual Science 50, no. 12 (2009): 5544-5551. Full Text
  - Ji, X, Zhang, J, Cheng, L, Wei, F, Li, H, Liu, X, Chen, X, Li, C, Wang, Y, and Huang, Q. "Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model." Experimental Eye Research 89, no. 2 (2009): 193-199. Full Text
  - Liu, X, Wu, J, Zhang, S, Li, C, and Huang, Q. "Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy." Cancer Gene Therapy 16, no. 11 (2009): 861-872. Full Text
  - Liu, X-J, Ji, X-D, Tian, Y-H, Chen, X-F, Xie, K-C, Wu, J-H, Zhang, S-H, Xu, P, Li, C-Y, and Huang, Q. "The effect of cobalt chloride on adenovirus gene expression." Tumor 29, no. 7 (2009): 603-610. Full Text
  - Wei, F, Wang, H-P, Chen, X-F, Li, C-Y, and Huang, Q. "Construction and characterization of oncolytic adenovirus controlled under heat shock protein70 gene promoter." Progress in Biochemistry and Biophysics 36, no. 12 (2009): 1536-1543. Full Text
  - Yan, B, Peng, Y, and Li, C-Y. "Molecular analysis of genetic instability caused by chronic inflammation." Methods in molecular biology (Clifton, N.J.) 512 (2009): 15-28. Full Text
  - Viola, RJ, Provenzale, JM, Li, F, Li, C-Y, Yuan, H, Tashjian, J, and Dewhirst, MW. "In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy." AJR Am J Roentgenol 191, no. 6 (December 2008): 1779-1784. Full Text Link to Item
  - Siddiqui, F, Avery, PR, Li, C-Y, Zhang, X, LaRue, SM, Dewhirst, MW, and Ullrich, RL. "Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy." Cancer Invest 26, no. 6 (July 2008): 553-561. Full Text Link to Item
  - Li, W, Li, F, Huang, Q, Frederick, B, Bao, S, and Li, C-Y. "Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo." Cancer Research 68, no. 13 (2008): 4990-4997. Full Text
  - Wang, F, Chen, X-F, Wei, F, Wu, J-H, Xie, K-C, Han, Y-H, Yi, M-Y, Li, C-Y, and Huang, Q. "Response of hypoxia-response element in human liver cancer cells to different microenvironments." Tumor 28, no. 5 (2008): 367-371. Full Text
  - Wu, J, Zhang, S, Wu, X, Dong, X, Xu, P, Liu, X, Li, C, and Huang, Q. "Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus." Vision Research 48, no. 15 (2008): 1648-1654. Full Text
  - Zhang, S-H, Wu, J-H, Wu, X-B, Dong, X-Y, Liu, X-J, Li, C-Y, and Huang, Q. "Distinctive gene transduction efficiencies of commonly used viral vectors in the retina." Current Eye Research 33, no. 1 (2008): 81-90. Full Text
  - Dewhirst, MW, Cao, Y, Li, CY, and Moeller, B. "Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy." Radiother Oncol 83, no. 3 (June 2007): 249-255. (Review) Full Text Link to Item
  - Cao, Y, Sonveaux, P, Liu, S, Zhao, Y, Mi, J, Clary, BM, Li, C-Y, Kontos, CD, and Dewhirst, MW. "Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth." Cancer Res 67, no. 8 (April 15, 2007): 3835-3844. Full Text Link to Item
  - Li, F, Sonveaux, P, Rabbani, ZN, Liu, S, Yan, B, Huang, Q, Vujaskovic, Z, Dewhirst, MW, and Li, C-Y. "Regulation of HIF-1alpha stability through S-nitrosylation." Mol Cell 26, no. 1 (April 13, 2007): 63-74. Full Text Link to Item
  - Siddiqui, F, Li, C-Y, Larue, SM, Poulson, JM, Avery, PR, Pruitt, AF, Zhang, X, Ullrich, RL, Thrall, DE, Dewhirst, MW, and Hauck, ML. "A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas." Mol Cancer Ther 6, no. 1 (January 2007): 380-389. Full Text Link to Item
  - Yan, B, Wang, H, Li, F, and Li, C-Y. "Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation." Br J Cancer 95, no. 12 (December 18, 2006): 1696-1700. Full Text Link to Item
  - Yan, B, Wang, H, Rabbani, ZN, Zhao, Y, Li, W, Yuan, Y, Li, F, Dewhirst, MW, and Li, C-Y. "Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation." Cancer Res 66, no. 24 (December 15, 2006): 11565-11570. Full Text Link to Item
  - Siddiqui, F, Ehrhart, EJ, Charles, B, Chubb, L, Li, C-Y, Zhang, X, Larue, SM, Avery, PR, Dewhirst, MW, and Ullrich, RL. "Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct." Int J Hyperthermia 22, no. 7 (November 2006): 587-606. Full Text Link to Item
  - Yan, B, Wang, H, Wang, H, Zhuo, D, Li, F, Kon, T, Dewhirst, M, and Li, C-Y. "Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner." Oncogene 25, no. 39 (August 31, 2006): 5370-5376. Full Text Link to Item
  - Liu, Y, Kon, T, Li, C, and Zhong, P. "High intensity focused ultrasound-induced gene activation in solid tumors." J Acoust Soc Am 120, no. 1 (July 2006): 492-501. Link to Item
  - Yan, B, Wang, H, Bedford, JS, Dewhirst, MW, and Li, C. "A novel role of DNA fragmentation factor as a tumor suppressor through maintaining genomic stability." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 24, no. 18_suppl (June 2006): 10023-.
  - Mi, J, Sarraf-Yazdi, S, Zhang, X, Cao, Y, Dewhirst, MW, Kontos, CD, Li, C-Y, and Clary, BM. "A comparison of antiangiogenic therapies for the prevention of liver metastases." J Surg Res 131, no. 1 (March 2006): 97-104. Full Text Link to Item
  - Siddiqui, F, Li, C-Y, Zhang, X, Larue, SM, Dewhirst, MW, Ullrich, RL, and Avery, PR. "Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy." Int J Hyperthermia 22, no. 2 (March 2006): 117-134. Full Text Link to Item
  - Wang, Y, Wang, H, Li, C-Y, and Yuan, F. "Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery." Mol Cancer Ther 5, no. 2 (February 2006): 362-366. Full Text Link to Item
  - Yan, B, Wang, H, Kon, T, and Li, C-Y. "Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection." Braz J Med Biol Res 39, no. 2 (February 2006): 169-176. Link to Item
  - Yan, B, Wang, H, Peng, Y, Hu, Y, Wang, H, Zhang, X, Chen, Q, Bedford, JS, Dewhirst, MW, and Li, C-Y. "A unique role of the DNA fragmentation factor in maintaining genomic stability." Proc Natl Acad Sci U S A 103, no. 5 (January 31, 2006): 1504-1509. Full Text Link to Item
  - Chuang, EY, Chen, X, Tsai, M-H, Yan, H, Li, C-Y, Mitchell, JB, Nagasawa, H, Wilson, PF, Peng, Y, Fitzek, MM, Bedford, JS, and Little, JB. "Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma." Cancer Research 66, no. 7 (2006): 3428-3433. Full Text
  - Liu, S, Zhu, J, Wang, H, Kon, T, and Yuan Li, C. "427. Adenovirus Mediated GRP94/gp96 Expression in Treatment of Neuroblastoma." Molecular Therapy 13 (2006): S164-S164. Full Text
  - Liu, Y, Hu, Z, Lu, X, Kon, T, Li, C, and Zhong, P. "954. High Intensity Focused Ultrasound (HIFU) Induced Trans-Gene Activation in Solid Tumors." Molecular Therapy 13 (2006): S368-S368. Full Text
  - Liu, Y, Kon, T, Li, C, and Zhong, P. "High intensity focused ultrasound induced gene activation in solid tumors." AIP Conference Proceedings 829 (2006): 588-592. Full Text
  - Liu, Y, Kon, T, Li, C, and Zhong, P. "High intensity focused ultrasound-induced gene activation in sublethally injured tumor cells in vitro." J Acoust Soc Am 118, no. 5 (November 2005): 3328-3336. Link to Item
  - Liu, S, Wang, H, Yang, Z, Kon, T, Zhu, J, Cao, Y, Li, F, Kirkpatrick, J, Nicchitta, CV, and Li, C-Y. "Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression." Cancer Res 65, no. 20 (October 15, 2005): 9126-9131. Full Text Link to Item
  - Wang, Y, Liu, S, Li, C-Y, and Yuan, F. "A novel method for viral gene delivery in solid tumors." Cancer Res 65, no. 17 (September 1, 2005): 7541-7545. Full Text Link to Item
  - Moeller, BJ, Dreher, MR, Rabbani, ZN, Schroeder, T, Cao, Y, Li, CY, and Dewhirst, MW. "Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity." Cancer Cell 8, no. 2 (August 2005): 99-110. Full Text Link to Item
  - Cao, Y, Li, C-Y, Moeller, BJ, Yu, D, Zhao, Y, Dreher, MR, Shan, S, and Dewhirst, MW. "Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation." Cancer Res 65, no. 13 (July 1, 2005): 5498-5505. Full Text Link to Item
  - Rao, PV, Deng, P, Maddala, R, Epstein, DL, Li, C-Y, and Shimokawa, H. "Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. (Published online)" Mol Vis 11 (April 27, 2005): 288-297. Link to Item
  - Wang, Y, Yang, Z, Liu, S, Kon, T, Krol, A, Li, C-Y, and Yuan, F. "Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery." Br J Cancer 92, no. 8 (April 25, 2005): 1414-1420. Full Text Link to Item
  - Li, C-Y, Huang, Q, and Kung, H-F. "Cytokine and immuno-gene therapy for solid tumors." Cellular & molecular immunology. 2, no. 2 (2005): 81-91.
  - Plathow, C, Lohr, F, Divkovic, G, Rademaker, G, Farhan, N, Peschke, P, Zuna, I, Debus, J, Claussen, CD, Kauczor, H-U, Li, CY, Jenne, J, and Huber, P. "Focal gene induction in the liver of rats by a heat-inducible promoter using focused ultrasound hyperthermia: Preliminary results." Investigative Radiology 40, no. 11 (2005): 729-735. Full Text
  - Zhang, X, Kon, T, Wang, H, Li, F, Huang, Q, Rabbani, ZN, Kirkpatrick, JP, Vujaskovic, Z, Dewhirst, MW, and Li, C-Y. "Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha." Cancer Res 64, no. 22 (November 15, 2004): 8139-8142. Full Text Link to Item
  - Moeller, BJ, Cao, Y, Vujaskovic, Z, Li, CY, Haroon, ZA, and Dewhirst, MW. "The relationship between hypoxia and angiogenesis." Semin Radiat Oncol 14, no. 3 (July 2004): 215-221. (Review) Full Text Link to Item
  - Herskind, C, Fleckenstein, K, Lohr, J, Li, CY, Wenz, F, and Lohr, F. "Antitumoral action of interferons and interleukins in combination with radiotherapy. Part II: Radiobiological and immunologic strategies." Strahlentherapie und Onkologie 180, no. 6 (June 1, 2004): 331-339. (Review) Full Text
  - Moeller, BJ, Cao, Y, Li, CY, and Dewhirst, MW. "Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules." Cancer Cell 5, no. 5 (May 2004): 429-441. Link to Item
  - Herskind, C, Fleckenstein, K, Lohr, J, Li, CY, Wenz, F, and Lohr, F. "Antitumoral Action of Interferons and Interleukins in Combination with Radiotherapy. Part I: Immunologic Basis." Strahlentherapie und Onkologie 180, no. 4 (April 1, 2004): 187-193. (Review) Full Text
  - Zhang, X, Huang, Q, Yang, Z, Li, Y, and Li, C-Y. "GW112, a novel antiapoptotic protein that promotes tumor growth." Cancer Res 64, no. 7 (April 1, 2004): 2474-2481. Link to Item
  - Huang, Q, Zhang, X, Wang, H, Yan, B, Kirkpatrick, J, Dewhrist, MW, and Li, C-Y. "A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells." Clin Cancer Res 10, no. 4 (February 15, 2004): 1439-1445. Link to Item
  - Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, no. 2 (February 2004): 326-328. (Academic Article)
  - Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia-Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." FASEB JOURNAL 18, no. 2 (February 2004): 326-328. Full Text Link to Item
  - Herskind, C, Fleckenstein, K, Lohr, J, Li, C-Y, Wenz, F, and Lohr, F. "Antitumoral action of interferons and interleukins in combination with radiotherapy. Part II: Radiobiological and immunologic strategies." Strahlentherapie und Onkologie 180, no. 6 (2004): 331-339. Full Text
  - Herskind, C, Fleckenstein, K, Lohr, J, Li, C-Y, Wenz, F, and Lohr, F. "Antitumoral Action of Interferons and Interleukins in Combination with Radiotherapy. Part I: Immunologic Basis." Strahlentherapie und Onkologie 180, no. 4 (2004): 187-193. Full Text
  - Wang, Y, Li, C-Y, and Yuan, F. "Systemic virus dissemination during local gene delivery in solid tumors and its control with an alginate solution." Conf Proc IEEE Eng Med Biol Soc 5 (2004): 3524-3526. Full Text Link to Item
  - Wang, Y, Hu, JK, Krol, A, Li, Y-P, Li, C-Y, and Yuan, F. "Systemic dissemination of viral vectors during intratumoral injection." Mol Cancer Ther 2, no. 11 (November 2003): 1233-1242. Link to Item
  - Rabbani, ZN, Anscher, MS, Zhang, X, Chen, L, Samulski, TV, Li, C-Y, and Vujaskovic, Z. "Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats." Int J Radiat Oncol Biol Phys 57, no. 2 (October 1, 2003): 563-572. Link to Item
  - Zhang, X, Li, Y, Huang, Q, Wang, H, Yan, B, Dewhirst, MW, and Li, C-Y. "Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase." Clin Cancer Res 9, no. 3 (March 2003): 1155-1160. Link to Item
  - Wang, F, Wu, J, Tian, Y, Chen, X, Hu, H, Wu, W, Li, C, and Huang, Q. "Role of VEGF in the growth and metastasis of a murine bladder carcinoma." Chinese Science Bulletin 48, no. 22 (2003): 2404-2410. Full Text
  - Baker-LePain, JC, Sarzotti, M, Fields, TA, Li, C-Y, and Nicchitta, CV. "GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression." J Exp Med 196, no. 11 (December 2, 2002): 1447-1459. Link to Item
  - Li, CY, and Dewhirst, MW. "Hyperthermia-regulated immunogene therapy." Int J Hyperthermia 18, no. 6 (November 2002): 586-596. (Review) Full Text Link to Item
  - Zaharoff, DA, Barr, RC, Li, C-Y, and Yuan, F. "Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery." Gene Ther 9, no. 19 (October 2002): 1286-1290. Full Text Link to Item
  - Azzam, EI, Nagasawa, H, Yu, Y, Li, C-Y, and Little, JB. "Cell cycle deregulation and xeroderma pigmentosum group C cell transformation." Journal of Investigative Dermatology 119, no. 6 (2002): 1350-1354. Full Text
  - Dewhirst, MW, Shan, S, Cao, Y, Moeller, B, Yuan, F, and Li, C-Y. "Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals." Dis Markers 18, no. 5-6 (2002): 293-311. (Review) Link to Item
  - Li, L, Xu, P, Hu, H-H, Liu, W-W, Yi, M-Y, Li, C-Y, and Huang, Q. "A novel model for visualization of tumor cell-induced angiogenesis in vivo." Acta Biochimica et Biophysica Sinica 34, no. 1 (2002): 21-27.
  - Wang, F, Chen, X-F, Tian, Y-H, Wu, J-H, Li, L, Li, C-Y, and Huang, Q. "Target gene transfer mediated by electroporation for cancer therapy in vivo." Progress in Biochemistry and Biophysics 29, no. 5 (2002): 734-740.
  - Wang, F, Tian, Y-H, Li, L, Chen, X-F, Hu, H-H, Li, C-Y, and Huang, Q. "Inhibitation of tumor angiogenesis, growth and metastasis by blocking VEGF paracrine pathway." Acta Biochimica et Biophysica Sinica 34, no. 2 (2002): 165-170.
  - Wang, Y, Hu, JK, Krol, A, Li, Y-P, Li, C-Y, and Yuan, F. "Reducing systemic toxicity in local tumor gene therapy using an alginate solution." Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 1 (2002): 565--.
  - Zhang, X, Hu, K, and Li, CY. "Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase." Circulation 104, no. 23 (December 4, 2001): 2762-2766. Link to Item
  - Lohr, F, Huang, Q, Hu, K, Dewhirst, MW, and Li, CY. "Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors." Clin Cancer Res 7, no. 11 (November 2001): 3625-3628. Link to Item
  - Shan, S, Hu, K, Saito, W, Li, C, and Dewhirst, MW. "Effects of soluble Tie-2 receptor and bFGF on GFP-4T1 tumor growth and initiation of angiogenesis in BALB/C mouse dorsal skinfold window chamber." CLINICAL CANCER RESEARCH 7, no. 11 (November 2001): 3658S-3658S. Link to Item
  - Zhang, X, and Li, CY. "Generation of recombinant adeno-associated virus vectors by a complete adenovirus-mediated approach." Mol Ther 3, no. 5 Pt 1 (May 2001): 787-792. Full Text Link to Item
  - Lohr, F, Lo, DY, Zaharoff, DA, Hu, K, Zhang, X, Li, Y, Zhao, Y, Dewhirst, MW, Yuan, F, and Li, CY. "Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation." Cancer Res 61, no. 8 (April 15, 2001): 3281-3284. Link to Item
  - Li, CY, Little, JB, Hu, K, Zhang, W, Zhang, L, Dewhirst, MW, and Huang, Q. "Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures." Cancer Res 61, no. 2 (January 15, 2001): 428-432. Link to Item
  - Huang, Q, Xu, P, Liu, W, Wang, F, Gu, Q, Tian, S, Fan, Y, Xig, K, Chen, X, and Li, C. "Preparation of green fluorescent protein retrovirus and its application in mediating gene transfer into retinal pigment epithelial cells." [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 37, no. 4 (2001): 248-251.
  - Huang, Q, and Li, C. "Using Hsp70 promoter to regulate target gene expression in tumor." Zhonghua bing li xue za zhi Chinese journal of pathology 30, no. 3 (2001): 198-201.
  - Lohr, F, Hu, K, Huang, Q, Zhang, L, Samulski, TV, Dewhirst, MW, and Li, CY. "Enhancement of radiotherapy by hyperthermia-regulated gene therapy." Int J Radiat Oncol Biol Phys 48, no. 5 (December 1, 2000): 1513-1518. Link to Item
  - Li, CY, Shan, S, Huang, Q, and Dewhirst, MW. "RESPONSE: re: initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models." J Natl Cancer Inst 92, no. 17 (September 6, 2000): 1445-1446. Link to Item
  - Lohr, F, Hu, K, Haroon, Z, Samulski, TV, Huang, Q, Beaty, J, Dewhirst, MW, and Li, CY. "Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy." Mol Ther 2, no. 3 (September 2000): 195-203. Full Text Link to Item
  - Huang, Q, Hu, JK, Lohr, F, Zhang, L, Braun, R, Lanzen, J, Little, JB, Dewhirst, MW, and Li, CY. "Heat-induced gene expression as a novel targeted cancer gene therapy strategy." Cancer Res 60, no. 13 (July 1, 2000): 3435-3439. Link to Item
  - Li, CY, Shan, S, Huang, Q, Braun, RD, Lanzen, J, Hu, K, Lin, P, and Dewhirst, MW. "Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models." J Natl Cancer Inst 92, no. 2 (January 19, 2000): 143-147. Link to Item
  - Hoffman, RM, Li, C-Y, Shan, S, Huang, Q, and Dewhirst, MW. "Re: Initial stages of tumor cell-induced angiogenesis: Evaluation via skin window chambers in rodent models [3] (multiple letters)." Journal of the National Cancer Institute 92, no. 17 (2000): 1445-1446.
  - Li, CY, Shan, S, Cao, Y, and Dewhirst, MW. "Role of incipient angiogenesis in cancer metastasis." Cancer Metastasis Rev 19, no. 1-2 (2000): 7-11. (Review) Link to Item
  - Yuan, F, Zaharoff, D, Zhang, X-Y, Lohr, F, Dewhirst, MW, and Li, C-Y. "Delivery of plasmid DNA through intratumoral infusion and electroporation." American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 48 (2000): 173-176.
  - Zaharoff, D, Barr, R, Li, C-Y, and Yuan, F. "Mobility of plasmid DNA subject to pulsed electric fields." Annals of Biomedical Engineering 28, no. SUPPL. 1 (2000): S-25.
  - Huang, Q, Shan, S, Braun, RD, Lanzen, J, Anyrhambatla, G, Kong, G, Borelli, M, Corry, P, Dewhirst, MW, and Li, CY. "Noninvasive visualization of tumors in rodent dorsal skin window chambers." Nat Biotechnol 17, no. 10 (October 1999): 1033-1035. Full Text Link to Item
  - Yonghao, T, Qian, H, Chuanyuan, L, and Yandell, DW. "Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines." Chinese medical sciences journal = Chung-kuo i hsueh ko hsueh tsa chih / Chinese Academy of Medical Sciences 14, no. 4 (1999): 200-205.
  - Little, JB, Li, CY, Nagasawa, H, and Huang, H. "Influence of p53 expression on radiosensitivity of human normal and tumor cells." Journal de Chimie Physique et de Physico-Chimie Biologique 95, no. 4 (1998): 820-829.
  - Yu, Y, Li, C-Y, and Little, JB. "Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells." Oncogene 14, no. 14 (1997): 1661-1667.
  - Suardet, L, Li, C, and Little, JB. "Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line." International journal of cancer 68, no. 1 (September 1996): 126-131. Full Text
  - Huang, H, Li, C-Y, and Little, JB. "Abrogation of p53 function by transfection of HPV16 E6 gene does not enhance resistance of human tumour cells to ionizing radiation." International Journal of Radiation Biology 70, no. 2 (1996): 151-160. Full Text
  - Li, C-Y, Nagasawa, H, and Little, JB. "Role of tumor suppressor genes in determining radiation-induced G₁ arrest and transformation in human cells." Radiation Oncology Investigations 3, no. 6 (1996): 268-271.
  - Little, J, Li, C, Nagasawa, H, Pfenning, T, and Vetrovs, H. "Genomic instability and radiation mutagenesis." Journal de Chimie Physique 93 (1996): 157-164. Full Text
  - Suardet, L, Chuan, LI, and Little, JB. "Radio-induced modulation of transforming growth factor β1 sensitivity in a p53 wild-type human colorectal-cancer cell line." International Journal of Cancer 68, no. 1 (1996): 126-131. Full Text
  - Li, C, Nagasawa, H, Tsang, NM, and Little, JB. "Radiation-induced irreversible G(0)/G(1) block is abolished in human diploid fibroblasts transfected with the human papilloma virus E6 gene: Implication of the p53-Cip1/WAF1 pathway." International Journal of Oncology 6, no. 1 (January 1, 1995): 233-236.
  - Li, C-Y, Nagasawa, H, Dahlberg, WK, and Little, JB. "Diminished capacity for p53 in mediating a radiation-induced G₁ arrest in established human tumor cell lines." Oncogene 11, no. 9 (1995): 1885-1892.
  - Li, C-Y, Suardet, L, and Little, JB. "Potential role of WAF1/Cip1/p21 as a mediator of TGF-β cytoinhibitory effect." Journal of Biological Chemistry 270, no. 10 (1995): 4971-4974. Full Text
  - Little, JB, Nagasawa, H, Keng, PC, Yu, Y, and Li, C-Y. "Absence of radiation-induced G₁ arrest in two closely related human lymphoblast cell lines that differ in p53 status." Journal of Biological Chemistry 270, no. 19 (1995): 11033-11036. Full Text
  - Nagasawa, H, Li, C-Y, Maki, CG, Imrich, AC, and Little, JB. "Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells." Cancer Research 55, no. 9 (1995): 1842-1846.
  - Tsang, N-M, Nagasawa, H, Li, C, and Little, JB. "Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation." Oncogene 10, no. 12 (1995): 2403-2408.
  - Li, C-Y, Yandell, DW, and Little, JB. "Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus." Molecular and Cellular Biology 14, no. 7 (1994): 4373-4379.
  - Poremba, C, Dockhorn-Dworniczak, B, Merritt, V, Li, C-Y, Heidl, G, Tauber, PF, Bocker, W, and Yandell, DW. "Immature teratomas of different origin carried by a pregnant mother and her fetus." Diagnostic Molecular Pathology 2, no. 2 (1993): 131-136.
  - Spiro, IJ, Yandell, DW, Li, C, Saini, S, Ferry, J, Powelson, J, Katkov, WN, and Cosimi, AB. "Brief report: Lymphoma of donor origin occurring in the porta hepatis of a transplanted liver." New England Journal of Medicine 329, no. 1 (1993): 27-29. Full Text
  - Li, C-Y, Yandell, DW, and Little, JB. "Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene." Molecular Carcinogenesis 5, no. 4 (1992): 270-277. Full Text
  - Li, C-Y, Yandell, DW, and Little, JB. "Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro." Somatic Cell and Molecular Genetics 18, no. 1 (1992): 77-87. Full Text
Teaching & Mentoring
Recent Courses
- MOLCAN 780: Graduate Student Seminar 2018
- PHARM 393: Research Independent Study 2018
- PHARM 493: Research Independent Study 2018
- PHARM 494: Research Independent Study 2018
- PHARM 495: Research Independent Study 2018
- PHARM 780S: Graduate Student Seminar 2018
Scholarly, Clinical, & Service Activities
Service to the Profession
- Ad Hoc Member. Grant Review Committee. NIH Study of Metabolic Pathology. 2001 - 2003 2001 - 2003

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