Chi Wei Cliburn Chan
Associate Professor of Biostatistics and Bioinformatics
Computational immunology (stochastic and spatial models and simulations, T cell signaling, immune regulation)
Statistical methodology for immunological laboratory techniques (flow cytometry, CFSE analysis, receptor-ligand binding and signaling kinetics)
Informatics of the immune system (reference and application ontologies, meta-programming, text mining and machine learning)
Statistical methodology for immunological laboratory techniques (flow cytometry, CFSE analysis, receptor-ligand binding and signaling kinetics)
Informatics of the immune system (reference and application ontologies, meta-programming, text mining and machine learning)
Current Appointments & Affiliations
- Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2014
Contact Information
- 2424 Erwin Road Ste 1102, 11078 Hock Plaza Duke Box 2721, Durham, NC 27705
- Duke Box 2721, Durham, NC 27710
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cliburn.chan@duke.edu
(919) 668-2459
- Background
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Education, Training, & Certifications
- Ph.D., University College London (United Kingdom) 2002
- M.S., University College London (United Kingdom) 1998
- B.S., University of London (United Kingdom) 1997
- M.B.B.S., National University of Singapore (Singapore) 1991
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Duke Appointment History
- Associate Research Professor of Statistical Science, Statistical Science, Trinity College of Arts & Sciences 2016 - 2019
- Associate Professor in the Department of Statistical Science, Statistical Science, Trinity College of Arts & Sciences 2014 - 2016
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2007 - 2014
- Assistant Research Professor in the Department of Statistical Science, Statistical Science, Trinity College of Arts & Sciences 2013 - 2014
- Assistant Research Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2006 - 2007
- Research
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Selected Grants
- EQAPOL - Years 2017 to 2024 - BASE awarded by National Institutes of Health 2017 - 2024
- Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users awarded by National Institutes of Health 2019 - 2024
- Quantitative Methods for HIV/AIDS Research awarded by National Institutes of Health 2018 - 2023
- Role of cannabis on HIV-related cognitive impairment: a brain connectomics study awarded by National Institutes of Health 2018 - 2023
- VTEU Task D Option 2 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2022
- VTEU Task D Option 3 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2022
- VTEU Task D Option 4 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2022
- CXCL10/CXCR3 regulation of ozone-induced epithelial permeability awarded by National Institutes of Health 2017 - 2022
- Consequences of marijuana use on inflammatory pathways in HIV-infected youth awarded by National Institutes of Health 2017 - 2022
- Impact of maternal HIV infection on immune priming of their uninfected infants awarded by National Institutes of Health 2020 - 2022
- Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2022
- Antigenome Signatures as Biomarkers for Subtyping Disease Heterogeneity in Lupus Patients awarded by Department of Defense 2019 - 2021
- A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation awarded by National Institutes of Health 2016 - 2021
- Innate antiviral factors in breast milk and the oral HIV-1 reservoir awarded by National Institutes of Health 2015 - 2021
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Evaluating Effects of Age-related Microbiota Modulations in Hematopoietic Stem Cell Transplant Patients awarded by National Institutes of Health 2019 - 2021
- Adjuvant Discovery Program (Option #3) awarded by National Institutes of Health 2014 - 2020
- Eqapol Opt 1 -2019-2020 awarded by National Institutes of Health 2017 - 2020
- A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health 2016 - 2020
- Immunological biomarker studies in myasthenia gravis awarded by National Institutes of Health 2014 - 2020
- Molecular Atlas of Lung Development - Data Coordinating Center awarded by National Institutes of Health 2014 - 2020
- Role of CD4 T cell subsets as drivers of MG disease 2016 - 2019
- Adjuvant Discovery Program (Option #2) awarded by National Institutes of Health 2014 - 2019
- Reversible Immunomodulation as a Strategy for Ischemia Tolerance in Hibernation awarded by Foundation for Anesthesia Education and Research 2017 - 2019
- Development of a Therapeutic for Brain Tumor Immunotherapy awarded by National Institutes of Health 2018 - 2019
- The impact of Epstein Barr virus infection on the immune response in pediatric transplant recipients awarded by Stanford University 2018 - 2019
- mHealth Peer Support to Reduce Rates of STIs in Black MSM PrEP Users awarded by National Institutes of Health 2018
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
- Adjuvant Discovery Program (Option #1) awarded by National Institutes of Health 2014 - 2017
- EQAPOL - 2016 to 2017 - Option 6 - FLOW awarded by National Institutes of Health 2010 - 2017
- EQAPOL Option 5 awarded by National Institutes of Health 2010 - 2017
- Innate immune adaptations of hibernation as a new approach to protection against acute organ injury 2015 - 2017
- Adjuvant Discovery Program awarded by National Institutes of Health 2014 - 2017
- Longitudinal assessment of CMV and BK virus immunity in renal transplant patients awarded by National Institutes of Health 2013 - 2016
- Multiscale Systems Immunology awarded by National Institutes of Health 2010 - 2015
- Novel Cellular Immune Profiles to Predict Lung Disease Outcomes awarded by National Institutes of Health 2011 - 2013
- Immune profiling of multi-parameter flow cytometry using computational statistics awarded by National Institutes of Health 2009 - 2012
- Multiscale Integrative Immunology for Adjuvant Development awarded by National Institutes of Health 2005 - 2010
- Microsimulation of anthracis-immune system interaction awarded by National Institutes of Health 2004 - 2007
- missing activity
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External Relationships
- Duke-NUS
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Kim-Chang, Julie J., Lorena Wilson, Cliburn Chan, Bernard Fischer, Guglielmo Venturi, Maureen M. Goodenow, Grace Aldrovandi, Thomas J. Weber, John W. Sleasman, and John W. Adolescent Medicine Trials Network for HIV/AIDS Interventions. “Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy.” Aids Res Hum Retroviruses 35, no. 8 (August 2019): 746–54. https://doi.org/10.1089/AID.2018.0270.Full Text Link to Item
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Gouttefangeas, C., C. Chan, S. Attig, T. T. Køllgaard, H. -. G. Rammensee, S. Stevanović, D. Wernet, et al. “Data analysis as a source of variability of the HLA-peptide multimer assay: From manual gating to automated recognition of cell clusters.” Cancer Immunology, Immunotherapy 64, no. 5 (2015): 585–98. https://doi.org/10.1007/s00262-014-1649-1.Full Text
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Gouttefangeas, C., S. Walter, M. J. P. Welters, C. Ottensmeier, S. H. V. D. Burg, C. M. Britten, and C. Chan. “Flow cytometry in cancer immunotherapy: Applications, quality assurance, and future.” Cancer Immunology: A Translational Medicine Context, 2015, 471–90. https://doi.org/10.1007/978-3-662-44006-3_25.Full Text
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Richards, Adam J., Janet Staats, Jennifer Enzor, Katherine McKinnon, Jacob Frelinger, Thomas N. Denny, Kent J. Weinhold, and Cliburn Chan. “Setting objective thresholds for rare event detection in flow cytometry.” J Immunol Methods 409 (July 2014): 54–61. https://doi.org/10.1016/j.jim.2014.04.002.Full Text Open Access Copy Link to Item
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Staats, Janet S., Jennifer H. Enzor, Ana M. Sanchez, Wes Rountree, Cliburn Chan, Maria Jaimes, Ray Chun-Fai Chan, Amitabh Gaur, Thomas N. Denny, and Kent J. Weinhold. “Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays.” J Immunol Methods 409 (July 2014): 44–53. https://doi.org/10.1016/j.jim.2014.05.021.Full Text Open Access Copy Link to Item
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Nair, Smita K., Georgia D. Tomaras, Ana Paula Sales, David Boczkowski, Cliburn Chan, Kelly Plonk, Yongting Cai, et al. “High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.” Sci Rep 4 (April 23, 2014): 4632. https://doi.org/10.1038/srep04632.Full Text Link to Item
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Lin, Lin, Cliburn Chan, Sine R. Hadrup, Thomas M. Froesig, Quanli Wang, and Mike West. “Hierarchical Bayesian mixture modelling for antigen-specific T-cell subtyping in combinatorially encoded flow cytometry studies.” Stat Appl Genet Mol Biol 12, no. 3 (June 2013): 309–31. https://doi.org/10.1515/sagmb-2012-0001.Full Text Link to Item
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Shetty, Gina, Georgia M. Beasley, Sara Sparks, Michael Barfield, Melanie Masoud, Paul J. Mosca, Scott K. Pruitt, et al. “Plasma cytokine analysis in patients with advanced extremity melanoma undergoing isolated limb infusion.” Ann Surg Oncol 20, no. 4 (April 2013): 1128–35. https://doi.org/10.1245/s10434-012-2785-5.Full Text Link to Item
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Aghaeepour, Nima, Greg Finak, Greg FlowCAP Consortium, Greg DREAM Consortium, Holger Hoos, Tim R. Mosmann, Ryan Brinkman, Raphael Gottardo, and Richard H. Scheuermann. “Critical assessment of automated flow cytometry data analysis techniques.” Nat Methods 10, no. 3 (March 2013): 228–38. https://doi.org/10.1038/nmeth.2365.Full Text Link to Item
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Chan, C., M. Billard, S. A. Ramirez, H. Schmidl, E. Monson, and T. B. Kepler. “A Model for Migratory B Cell Oscillations from Receptor Down-Regulation Induced by External Chemokine Fields.” Bulletin of Mathematical Biology 75, no. 1 (2013): 185–205. https://doi.org/10.1007/s11538-012-9799-9.Full Text
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Chan, Cliburn, Matthew Billard, Samuel A. Ramirez, Harald Schmidl, Eric Monson, and Thomas B. Kepler. “A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields.” Bull Math Biol 75, no. 1 (January 2013): 185–205. https://doi.org/10.1007/s11538-012-9799-9.Full Text Link to Item
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Cron, Andrew, Cécile Gouttefangeas, Jacob Frelinger, Lin Lin, Satwinder K. Singh, Cedrik M. Britten, Marij J. P. Welters, Sjoerd H. van der Burg, Mike West, and Cliburn Chan. “Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples.” Plos Comput Biol 9, no. 7 (2013): e1003130. https://doi.org/10.1371/journal.pcbi.1003130.Full Text Link to Item
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Snyder, L. D., R. Medinas, C. Chan, S. Sparks, W. A. Davis, S. M. Palmer, and K. J. Weinhold. “Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis.” Am J Transplant 11, no. 3 (March 2011): 553–60. https://doi.org/10.1111/j.1600-6143.2010.03405.x.Full Text Link to Item
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Chan, Cliburn, Lin Lin, Jacob Frelinger, Valérie Hérbert, Dominic Gagnon, Claire Landry, Rafick-Pierre Sékaly, et al. “Optimization of a highly standardized carboxyfluorescein succinimidyl ester flow cytometry panel and gating strategy design using discriminative information measure evaluation.” Cytometry A 77, no. 12 (December 2010): 1126–36. https://doi.org/10.1002/cyto.a.20987.Full Text Link to Item
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Manolopoulou, I., C. Chan, and M. West. “Rejoinder.” Bayesian Analysis 5, no. 3 (December 1, 2010): 461–64. https://doi.org/10.1214/10-BA517REJ.Full Text
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Suchard, Marc A., Quanli Wang, Cliburn Chan, Jacob Frelinger, Andrew Cron, and Mike West. “Understanding GPU Programming for Statistical Computation: Studies in Massively Parallel Massive Mixtures.” J Comput Graph Stat 19, no. 2 (June 1, 2010): 419–38. https://doi.org/10.1198/jcgs.2010.10016.Full Text Open Access Copy Link to Item
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Frelinger, J., J. Ottinger, C. Gouttefangeas, and C. Chan. “Modeling flow cytometry data for cancer vaccine immune monitoring.” Cancer Immunology, Immunotherapy 59, no. 9 (2010): 1435–41. https://doi.org/10.1007/s00262-010-0883-4.Full Text
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Manolopoulou, I., C. Chan, and M. West. “Selection sampling from large data sets for targeted inference in mixture modeling.” Bayesian Analysis 5, no. 3 (2010): 429–50. https://doi.org/10.1214/10-BA517.Full Text
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Chan, Cliburn, Feng Feng, Janet Ottinger, David Foster, Mike West, and Thomas B. Kepler. “Statistical mixture modeling for cell subtype identification in flow cytometry.” Cytometry A 73, no. 8 (August 2008): 693–701. https://doi.org/10.1002/cyto.a.20583.Full Text Link to Item
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Frelinger, Jacob, Thomas B. Kepler, and Cliburn Chan. “Flow: Statistics, visualization and informatics for flow cytometry.” Source Code Biol Med 3 (June 17, 2008): 10. https://doi.org/10.1186/1751-0473-3-10.Full Text Link to Item
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Mitha, Faheem, Timothy A. Lucas, Feng Feng, Thomas B. Kepler, and Cliburn Chan. “The Multiscale Systems Immunology project: software for cell-based immunological simulation.” Source Code Biol Med 3 (April 28, 2008): 6. https://doi.org/10.1186/1751-0473-3-6.Full Text Open Access Copy Link to Item
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Yates, Andrew, Cliburn Chan, Jessica Strid, Simon Moon, Robin Callard, Andrew J. T. George, and Jaroslav Stark. “Reconstruction of cell population dynamics using CFSE.” Bmc Bioinformatics 8 (June 12, 2007): 196. https://doi.org/10.1186/1471-2105-8-196.Full Text Link to Item
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Kepler, Thomas B., and Cliburn Chan. “Spatiotemporal programming of a simple inflammatory process.” Immunol Rev 216 (April 2007): 153–63. https://doi.org/10.1111/j.1600-065X.2007.00500.x.Full Text Link to Item
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Stark, Jaroslav, Cliburn Chan, and Andrew J. T. George. “Oscillations in the immune system.” Immunol Rev 216 (April 2007): 213–31. https://doi.org/10.1111/j.1600-065X.2007.00501.x.Full Text Link to Item
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Chan, Cliburn, and Thomas B. Kepler. “Computational immunology--from bench to virtual reality.” Ann Acad Med Singapore 36, no. 2 (February 2007): 123–27.Link to Item
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Chan, C., A. J. T. George, and J. Stark. “Cytotoxic killing and immune evasion by repair.” Journal of Statistical Physics 128, no. 1–2 (2007): 393–411. https://doi.org/10.1007/s10955-006-9242-4.Full Text
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Alam, AKM Shamsul, Oliver Florey, Michele Weber, Radhakrishna G. Pillai, Cliburn Chan, Peng H. Tan, Robert I. Lechler, Myra O. McClure, Dorian O. Haskard, and Andrew J. T. George. “Knockdown of mouse VCAM-1 by vector-based siRNA.” Transplant Immunology 16, no. 3–4 (November 2006): 185–93. https://doi.org/10.1016/j.trim.2006.08.004.Full Text
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George, Andrew J. T., Jaroslav Stark, and Cliburn Chan. “Understanding specificity and sensitivity of T-cell recognition.” Trends Immunol 26, no. 12 (December 2005): 653–59. https://doi.org/10.1016/j.it.2005.09.011.Full Text Link to Item
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Tan, P. H., C. L. H. Chan, C. Chan, and A. J. T. George. “The evolving role of gene-based treatment in surgery.” Br J Surg 92, no. 12 (December 2005): 1466–80. https://doi.org/10.1002/bjs.5181.Full Text Link to Item
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Yates, A. J., C. C. T. Chan, and R. E. Callard. “16 Modelling T cell activation, proliferation, and homeostasis.” Studies in Multidisciplinarity 3, no. C (December 1, 2005): 281–308. https://doi.org/10.1016/S1571-0831(06)80020-1.Full Text
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Tan, Peng H., John B. Yates, Shao-An Xue, Cliburn Chan, William J. Jordan, Jennifer E. Harper, Martin P. Watson, et al. “Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.” Blood 106, no. 9 (November 1, 2005): 2936–43. https://doi.org/10.1182/blood-2005-05-1826.Full Text Link to Item
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Tan, Peng H., Pervinder Sagoo, Cliburn Chan, John B. Yates, Jamie Campbell, Sven C. Beutelspacher, Brian M. J. Foxwell, Giovanna Lombardi, and Andrew J. T. George. “Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells.” J Immunol 174, no. 12 (June 15, 2005): 7633–44. https://doi.org/10.4049/jimmunol.174.12.7633.Full Text Link to Item
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Chan, C., J. Stark, and A. J. T. George. “The impact of multiple T cell - APC encounters and the role of anergy.” Journal of Computational and Applied Mathematics 184, no. 1 (2005): 101–20. https://doi.org/10.1016/j.cam.2004.07.036.Full Text
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Chan, Cliburn, Jaroslav Stark, and Andrew J. T. George. “Feedback control of T-cell receptor activation.” Proc Biol Sci 271, no. 1542 (May 7, 2004): 931–39. https://doi.org/10.1098/rspb.2003.2587.Full Text Link to Item
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Tan, P. H., C. Chan, S. A. Xue, R. Dong, B. Ananthesayanan, M. Manunta, C. Kerouedan, et al. “Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells.” Atherosclerosis 173, no. 2 (April 2004): 171–83. https://doi.org/10.1016/j.atherosclerosis.2003.12.011.Full Text Link to Item
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Chan, C., R. I. Lechler, and A. J. George. “Tolerance mechanisms and recent progress.” Transplantation Proceedings 36, no. 2 Suppl (March 2004): 561S-569S. https://doi.org/10.1016/j.transproceed.2004.01.019.Full Text
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Chan, C., A. J. T. George, and J. Stark. “T cell sensitivity and specificity - Kinetic proofreading revisited.” Discrete and Continuous Dynamical Systems Series B 3, no. 3 (2003): 343–60.
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Yates, A., C. C. Chan, R. E. Callard, A. J. George, and J. Stark. “An approach to modelling in immunology.” Brief Bioinform 2, no. 3 (September 2001): 245–57. https://doi.org/10.1093/bib/2.3.245.Full Text Link to Item
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Chan, C., A. J. George, and J. Stark. “Cooperative enhancement of specificity in a lattice of T cell receptors.” Proc Natl Acad Sci U S A 98, no. 10 (May 8, 2001): 5758–63. https://doi.org/10.1073/pnas.101113698.Full Text Link to Item
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Chan, C. C., J. Stark, and A. J. George. “Analysis of cytokine dynamics in corneal allograft rejection.” Proc Biol Sci 266, no. 1434 (November 7, 1999): 2217–23. https://doi.org/10.1098/rspb.1999.0911.Full Text Link to Item
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Other Articles
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Kvistborg, Pia, Cécile Gouttefangeas, Nima Aghaeepour, Angelica Cazaly, Pratip K. Chattopadhyay, Cliburn Chan, Judith Eckl, et al. “Thinking outside the gate: single-cell assessments in multiple dimensions.” Immunity, April 21, 2015. https://doi.org/10.1016/j.immuni.2015.04.006.Full Text Link to Item
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- Teaching & Mentoring
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Recent Courses
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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