Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University College London (United Kingdom) 2002
  • M.S., University College London (United Kingdom) 1998
  • B.S., University of London (UK) 1997
  • M.B.B.S., National University of Singapore 1991
• 

  Duke Appointment History

  • Associate Professor in the Department of Statistical Science, Statistical Science, Trinity College of Arts & Sciences 2014 - 2016
  • Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2007 - 2014
  • Assistant Research Professor in the Department of Statistical Science, Statistical Science, Trinity College of Arts & Sciences 2013 - 2014
  • Assistant Research Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2006 - 2007
• Research
• 

  Selected Grants

  • EQAPOL - Years 2017 to 2024 - BASE awarded by National Institutes of Health 2017 - 2024
  • Quantitative Methods for HIV/AIDS Research awarded by National Institutes of Health 2018 - 2023
  • Role of cannabis on HIV-related cognitive impairment: a brain connectomics study awarded by National Institutes of Health 2018 - 2023
  • CXCL10/CXCR3 regulation of ozone-induced epithelial permeability awarded by National Institutes of Health 2017 - 2022
  • Consequences of marijuana use on inflammatory pathways in HIV-infected youth awarded by National Institutes of Health 2017 - 2022
  • Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2022
  • A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation awarded by National Institutes of Health 2016 - 2021
  • Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
  • Eqapol Opt 1 -2018-2019 awarded by National Institutes of Health 2017 - 2019
  • Adjuvant Discovery Program (Option #2) awarded by National Institutes of Health 2014 - 2019
  • Adjuvant Discovery Program (Option #3) awarded by National Institutes of Health 2014 - 2019
  • VTEU Task D Option 2 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2019
  • VTEU Task D Option 3 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2019
  • VTEU Task D Option 4 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2019
  • Immunological biomarker studies in myasthenia gravis awarded by National Institutes of Health 2014 - 2019
  • Reversible Immunomodulation as a Strategy for Ischemia Tolerance in Hibernation awarded by Foundation for Anesthesia Education and Research 2017 - 2019
  • A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health 2016 - 2019
  • Role of CD4 T cell subsets as drivers of MG disease awarded by Myasthenia Gravis Foundation 2016 - 2019
  • Molecular Atlas of Lung Development - Data Coordinating Center awarded by National Institutes of Health 2014 - 2019
  • Development of a Therapeutic for Brain Tumor Immunotherapy awarded by National Institutes of Health 2018 - 2019
  • The impact of Epstein Barr virus infection on the immune response in pediatric transplant recipients awarded by Stanford University 2018 - 2019
  • mHealth Peer Support to Reduce Rates of STIs in Black MSM PrEP Users awarded by National Institutes of Health 2018
  • Adjuvant Discovery Program (Option #1) awarded by National Institutes of Health 2014 - 2017
  • EQAPOL - 2016 to 2017 - Option 6 - FLOW awarded by National Institutes of Health 2010 - 2017
  • EQAPOL Option 5 awarded by National Institutes of Health 2010 - 2017
  • Innate immune adaptations of hibernation as a new approach to protection against acute organ injury awarded by Society of Cardiovascular Anesthesiologists 2015 - 2017
  • Adjuvant Discovery Program awarded by National Institutes of Health 2014 - 2017
  • Longitudinal assessment of CMV and BK virus immunity in renal transplant patients awarded by National Institutes of Health 2013 - 2016
  • Multiscale Systems Immunology awarded by National Institutes of Health 2010 - 2015
  • Novel Cellular Immune Profiles to Predict Lung Disease Outcomes awarded by National Institutes of Health 2011 - 2013
  • Immune profiling of multi-parameter flow cytometry using computational statistics awarded by National Institutes of Health 2009 - 2012
  • Multiscale Integrative Immunology for Adjuvant Develpmnt awarded by National Institutes of Health 2005 - 2010
  • Microsimulation of anthracis-immune system interaction awarded by National Institutes of Health 2004 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Gouttefangeas, C., C. Chan, S. Attig, T. T. Køllgaard, H. -. G. Rammensee, S. Stevanović, D. Wernet, et al. “Data analysis as a source of variability of the HLA-peptide multimer assay: From manual gating to automated recognition of cell clusters.” Cancer Immunology, Immunotherapy 64, no. 5 (2015): 585–98. https://doi.org/10.1007/s00262-014-1649-1.
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    • Gouttefangeas, C., S. Walter, M. J. P. Welters, C. Ottensmeier, S. H. V. D. Burg, C. M. Britten, and C. Chan. “Flow cytometry in cancer immunotherapy: Applications, quality assurance, and future.” Cancer Immunology: A Translational Medicine Context, 2015, 471–90. https://doi.org/10.1007/978-3-662-44006-3_25.
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    • Richards, Adam J., Janet Staats, Jennifer Enzor, Katherine McKinnon, Jacob Frelinger, Thomas N. Denny, Kent J. Weinhold, and Cliburn Chan. “Setting objective thresholds for rare event detection in flow cytometry..” Journal of Immunological Methods 409 (July 2014): 54–61. https://doi.org/10.1016/j.jim.2014.04.002.
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    • Staats, Janet S., Jennifer H. Enzor, Ana M. Sanchez, Wes Rountree, Cliburn Chan, Maria Jaimes, Ray Chun-Fai Chan, Amitabh Gaur, Thomas N. Denny, and Kent J. Weinhold. “Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays..” Journal of Immunological Methods 409 (July 2014): 44–53. https://doi.org/10.1016/j.jim.2014.05.021.
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    • Nair, Smita K., Georgia D. Tomaras, Ana Paula Sales, David Boczkowski, Cliburn Chan, Kelly Plonk, Yongting Cai, et al. “High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes..” Scientific Reports 4 (April 23, 2014). https://doi.org/10.1038/srep04632.
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    • Richards, A. J., J. Staats, J. Enzor, K. McKinnon, J. Frelinger, T. N. Denny, K. J. Weinhold, and C. Chan. “Setting objective thresholds for rare event detection in flow cytometry.” Journal of Immunological Methods 409 (January 1, 2014): 54–61. https://doi.org/10.1016/j.jim.2014.04.002.
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    • Staats, J. S., J. H. Enzor, A. M. Sanchez, W. Rountree, C. Chan, M. Jaimes, R. C. F. Chan, A. Gaur, T. N. Denny, and K. J. Weinhold. “Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays.” Journal of Immunological Methods 409 (January 1, 2014): 44–53. https://doi.org/10.1016/j.jim.2014.05.021.
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    • Lin, Lin, Cliburn Chan, Sine R. Hadrup, Thomas M. Froesig, Quanli Wang, and Mike West. “Hierarchical Bayesian mixture modelling for antigen-specific T-cell subtyping in combinatorially encoded flow cytometry studies..” Statistical Applications in Genetics and Molecular Biology 12, no. 3 (June 2013): 309–31. https://doi.org/10.1515/sagmb-2012-0001.
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    • Shetty, Gina, Georgia M. Beasley, Sara Sparks, Michael Barfield, Melanie Masoud, Paul J. Mosca, Scott K. Pruitt, et al. “Plasma cytokine analysis in patients with advanced extremity melanoma undergoing isolated limb infusion..” Ann Surg Oncol 20, no. 4 (April 2013): 1128–35. https://doi.org/10.1245/s10434-012-2785-5.
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    • Aghaeepour, Nima, Greg Finak, Greg FlowCAP Consortium, Greg DREAM Consortium, Holger Hoos, Tim R. Mosmann, Ryan Brinkman, Raphael Gottardo, and Richard H. Scheuermann. “Critical assessment of automated flow cytometry data analysis techniques..” Nature Methods 10, no. 3 (March 2013): 228–38. https://doi.org/10.1038/nmeth.2365.
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    • Chan, Cliburn, Matthew Billard, Samuel A. Ramirez, Harald Schmidl, Eric Monson, and Thomas B. Kepler. “A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields..” Bulletin of Mathematical Biology 75, no. 1 (January 8, 2013): 185–205. https://doi.org/10.1007/s11538-012-9799-9.
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    • Chan, C., M. Billard, S. A. Ramirez, H. Schmidl, E. Monson, and T. B. Kepler. “A Model for Migratory B Cell Oscillations from Receptor Down-Regulation Induced by External Chemokine Fields.” Bulletin of Mathematical Biology 75, no. 1 (2013): 185–205. https://doi.org/10.1007/s11538-012-9799-9.
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    • Cron, Andrew, Cécile Gouttefangeas, Jacob Frelinger, Lin Lin, Satwinder K. Singh, Cedrik M. Britten, Marij J. P. Welters, Sjoerd H. van der Burg, Mike West, and Cliburn Chan. “Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples..” Plos Computational Biology 9, no. 7 (January 2013). https://doi.org/10.1371/journal.pcbi.1003130.
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    • Snyder, L. D., R. Medinas, C. Chan, S. Sparks, W. A. Davis, S. M. Palmer, and K. J. Weinhold. “Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis..” American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 11, no. 3 (March 2011): 553–60. https://doi.org/10.1111/j.1600-6143.2010.03405.x.
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    • Chan, Cliburn, Lin Lin, Jacob Frelinger, Valérie Hérbert, Dominic Gagnon, Claire Landry, Rafick-Pierre Sékaly, et al. “Optimization of a highly standardized carboxyfluorescein succinimidyl ester flow cytometry panel and gating strategy design using discriminative information measure evaluation..” Cytometry. Part a : The Journal of the International Society for Analytical Cytology 77, no. 12 (December 2010): 1126–36. https://doi.org/10.1002/cyto.a.20987.
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    • Manolopoulou, I., C. Chan, and M. West. “Rejoinder.” Bayesian Analysis 5, no. 3 (December 1, 2010): 461–64. https://doi.org/10.1214/10-BA517REJ.
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    • Suchard, Marc A., Quanli Wang, Cliburn Chan, Jacob Frelinger, Andrew Cron, and Mike West. “Understanding GPU Programming for Statistical Computation: Studies in Massively Parallel Massive Mixtures..” Journal of Computational and Graphical Statistics : A Joint Publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America 19, no. 2 (June 2010): 419–38. https://doi.org/10.1198/jcgs.2010.10016.
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    • Frelinger, J., J. Ottinger, C. Gouttefangeas, and C. Chan. “Modeling flow cytometry data for cancer vaccine immune monitoring.” Cancer Immunology, Immunotherapy 59, no. 9 (2010): 1435–41. https://doi.org/10.1007/s00262-010-0883-4.
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    • Manolopoulou, I., C. Chan, and M. West. “Selection sampling from large data sets for targeted inference in mixture modeling.” Bayesian Analysis 5, no. 3 (2010): 429–50. https://doi.org/10.1214/10-BA517.
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    • Chan, Cliburn, Feng Feng, Janet Ottinger, David Foster, Mike West, and Thomas B. Kepler. “Statistical mixture modeling for cell subtype identification in flow cytometry..” Cytometry. Part a : The Journal of the International Society for Analytical Cytology 73, no. 8 (August 2008): 693–701. https://doi.org/10.1002/cyto.a.20583.
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    • Mitha, Faheem, Timothy A. Lucas, Feng Feng, Thomas B. Kepler, and Cliburn Chan. “The Multiscale Systems Immunology project: software for cell-based immunological simulation..” Source Code for Biology and Medicine 3 (April 28, 2008). https://doi.org/10.1186/1751-0473-3-6.
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    • Frelinger, Jacob, Thomas B. Kepler, and Cliburn Chan. “Flow: Statistics, visualization and informatics for flow cytometry..” Source Code for Biology and Medicine 3 (January 2008). https://doi.org/10.1186/1751-0473-3-10.
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    • Yates, Andrew, Cliburn Chan, Jessica Strid, Simon Moon, Robin Callard, Andrew J. T. George, and Jaroslav Stark. “Reconstruction of cell population dynamics using CFSE..” Bmc Bioinformatics 8 (June 12, 2007). https://doi.org/10.1186/1471-2105-8-196.
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    • Kepler, Thomas B., and Cliburn Chan. “Spatiotemporal programming of a simple inflammatory process..” Immunological Reviews 216 (April 2007): 153–63. https://doi.org/10.1111/j.1600-065x.2007.00500.x.
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    • Stark, Jaroslav, Cliburn Chan, and Andrew J. T. George. “Oscillations in the immune system..” Immunological Reviews 216 (April 2007): 213–31. https://doi.org/10.1111/j.1600-065x.2007.00501.x.
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    • Chan, Cliburn, and Thomas B. Kepler. “Computational immunology--from bench to virtual reality..” Annals of the Academy of Medicine, Singapore 36, no. 2 (February 2007): 123–27.
    • Chan, C., A. J. T. George, and J. Stark. “Cytotoxic killing and immune evasion by repair.” Journal of Statistical Physics 128, no. 1–2 (2007): 393–411. https://doi.org/10.1007/s10955-006-9242-4.
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    • Alam, AKM Shamsul, Oliver Florey, Michele Weber, Radhakrishna G. Pillai, Cliburn Chan, Peng H. Tan, Robert I. Lechler, Myra O. McClure, Dorian O. Haskard, and Andrew J. T. George. “Knockdown of mouse VCAM-1 by vector-based siRNA..” Transplant Immunology 16, no. 3–4 (November 2006): 185–93. https://doi.org/10.1016/j.trim.2006.08.004.
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    • George, Andrew J. T., Jaroslav Stark, and Cliburn Chan. “Understanding specificity and sensitivity of T-cell recognition..” Trends in Immunology 26, no. 12 (December 2005): 653–59. https://doi.org/10.1016/j.it.2005.09.011.
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    • Tan, P. H., C. L. Chan, C. Chan, and A. J. George. “The evolving role of gene-based treatment in surgery..” The British Journal of Surgery 92, no. 12 (December 2005): 1466–80. https://doi.org/10.1002/bjs.5181.
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    • Yates, A. J., C. C. T. Chan, and R. E. Callard. “16 Modelling T cell activation, proliferation, and homeostasis.” Studies in Multidisciplinarity 3, no. C (December 1, 2005): 281–308. https://doi.org/10.1016/S1571-0831(06)80020-1.
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    • Tan, Peng H., John B. Yates, Shao-An Xue, Cliburn Chan, William J. Jordan, Jennifer E. Harper, Martin P. Watson, et al. “Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression..” Blood 106, no. 9 (November 2005): 2936–43. https://doi.org/10.1182/blood-2005-05-1826.
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    • Tan, Peng H., Pervinder Sagoo, Cliburn Chan, John B. Yates, Jamie Campbell, Sven C. Beutelspacher, Brian M. J. Foxwell, Giovanna Lombardi, and Andrew J. T. George. “Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells..” Journal of Immunology (Baltimore, Md. : 1950) 174, no. 12 (June 2005): 7633–44. https://doi.org/10.4049/jimmunol.174.12.7633.
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    • Chan, C., J. Stark, and A. J. T. George. “The impact of multiple T cell - APC encounters and the role of anergy.” Journal of Computational and Applied Mathematics 184, no. 1 (2005): 101–20. https://doi.org/10.1016/j.cam.2004.07.036.
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    • Chan, Cliburn, Jaroslav Stark, and Andrew J. T. George. “Feedback control of T-cell receptor activation..” Proceedings. Biological Sciences 271, no. 1542 (May 2004): 931–39. https://doi.org/10.1098/rspb.2003.2587.
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    • Tan, P. H., C. Chan, S. A. Xue, R. Dong, B. Ananthesayanan, M. Manunta, C. Kerouedan, et al. “Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells..” Atherosclerosis 173, no. 2 (April 2004): 171–83. https://doi.org/10.1016/j.atherosclerosis.2003.12.011.
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    • Chan, C., R. I. Lechler, and A. J. George. “Tolerance mechanisms and recent progress..” Transplantation Proceedings 36, no. 2 Suppl (March 2004): 561S-569S. https://doi.org/10.1016/j.transproceed.2004.01.019.
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    • Chan, C., A. J. T. George, and J. Stark. “T cell sensitivity and specificity - Kinetic proofreading revisited.” Discrete and Continuous Dynamical Systems  Series B 3, no. 3 (2003): 343–60.
    • Yates, A., C. C. Chan, R. E. Callard, A. J. George, and J. Stark. “An approach to modelling in immunology..” Briefings in Bioinformatics 2, no. 3 (September 2001): 245–57. https://doi.org/10.1093/bib/2.3.245.
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    • Chan, C., A. J. George, and J. Stark. “Cooperative enhancement of specificity in a lattice of T cell receptors..” Proceedings of the National Academy of Sciences of the United States of America 98, no. 10 (May 2001): 5758–63. https://doi.org/10.1073/pnas.101113698.
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    • Chan, C. C., J. Stark, and A. J. George. “Analysis of cytokine dynamics in corneal allograft rejection..” Proceedings. Biological Sciences 266, no. 1434 (November 1999): 2217–23. https://doi.org/10.1098/rspb.1999.0911.
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  • Other Articles

    • Kvistborg, Pia, Cécile Gouttefangeas, Nima Aghaeepour, Angelica Cazaly, Pratip K. Chattopadhyay, Cliburn Chan, Judith Eckl, et al. “Thinking outside the gate: single-cell assessments in multiple dimensions..” Immunity, April 2015. https://doi.org/10.1016/j.immuni.2015.04.006.
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• Teaching & Mentoring
• 

  Recent Courses

  • BIOSTAT 823: Statistical Program for Big Data 2019
  • STA 663L: Statistical Computing and Computation 2019
  • BIOSTAT 703: Introduction to the Practice of Biostatistics I 2017
  • BIOSTAT 821: Software Tools for Data Science 2017
• Scholarly, Clinical, & Service Activities
• 

  Outreach & Engaged Scholarship

  • Bass Connections Faculty Team Member. Data+ Project Lead. 2018  2018
  • Bass Connections Faculty Team Member. Data+. June 2016 - July 2016  2016

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