Overview
Statistical methodology for immunological laboratory techniques (flow cytometry, CFSE analysis, receptor-ligand binding and signaling kinetics)
Informatics of the immune system (reference and application ontologies, meta-programming, text mining and machine learning)
Current Appointments & Affiliations
Professor of Biostatistics & Bioinformatics
·
2022 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Research Professor of Statistical Science
·
2022 - Present
Statistical Science,
Trinity College of Arts & Sciences
Research Professor of Mathematics
·
2025 - Present
Mathematics,
Trinity College of Arts & Sciences
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques.
Journal Article Sci Transl Med · March 12, 2025 Congenital cytomegalovirus (cCMV) is the leading infectious cause of neonatal neurological impairment worldwide, but the viral factors enabling vertical spread across the placenta remain undetermined. The pentameric complex (PC), composed of the subunits g ... Full text Link to item CiteRhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity.
Journal Article Nat Commun · January 31, 2025 Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro, but their role in infection and pathogenesis is unknown. To examine their in vivo function in an animal model evolutionarily ... Full text Link to item CiteCoinfection with HIV-1 skews iNKT cells toward TCR anergy and limited expansion potential in people with hepatitis C.
Journal Article Front Immunol · 2025 INTRODUCTION: Hepatitis C virus (HCV) infection remains a leading cause of morbidity and mortality in people with human immunodeficiency virus (HIV). Liver fibrosis progression is more rapid in people with HIV/HCV coinfection compared to HCV monoinfection ... Full text Link to item CiteRecent Grants
Center for Multiscale Immune Systems Modeling
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030Multiscale Modeling of Influenza Neutralizing Antibody and Fc Effector Biology
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029Immunologic and Virologic Determinants of Congenital Cytomegalovirus Transmission and Disease in Rhesus Monkeys
ResearchPrincipal Investigator · Awarded by Weill Cornell Medicine · 2020 - 2029View All Grants
Education, Training & Certifications
University College London (United Kingdom) ·
2002
Ph.D.
University College London (United Kingdom) ·
1998
M.S.
University of London (United Kingdom) ·
1997
B.S.
National University of Singapore (Singapore) ·
1991
M.B.B.S.