Chi Wei Cliburn Chan | Scholars@Duke

Chi Wei Cliburn Chan
Associate Professor of Biostatistics and Bioinformatics

Computational immunology (stochastic and spatial models and simulations, T cell signaling, immune regulation)
Statistical methodology for immunological laboratory techniques (flow cytometry, CFSE analysis, receptor-ligand binding and signaling kinetics)
Informatics of the immune system (reference and application ontologies, meta-programming, text mining and machine learning)

Current Appointments & Affiliations

Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2014
Associate Research Professor of Statistical Science, Statistical Science, Trinity College of Arts & Sciences 2016

Contact Information

2424 Erwin Road Ste 1102, 11078 Hock Plaza Duke Box 2721, Durham, NC 27705
Duke Box 2721, Durham, NC 27710
cliburn.chan@duke.edu (919) 668-2459

Background
Education, Training, & Certifications
- Ph.D., University College London (United Kingdom) 2002
- M.S., University College London (United Kingdom) 1998
- B.S., University of London (UK) 1997
- M.B.B.S., National University of Singapore 1991
Duke Appointment History
- Associate Professor in the Department of Statistical Science, Statistical Science, Trinity College of Arts & Sciences 2014 - 2016
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2007 - 2014
- Assistant Research Professor in the Department of Statistical Science, Statistical Science, Trinity College of Arts & Sciences 2013 - 2014
- Assistant Research Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2006 - 2007
Research
Selected Grants
- EQAPOL - Years 2017 to 2024 - BASE awarded by National Institutes of Health 2017 - 2024
- Role of cannabis on HIV-related cognitive impairment: a brain connectomics study awarded by National Institutes of Health 2018 - 2023
- Development of a Therapeutic for Brain Tumor Immunotherapy awarded by National Institutes of Health 2018 - 2023
- CXCL10/CXCR3 regulation of ozone-induced epithelial permeability awarded by National Institutes of Health 2017 - 2022
- Consequences of marijuana use on inflammatory pathways in HIV-infected youth awarded by National Institutes of Health 2017 - 2022
- Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2022
- A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation awarded by National Institutes of Health 2016 - 2021
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Adjuvant Discovery Program (Option #2) awarded by National Institutes of Health 2014 - 2019
- VTEU Task D Option 2 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2019
- VTEU Task D Option 3 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2019
- VTEU Task D Option 4 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2019
- Immunological biomarker studies in myasthenia gravis awarded by National Institutes of Health 2014 - 2019
- Reversible Immunomodulation as a Strategy for Ischemia Tolerance in Hibernation awarded by Foundation for Anesthesia Education and Research 2017 - 2019
- A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health 2016 - 2019
- Molecular Atlas of Lung Development - Data Coordinating Center awarded by National Institutes of Health 2014 - 2019
- Role of CD4 T cell subsets as drivers of MG disease awarded by Myasthenia Gravis Foundation 2016 - 2018
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
- Adjuvant Discovery Program (Option #1) awarded by National Institutes of Health 2014 - 2017
- EQAPOL - 2016 to 2017 - Option 6 - FLOW awarded by National Institutes of Health 2010 - 2017
- EQAPOL Option 5 awarded by National Institutes of Health 2010 - 2017
- Innate immune adaptations of hibernation as a new approach to protection against acute organ injury awarded by Society of Cardiovascular Anesthesiologists 2015 - 2017
- Adjuvant Discovery Program awarded by National Institutes of Health 2014 - 2017
- Longitudinal assessment of CMV and BK virus immunity in renal transplant patients awarded by National Institutes of Health 2013 - 2016
- Multiscale Systems Immunology awarded by National Institutes of Health 2010 - 2015
- Novel Cellular Immune Profiles to Predict Lung Disease Outcomes awarded by National Institutes of Health 2011 - 2013
- Immune profiling of multi-parameter flow cytometry using computational statistics awarded by National Institutes of Health 2009 - 2012
- Multiscale Integrative Immunology for Adjuvant Develpmnt awarded by National Institutes of Health 2005 - 2010
- Microsimulation of anthracis-immune system interaction awarded by National Institutes of Health 2004 - 2007
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Gouttefangeas, C, Chan, C, Attig, S, Køllgaard, TT, Rammensee, H-G, Stevanović, S, Wernet, D, thor Straten, P, Welters, MJP, Ottensmeier, C, van der Burg, SH, and Britten, CM. "Data analysis as a source of variability of the HLA-peptide multimer assay: from manual gating to automated recognition of cell clusters." Cancer Immunology, Immunotherapy 64, no. 5 (May 2015): 585-598. Full Text
  - Gouttefangeas, C, Walter, S, Welters, MJP, Ottensmeier, C, Burg, SHVD, Britten, CM, and Chan, C. "Flow cytometry in cancer immunotherapy: Applications, quality assurance, and future." Cancer Immunology: A Translational Medicine Context (2015): 471-490. Full Text
  - Richards, AJ, Staats, J, Enzor, J, McKinnon, K, Frelinger, J, Denny, TN, Weinhold, KJ, and Chan, C. "Setting objective thresholds for rare event detection in flow cytometry." Journal of immunological methods 409 (July 2014): 54-61. Full Text Open Access Copy
  - Staats, JS, Enzor, JH, Sanchez, AM, Rountree, W, Chan, C, Jaimes, M, Chan, RC-F, Gaur, A, Denny, TN, and Weinhold, KJ. "Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays." Journal of immunological methods 409 (July 2014): 44-53. Full Text Open Access Copy
  - Nair, SK, Tomaras, GD, Sales, AP, Boczkowski, D, Chan, C, Plonk, K, Cai, Y, Dannull, J, Kepler, TB, Pruitt, SK, and Weinhold, KJ. "High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes." Scientific reports 4 (April 23, 2014): 4632-. Full Text
  - Richards, AJ, Staats, J, Enzor, J, McKinnon, K, Frelinger, J, Denny, TN, Weinhold, KJ, and Chan, C. "Setting objective thresholds for rare event detection in flow cytometry." Journal of Immunological Methods 409 (January 1, 2014): 54-61. Full Text
  - Staats, JS, Enzor, JH, Sanchez, AM, Rountree, W, Chan, C, Jaimes, M, Chan, RCF, Gaur, A, Denny, TN, and Weinhold, KJ. "Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays." Journal of Immunological Methods 409 (January 1, 2014): 44-53. (Review) Full Text
  - Shetty, G, Beasley, GM, Sparks, S, Barfield, M, Masoud, M, Mosca, PJ, Pruitt, SK, Salama, AKS, Chan, C, Tyler, DS, and Weinhold, KJ. "Plasma cytokine analysis in patients with advanced extremity melanoma undergoing isolated limb infusion." Ann Surg Oncol 20, no. 4 (April 2013): 1128-1135. Full Text Link to Item
  - Aghaeepour, N, Finak, G, Hoos, H, Mosmann, TR, Brinkman, R, Gottardo, R, Scheuermann, RH, Dougall, D, Khodabakhshi, AH, Mah, P, Obermoser, G, Spidlen, J, Taylor, I, Wuensch, SA, Bramson, J, Eaves, C, Weng, AP, Fortuno, ES, Ho, K, Kollmann, TR, Rogers, W, De Rosa, S, Dalai, B, Azad, A, Pothen, A, Brandes, A, Bretschneider, H, Bruggner, R, Finck, R, Jia, R, Zimmerman, N, Linderman, M, Dill, D, Nolan, G, Chan, C, Khettabi, FE, O'Neill, K, Chikina, M, Ge, Y, Sealfon, S, Sugár, I, and Gupta, A et al. "Critical assessment of automated flow cytometry data analysis techniques." Nature Methods 10, no. 3 (March 1, 2013): 228-238. Full Text
  - Chan, C, Billard, M, Ramirez, SA, Schmidl, H, Monson, E, and Kepler, TB. "A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields." Bull Math Biol 75, no. 1 (January 2013): 185-205. Full Text Link to Item
  - Chan, C, Billard, M, Ramirez, SA, Schmidl, H, Monson, E, and Kepler, TB. "A Model for Migratory B Cell Oscillations from Receptor Down-Regulation Induced by External Chemokine Fields." Bulletin of Mathematical Biology 75, no. 1 (2013): 185-205. Full Text
  - Cron, A, Gouttefangeas, C, Frelinger, J, Lin, L, Singh, SK, Britten, CM, Welters, MJP, van der Burg, SH, West, M, and Chan, C. "Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples." PLoS Comput Biol 9, no. 7 (2013): e1003130-. Full Text Link to Item
  - Lin, L, Chan, C, Hadrup, SR, Froesig, TM, Wang, Q, and West, M. "Hierarchical Bayesian mixture modelling for antigen-specific T-cell subtyping in combinatorially encoded flow cytometry studies." STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY 12, no. 3 (2013): 309-331. Full Text Link to Item
  - Snyder, LD, Medinas, R, Chan, C, Sparks, S, Davis, WA, Palmer, SM, and Weinhold, KJ. "Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis." Am J Transplant 11, no. 3 (March 2011): 553-560. Full Text Link to Item
  - Chan, C, Lin, L, Frelinger, J, Hérbert, V, Gagnon, D, Landry, C, Sékaly, R-P, Enzor, J, Staats, J, Weinhold, KJ, Jaimes, M, and West, M. "Optimization of a highly standardized carboxyfluorescein succinimidyl ester flow cytometry panel and gating strategy design using discriminative information measure evaluation." Cytometry A 77, no. 12 (December 2010): 1126-1136. Full Text Link to Item
  - Frelinger, J, Ottinger, J, Gouttefangeas, C, and Chan, C. "Modeling flow cytometry data for cancer vaccine immune monitoring." Cancer Immunology, Immunotherapy 59, no. 9 (2010): 1435-1441. Full Text
  - Manolopoulou, I, Chan, C, and West, M. "Selection sampling from large data sets for targeted inference in mixture modeling." Bayesian Analysis 5, no. 3 (2010): 429-450. Full Text
  - Manolopoulou, I, Chan, C, and West, M. "Rejoinder." Bayesian Analysis 5, no. 3 (2010): 461-464. Full Text
  - Suchard, MA, Wang, Q, Chan, C, Frelinger, J, Cron, A, and West, M. "Understanding GPU programming for statistical computation: Studies in massively parallel massive mixtures." Journal of Computational and Graphical Statistics 19, no. 2 (2010): 419-438. Full Text Open Access Copy
  - Chan, C, Feng, F, Ottinger, J, Foster, D, West, M, and Kepler, TB. "Statistical mixture modeling for cell subtype identification in flow cytometry." Cytometry A 73, no. 8 (August 2008): 693-701. Full Text Link to Item
  - Frelinger, J, Kepler, TB, and Chan, C. "Flow: Statistics, visualization and informatics for flow cytometry. (Published online)" Source Code Biol Med 3 (June 17, 2008): 10-. Full Text Link to Item
  - Mitha, F, Lucas, TA, Feng, F, Kepler, TB, and Chan, C. "The Multiscale Systems Immunology project: software for cell-based immunological simulation. (Published online)" Source Code Biol Med 3 (April 28, 2008): 6-. Full Text Open Access Copy Link to Item
  - Yates, A, Chan, C, Strid, J, Moon, S, Callard, R, George, AJT, and Stark, J. "Reconstruction of cell population dynamics using CFSE. (Published online)" BMC Bioinformatics 8 (June 12, 2007): 196-. Full Text Link to Item
  - Kepler, TB, and Chan, C. "Spatiotemporal programming of a simple inflammatory process." Immunol Rev 216 (April 2007): 153-163. (Review) Full Text Link to Item
  - Stark, J, Chan, C, and George, AJT. "Oscillations in the immune system." Immunol Rev 216 (April 2007): 213-231. (Review) Full Text Link to Item
  - Chan, C, and Kepler, TB. "Computational immunology--from bench to virtual reality." Ann Acad Med Singapore 36, no. 2 (February 2007): 123-127. (Review) Link to Item
  - Chan, C, George, AJT, and Stark, J. "Cytotoxic killing and immune evasion by repair." Journal of Statistical Physics 128, no. 1-2 (2007): 393-411. Full Text
  - Alam, AKMS, Florey, O, Weber, M, Pillai, RG, Chan, C, Tan, PH, Lechler, RI, McClure, MO, Haskard, DO, and George, AJT. "Knockdown of mouse VCAM-1 by vector-based siRNA." Transpl Immunol 16, no. 3-4 (November 2006): 185-193. Full Text Link to Item
  - George, AJT, Stark, J, and Chan, C. "Understanding specificity and sensitivity of T-cell recognition." Trends Immunol 26, no. 12 (December 2005): 653-659. (Review) Full Text Link to Item
  - Tan, PH, Chan, CLH, Chan, C, and George, AJT. "The evolving role of gene-based treatment in surgery." Br J Surg 92, no. 12 (December 2005): 1466-1480. (Review) Full Text Link to Item
  - Tan, PH, Yates, JB, Xue, S-A, Chan, C, Jordan, WJ, Harper, JE, Watson, MP, Dong, R, Ritter, MA, Lechler, RI, Lombardi, G, and George, AJT. "Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression." Blood 106, no. 9 (November 1, 2005): 2936-2943. Full Text Link to Item
  - Tan, PH, Sagoo, P, Chan, C, Yates, JB, Campbell, J, Beutelspacher, SC, Foxwell, BMJ, Lombardi, G, and George, AJT. "Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells." J Immunol 174, no. 12 (June 15, 2005): 7633-7644. Link to Item
  - Chan, C, Stark, J, and George, AJT. "The impact of multiple T cell - APC encounters and the role of anergy." Journal of Computational and Applied Mathematics 184, no. 1 (2005): 101-120. Full Text
  - Yates, AJ, Chan, CCT, and Callard, RE. "16 Modelling T cell activation, proliferation, and homeostasis." Studies in Multidisciplinarity 3, no. C (2005): 281-308. Full Text
  - Chan, C, Stark, J, and George, AJT. "Feedback control of T-cell receptor activation." Proc Biol Sci 271, no. 1542 (May 7, 2004): 931-939. Full Text Link to Item
  - Tan, PH, Chan, C, Xue, SA, Dong, R, Ananthesayanan, B, Manunta, M, Kerouedan, C, Cheshire, NJW, Wolfe, JH, Haskard, DO, Taylor, KM, and George, AJT. "Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells." Atherosclerosis 173, no. 2 (April 2004): 171-183. Full Text Link to Item
  - Chan, C, Lechler, RI, and George, AJT. "Tolerance mechanisms and recent progress." Transplant Proc 36, no. 2 Suppl (March 2004): 561S-569S. (Review) Full Text Link to Item
  - Chan, C, George, AJT, and Stark, J. "T cell sensitivity and specificity - Kinetic proofreading revisited." Discrete and Continuous Dynamical Systems - Series B 3, no. 3 (2003): 343-360.
  - Yates, A, Chan, CC, Callard, RE, George, AJ, and Stark, J. "An approach to modelling in immunology." Brief Bioinform 2, no. 3 (September 2001): 245-257. Link to Item
  - Chan, C, George, AJ, and Stark, J. "Cooperative enhancement of specificity in a lattice of T cell receptors." Proc Natl Acad Sci U S A 98, no. 10 (May 8, 2001): 5758-5763. Full Text Link to Item
  - Chan, CC, Stark, J, and George, AJ. "Analysis of cytokine dynamics in corneal allograft rejection." Proc Biol Sci 266, no. 1434 (November 7, 1999): 2217-2223. Full Text Link to Item
- Other Articles
  - Kvistborg, P, Gouttefangeas, C, Aghaeepour, N, Cazaly, A, Chattopadhyay, PK, Chan, C, Eckl, J, Finak, G, Hadrup, SR, Maecker, HT, Maurer, D, Mosmann, T, Qiu, P, Scheuermann, RH, Welters, MJP, Ferrari, G, Brinkman, RR, and Britten, CM. "Thinking outside the gate: single-cell assessments in multiple dimensions." Immunity 42, no. 4 (April 2015): 591-592. (Letter) Full Text
Teaching & Mentoring
Recent Courses
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Bass Connections Faculty Team Member. Data+. June 2016 - July 2016 2016

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Journal Articles

Other Articles

Recent Courses

Outreach & Engaged Scholarship