Chi Wei Cliburn Chan

Journal article Br J Surg · December 2005 Featured Publication BACKGROUND: The completion of the sequencing of the human genome in 2003 marked the dawn of a new era of human biology and medicine. Although these remarkable scientific advances improve the understanding of human biology, the question remains how this rap ... Full text Link to item Cite

Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.

Journal article Blood · November 1, 2005 Featured Publication Activation of T lymphocytes requires the recognition of peptide-major histocompatibility complexes (MHCs) and costimulatory signals provided by antigen-presenting cells (APCs). It has been shown that T-cell activation without costimulation can lead to aner ... Full text Link to item Cite

Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells.

Journal article J Immunol · June 15, 2005 Featured Publication Dendritic cells (DCs) are central to T cell immunity, and many strategies have been used to manipulate DCs to modify immune responses. We investigated the effects of antioxidants ascorbate (vitamin C) and alpha-tocopherol (vitamin E) on DC phenotype and fu ... Full text Link to item Cite

Feedback control of T-cell receptor activation.

Journal article Proc Biol Sci · May 7, 2004 Featured Publication The specificity and sensitivity of T-cell recognition is vital to the immune response. Ligand engagement with the T-cell receptor (TCR) results in the activation of a complex sequence of signalling events, both on the cell membrane and intracellularly. Fee ... Full text Link to item Cite

Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells.

Journal article Atherosclerosis · April 2004 Featured Publication The vascular endothelial cell (EC) plays an essential role in the pathogenesis of inflammation, transplant rejection and tumour metastasis. Most research on vascular ECs uses human umbilical vein endothelial cells (HUVECs). However, HUVECs are derived from ... Full text Link to item Cite

Tolerance mechanisms and recent progress.

Journal article Transplant Proc · March 2004 Featured Publication There has been tremendous progress in our understanding of the mechanisms mediating allograft tolerance, which have been revealed to be far more complex and regulated than hitherto suspected. New results have enriched our understanding of the relative cont ... Full text Link to item Cite

Cooperative enhancement of specificity in a lattice of T cell receptors.

Journal article Proc Natl Acad Sci U S A · May 8, 2001 Featured Publication Two of the most important models to account for the specificity and sensitivity of the T cell receptor (TCR) are the kinetic proofreading and serial ligation models. However, although kinetic proofreading provides a means for individual TCRs to measure acc ... Full text Link to item Cite